mutLBSgeneDB |
Gene summary for CRHR1 |
Gene summary |
Basic gene Info. | Gene symbol | CRHR1 |
Gene name | corticotropin releasing hormone receptor 1 | |
Synonyms | CRF-R|CRF-R-1|CRF-R1|CRF1|CRFR-1|CRFR1|CRH-R-1|CRH-R1|CRHR|CRHR1L | |
Cytomap | UCSC genome browser: 17q21.31 | |
Type of gene | protein-coding | |
RefGenes | NM_001145146.1, NM_001145147.1,NM_001145148.1,NM_001303018.1,NM_001303020.1, NM_004382.4, | |
Description | CRH receptor 1corticotropin-releasing factor receptor 1corticotropin-releasing factor type 1 receptorseven transmembrane helix receptor | |
Modification date | 20141222 | |
dbXrefs | MIM : 122561 | |
HGNC : HGNC | ||
Ensembl : ENSG00000120088 | ||
HPRD : 08830 | ||
Vega : OTTHUMG00000178271 | ||
Protein | UniProt: P34998 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CRHR1 | |
BioGPS: 1394 | ||
Pathway | NCI Pathway Interaction Database: CRHR1 | |
KEGG: CRHR1 | ||
REACTOME: CRHR1 | ||
Pathway Commons: CRHR1 | ||
Context | iHOP: CRHR1 | |
ligand binding site mutation search in PubMed: CRHR1 | ||
UCL Cancer Institute: CRHR1 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0010579 | positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway | 18292205 | GO:0071376 | cellular response to corticotropin-releasing hormone stimulus | 18292205 | GO:1901386 | negative regulation of voltage-gated calcium channel activity | 18292205 |
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Ligand binding site mutations for CRHR1 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | F191 | A190T | STAD | 2 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CRHR1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | F191 | A190T | -0.82906111 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CRHR1 from PDB |
PDB ID | PDB title | PDB structure | 2L27 | NMR Structure of the ECD1 of CRF-R1 in complex with a peptide agonist |
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Differential gene expression and gene-gene network for CRHR1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CRHR1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0003469 | Anxiety Disorders | 12 | Biomarker, GeneticVariation |
umls:C1269683 | Depressive Disorder, Major | 8 | Biomarker, GeneticVariation |
umls:C0236736 | Cocaine-Related Disorders | 2 | Biomarker |
umls:C0003123 | Anorexia | 1 | Biomarker |
umls:C0011616 | Dermatitis, Contact | 1 | Biomarker |
umls:C0424295 | Hyperkinesis | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CRHR1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CRHR1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of CRHR1 |
Multiple alignments for P34998 in multiple species |
LBS | AA sequence | # species | Species | F191 | NLISAFILRNA | 4 | Homo sapiens, Macaca mulatta, Rattus norvegicus, Mus musculus | F191 | NLITAFILRNA | 1 | Gallus gallus | F232 | FHVTNFFWMFG | 5 | Homo sapiens, Gallus gallus, Macaca mulatta, Rattus norvegicus, Mus musculus | F313 | VLLINFIFLFN | 5 | Homo sapiens, Gallus gallus, Macaca mulatta, Rattus norvegicus, Mus musculus | G239 | WMFGEGCYLHT | 5 | Homo sapiens, Gallus gallus, Macaca mulatta, Rattus norvegicus, Mus musculus | L309 | PMILVLLINFI | 5 | Homo sapiens, Gallus gallus, Macaca mulatta, Rattus norvegicus, Mus musculus | L349 | ATLVLLPLLGI | 4 | Homo sapiens, Macaca mulatta, Rattus norvegicus, Mus musculus | L349 | ATLVLLSLLGI | 1 | Gallus gallus | L352 | VLLPLLGITYM | 4 | Homo sapiens, Macaca mulatta, Rattus norvegicus, Mus musculus | L352 | VLLSLLGITYM | 1 | Gallus gallus | M235 | TNFFWMFGEGC | 5 | Homo sapiens, Gallus gallus, Macaca mulatta, Rattus norvegicus, Mus musculus | N312 | LVLLINFIFLF | 5 | Homo sapiens, Gallus gallus, Macaca mulatta, Rattus norvegicus, Mus musculus | T345 | KAVKATLVLLP | 4 | Homo sapiens, Macaca mulatta, Rattus norvegicus, Mus musculus | T345 | KAVKATLVLLS | 1 | Gallus gallus |
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