mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CNP
Gene summary
Basic gene Info.Gene symbolCNP
Gene name2',3'-cyclic nucleotide 3' phosphodiesterase
CytomapUCSC genome browser: 17q21
Type of geneprotein-coding
Description2', 3' cyclic nucleotide 3' phosphohydrolase2',3'-cyclic-nucleotide 3'-phosphodiesteraseCNPase
Modification date20141207
dbXrefs MIM : 123830
Ensembl : ENSG00000173786
HPRD : 00448
Vega : OTTHUMG00000133502
ProteinUniProt: P09543
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CNP
BioGPS: 1267
PathwayNCI Pathway Interaction Database: CNP
Pathway Commons: CNP
ContextiHOP: CNP
ligand binding site mutation search in PubMed: CNP
UCL Cancer Institute: CNP
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for CNP

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for CNP
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CNP from PDB

Differential gene expression and gene-gene network for CNP
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CNP and the right PPI network was created from samples without mutations in the LBS of CNP. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for CNP
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for CNP
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CNP go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of CNP
Multiple alignments for P09543 in multiple species
LBSAA sequence# speciesSpecies
A341AADVQPVQTGL2Mus musculus, Rattus norvegicus
A341AADVEAVQTGL1Homo sapiens
A341AGDVEAVQTGI1Bos taurus
H251PPGVLHCTTKF4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H330RGSRAHITLGC2Homo sapiens, Bos taurus
H330PGSRAHVTLGC2Mus musculus, Rattus norvegicus
T253GVLHCTTKFCD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T332SRAHVTLGCAA2Mus musculus, Rattus norvegicus
T332SRAHITLGCAA1Homo sapiens
T332SRAHITLGCAG1Bos taurus

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