mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MAP3K8
Gene summary
Basic gene Info.Gene symbolMAP3K8
Gene namemitogen-activated protein kinase kinase kinase 8
CytomapUCSC genome browser: 10p11.23
Type of geneprotein-coding
DescriptionEwing sarcoma transformantcot (cancer Osaka thyroid) oncogeneproto-oncogene c-Cotproto-oncogene serine/threoine protein kinasetumor progression locus 2
Modification date20141222
dbXrefs MIM : 191195
Ensembl : ENSG00000107968
HPRD : 01863
Vega : OTTHUMG00000017889
ProteinUniProt: P41279
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAP3K8
BioGPS: 1326
PathwayNCI Pathway Interaction Database: MAP3K8
Pathway Commons: MAP3K8
ContextiHOP: MAP3K8
ligand binding site mutation search in PubMed: MAP3K8
UCL Cancer Institute: MAP3K8
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for MAP3K8

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for MAP3K8
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MAP3K8 from PDB

Differential gene expression and gene-gene network for MAP3K8
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MAP3K8 and the right PPI network was created from samples without mutations in the LBS of MAP3K8. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for MAP3K8
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0024121Lung Neoplasms2AlteredExpression, Biomarker
umls:C0151744Myocardial Ischemia1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for MAP3K8
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MAP3K8 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
4995-[5-(1H-INDOL-3-YL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL]-1, 3,4-OXADIAZOL-2-AMINE4y85AA165
4995-[5-(1H-INDOL-3-YL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL]-1, 3,4-OXADIAZOL-2-AMINE4y85BA165
4995-[5-(1H-INDOL-3-YL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL]-1, 3,4-OXADIAZOL-2-AMINE4y85CA165

Conservation information for LBS of MAP3K8
Multiple alignments for P41279 in multiple species
LBSAA sequence# speciesSpecies
A165TKKRMACKLIP3Homo sapiens, Mus musculus, Rattus norvegicus
D270KAVLVDFGLSV3Homo sapiens, Mus musculus, Rattus norvegicus
E208VHLFMEAGEGG3Homo sapiens, Mus musculus, Rattus norvegicus
E217GGSVLEKLESC3Homo sapiens, Mus musculus, Rattus norvegicus
F143NIGSDFIPRGA1Homo sapiens
F143NIGSGFVPRGA1Mus musculus
F143SIGSGFVPRGA1Rattus norvegicus
G147GFVPRGAFGKV2Mus musculus, Rattus norvegicus
G147DFIPRGAFGKV1Homo sapiens
G210LFMEAGEGGSV3Homo sapiens, Mus musculus, Rattus norvegicus
G213EAGEGGSVLEK3Homo sapiens, Mus musculus, Rattus norvegicus
I144IGSGFVPRGAF2Mus musculus, Rattus norvegicus
I144IGSDFIPRGAF1Homo sapiens
K133LLIPWKLTYRN1Homo sapiens
K133LLVPWKLTYRN1Mus musculus
K133LLVPWKLTYRS1Rattus norvegicus
K167KRMACKLIPVD2Homo sapiens, Rattus norvegicus
K167KRMACKLIPID1Mus musculus
L134LIPWKLTYRNI1Homo sapiens
L134LVPWKLTYRNI1Mus musculus
L134LVPWKLTYRSI1Rattus norvegicus
M207TVHLFMEAGEG3Homo sapiens, Mus musculus, Rattus norvegicus
P145GSGFVPRGAFG2Mus musculus, Rattus norvegicus
P145GSDFIPRGAFG1Homo sapiens
R146SGFVPRGAFGK2Mus musculus, Rattus norvegicus
R146SDFIPRGAFGK1Homo sapiens
S214AGEGGSVLEKL3Homo sapiens, Mus musculus, Rattus norvegicus
V152GAFGKVYLAQD3Homo sapiens, Mus musculus, Rattus norvegicus
V260KPSNIVFMSTK3Homo sapiens, Mus musculus, Rattus norvegicus
V269TKAVLVDFGLS3Homo sapiens, Mus musculus, Rattus norvegicus
W132VLLVPWKLTYR2Mus musculus, Rattus norvegicus
W132VLLIPWKLTYR1Homo sapiens

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