|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for CLK1 |
 Gene summary |
| Basic gene Info. | Gene symbol | CLK1 |
| Gene name | CDC-like kinase 1 | |
| Synonyms | CLK|CLK/STY|STY | |
| Cytomap | UCSC genome browser: 2q33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001162407.1, NM_004071.3,NR_027855.1,NR_027856.1,NM_001024646.1, | |
| Description | CDC28/CDC2-like kinasedual specificity protein kinase CLK1protein tyrosine kinase STY | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601951 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000013441 | ||
| HPRD : 09058 | ||
| Vega : OTTHUMG00000132784 | ||
| Protein | UniProt: P49759 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CLK1 | |
| BioGPS: 1195 | ||
| Pathway | NCI Pathway Interaction Database: CLK1 | |
| KEGG: CLK1 | ||
| REACTOME: CLK1 | ||
| Pathway Commons: CLK1 | ||
| Context | iHOP: CLK1 | |
| ligand binding site mutation search in PubMed: CLK1 | ||
| UCL Cancer Institute: CLK1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
| Top |
| Ligand binding site mutations for CLK1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V225 | R223C | HNSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for CLK1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | V225 | R223C | -0.8890172 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CLK1 from PDB |
| Top |
| Differential gene expression and gene-gene network for CLK1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for CLK1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for CLK1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Gene-centered drug-gene interaction network |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB04367 | Debromohymenialdisine | Small molecule |  |
| Experimental | DB08691 | ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate | Small molecule |  |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of CLK1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | DBQ | DEBROMOHYMENIALDISINE | 1z57 | A | V225 |
| Top |
| Conservation information for LBS of CLK1 |
| Multiple alignments for P49759 in multiple species |
| LBS | AA sequence | # species | Species |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |