mutLBSgeneDB |
Gene summary for OSCAR |
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Basic gene Info. | Gene symbol | OSCAR |
Gene name | osteoclast associated, immunoglobulin-like receptor | |
Synonyms | PIGR3|PIgR-3 | |
Cytomap | UCSC genome browser: 19q13.42 | |
Type of gene | protein-coding | |
RefGenes | NM_001282349.1, NM_001282350.1,NM_130771.4,NM_133168.4,NM_133169.4, NM_206818.2,NM_206817.1, | |
Description | osteoclast associated receptor OSCAR-S1osteoclast associated receptor OSCAR-S2osteoclast-associated immunoglobulin-like receptorpoly-Ig receptor 3polymeric immunoglobulin receptor 3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 606862 | |
HGNC : HGNC | ||
Ensembl : ENSG00000170909 | ||
HPRD : 06035 | ||
Vega : OTTHUMG00000064966 | ||
Protein | UniProt: Q8IYS5 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OSCAR | |
BioGPS: 126014 | ||
Pathway | NCI Pathway Interaction Database: OSCAR | |
KEGG: OSCAR | ||
REACTOME: OSCAR | ||
Pathway Commons: OSCAR | ||
Context | iHOP: OSCAR | |
ligand binding site mutation search in PubMed: OSCAR | ||
UCL Cancer Institute: OSCAR | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for OSCAR |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | T50 | L51F | HNSC | 1 | V78 | V78L | LUAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for OSCAR |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | T50 | L51F | -1.3257006 | V78 | V78L | -0.65175103 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for OSCAR |
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Phenotype information for OSCAR |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for OSCAR |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of OSCAR |
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LBS | AA sequence | # species | Species |
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