mutLBSgeneDB |
Gene summary for CPB1 |
Gene summary |
Basic gene Info. | Gene symbol | CPB1 |
Gene name | carboxypeptidase B1 (tissue) | |
Synonyms | CPB|PASP|PCPB | |
Cytomap | UCSC genome browser: 3q24 | |
Type of gene | protein-coding | |
RefGenes | NM_001871.2, | |
Description | carboxypeptidase Bpancreas-specific proteinpancreatic carboxypeptidase Bprocarboxypeptidase Bprotaminasetissue carboxypeptidase B | |
Modification date | 20141207 | |
dbXrefs | MIM : 114852 | |
HGNC : HGNC | ||
Ensembl : ENSG00000153002 | ||
HPRD : 00271 | ||
Vega : OTTHUMG00000159520 | ||
Protein | UniProt: P15086 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CPB1 | |
BioGPS: 1360 | ||
Pathway | NCI Pathway Interaction Database: CPB1 | |
KEGG: CPB1 | ||
REACTOME: CPB1 | ||
Pathway Commons: CPB1 | ||
Context | iHOP: CPB1 | |
ligand binding site mutation search in PubMed: CPB1 | ||
UCL Cancer Institute: CPB1 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CPB1 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | E179 | R178K | BRCA | 1 | N251 | P250H | LUAD | 1 | N251 | P250H | LUSC | 1 | H304 | H304Y | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CPB1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | E179 | R178K | -1.2253781 | N251 | P250H | -1.1504555 | H304 | H304Y | -0.60313895 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CPB1 from PDB |
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Differential gene expression and gene-gene network for CPB1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CPB1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CPB1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Nutraceutical|vet_approved | DB04272 | Citric Acid | Small molecule | |
Experimental | DB04723 | 2-(3-GUANIDINOPHENYL)-3-MERCAPTOPROPANOIC ACID | Small molecule | |
Experimental | DB06835 | (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-{(S)-HYDROXY[(1R)-2-METHYL-1-{[(2-PHENYLETHYL)SULFONYL]AMINO}PROPYL]PHOSPHORYL}PROPANOIC ACID | Small molecule | |
Experimental | DB06921 | (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-HYDROXY{(1R)-2-METHYL-1-[(PHENYLSULFONYL)AMINO]PROPYL}PHOSPHORYL]PROPANOIC ACID | Small molecule | |
Experimental | DB07136 | (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-{(R)-HYDROXY[(1R)-2-METHYL-1-{[(3-PHENYLPROPYL)SULFONYL]AMINO}PROPYL]PHOSPHORYL}PROPANOIC ACID | Small molecule | |
Experimental | DB07157 | (5R,6S,8S)-8-[3-(AMINOMETHYL)PHENYL]-6-HYDROXY-5-ISOPROPYL-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC ACID 6-OXIDE | Small molecule | |
Experimental | DB07182 | (2S)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-[(S)-HYDROXY(3-PHENYLPROPYL)PHOSPHORYL]PROPANOIC ACID | Small molecule | |
Experimental | DB07269 | (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-[(1R)-1-{[(BENZYLOXY)CARBONYL]AMINO}-2-METHYLPROPYL](HYDROXY)PHOSPHORYL]PROPANOIC ACID | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CPB1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of CPB1 |
Multiple alignments for P15086 in multiple species |
LBS | AA sequence | # species | Species |
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