mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for COMT
Gene summary
Basic gene Info.Gene symbolCOMT
Gene namecatechol-O-methyltransferase
CytomapUCSC genome browser: 22q11.21
Type of geneprotein-coding
Descriptioncatechol O-methyltransferaseepididymis secretory sperm binding protein Li 98n
Modification date20141222
dbXrefs MIM : 116790
Ensembl : ENSG00000093010
HPRD : 00284
Vega : OTTHUMG00000150529
ProteinUniProt: P21964
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_COMT
BioGPS: 1312
PathwayNCI Pathway Interaction Database: COMT
Pathway Commons: COMT
ContextiHOP: COMT
ligand binding site mutation search in PubMed: COMT
UCL Cancer Institute: COMT
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for COMT
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for COMT
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for COMT from PDB

Differential gene expression and gene-gene network for COMT
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of COMT and the right PPI network was created from samples without mutations in the LBS of COMT. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for COMT
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0036341Schizophrenia268AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C1263846Attention Deficit Disorder with Hyperactivity60Biomarker, GeneticVariation
umls:C0005586Bipolar Disorder48Biomarker, GeneticVariation, PostTranslationalModification
umls:C0004936Mental Disorders36Biomarker, GeneticVariation
umls:C0001973Alcoholism27Biomarker, GeneticVariation
umls:C0030193Pain26Biomarker, GeneticVariation
umls:C0012236DiGeorge Syndrome25Biomarker, GeneticVariation
umls:C0030319Panic Disorder22AlteredExpression, Biomarker, GeneticVariation
umls:C1458155Breast Neoplasms11AlteredExpression, Biomarker, GeneticVariation
umls:C0004352Autistic Disorder5Biomarker, GeneticVariation
umls:C0236733Amphetamine-Related Disorders2Biomarker, GeneticVariation
umls:C0015934Fetal Growth Retardation2Biomarker, GeneticVariation
umls:C0024667Mammary Neoplasms, Animal2Biomarker, GeneticVariation
umls:C2239176Carcinoma, Hepatocellular2Biomarker
umls:C0236736Cocaine-Related Disorders1Biomarker, GeneticVariation
umls:C0009241Cognition Disorders1Biomarker
umls:C0033578Prostatic Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for COMT
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00118S-AdenosylmethionineSmall molecule
Approved|withdrawnDB00323TolcaponeSmall molecule
Approved|investigationalDB00494EntacaponeSmall molecule
ExperimentalDB021053,5-DinitrocatecholSmall molecule
InvestigationalDB023422-MethoxyestradiolSmall molecule
ExperimentalDB03336BIASmall molecule
ExperimentalDB03907N-{3-[5-(6-Amino-Purin-9-Yl)-3,4-Dihydroxy-Tetrahydro-Furan-2-Yl]-Allyl}-2,3-Dihydroxy-5-Nitro-BenzamideSmall molecule
WithdrawnDB04820NialamideSmall molecule
ExperimentalDB07462(3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONESmall molecule
ExperimentalDB080497,8-dihydroxy-4-phenyl-2H-chromen-2-oneSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of COMT go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of COMT
Multiple alignments for P21964 in multiple species
LBSAA sequence# speciesSpecies
A117LLELGAYCGYS2Homo sapiens, Bos taurus
A117VLELGAYCGYS2Mus musculus, Rattus norvegicus
A117MIELGGYVGYS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A117MVELGGYLGYS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A168TLVVGASQDII1Homo sapiens
A168TVVLGASQDII1Bos taurus
A168SILIGASQDLI1Mus musculus
A168TILNGASQDLI1Rattus norvegicus
A168TIIVGKATDSL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A168TIMIGKACDSL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C145EINPDCAAITQ1Homo sapiens
C145EFNPDYAAITQ1Bos taurus
C145EINPDYAAITQ1Mus musculus
C145EMNPDYAAITQ1Rattus norvegicus
C145EVNPKFAKIAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C145EVNEDYAKIAY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C223ADNVIVPGTPD2Mus musculus, Rattus norvegicus
C223ADNVICPGAPD1Homo sapiens
C223ADNVIYPGAPD1Bos taurus
C223ADNILRPGVPE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C223ADNIITPGAPE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D191DMVFLDHWKDR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D191DFVFIDHWKDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D191DMVFIDHWKDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D195LDHWKDRYLPD4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D195IDHWKDLYVPD2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D219TVLLADNVIVP2Mus musculus, Rattus norvegicus
D219TVLLADNVICP1Homo sapiens
D219TVLLADNVIYP1Bos taurus
D219SIIAADNILRP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D219TLLVADNIITP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E114PSVLLELGAYC2Homo sapiens, Bos taurus
E114PSLVLELGAYC2Mus musculus, Rattus norvegicus
E114PKVMIELGGYV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E114PKIMVELGGYL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E140RLITIEINPDC1Homo sapiens
E140RLLTIEFNPDY1Bos taurus
E140RLLTMEINPDY1Mus musculus
E140RLLTMEMNPDY1Rattus norvegicus
E140HYYSLEVNPKF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E140RYYSLEVNEDY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E249---YLEYMKVV2Mus musculus, Rattus norvegicus
E249---FLEYREVV1Homo sapiens
E249---YLEYSKVV1Bos taurus
E249GPQFIGKWNII1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E249GFDFIGRWDLI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E252YLEYMKVVDGL2Mus musculus, Rattus norvegicus
E252FLEYREVVDGL1Homo sapiens
E252YLEYSKVVDGL1Bos taurus
E252FIGKWNIIYKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E252FIGRWDLIYKT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G116VLLELGAYCGY2Homo sapiens, Bos taurus
G116LVLELGAYCGY2Mus musculus, Rattus norvegicus
G116VMIELGGYVGY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G116IMVELGGYLGY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G167VTLVVGASQDI1Homo sapiens
G167VTVVLGASQDI1Bos taurus
G167VSILIGASQDL1Mus musculus
G167VTILNGASQDL1Rattus norvegicus
G167VTIIVGKATDS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G167VTIMIGKACDS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H192MVFLDHWKDRY4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H192FVFIDHWKDLY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H192MVFIDHWKDLY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I139ARLITIEINPD1Homo sapiens
I139ARLLTIEFNPD1Bos taurus
I139ARLLTMEINPD1Mus musculus
I139ARLLTMEMNPD1Rattus norvegicus
I139AHYYSLEVNPK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I139GRYYSLEVNED1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I141LITIEINPDCA1Homo sapiens
I141LLTIEFNPDYA1Bos taurus
I141LLTMEINPDYA1Mus musculus
I141LLTMEMNPDYA1Rattus norvegicus
I141YYSLEVNPKFA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I141YYSLEVNEDYA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K194FLDHWKDRYLP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K194FIDHWKDLYVP2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L248----YLEYMKV2Mus musculus, Rattus norvegicus
L248----FLEYREV1Homo sapiens
L248----YLEYSKV1Bos taurus
L248NGPQFIGKWNI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L248NGFDFIGRWDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M90QKEWAMNVGDK1Homo sapiens
M90EKEWAMNVGDA1Mus musculus
M90QKEWAMNVGDA1Rattus norvegicus
M90QGHFLMNIGKL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M90GSGVRMCIGDV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N220VLLADNVIVPG2Mus musculus, Rattus norvegicus
N220VLLADNVICPG1Homo sapiens
N220VLLADNVIYPG1Bos taurus
N220IIAADNILRPG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N220LLVADNIITPG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N91KEWAMNVGDAK2Mus musculus, Rattus norvegicus
N91KEWAMNVGDKK1Homo sapiens
N91GHFLMNIGKLK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N91SGVRMCIGDVK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P224DNVIVPGTPDF2Mus musculus, Rattus norvegicus
P224DNVICPGAPDF1Homo sapiens
P224DNVIYPGAPDF1Bos taurus
P224DNILRPGVPEY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P224DNIITPGAPEY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q170VVGASQDIIPQ1Homo sapiens
Q170VLGASQDIIPQ1Bos taurus
Q170LIGASQDLIPQ1Mus musculus
Q170LNGASQDLIPQ1Rattus norvegicus
Q170IVGKATDSLVE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q170MIGKACDSLVE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R196DHWKDRYLPDT3Homo sapiens, Mus musculus, Rattus norvegicus
R196DHWKDLYVPDL2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R196DHWKDRYLPDM1Bos taurus
R251-YLEYMKVVDG2Mus musculus, Rattus norvegicus
R251-FLEYREVVDG1Homo sapiens
R251-YLEYSKVVDG1Bos taurus
R251QFIGKWNIIYK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R251DFIGRWDLIYK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S122AYCGYSAVRMA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S122GYVGYSAILFG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S122GYLGYSAILFG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S169LVVGASQDIIP1Homo sapiens
S169VVLGASQDIIP1Bos taurus
S169ILIGASQDLIP1Mus musculus
S169ILNGASQDLIP1Rattus norvegicus
S169IIVGKATDSLV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S169IMIGKACDSLV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V92EWAMNVGDAKG2Mus musculus, Rattus norvegicus
V92EWAMNVGDKKG1Homo sapiens
V92HFLMNIGKLKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V92GVRMCIGDVKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W193VFLDHWKDRYL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
W193VFIDHWKDLYV2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W88CEQKEWAMNVG1Homo sapiens
W88CSEKEWAMNVG1Mus musculus
W88CTQKEWAMNVG1Rattus norvegicus
W88VEQGHFLMNIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W88PDGSGVRMCIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y118LELGAYCGYSA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y118IELGGYVGYSA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y118VELGGYLGYSA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y121GAYCGYSAVRM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y121GGYVGYSAILF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y121GGYLGYSAILF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)

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