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mutLBSgeneDB |
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| Gene summary for DCUN1D3 |
 Gene summary |
| Basic gene Info. | Gene symbol | DCUN1D3 |
| Gene name | DCN1, defective in cullin neddylation 1, domain containing 3 | |
| Synonyms | 44M2.4 | |
| Cytomap | UCSC genome browser: 16p12.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_173475.2, | |
| Description | DCN1-like protein 3DCUN1 domain-containing protein 3defective in cullin neddylation protein 1-like protein 3 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| HPRD : 14660 | ||
| Protein | UniProt: Q8IWE4 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DCUN1D3 | |
| BioGPS: 123879 | ||
| Pathway | NCI Pathway Interaction Database: DCUN1D3 | |
| KEGG: DCUN1D3 | ||
| REACTOME: DCUN1D3 | ||
| Pathway Commons: DCUN1D3 | ||
| Context | iHOP: DCUN1D3 | |
| ligand binding site mutation search in PubMed: DCUN1D3 | ||
| UCL Cancer Institute: DCUN1D3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0010225 | response to UV-C | 18823379 | GO:0010332 | response to gamma radiation | 18823379 |
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| Ligand binding site mutations for DCUN1D3 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | F189 | Q188R | COAD | 2 | A207 | A205T | COAD | 1 | E112 | R113C | COAD | 1 | F189 | Q188H | COAD | 1 | F189 | Q188K | OV | 1 | E112 | F114V | SKCM | 1 | E194 | D192E | STAD | 1 | L128 | L128M | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for DCUN1D3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E194 | D192E | 0.19713474 | E112 | R113C | -1.405411 | F189 | Q188H | -1.0183424 | E112 | F114V | -0.906503 | F189 | Q188K | -0.88397157 | F189 | Q188R | -0.62643669 | A207 | A205T | -0.56836474 | L128 | L128M | -0.18917153 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DCUN1D3 from PDB |
| PDB ID | PDB title | PDB structure | 4GBA | DCNL complex with N-terminally acetylated NEDD8 E2 peptide |  |
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| Differential gene expression and gene-gene network for DCUN1D3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for DCUN1D3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for DCUN1D3 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of DCUN1D3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (AME,LEU,THR,LEU,ALA,SER,LYS,LEU,LYS) | 4gba | A | E112 L128 F189 E194 A207 | III | Peptide ligand (AME,LEU,THR,LEU,ALA,SER,LYS,LEU,LYS) | 4gba | B | L128 F189 A207 |
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| Conservation information for LBS of DCUN1D3 |
| Multiple alignments for Q8IWE4 in multiple species |
| LBS | AA sequence | # species | Species | A131 | RVLLLAWKFQA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | A131 | RVLVLAWKFQA | 1 | Xenopus tropicalis | A207 | REIAIALWKLV | 5 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | C140 | QAATMCKFTRK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C140 | QAATMCKFTRR | 1 | Xenopus tropicalis | E108 | EDAILEEGMER | 5 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | E112 | LEEGMERFCND | 5 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | E124 | CVDPTEFRVLL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E124 | YVDPTEFRVLV | 1 | Xenopus tropicalis | E194 | FGLDSEEGQRS | 5 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | F142 | ATMCKFTRKEF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F142 | ATMCKFTRREF | 1 | Xenopus tropicalis | F189 | RFTFQFGLDSE | 5 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | L128 | TEFRVLLLAWK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L128 | TEFRVLVLAWK | 1 | Xenopus tropicalis | L208 | EIAIALWKLVF | 5 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | L211 | IALWKLVFTQN | 5 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | M111 | ILEEGMERFCN | 5 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | M139 | FQAATMCKFTR | 5 | Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus | P122 | DLCVDPTEFRV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | P122 | DLYVDPTEFRV | 1 | Xenopus tropicalis | T123 | LCVDPTEFRVL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T123 | LYVDPTEFRVL | 1 | Xenopus tropicalis | V127 | PTEFRVLLLAW | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | V127 | PTEFRVLVLAW | 1 | Xenopus tropicalis |
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