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mutLBSgeneDB |
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| Gene summary for MRPL10 |
 Gene summary |
| Basic gene Info. | Gene symbol | MRPL10 |
| Gene name | mitochondrial ribosomal protein L10 | |
| Synonyms | L10MT|MRP-L10|MRP-L8|MRPL8|RPML8 | |
| Cytomap | UCSC genome browser: 17q21.32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_145255.3, NM_148887.2,NR_037575.1, | |
| Description | 39S ribosomal protein L10, mitochondrial39S ribosomal protein L8, mitochondrialL8mt | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611825 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000159111 | ||
| HPRD : 14738 | ||
| Vega : OTTHUMG00000156302 | ||
| Protein | UniProt: Q7Z7H8 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MRPL10 | |
| BioGPS: 124995 | ||
| Pathway | NCI Pathway Interaction Database: MRPL10 | |
| KEGG: MRPL10 | ||
| REACTOME: MRPL10 | ||
| Pathway Commons: MRPL10 | ||
| Context | iHOP: MRPL10 | |
| ligand binding site mutation search in PubMed: MRPL10 | ||
| UCL Cancer Institute: MRPL10 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for MRPL10 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | F126 | F126L | COAD | 1 | F126 | F126Y | COAD | 1 | K109 | E107D | LUAD | 1 | F126 | F126L | OV | 1 | R113,K109 | L111F | SKCM | 1 | K46 | L47R | UCEC | 1 | H41 | H41Y | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MRPL10 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K109 | E107D | -1.547775 | K46 | L47R | -1.1826735 | R113 | L111F | -1.1029654 | K109 | L111F | -1.1029654 | F126 | F126Y | -0.89681511 | F126 | F126L | -0.43314361 | H41 | H41Y | -0.25071427 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MRPL10 from PDB |
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| Differential gene expression and gene-gene network for MRPL10 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MRPL10 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MRPL10 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MRPL10 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3j7y | I | H41 K46 K109 R113 F126 |
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| Conservation information for LBS of MRPL10 |
| Multiple alignments for Q7Z7H8 in multiple species |
| LBS | AA sequence | # species | Species | F126 | ILMKVFPNQVL | 1 | Homo sapiens | F126 | LHLKSYGSKII | 1 | Drosophila melanogaster | F126 | INVKFFPNQVT | 1 | Danio rerio | F126 | IFIKVFPSQVL | 1 | Mus musculus | F126 | ILMKVFPNQIL | 1 | Bos taurus | F42 | RRVMHFQRQKL | 1 | Homo sapiens | F42 | PKAPHYERARV | 1 | Drosophila melanogaster | F42 | KKPVHFQKQKL | 1 | Danio rerio | F42 | WRVMHFQRQKL | 1 | Mus musculus | F42 | RRVMHFERQKL | 1 | Bos taurus | G149 | LPLFVGHNLLL | 2 | Mus musculus, Bos taurus | G149 | LPLFVGHNMLL | 1 | Homo sapiens | G149 | VPLFHSNHCIV | 1 | Drosophila melanogaster | G149 | SPLIFGETVLL | 1 | Danio rerio | H150 | PLFVGHNLLLV | 2 | Mus musculus, Bos taurus | H150 | PLFVGHNMLLV | 1 | Homo sapiens | H150 | PLFHSNHCIVF | 1 | Drosophila melanogaster | H150 | PLIFGETVLLA | 1 | Danio rerio | H41 | HRRVMHFQRQK | 1 | Homo sapiens | H41 | RPKAPHYERAR | 1 | Drosophila melanogaster | H41 | HKKPVHFQKQK | 1 | Danio rerio | H41 | HWRVMHFQRQK | 1 | Mus musculus | H41 | HRRVMHFERQK | 1 | Bos taurus | K109 | LSAEDKLLMRH | 1 | Homo sapiens | K109 | ITADDIFRVRV | 1 | Drosophila melanogaster | K109 | ISAEDMIHLKH | 1 | Danio rerio | K109 | LSAEDKLLLRH | 1 | Mus musculus | K109 | MSAEDKLLMRH | 1 | Bos taurus | K124 | HKILMKVFPNQ | 2 | Homo sapiens, Bos taurus | K124 | QNLHLKSYGSK | 1 | Drosophila melanogaster | K124 | HAINVKFFPNQ | 1 | Danio rerio | K124 | HKIFIKVFPSQ | 1 | Mus musculus | K31 | VRHGSKAVTRH | 2 | Danio rerio, Mus musculus | K31 | VRYGSKAVTRH | 1 | Homo sapiens | K31 | LRFRGKINIQR | 1 | Drosophila melanogaster | K31 | IRYGSKAVTRH | 1 | Bos taurus | K46 | HFQRQKLMAVT | 1 | Homo sapiens | K46 | HYERARVVAVT | 1 | Drosophila melanogaster | K46 | HFQKQKLLAVT | 1 | Danio rerio | K46 | HFQRQKLMAIT | 1 | Mus musculus | K46 | HFERQKLMAVT | 1 | Bos taurus | N128 | MKVFPNQVLKP | 1 | Homo sapiens | N128 | LKSYGSKIIEQ | 1 | Drosophila melanogaster | N128 | VKFFPNQVTRS | 1 | Danio rerio | N128 | IKVFPSQVLKP | 1 | Mus musculus | N128 | MKVFPNQILKP | 1 | Bos taurus | P127 | LMKVFPNQVLK | 1 | Homo sapiens | P127 | HLKSYGSKIIE | 1 | Drosophila melanogaster | P127 | NVKFFPNQVTR | 1 | Danio rerio | P127 | FIKVFPSQVLK | 1 | Mus musculus | P127 | LMKVFPNQILK | 1 | Bos taurus | Q43 | RVMHFQRQKLM | 2 | Homo sapiens, Mus musculus | Q43 | KAPHYERARVV | 1 | Drosophila melanogaster | Q43 | KPVHFQKQKLL | 1 | Danio rerio | Q43 | RVMHFERQKLM | 1 | Bos taurus | R113 | DKLLMRHQLRK | 2 | Homo sapiens, Bos taurus | R113 | DIFRVRVQLHK | 1 | Drosophila melanogaster | R113 | DMIHLKHRLKK | 1 | Danio rerio | R113 | DKLLLRHQLRK | 1 | Mus musculus | R35 | SKAVTRHRRVM | 2 | Homo sapiens, Bos taurus | R35 | GKINIQRPKAP | 1 | Drosophila melanogaster | R35 | SKAVTRHKKPV | 1 | Danio rerio | R35 | SKAVTRHWRVM | 1 | Mus musculus | R38 | VTRHRRVMHFQ | 1 | Homo sapiens | R38 | NIQRPKAPHYE | 1 | Drosophila melanogaster | R38 | VTRHKKPVHFQ | 1 | Danio rerio | R38 | VTRHWRVMHFQ | 1 | Mus musculus | R38 | VTRHRRVMHFE | 1 | Bos taurus | S30 | TVRYGSKAVTR | 1 | Homo sapiens | S30 | FLRFRGKINIQ | 1 | Drosophila melanogaster | S30 | SVRHGSKAVTR | 1 | Danio rerio | S30 | TVRHGSKAVTR | 1 | Mus musculus | S30 | FIRYGSKAVTR | 1 | Bos taurus | T34 | GSKAVTRHRRV | 2 | Homo sapiens, Bos taurus | T34 | RGKINIQRPKA | 1 | Drosophila melanogaster | T34 | GSKAVTRHKKP | 1 | Danio rerio | T34 | GSKAVTRHWRV | 1 | Mus musculus | V125 | KILMKVFPNQV | 1 | Homo sapiens | V125 | NLHLKSYGSKI | 1 | Drosophila melanogaster | V125 | AINVKFFPNQV | 1 | Danio rerio | V125 | KIFIKVFPSQV | 1 | Mus musculus | V125 | KILMKVFPNQI | 1 | Bos taurus | V33 | YGSKAVTRHRR | 2 | Homo sapiens, Bos taurus | V33 | FRGKINIQRPK | 1 | Drosophila melanogaster | V33 | HGSKAVTRHKK | 1 | Danio rerio | V33 | HGSKAVTRHWR | 1 | Mus musculus |
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