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mutLBSgeneDB |
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| Gene summary for CLK3 |
 Gene summary |
| Basic gene Info. | Gene symbol | CLK3 |
| Gene name | CDC-like kinase 3 | |
| Synonyms | PHCLK3|PHCLK3/152 | |
| Cytomap | UCSC genome browser: 15q24 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001130028.1, NM_003992.4,NM_001292.1, | |
| Description | dual specificity protein kinase CLK3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602990 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000179335 | ||
| HPRD : 04290 | ||
| Vega : OTTHUMG00000141320 | ||
| Protein | UniProt: P49761 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CLK3 | |
| BioGPS: 1198 | ||
| Pathway | NCI Pathway Interaction Database: CLK3 | |
| KEGG: CLK3 | ||
| REACTOME: CLK3 | ||
| Pathway Commons: CLK3 | ||
| Context | iHOP: CLK3 | |
| ligand binding site mutation search in PubMed: CLK3 | ||
| UCL Cancer Institute: CLK3 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 9637771 | GO:0043484 | regulation of RNA splicing | 9637771 |
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| Ligand binding site mutations for CLK3 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | A467 | E465K | STAD | 1 | G388 | K388T | STAD | 1 | L310 | K309N | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CLK3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CLK3 from PDB |
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| Differential gene expression and gene-gene network for CLK3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CLK3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CLK3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB07664 | 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE | Small molecule |  |
| Experimental | DB08691 | ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CLK3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of CLK3 |
| Multiple alignments for P49761 in multiple species |
| LBS | AA sequence | # species | Species | A332 | GKSQVALKIIR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | A467 | TSIRVADFGSA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D468 | SIRVADFGSAT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E312 | VGNLGEGTFGK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E385 | MCIAFELLGKN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E393 | GKNTFEFLKEN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E435 | TDLKPENILFV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F315 | LGEGTFGKVVE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F384 | HMCIAFELLGK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G311 | IVGNLGEGTFG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G388 | AFELLGKNTFE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K334 | SQVALKIIRNV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K389 | FELLGKNTFEF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L310 | EIVGNLGEGTF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L387 | IAFELLGKNTF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L438 | KPENILFVNSE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N436 | DLKPENILFVN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | V318 | GTFGKVVECLD | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | V368 | NKFLCVLMSDW | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus |
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