mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CPOX
Gene summary
Basic gene Info.Gene symbolCPOX
Gene namecoproporphyrinogen oxidase
CytomapUCSC genome browser: 3q12
Type of geneprotein-coding
DescriptionCOXcoprogen oxidasecoproporphyrinogen-III oxidase, mitochondrialcoproporphyrinogenaseoxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
Modification date20141219
dbXrefs MIM : 612732
Ensembl : ENSG00000080819
HPRD : 00417
Vega : OTTHUMG00000160016
ProteinUniProt: P36551
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CPOX
BioGPS: 1371
PathwayNCI Pathway Interaction Database: CPOX
Pathway Commons: CPOX
ContextiHOP: CPOX
ligand binding site mutation search in PubMed: CPOX
UCL Cancer Institute: CPOX
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for CPOX

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for CPOX
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CPOX from PDB

Differential gene expression and gene-gene network for CPOX
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CPOX and the right PPI network was created from samples without mutations in the LBS of CPOX. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for CPOX
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0162531Coproporphyria, Hereditary27Biomarker, GeneticVariation
umls:C0342859Harderoporphyria7Biomarker, GeneticVariation
umls:C0162566Porphyria Cutanea Tarda1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for CPOX
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CPOX go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of CPOX
Multiple alignments for P36551 in multiple species
LBSAA sequence# speciesSpecies
G406RGTKFGLFTPG3Homo sapiens, Mus musculus, Rattus norvegicus
G406RGTTFGLKT-G2Arabidopsis thaliana, Oryza sativa subsp. japonica
G406RGTKFGLYTPG1Drosophila melanogaster
G406RGTWFGLQAPE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G406RGTQFGLRTPG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G411GLFTPGSRIES3Homo sapiens, Mus musculus, Rattus norvegicus
G411GLKT-GGRIES2Arabidopsis thaliana, Oryza sativa subsp. japonica
G411GLYTPGARYES1Drosophila melanogaster
G411GLQAPEPRVES1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G411GLRTPGSRVES1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H258FAPTLHFNYRY2Arabidopsis thaliana, Oryza sativa subsp. japonica
H258YAPTMHFNYRY2Mus musculus, Rattus norvegicus
H258HAPTIHFNYRY1Homo sapiens
H258HVPTIHFNYRY1Drosophila melanogaster
H258MAPTTHLNYRY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H258HAPTTHLNYRY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L407GTKFGLFTPGS3Homo sapiens, Mus musculus, Rattus norvegicus
L407GTTFGLKT-GG2Arabidopsis thaliana, Oryza sativa subsp. japonica
L407GTKFGLYTPGA1Drosophila melanogaster
L407GTWFGLQAPEP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L407GTQFGLRTPGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N260PTIHFNYRYFE2Homo sapiens, Drosophila melanogaster
N260PTLHFNYRYFE2Arabidopsis thaliana, Oryza sativa subsp. japonica
N260PTMHFNYRYFE2Mus musculus, Rattus norvegicus
N260PTTHLNYRYFE2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R262IHFNYRYFEVE2Homo sapiens, Drosophila melanogaster
R262LHFNYRYFETD2Arabidopsis thaliana, Oryza sativa subsp. japonica
R262MHFNYRYFEVE2Mus musculus, Rattus norvegicus
R262THLNYRYFELV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R262THLNYRYFETW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R413FTPGSRIESIL3Homo sapiens, Mus musculus, Rattus norvegicus
R413KT-GGRIESIL2Arabidopsis thaliana, Oryza sativa subsp. japonica
R413YTPGARYESIL1Drosophila melanogaster
R413QAPEPRVESIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R413RTPGSRVESIL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S244CAMGVSSVIHP1Homo sapiens
S244FAAGVSSVLHP1Arabidopsis thaliana
S244FAAGISSVLHP1Oryza sativa subsp. japonica
S244FASGVSAVIHP1Drosophila melanogaster
S244TAMGVSSVIHP1Mus musculus
S244TAMGISSVIHP1Rattus norvegicus
S244FAAGISMVIHP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S244FACGLSMVIHP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S412LFTPGSRIESI3Homo sapiens, Mus musculus, Rattus norvegicus
S412LKT-GGRIESI2Arabidopsis thaliana, Oryza sativa subsp. japonica
S412LYTPGARYESI1Drosophila melanogaster
S412LQAPEPRVESI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S412LRTPGSRVESI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S416GSRIESILMSL3Homo sapiens, Mus musculus, Rattus norvegicus
S416GGRIESILVSL2Arabidopsis thaliana, Oryza sativa subsp. japonica
S416GARYESILMSL1Drosophila melanogaster
S416EPRVESILMTL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S416GSRVESILMSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

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