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mutLBSgeneDB |
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| Gene summary for CPA1 |
 Gene summary |
| Basic gene Info. | Gene symbol | CPA1 |
| Gene name | carboxypeptidase A1 (pancreatic) | |
| Synonyms | CPA | |
| Cytomap | UCSC genome browser: 7q32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001868.2, | |
| Description | carboxypeptidase A1pancreatic carboxypeptidase A | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 114850 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000091704 | ||
| HPRD : 00269 | ||
| Vega : OTTHUMG00000157826 | ||
| Protein | UniProt: P15085 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CPA1 | |
| BioGPS: 1357 | ||
| Pathway | NCI Pathway Interaction Database: CPA1 | |
| KEGG: CPA1 | ||
| REACTOME: CPA1 | ||
| Pathway Commons: CPA1 | ||
| Context | iHOP: CPA1 | |
| ligand binding site mutation search in PubMed: CPA1 | ||
| UCL Cancer Institute: CPA1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CPA1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H179 | H179R | BRCA | 1 | Y308 | Q310H | COAD | 1 | E380 | R382L | LUAD | 1 | R181 | R181L | LUAD | 1 | Y358 | Q359E | LUAD | 1 | E380 | E380K | UCEC | 1 | E380 | R382W | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CPA1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E380 | E380K | -0.95957756 | E380 | R382W | -0.95316631 | E380 | R382L | -0.74225768 | Y358 | Q359E | -0.24535884 | R181 | R181L | -0.22131494 | Y308 | Q310H | -0.18058294 | H179 | H179R | -0.050656245 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CPA1 from PDB |
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| Differential gene expression and gene-gene network for CPA1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CPA1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0149521 | Pancreatitis, Chronic | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CPA1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB02494 | Alpha-Hydroxy-Beta-Phenyl-Propionic Acid | Small molecule |  |
| Experimental | DB02652 | L-[(N-Hydroxyamino)Carbonyl]Phenylalanine | Small molecule |  |
| Experimental | DB03012 | Phenylalanine-N-Sulfonamide | Small molecule |  |
| Experimental | DB03201 | D-Cysteine | Small molecule |  |
| Experimental | DB03441 | 2-Benzyl-3-Iodopropanoic Acid | Small molecule |  |
| Experimental | DB04058 | D-[(Amino)Carbonyl]Phenylalanine | Small molecule |  |
| Experimental | DB04316 | D-[(N-Hydroxyamino)Carbonyl]Phenylalanine | Small molecule |  |
| Experimental | DB06924 | (2R)-2-benzyl-3-nitropropanoic acid | Small molecule |  |
| Experimental | DB07351 | O-(((1R)-((N-(PHENYL-METHOXY-CARBONYL)-ALANYL)-AMINO)METHYL)HYDROXYPHOSPHINYL)3-L-PHENYLLACTATE | Small molecule |  |
| Experimental | DB07484 | (2R)-4,4-dihydroxy-5-nitro-2-(phenylmethyl)pentanoic acid | Small molecule |  |
| Experimental | DB07506 | L-BENZYLSUCCINIC ACID | Small molecule |  |
| Experimental | DB08368 | OCTANE-1,3,5,7-TETRACARBOXYLIC ACID | Small molecule |  |
| Experimental | DB08762 | O-(((1R)-((N-PHENYLMETHOXYCARBONYL-L-ALANYL)AMINO)ETHYL)HYDROXYPHOSPHONO)-L-BENZYLACETIC ACID | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CPA1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of CPA1 |
| Multiple alignments for P15085 in multiple species |
| LBS | AA sequence | # species | Species | D130 | LDEIYEFMDLL | 2 | Mus musculus, Rattus norvegicus | D130 | LEEIYDFLDLL | 1 | Homo sapiens | D130 | LDEIYDFMDLL | 1 | Bos taurus | D130 | LDDTYAWLQSL | 1 | Drosophila melanogaster | D130 | LEEIHAWLDQL | 1 | Anopheles gambiae | E126 | TYHTLDEIYEF | 2 | Mus musculus, Rattus norvegicus | E126 | TYHTLEEIYDF | 1 | Homo sapiens | E126 | TYHTLDEIYDF | 1 | Bos taurus | E126 | QYYELDDTYAW | 1 | Drosophila melanogaster | E126 | DYHTLEEIHAW | 1 | Anopheles gambiae | E182 | GIHSREWVTQA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E182 | GIHSREWITQA | 1 | Bos taurus | E182 | GIHAREWIAPA | 1 | Drosophila melanogaster | E182 | GIHAREWISPA | 1 | Anopheles gambiae | E380 | YSFTFELRDTG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E380 | MAFCYELRPSS | 1 | Drosophila melanogaster | E380 | IAYTYELRPDG | 1 | Anopheles gambiae | F389 | ---YGFLLPAS | 2 | Homo sapiens, Bos taurus | F389 | ---RGFLLPAS | 2 | Mus musculus, Rattus norvegicus | F389 | SYLTGFKLPAE | 1 | Drosophila melanogaster | F389 | AW-NGFVLPPN | 1 | Anopheles gambiae | H179 | IDTGIHSREWV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H179 | IDLGIHSREWI | 1 | Bos taurus | H179 | LEAGIHAREWI | 1 | Drosophila melanogaster | H179 | LEGGIHAREWI | 1 | Anopheles gambiae | H306 | AFISIHSYSQL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H306 | AFLSIHSYSQL | 1 | Bos taurus | H306 | LYLSLHAYSQY | 1 | Drosophila melanogaster | H306 | AYIAFHSYSQL | 1 | Anopheles gambiae | I357 | SIIDTIYQASG | 2 | Mus musculus, Rattus norvegicus | I357 | SIIKAIYQASG | 1 | Homo sapiens | I357 | SIITTIYQASG | 1 | Bos taurus | I357 | NIYDAIYPAAG | 1 | Drosophila melanogaster | I357 | NVYDAIYPASG | 1 | Anopheles gambiae | M313 | YSQLLLYPYGY | 3 | Bos taurus, Mus musculus, Rattus norvegicus | M313 | YSQLLMYPYGY | 1 | Homo sapiens | M313 | YSQYLLYPYGH | 1 | Drosophila melanogaster | M313 | YSQLLLFPYGH | 1 | Anopheles gambiae | N254 | VGVDPNRNWDA | 2 | Mus musculus, Rattus norvegicus | N254 | IGVDPNRNWDA | 1 | Homo sapiens | N254 | VGVDANRNWDA | 1 | Bos taurus | N254 | FGADPNRNWGF | 1 | Drosophila melanogaster | N254 | YGADPNRNWDF | 1 | Anopheles gambiae | R181 | TGIHSREWVTQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R181 | LGIHSREWITQ | 1 | Bos taurus | R181 | AGIHAREWIAP | 1 | Drosophila melanogaster | R181 | GGIHAREWISP | 1 | Anopheles gambiae | R237 | TNRMWRKTRSH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R237 | QNRLWRKTRSV | 1 | Bos taurus | R237 | TNRLWRKTRT- | 1 | Drosophila melanogaster | R237 | VNRLWRKTRK- | 1 | Anopheles gambiae | R255 | GVDPNRNWDAG | 2 | Homo sapiens, Rattus norvegicus | R255 | GVDANRNWDAG | 1 | Bos taurus | R255 | GVDPNRNWDAA | 1 | Mus musculus | R255 | GADPNRNWGFH | 1 | Drosophila melanogaster | R255 | GADPNRNWDFH | 1 | Anopheles gambiae | S307 | FISIHSYSQLL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S307 | FLSIHSYSQLL | 1 | Bos taurus | S307 | YLSLHAYSQYL | 1 | Drosophila melanogaster | S307 | YIAFHSYSQLL | 1 | Anopheles gambiae | T378 | IKYSFTFELRD | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T378 | VRMAFCYELRP | 1 | Drosophila melanogaster | T378 | VKIAYTYELRP | 1 | Anopheles gambiae | Y308 | ISIHSYSQLLL | 2 | Mus musculus, Rattus norvegicus | Y308 | ISIHSYSQLLM | 1 | Homo sapiens | Y308 | LSIHSYSQLLL | 1 | Bos taurus | Y308 | LSLHAYSQYLL | 1 | Drosophila melanogaster | Y308 | IAFHSYSQLLL | 1 | Anopheles gambiae | Y358 | IIDTIYQASGS | 2 | Mus musculus, Rattus norvegicus | Y358 | IIKAIYQASGS | 1 | Homo sapiens | Y358 | IITTIYQASGG | 1 | Bos taurus | Y358 | IYDAIYPAAGA | 1 | Drosophila melanogaster | Y358 | VYDAIYPASGS | 1 | Anopheles gambiae |
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