mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ADK
Gene summary
Basic gene Info.Gene symbolADK
Gene nameadenosine kinase
CytomapUCSC genome browser: 10q22|10q11-q24
Type of geneprotein-coding
Descriptionadenosine 5'-phosphotransferase
Modification date20141207
dbXrefs MIM : 102750
Ensembl : ENSG00000156110
HPRD : 00039
Vega : OTTHUMG00000018506
ProteinUniProt: P55263
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ADK
BioGPS: 132
PathwayNCI Pathway Interaction Database: ADK
Pathway Commons: ADK
ContextiHOP: ADK
ligand binding site mutation search in PubMed: ADK
UCL Cancer Institute: ADK
Assigned class in mutLBSgeneDBA: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for ADK.1. "Thach TT, Luong TT, Lee S, Rhee DK. Adenylate kinase from Streptococcus pneumoniae is essential for growth through its catalytic activity. FEBS Open Bio. 2014 Jul 8;4:672-82. doi: 10.1016/j.fob.2014.07.002. eCollection 2014. PubMed PMID: 25180151; PubMed Central PMCID: PMC4141199." 25180151

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for ADK
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ADK
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ADK from PDB
PDB IDPDB titlePDB structure

Differential gene expression and gene-gene network for ADK
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ADK and the right PPI network was created from samples without mutations in the LBS of ADK. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ADK
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0003130Anoxia2AlteredExpression, Biomarker
umls:C3714756Intellectual Disability1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ADK
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00131Adenosine monophosphateSmall molecule
ApprovedDB00811RibavirinSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ADK go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ADK
Multiple alignments for P55263 in multiple species
LBSAA sequence# speciesSpecies
A153ERSLIANLSAA2Arabidopsis thaliana, Arabidopsis thaliana
A153NRSLVANLAAA2Mus musculus, Rattus norvegicus
A153NRSLIANLAAA1Homo sapiens
A185KFYYIAGFFLT2Arabidopsis thaliana, Arabidopsis thaliana
A185RVYYIAGFFLT2Mus musculus, Rattus norvegicus
A185RVCYIAGFFLT1Homo sapiens
A315VDTNGAGDAFV3Arabidopsis thaliana, Arabidopsis thaliana, Rattus norvegicus
A315IDTNGAGDAFV2Homo sapiens, Mus musculus
A344AGCYASNVVIQ2Arabidopsis thaliana, Arabidopsis thaliana
A344AGHYAASVIIR2Mus musculus, Rattus norvegicus
A344AGHYAASIIIR1Homo sapiens
C140QPTGTCAACIT3Homo sapiens, Mus musculus, Rattus norvegicus
C140APTGTCGVCVV1Arabidopsis thaliana
C140TPTGTCGVCVL1Arabidopsis thaliana
D147ACITGGNRSLV2Mus musculus, Rattus norvegicus
D147ACITGDNRSLI1Homo sapiens
D147VCVVGGERSLI1Arabidopsis thaliana
D147VCVLGGERSLI1Arabidopsis thaliana
D303KYPVIPLPKEK2Arabidopsis thaliana, Arabidopsis thaliana
D303AFPVLDQNQEE2Mus musculus, Rattus norvegicus
D303AFAVLDQDQKE1Homo sapiens
D317TNGAGDAFVGG5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
D35GNPLLDISAVV4Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
D35GNPLLDVSAVV1Arabidopsis thaliana
F187YYIAGFFLTVS4Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
F187CYIAGFFLTVS1Homo sapiens
F218NLSAPFICEFF2Arabidopsis thaliana, Arabidopsis thaliana
F218NLSAPFISQFF2Mus musculus, Rattus norvegicus
F218NLSAPFISQFY1Homo sapiens
G284VIFTQGRDDTI3Homo sapiens, Mus musculus, Rattus norvegicus
G284TVITQGADPVV2Arabidopsis thaliana, Arabidopsis thaliana
G30ILLGMGNPLLD2Arabidopsis thaliana, Arabidopsis thaliana
G30VLFGMGNPLLD2Mus musculus, Rattus norvegicus
G30ILFGMGNPLLD1Homo sapiens
G314IIDTNGAGDAF2Homo sapiens, Mus musculus
G314LVDTNGAGDAF2Arabidopsis thaliana, Arabidopsis thaliana
G314IVDTNGAGDAF1Rattus norvegicus
G316DTNGAGDAFVG5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
G80VEYHAGGSTQN3Homo sapiens, Mus musculus, Rattus norvegicus
G80VEYIAGGATQN2Arabidopsis thaliana, Arabidopsis thaliana
G81EYHAGGSTQNS3Homo sapiens, Mus musculus, Rattus norvegicus
G81EYIAGGATQNS2Arabidopsis thaliana, Arabidopsis thaliana
H341CIRAGHYAASV2Mus musculus, Rattus norvegicus
H341CIRAGHYAASI1Homo sapiens
H341CVKAGCYASNV1Arabidopsis thaliana
H341CVRAGCYASNV1Arabidopsis thaliana
I25ALSENVLFGMG2Mus musculus, Rattus norvegicus
I25ALRENILFGMG1Homo sapiens
I25--YDGILLGMG1Arabidopsis thaliana
I25--FDGILLGMG1Arabidopsis thaliana
I309LPKEKLVDTNG2Arabidopsis thaliana, Arabidopsis thaliana
I309QDQKEIIDTNG1Homo sapiens
I309QNQEEIIDTNG1Mus musculus
I309QNQEEIVDTNG1Rattus norvegicus
I348ASNVVIQRSGC2Arabidopsis thaliana, Arabidopsis thaliana
I348AASVIIRRTGC2Mus musculus, Rattus norvegicus
I348AASIIIRRTGC1Homo sapiens
I56KPNDQILAEDK3Homo sapiens, Mus musculus, Rattus norvegicus
I56KLNNAILAEDK2Arabidopsis thaliana, Arabidopsis thaliana
L151GGERSLIANLS2Arabidopsis thaliana, Arabidopsis thaliana
L151GGNRSLVANLA2Mus musculus, Rattus norvegicus
L151GDNRSLIANLA1Homo sapiens
L155SLIANLSAANC2Arabidopsis thaliana, Arabidopsis thaliana
L155SLVANLAAANC2Mus musculus, Rattus norvegicus
L155SLIANLAAANC1Homo sapiens
L33GMGNPLLDISA4Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
L33GMGNPLLDVSA1Arabidopsis thaliana
L57PNDQILAEDKH3Homo sapiens, Mus musculus, Rattus norvegicus
L57LNNAILAEDKH2Arabidopsis thaliana, Arabidopsis thaliana
N148CITGGNRSLVA2Mus musculus, Rattus norvegicus
N148CITGDNRSLIA1Homo sapiens
N148CVVGGERSLIA1Arabidopsis thaliana
N148CVLGGERSLIA1Arabidopsis thaliana
N31LFGMGNPLLDI3Homo sapiens, Mus musculus, Rattus norvegicus
N31LLGMGNPLLDI1Arabidopsis thaliana
N31LLGMGNPLLDV1Arabidopsis thaliana
N313EIIDTNGAGDA2Homo sapiens, Mus musculus
N313KLVDTNGAGDA2Arabidopsis thaliana, Arabidopsis thaliana
N313EIVDTNGAGDA1Rattus norvegicus
N85GGATQNSIKVA2Arabidopsis thaliana, Arabidopsis thaliana
N85GGSTQNSMKVA2Mus musculus, Rattus norvegicus
N85GGSTQNSIKVA1Homo sapiens
Q306VIPLPKEKLVD2Arabidopsis thaliana, Arabidopsis thaliana
Q306VLDQDQKEIID1Homo sapiens
Q306VLDQNQEEIID1Mus musculus
Q306VLDQNQEEIVD1Rattus norvegicus
Q55LKPNDQILAED3Homo sapiens, Mus musculus, Rattus norvegicus
Q55IKLNNAILAED2Arabidopsis thaliana, Arabidopsis thaliana
R285VITQGADPVVV2Arabidopsis thaliana, Arabidopsis thaliana
R285IFTQGRDDTIV2Mus musculus, Rattus norvegicus
R285IFTQGRDDTIM1Homo sapiens
S82YIAGGATQNSI2Arabidopsis thaliana, Arabidopsis thaliana
S82YHAGGSTQNSM2Mus musculus, Rattus norvegicus
S82YHAGGSTQNSI1Homo sapiens
T190AGFFLTVSPES5Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
T282RTTVITQGADP2Arabidopsis thaliana, Arabidopsis thaliana
T282RTVIFTQGRDD2Mus musculus, Rattus norvegicus
T282RIVIFTQGRDD1Homo sapiens
T312EKLVDTNGAGD2Arabidopsis thaliana, Arabidopsis thaliana
T312KEIIDTNGAGD1Homo sapiens
T312EEIIDTNGAGD1Mus musculus
T312EEIVDTNGAGD1Rattus norvegicus
T83IAGGATQNSIK2Arabidopsis thaliana, Arabidopsis thaliana
T83HAGGSTQNSMK2Mus musculus, Rattus norvegicus
T83HAGGSTQNSIK1Homo sapiens
V301VKKYPVIPLPK2Arabidopsis thaliana, Arabidopsis thaliana
V301VTAFPVLDQNQ2Mus musculus, Rattus norvegicus
V301VTAFAVLDQDQ1Homo sapiens
Y223FICEFFKDVQE2Arabidopsis thaliana, Arabidopsis thaliana
Y223FISQFFKEALM2Mus musculus, Rattus norvegicus
Y223FISQFYKESLM1Homo sapiens

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