|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for ZFAND2B |
 Gene summary |
| Basic gene Info. | Gene symbol | ZFAND2B |
| Gene name | zinc finger, AN1-type domain 2B | |
| Synonyms | AIRAPL | |
| Cytomap | UCSC genome browser: 2q35 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001270998.1, NM_001270999.1,NM_138802.2, | |
| Description | AIRAP-like proteinAN1-type zinc finger protein 2Barsenite-inducible RNA-associated protein-like protein | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 613474 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000158552 | ||
| HPRD : 11234 | ||
| Vega : OTTHUMG00000133135 | ||
| Protein | UniProt: Q8WV99 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZFAND2B | |
| BioGPS: 130617 | ||
| Pathway | NCI Pathway Interaction Database: ZFAND2B | |
| KEGG: ZFAND2B | ||
| REACTOME: ZFAND2B | ||
| Pathway Commons: ZFAND2B | ||
| Context | iHOP: ZFAND2B | |
| ligand binding site mutation search in PubMed: ZFAND2B | ||
| UCL Cancer Institute: ZFAND2B | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
| Top |
| Ligand binding site mutations for ZFAND2B |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C118 | S119I | UCEC | 1 | C100 | N98S | UCEC | 1 | C118 | R120G | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for ZFAND2B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | C118 | R120G | -0.93275894 | C100 | N98S | -0.68137132 | C118 | S119I | -0.27457734 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ZFAND2B from PDB |
| Top |
| Differential gene expression and gene-gene network for ZFAND2B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for ZFAND2B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for ZFAND2B |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of ZFAND2B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
| Top |
| Conservation information for LBS of ZFAND2B |
| Multiple alignments for Q8WV99 in multiple species |
| LBS | AA sequence | # species | Species | C100 | IFTNKCERSGC | 2 | Mus musculus, Rattus norvegicus | C100 | IFTNKCERAGC | 1 | Homo sapiens | C105 | CERSGCRQREM | 2 | Mus musculus, Rattus norvegicus | C105 | CERAGCRQREM | 1 | Homo sapiens | C115 | MMKLTCDRCGR | 2 | Mus musculus, Rattus norvegicus | C115 | MMKLTCERCSR | 1 | Homo sapiens | C118 | LTCDRCGRNFC | 2 | Mus musculus, Rattus norvegicus | C118 | LTCERCSRNFC | 1 | Homo sapiens | C123 | CGRNFCIKHRH | 2 | Mus musculus, Rattus norvegicus | C123 | CSRNFCIKHRH | 1 | Homo sapiens | C134 | PLDHDCSGEGH | 2 | Homo sapiens, Rattus norvegicus | C134 | PLDHECSGEGH | 1 | Mus musculus | H126 | NFCIKHRHPLD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H132 | RHPLDHDCSGE | 2 | Homo sapiens, Rattus norvegicus | H132 | RHPLDHECSGE | 1 | Mus musculus |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |