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mutLBSgeneDB |
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| Gene summary for CLK2 |
 Gene summary |
| Basic gene Info. | Gene symbol | CLK2 |
| Gene name | CDC-like kinase 2 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 1q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001294338.1, NM_001294339.1,NM_003993.3,NM_001291.2, | |
| Description | CLK kinasedual specificity protein kinase CLK2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602989 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000176444 | ||
| HPRD : 04289 | ||
| Vega : OTTHUMG00000035873 | ||
| Protein | UniProt: P49760 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CLK2 | |
| BioGPS: 1196 | ||
| Pathway | NCI Pathway Interaction Database: CLK2 | |
| KEGG: CLK2 | ||
| REACTOME: CLK2 | ||
| Pathway Commons: CLK2 | ||
| Context | iHOP: CLK2 | |
| ligand binding site mutation search in PubMed: CLK2 | ||
| UCL Cancer Institute: CLK2 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 20682768 | GO:0043484 | regulation of RNA splicing | 9637771 |
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| Ligand binding site mutations for CLK2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E208 | N210S | LUAD | 1 | K193 | I195V | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CLK2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K193 | I195V | -1.7251123 | E208 | N210S | -0.59414338 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CLK2 from PDB |
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| Differential gene expression and gene-gene network for CLK2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CLK2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CLK2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CLK2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NR9 | (5Z)-5-(QUINOLIN-6-YLMETHYLIDENE)-2-[(THIOPHEN-2-YLMETHYL)AMINO]-1,3-THIAZOL-4(5H)-ONE | 3nr9 | C | K193 | NR9 | (5Z)-5-(QUINOLIN-6-YLMETHYLIDENE)-2-[(THIOPHEN-2-YLMETHYL)AMINO]-1,3-THIAZOL-4(5H)-ONE | 3nr9 | A | K193 E208 | NR9 | (5Z)-5-(QUINOLIN-6-YLMETHYLIDENE)-2-[(THIOPHEN-2-YLMETHYL)AMINO]-1,3-THIAZOL-4(5H)-ONE | 3nr9 | B | K193 E208 |
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| Conservation information for LBS of CLK2 |
| Multiple alignments for P49760 in multiple species |
| LBS | AA sequence | # species | Species | A191 | GGARVALKIIK | 1 | Homo sapiens | A191 | KEM-VAVKIVR | 1 | Arabidopsis thaliana | A191 | GGTQVALKIIK | 1 | Mus musculus | D327 | AVRVVDFGSAT | 2 | Homo sapiens, Mus musculus | D327 | AIKVIDFGSTT | 1 | Arabidopsis thaliana | E171 | VSTLGEGTFGR | 2 | Homo sapiens, Mus musculus | E171 | YSKMGEGTFGQ | 1 | Arabidopsis thaliana | E208 | EAARLEINVLE | 2 | Homo sapiens, Mus musculus | E208 | EAAMIEIEMLQ | 1 | Arabidopsis thaliana | E244 | MCISFELLGLS | 2 | Homo sapiens, Mus musculus | E244 | ICIVFEKLGSS | 1 | Arabidopsis thaliana | F174 | LGEGTFGRVVQ | 2 | Homo sapiens, Mus musculus | F174 | MGEGTFGQVLE | 1 | Arabidopsis thaliana | F243 | HMCISFELLGL | 2 | Homo sapiens, Mus musculus | F243 | HICIVFEKLGS | 1 | Arabidopsis thaliana | G172 | STLGEGTFGRV | 2 | Homo sapiens, Mus musculus | G172 | SKMGEGTFGQV | 1 | Arabidopsis thaliana | K193 | ARVALKIIKNV | 1 | Homo sapiens | K193 | M-VAVKIVRGV | 1 | Arabidopsis thaliana | K193 | TQVALKIIKNV | 1 | Mus musculus | L169 | EIVSTLGEGTF | 2 | Homo sapiens, Mus musculus | L169 | KIYSKMGEGTF | 1 | Arabidopsis thaliana | L245 | CISFELLGLST | 2 | Homo sapiens, Mus musculus | L245 | CIVFEKLGSSL | 1 | Arabidopsis thaliana | L246 | ISFELLGLSTF | 2 | Homo sapiens, Mus musculus | L246 | IVFEKLGSSLY | 1 | Arabidopsis thaliana | L297 | KPENILFVNSD | 2 | Homo sapiens, Mus musculus | L297 | KPENILLVSSD | 1 | Arabidopsis thaliana | N295 | DLKPENILFVN | 2 | Homo sapiens, Mus musculus | N295 | DLKPENILLVS | 1 | Arabidopsis thaliana | V177 | GTFGRVVQCVD | 2 | Homo sapiens, Mus musculus | V177 | GTFGQVLECWD | 1 | Arabidopsis thaliana | V326 | TAVRVVDFGSA | 2 | Homo sapiens, Mus musculus | V326 | SAIKVIDFGST | 1 | Arabidopsis thaliana |
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