mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ALKBH2
Gene summary
Basic gene Info.Gene symbolALKBH2
Gene namealkB, alkylation repair homolog 2 (E. coli)
CytomapUCSC genome browser: 12q24.11
Type of geneprotein-coding
Description2OG-Fe(II) oxy DC1DNA oxidative demethylase ALKBH2alkylated DNA repair protein alkB homolog 2alpha-ketoglutarate-dependent dioxygenase alkB homolog 2oxy DC1
Modification date20141207
dbXrefs MIM : 610602
Ensembl : ENSG00000189046
HPRD : 14712
Vega : OTTHUMG00000169246
ProteinUniProt: Q6NS38
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ALKBH2
BioGPS: 121642
PathwayNCI Pathway Interaction Database: ALKBH2
Pathway Commons: ALKBH2
ContextiHOP: ALKBH2
ligand binding site mutation search in PubMed: ALKBH2
UCL Cancer Institute: ALKBH2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006307DNA dealkylation involved in DNA repair18432238
GO:0035511oxidative DNA demethylation18432238

Ligand binding site mutations for ALKBH2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ALKBH2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ALKBH2 from PDB

Differential gene expression and gene-gene network for ALKBH2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ALKBH2 and the right PPI network was created from samples without mutations in the LBS of ALKBH2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ALKBH2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ALKBH2

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00126Vitamin CSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ALKBH2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3btxAG169
NUCNucleic Acids3btzAG169
NUCNucleic Acids3bu0AG169
NUCNucleic Acids3h8oAG169
NUCNucleic Acids3h8rAG169
NUCNucleic Acids3h8xAG169

Conservation information for LBS of ALKBH2
Multiple alignments for Q6NS38 in multiple species
LBSAA sequence# speciesSpecies
A97FTGALARVQVF2Homo sapiens, Bos taurus
A97FTGALAKVQVF1Mus musculus
D173IGEHRDDEREL3Homo sapiens, Mus musculus, Bos taurus
D174GEHRDDERELA3Homo sapiens, Mus musculus, Bos taurus
E170CDHIGEHRDDE2Homo sapiens, Mus musculus
E170QDHIGEHRDDE1Bos taurus
E175EHRDDERELAP2Homo sapiens, Mus musculus
E175EHRDDERELAL1Bos taurus
F102ARVQVFGKWHS2Homo sapiens, Bos taurus
F102AKVQVFGKWHS1Mus musculus
F124GLTYTFSGLTL3Homo sapiens, Mus musculus, Bos taurus
F195GACRDFVFRHK2Homo sapiens, Bos taurus
F195GACRDFIFRHK1Mus musculus
G103RVQVFGKWHSV2Homo sapiens, Bos taurus
G103KVQVFGKWHSV1Mus musculus
G126TYTFSGLTLSP2Homo sapiens, Bos taurus
G126TYTFSGLTLTP1Mus musculus
G169GCDHIGEHRDD2Homo sapiens, Mus musculus
G169GQDHIGEHRDD1Bos taurus
G204HKDSRGKSPSR1Homo sapiens
G204HKDSRGKRPRR1Mus musculus
G204HKDSRGKHPSR1Bos taurus
H106VFGKWHSVPRK3Homo sapiens, Mus musculus, Bos taurus
H167KDGCDHIGEHR2Homo sapiens, Mus musculus
H167KDGQDHIGEHR1Bos taurus
H171DHIGEHRDDER3Homo sapiens, Mus musculus, Bos taurus
H236NTHWYHSLPVR2Homo sapiens, Bos taurus
H236NTHWYHSLPIR1Mus musculus
I168DGCDHIGEHRD2Homo sapiens, Mus musculus
I168DGQDHIGEHRD1Bos taurus
K104VQVFGKWHSVP3Homo sapiens, Mus musculus, Bos taurus
K205KDSRGKSPSRR1Homo sapiens
K205KDSRGKRPRRT1Mus musculus
K205KDSRGKHPSRR1Bos taurus
K242SLPVRKKVLAP2Homo sapiens, Bos taurus
K242SLPIRKRVLAP1Mus musculus
K243LPVRKKVLAPR2Homo sapiens, Bos taurus
K243LPIRKRVLAPR1Mus musculus
L157TFNFVLINRYK2Homo sapiens, Bos taurus
L157TFNFVLVNRYK1Mus musculus
L178DDERELAPGSP2Homo sapiens, Mus musculus
L178DDERELALGSP1Bos taurus
N159NFVLINRYKDG2Homo sapiens, Bos taurus
N159NFVLVNRYKDG1Mus musculus
N250LAPRVNLTFRK3Homo sapiens, Mus musculus, Bos taurus
P109KWHSVPRKQAT3Homo sapiens, Mus musculus, Bos taurus
Q100ALARVQVFGKW2Homo sapiens, Bos taurus
Q100ALAKVQVFGKW1Mus musculus
R110WHSVPRKQATY3Homo sapiens, Mus musculus, Bos taurus
R172HIGEHRDDERE3Homo sapiens, Mus musculus, Bos taurus
R176HRDDERELAPG2Homo sapiens, Mus musculus
R176HRDDERELALG1Bos taurus
R198RDFVFRHKDSR2Homo sapiens, Bos taurus
R198RDFIFRHKDSR1Mus musculus
R203RHKDSRGKSPS1Homo sapiens
R203RHKDSRGKRPR1Mus musculus
R203RHKDSRGKHPS1Bos taurus
R215RVAVVRLPLAH1Homo sapiens
R215TVEVVRLQLAH1Mus musculus
R215RLEVVRLQLAH1Bos taurus
R241HSLPVRKKVLA2Homo sapiens, Bos taurus
R241HSLPIRKRVLA1Mus musculus
R248KVLAPRVNLTF2Homo sapiens, Bos taurus
R248RVLAPRVNLTF1Mus musculus
R254VNLTFRKILPT2Mus musculus, Bos taurus
R254VNLTFRKILLT1Homo sapiens
R98TGALARVQVFG2Homo sapiens, Bos taurus
R98TGALAKVQVFG1Mus musculus
S125LTYTFSGLTLS2Homo sapiens, Bos taurus
S125LTYTFSGLTLT1Mus musculus
T123AGLTYTFSGLT2Homo sapiens, Mus musculus
T123TGLTYTFSGLT1Bos taurus
T252PRVNLTFRKIL3Homo sapiens, Mus musculus, Bos taurus
V101LARVQVFGKWH2Homo sapiens, Bos taurus
V101LAKVQVFGKWH1Mus musculus
V240YHSLPVRKKVL2Homo sapiens, Bos taurus
V240YHSLPIRKRVL1Mus musculus
V99GALARVQVFGK2Homo sapiens, Bos taurus
V99GALAKVQVFGK1Mus musculus
W105QVFGKWHSVPR3Homo sapiens, Mus musculus, Bos taurus
Y122DAGLTYTFSGL2Homo sapiens, Mus musculus
Y122DTGLTYTFSGL1Bos taurus
Y235TNTHWYHSLPV2Homo sapiens, Bos taurus
Y235TNTHWYHSLPI1Mus musculus

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas