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mutLBSgeneDB |
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| Gene summary for CRK |
 Gene summary |
| Basic gene Info. | Gene symbol | CRK |
| Gene name | v-crk avian sarcoma virus CT10 oncogene homolog | |
| Synonyms | CRKII|p38 | |
| Cytomap | UCSC genome browser: 17p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005206.4, NM_016823.3, | |
| Description | adapter molecule crkproto-oncogene c-Crk | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 164762 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000167193 | ||
| HPRD : 01267 | ||
| Vega : OTTHUMG00000090317 | ||
| Protein | UniProt: P46108 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CRK | |
| BioGPS: 1398 | ||
| Pathway | NCI Pathway Interaction Database: CRK | |
| KEGG: CRK | ||
| REACTOME: CRK | ||
| Pathway Commons: CRK | ||
| Context | iHOP: CRK | |
| ligand binding site mutation search in PubMed: CRK | ||
| UCL Cancer Institute: CRK | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0032319 | regulation of Rho GTPase activity | 11870224 | GO:0032956 | regulation of actin cytoskeleton organization | 11870224 | GO:0048013 | ephrin receptor signaling pathway | 11870224 |
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| Ligand binding site mutations for CRK |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H59 | S58A | PRAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CRK |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H59 | S58A | -0.95381934 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CRK from PDB |
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| Differential gene expression and gene-gene network for CRK |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CRK |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0151744 | Myocardial Ischemia | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CRK |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CRK go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (GLU,PRO,GLY,PRO,TYR,ALA,GLN,PRO,SER,VAL,ASN,THR,LYS) | 1ju5 | A | H59 |
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| Conservation information for LBS of CRK |
| Multiple alignments for P46108 in multiple species |
| LBS | AA sequence | # species | Species | G90 | SRLRIGDQEFD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G90 | AGVKIANQSFP | 1 | Caenorhabditis elegans | G90 | IVYRIGDQSFD | 1 | Drosophila melanogaster | G90 | TRFRIGDQEFD | 1 | Gallus gallus | H59 | ---VSHYIINS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H59 | GNAVCHYLIER | 1 | Caenorhabditis elegans | H59 | ---VSNYIINK | 1 | Drosophila melanogaster | H59 | ---VSHYIVNS | 1 | Gallus gallus | I61 | -VSHYIINSSG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I61 | AVCHYLIERGE | 1 | Caenorhabditis elegans | I61 | -VSNYIINKVQ | 1 | Drosophila melanogaster | I61 | -VSHYIVNSLG | 1 | Gallus gallus | L109 | YKIHYLDTTTL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus | L109 | FKMRVLTEASL | 1 | Caenorhabditis elegans | L109 | YTLHYLDTTPL | 1 | Drosophila melanogaster | R20 | WGRLSRQEAVA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R20 | FPGMSREEAHK | 1 | Caenorhabditis elegans | R20 | FGPMSRQDATE | 1 | Drosophila melanogaster | R20 | WGRLSRGDAVS | 1 | Gallus gallus | R38 | GVFLVRDSSTS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R38 | GTFLMRDSSR- | 1 | Caenorhabditis elegans | R38 | GVFLVRDSNSI | 1 | Drosophila melanogaster | R38 | GTFLVRDSGSI | 1 | Gallus gallus | S40 | FLVRDSSTSPG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S40 | FLMRDSSR-PG | 1 | Caenorhabditis elegans | S40 | FLVRDSNSIAG | 1 | Drosophila melanogaster | S40 | FLVRDSGSIPG | 1 | Gallus gallus | S41 | LVRDSSTSPGD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S41 | LMRDSSR-PGE | 1 | Caenorhabditis elegans | S41 | LVRDSNSIAGD | 1 | Drosophila melanogaster | S41 | LVRDSGSIPGD | 1 | Gallus gallus | S43 | RDSSTSPGDYV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S43 | RDSSR-PGEYS | 1 | Caenorhabditis elegans | S43 | RDSNSIAGDYV | 1 | Drosophila melanogaster | S43 | RDSGSIPGDFV | 1 | Gallus gallus | T42 | VRDSSTSPGDY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T42 | MRDSSR-PGEY | 1 | Caenorhabditis elegans | T42 | VRDSNSIAGDY | 1 | Drosophila melanogaster | T42 | VRDSGSIPGDF | 1 | Gallus gallus | Y104 | ALLEFYKIHYL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y104 | ALLNHFKMRVL | 1 | Caenorhabditis elegans | Y104 | KLLTFYTLHYL | 1 | Drosophila melanogaster | Y104 | SLLEFYKIHYL | 1 | Gallus gallus | Y60 | --VSHYIINSS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y60 | NAVCHYLIERG | 1 | Caenorhabditis elegans | Y60 | --VSNYIINKV | 1 | Drosophila melanogaster | Y60 | --VSHYIVNSL | 1 | Gallus gallus |
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