mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ADH4
Gene summary
Basic gene Info.Gene symbolADH4
Gene namealcohol dehydrogenase 4 (class II), pi polypeptide
CytomapUCSC genome browser: 4q22
Type of geneprotein-coding
Descriptionalcohol dehydrogenase 4alcohol dehydrogenase class II pi chainaldehyde reductaseepididymis secretory protein Li 4
Modification date20141207
dbXrefs MIM : 103740
Ensembl : ENSG00000198099
HPRD : 00068
Vega : OTTHUMG00000161227
ProteinUniProt: P08319
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ADH4
BioGPS: 127
PathwayNCI Pathway Interaction Database: ADH4
Pathway Commons: ADH4
ContextiHOP: ADH4
ligand binding site mutation search in PubMed: ADH4
UCL Cancer Institute: ADH4
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0001523retinoid metabolic process15369820
GO:0006066alcohol metabolic process3466164
GO:0006069ethanol oxidation16787387
GO:0006081cellular aldehyde metabolic process3466164
GO:0042572retinol metabolic process16787387

Ligand binding site mutations for ADH4
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ADH4
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ADH4 from PDB

Differential gene expression and gene-gene network for ADH4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ADH4 and the right PPI network was created from samples without mutations in the LBS of ADH4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ADH4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0023893Liver Cirrhosis, Experimental1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ADH4

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
NutraceuticalDB00157NADHSmall molecule
ExperimentalDB03559CyclohexylformamideSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ADH4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NADNAD ZWITTERION3cosAV209 D229 K234 A275 F324
NADNAD ZWITTERION3cosBV209 D229 K234 A275 F324
NADNAD ZWITTERION3cosCV209 D229 K234 A275 F324
NADNAD ZWITTERION3cosDV209 D229 K234 A275 F324

Conservation information for LBS of ADH4
Multiple alignments for P08319 in multiple species
LBSAA sequence# speciesSpecies
A275FALDCAGGSET1Homo sapiens
A275RSVECTGSVQA1Arabidopsis thaliana
A275RSVECTGNINA1Oryza sativa subsp. japonica
A275RAVECTGNINA1Oryza sativa subsp. japonica
A275YSLDCAGTAQT1Mus musculus
C102PLCRKCKFCLS1Homo sapiens
C102GECGECRHCHS1Arabidopsis thaliana
C102GECKECAHCKS1Oryza sativa subsp. japonica
C102GECKECDHCKS1Oryza sativa subsp. japonica
C102PQCKRCKLCLS1Mus musculus
C105RKCKFCLSPLT1Homo sapiens
C105GECRHCHSEES1Arabidopsis thaliana
C105KECAHCKSAES1Oryza sativa subsp. japonica
C105KECDHCKSEES1Oryza sativa subsp. japonica
C105KRCKLCLSPLT1Mus musculus
C113EESNMCDLLR-2Arabidopsis thaliana, Oryza sativa subsp. japonica
C113PLTNLCGKISN1Homo sapiens
C113AESNMCDLLR-1Oryza sativa subsp. japonica
C113PLTNLCGKLRN1Mus musculus
C180VCLLGCGFSTG1Homo sapiens
C180VCIVSCGLSTG1Arabidopsis thaliana
C180VCVLSCGISTG1Oryza sativa subsp. japonica
C180VCILSCGFSTG1Oryza sativa subsp. japonica
C180VCLIGCGFSSG1Mus musculus
C274DFALDCAGGSE1Homo sapiens
C274DRSVECTGSVQ1Arabidopsis thaliana
C274DRSVECTGNIN1Oryza sativa subsp. japonica
C274DRAVECTGNIN1Oryza sativa subsp. japonica
C274DYSLDCAGTAQ1Mus musculus
C47LFTSLCHTDVY2Arabidopsis thaliana, Oryza sativa subsp. japonica
C47IATSLCHTDAT1Homo sapiens
C47LYTALCHTDVY1Oryza sativa subsp. japonica
C47IATCVCPTDIN1Mus musculus
C99LYAPLCRKCKF1Homo sapiens
C99IFTGECGECRH1Arabidopsis thaliana
C99VFTGECKECAH1Oryza sativa subsp. japonica
C99VFTGECKECDH1Oryza sativa subsp. japonica
C99FFAPQCKRCKL1Mus musculus
D229RIIGIDINSEK1Homo sapiens
D229RIIGVDFNSKR1Arabidopsis thaliana
D229RIIGIDLNANR1Oryza sativa subsp. japonica
D229RIIGVDLNPAK1Oryza sativa subsp. japonica
D229RIIAIDINGEK1Mus musculus
F324TLKGTFFGNYK3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
F324TINGTFFGGWK1Homo sapiens
F324SINGTFFGGWK1Mus musculus
F325LKGTFFGNYKP3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
F325INGTFFGGWKS2Homo sapiens, Mus musculus
G205TVAIFGLGAVG2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
G205TCAVFGLGGVG1Homo sapiens
G205SVAIFGLGAVG1Arabidopsis thaliana
G205TCAVFGLGCVG1Mus musculus
G207AIFGLGAVGLA2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
G207AVFGLGGVGLS1Homo sapiens
G207AIFGLGAVGLG1Arabidopsis thaliana
G207AVFGLGCVGLS1Mus musculus
G208IFGLGAVGLAA2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
G208VFGLGGVGLSA1Homo sapiens
G208IFGLGAVGLGA1Arabidopsis thaliana
G208VFGLGCVGLSA1Mus musculus
G299SCTFIGVAAGS1Homo sapiens
G299VAVLVGVPSKD1Arabidopsis thaliana
G299VAVLVGVPHKD1Oryza sativa subsp. japonica
G299VAVLVGVPTKD1Oryza sativa subsp. japonica
G299SCTVVG--AKV1Mus musculus
H48FTSLCHTDVYF2Arabidopsis thaliana, Oryza sativa subsp. japonica
H48ATSLCHTDATV1Homo sapiens
H48YTALCHTDVYF1Oryza sativa subsp. japonica
H48ATCVCPTDINA1Mus musculus
H69PRIFGHEAGGI2Arabidopsis thaliana, Oryza sativa subsp. japonica
H69PVIVGHEAAGI1Homo sapiens
H69PRILGHEAGGI1Oryza sativa subsp. japonica
H69PVVLGHECAGI1Mus musculus
I230IIGIDINSEKF1Homo sapiens
I230IIGVDFNSKRF1Arabidopsis thaliana
I230IIGIDLNANRF1Oryza sativa subsp. japonica
I230IIGVDLNPAKF1Oryza sativa subsp. japonica
I230IIAIDINGEKF1Mus musculus
I298GSCTFIGVAAG1Homo sapiens
I298GVAVLVGVPSK1Arabidopsis thaliana
I298GVAVLVGVPHK1Oryza sativa subsp. japonica
I298GVAVLVGVPTK1Oryza sativa subsp. japonica
I298GSCTVVG--AK1Mus musculus
K234DINSEKFVKAK1Homo sapiens
K234DFNSKRFDQAK1Arabidopsis thaliana
K234DLNANRFEEAR1Oryza sativa subsp. japonica
K234DLNPAKFEQAK1Oryza sativa subsp. japonica
K234DINGEKFPKAK1Mus musculus
R375QGKSVRTILIF1Homo sapiens
R375KGESIRCIITM1Arabidopsis thaliana
R375KGEGIRCIIRM1Oryza sativa subsp. japonica
R375KGESLRCVMRM1Oryza sativa subsp. japonica
R375EGKSIRTILTF1Mus musculus
T184GCGFSTGYGAA1Homo sapiens
T184SCGLSTGLGAT1Arabidopsis thaliana
T184SCGISTGLGAT1Oryza sativa subsp. japonica
T184SCGFSTGFGAT1Oryza sativa subsp. japonica
T184GCGFSSGYGAA1Mus musculus
T280AGGSETMKAAL1Homo sapiens
T280TGSVQAMIQAF1Arabidopsis thaliana
T280TGNINAMIQAF1Oryza sativa subsp. japonica
T280TGNINAMISCF1Oryza sativa subsp. japonica
T280AGTAQTLKAAV1Mus musculus
T323RTLKGTFFGNY2Arabidopsis thaliana, Oryza sativa subsp. japonica
T323RTINGTFFGGW1Homo sapiens
T323KTLKGTFFGNY1Oryza sativa subsp. japonica
T323RSINGTFFGGW1Mus musculus
T49TSLCHTDVYFW2Arabidopsis thaliana, Oryza sativa subsp. japonica
T49TSLCHTDATVI1Homo sapiens
T49TALCHTDVYFW1Oryza sativa subsp. japonica
T49TCVCPTDINAT1Mus musculus
V209FGLGGVGLSAV1Homo sapiens
V209FGLGAVGLGAA1Arabidopsis thaliana
V209FGLGAVGLAAA1Oryza sativa subsp. japonica
V209FGLGAVGLAAM1Oryza sativa subsp. japonica
V209FGLGCVGLSAI1Mus musculus
V300CTFIGVAAGSK1Homo sapiens
V300AVLVGVPSKDD1Arabidopsis thaliana
V300AVLVGVPHKDA1Oryza sativa subsp. japonica
V300AVLVGVPTKDD1Oryza sativa subsp. japonica
V300CTVVG--AKVD1Mus musculus

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