mutLBSgeneDB |
Gene summary for CNP |
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Basic gene Info. | Gene symbol | CNP |
Gene name | 2',3'-cyclic nucleotide 3' phosphodiesterase | |
Synonyms | CNP1 | |
Cytomap | UCSC genome browser: 17q21 | |
Type of gene | protein-coding | |
RefGenes | NM_033133.4, | |
Description | 2', 3' cyclic nucleotide 3' phosphohydrolase2',3'-cyclic-nucleotide 3'-phosphodiesteraseCNPase | |
Modification date | 20141207 | |
dbXrefs | MIM : 123830 | |
HGNC : HGNC | ||
Ensembl : ENSG00000173786 | ||
HPRD : 00448 | ||
Vega : OTTHUMG00000133502 | ||
Protein | UniProt: P09543 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CNP | |
BioGPS: 1267 | ||
Pathway | NCI Pathway Interaction Database: CNP | |
KEGG: CNP | ||
REACTOME: CNP | ||
Pathway Commons: CNP | ||
Context | iHOP: CNP | |
ligand binding site mutation search in PubMed: CNP | ||
UCL Cancer Institute: CNP | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CNP |
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LBS | AAchange of nsSNV | Cancer type | # samples | T332 | G334S | HNSC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CNP |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | T332 | G334S | -0.72961185 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for CNP |
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Phenotype information for CNP |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CNP |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of CNP |
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LBS | AA sequence | # species | Species | A341 | AADVQPVQTGL | 2 | Mus musculus, Rattus norvegicus | A341 | AADVEAVQTGL | 1 | Homo sapiens | A341 | AGDVEAVQTGI | 1 | Bos taurus | H251 | PPGVLHCTTKF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | H330 | RGSRAHITLGC | 2 | Homo sapiens, Bos taurus | H330 | PGSRAHVTLGC | 2 | Mus musculus, Rattus norvegicus | T253 | GVLHCTTKFCD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | T332 | SRAHVTLGCAA | 2 | Mus musculus, Rattus norvegicus | T332 | SRAHITLGCAA | 1 | Homo sapiens | T332 | SRAHITLGCAG | 1 | Bos taurus |
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