mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for OSCAR
Gene summary
Basic gene Info.Gene symbolOSCAR
Gene nameosteoclast associated, immunoglobulin-like receptor
SynonymsPIGR3|PIgR-3
CytomapUCSC genome browser: 19q13.42
Type of geneprotein-coding
RefGenesNM_001282349.1,
NM_001282350.1,NM_130771.4,NM_133168.4,NM_133169.4,
NM_206818.2,NM_206817.1,
Descriptionosteoclast associated receptor OSCAR-S1osteoclast associated receptor OSCAR-S2osteoclast-associated immunoglobulin-like receptorpoly-Ig receptor 3polymeric immunoglobulin receptor 3
Modification date20141207
dbXrefs MIM : 606862
HGNC : HGNC
Ensembl : ENSG00000170909
HPRD : 06035
Vega : OTTHUMG00000064966
ProteinUniProt: Q8IYS5
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_OSCAR
BioGPS: 126014
PathwayNCI Pathway Interaction Database: OSCAR
KEGG: OSCAR
REACTOME: OSCAR
Pathway Commons: OSCAR
ContextiHOP: OSCAR
ligand binding site mutation search in PubMed: OSCAR
UCL Cancer Institute: OSCAR
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for OSCAR
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
T50L51FHNSC1
V78V78LLUAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for OSCAR
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
T50L51F-1.3257006
V78V78L-0.65175103
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for OSCAR from PDB

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Differential gene expression and gene-gene network for OSCAR
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of OSCAR and the right PPI network was created from samples without mutations in the LBS of OSCAR. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for OSCAR
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for OSCAR
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of OSCAR go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of OSCAR
Multiple alignments for Q8IYS5 in multiple species
LBSAA sequence# speciesSpecies


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