mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CRP
Gene summary
Basic gene Info.Gene symbolCRP
Gene nameC-reactive protein, pentraxin-related
SynonymsPTX1
CytomapUCSC genome browser: 1q23.2
Type of geneprotein-coding
RefGenesNM_000567.2,
DescriptionC-reactive proteinpentraxin 1
Modification date20141222
dbXrefs MIM : 123260
HGNC : HGNC
Ensembl : ENSG00000132693
HPRD : 00422
Vega : OTTHUMG00000035344
ProteinUniProt: P02741
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CRP
BioGPS: 1401
PathwayNCI Pathway Interaction Database: CRP
KEGG: CRP
REACTOME: CRP
Pathway Commons: CRP
ContextiHOP: CRP
ligand binding site mutation search in PubMed: CRP
UCL Cancer Institute: CRP
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0010628positive regulation of gene expression24141169
GO:0010745negative regulation of macrophage derived foam cell differentiation18322245
GO:0010888negative regulation of lipid storage18322245
GO:0032930positive regulation of superoxide anion generation24141169
GO:0045908negative regulation of vasodilation24141169
GO:2000482regulation of interleukin-8 secretion21037097


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Ligand binding site mutations for CRP
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
S92Y91FLUAD1
E156E156VLUSC1
D78R76KSKCM1
N163N163YSTAD1
D158D158NSTAD1
Q168S169PUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CRP
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S92Y91F-1.23779
D158D158N-1.0235748
Q168S169P-0.83153747
D78R76K-0.72951087
N163N163Y-0.19161875
E156E156V-0.17686015
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CRP from PDB

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Differential gene expression and gene-gene network for CRP
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CRP and the right PPI network was created from samples without mutations in the LBS of CRP. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CRP
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007222Cardiovascular Diseases135AlteredExpression, Biomarker, GeneticVariation
umls:C0004153Atherosclerosis91AlteredExpression, Biomarker, GeneticVariation
umls:C0003873Arthritis, Rheumatoid61AlteredExpression, Biomarker, GeneticVariation
umls:C0524620Metabolic Syndrome X36AlteredExpression, Biomarker, GeneticVariation
umls:C0020538Hypertension35AlteredExpression, Biomarker, GeneticVariation
umls:C0021368Inflammation32AlteredExpression, Biomarker, GeneticVariation
umls:C0024141Lupus Erythematosus, Systemic23Biomarker, GeneticVariation
umls:C0948089Acute Coronary Syndrome16Biomarker, GeneticVariation
umls:C0151744Myocardial Ischemia14Biomarker, GeneticVariation
umls:C2239176Carcinoma, Hepatocellular13AlteredExpression, Biomarker, GeneticVariation
umls:C0010346Crohn Disease11AlteredExpression, Biomarker, GeneticVariation
umls:C0018799Heart Diseases10Biomarker, GeneticVariation
umls:C0018801Heart Failure8Biomarker
umls:C3714514Infection7AlteredExpression, Biomarker, GeneticVariation
umls:C0031099Periodontitis7Biomarker
umls:C0022661Kidney Failure, Chronic6AlteredExpression, Biomarker, GeneticVariation
umls:C0024530Malaria6Biomarker, GeneticVariation
umls:C0025517Metabolic Diseases5Biomarker, GeneticVariation
umls:C0011854Diabetes Mellitus, Type 15Biomarker
umls:C0033860Psoriasis5Biomarker
umls:C0024121Lung Neoplasms2Biomarker
umls:C0040053Thrombosis2Biomarker
umls:C0011884Diabetic Retinopathy2Biomarker
umls:C0025289Meningitis2Biomarker
umls:C0027059Myocarditis2Biomarker
umls:C0003469Anxiety Disorders1Biomarker
umls:C0993582Arthritis, Experimental1Biomarker
umls:C0020503Hyperparathyroidism, Secondary1Biomarker
umls:C0020557Hypertriglyceridemia1Therapeutic
umls:C0023281Leishmaniasis1Biomarker
umls:C0023290Leishmaniasis, Visceral1Biomarker
umls:C0027707Nephritis, Interstitial1Biomarker
umls:C0085397Pasteurellaceae Infections1Biomarker
umls:C0038587Substance Withdrawal Syndrome1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CRP
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB03945PhosphocholineSmall molecule
InvestigationalDB05744CRx-139Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CRP go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of CRP
Multiple alignments for P02741 in multiple species
LBSAA sequence# speciesSpecies
D158LGQEQDSFGGN1Homo sapiens
D158LGQEQDSYGGG1Rattus norvegicus
D158LGQEQDSYGGD1Mus musculus
D78ATKRQDNEILI1Homo sapiens
D78ATKTSFNEILL1Rattus norvegicus
D78ATKKNSNDILI1Mus musculus
E156IILGQEQDSYG2Rattus norvegicus, Mus musculus
E156IILGQEQDSFG1Homo sapiens
E165FGGNFEGSQSL1Homo sapiens
E165YGGGFDANQSL1Rattus norvegicus
E165YGGDFDAKQSL1Mus musculus
E99TVGGSEILFEV1Homo sapiens
E99AVGGPEILFSA1Rattus norvegicus
E99GVGGAEVRFMV1Mus musculus
F164SFGGNFEGSQS1Homo sapiens
F164SYGGGFDANQS1Rattus norvegicus
F164SYGGDFDAKQS1Mus musculus
F84NEILIFWSKDI1Homo sapiens
F84NEILLFWTRGQ1Rattus norvegicus
F84NDILIFWNKDK1Mus musculus
L82QDNEILIFWSK1Homo sapiens
L82SFNEILLFWTR1Rattus norvegicus
L82NSNDILIFWNK1Mus musculus
N163DSFGGNFEGSQ1Homo sapiens
N163DSYGGGFDANQ1Rattus norvegicus
N163DSYGGDFDAKQ1Mus musculus
N79TKRQDNEILIF1Homo sapiens
N79TKTSFNEILLF1Rattus norvegicus
N79TKKNSNDILIF1Mus musculus
Q157ILGQEQDSYGG2Rattus norvegicus, Mus musculus
Q157ILGQEQDSFGG1Homo sapiens
Q168NFEGSQSLVGD1Homo sapiens
Q168GFDANQSLVGD1Rattus norvegicus
Q168DFDAKQSLVGD1Mus musculus
S92KDIGYSFTVGG1Homo sapiens
S92RGQGFSIAVGG1Rattus norvegicus
S92KDKQYTFGVGG1Mus musculus


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