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mutLBSgeneDB |
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| Gene summary for NEK7 |
 Gene summary |
| Basic gene Info. | Gene symbol | NEK7 |
| Gene name | NIMA-related kinase 7 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 1q31.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_133494.2, | |
| Description | NIMA (never in mitosis gene a)-related kinase 7never in mitosis A-related kinase 7nimA-related protein kinase 7serine/threonine-protein kinase Nek7 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606848 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000151414 | ||
| HPRD : 06027 | ||
| Vega : OTTHUMG00000035658 | ||
| Protein | UniProt: Q8TDX7 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NEK7 | |
| BioGPS: 140609 | ||
| Pathway | NCI Pathway Interaction Database: NEK7 | |
| KEGG: NEK7 | ||
| REACTOME: NEK7 | ||
| Pathway Commons: NEK7 | ||
| Context | iHOP: NEK7 | |
| ligand binding site mutation search in PubMed: NEK7 | ||
| UCL Cancer Institute: NEK7 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 12840024 |
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| Ligand binding site mutations for NEK7 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | P134 | P134S | COAD | 1 | E112 | V110L | COAD | 1 | P134 | P134S | SKCM | 1 | I169 | V167M | UCEC | 1 | A114 | A114V | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for NEK7 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E112 | V110L | -1.0288509 | P134 | P134S | -0.93530151 | A114 | A114V | -0.60140581 | I169 | V167M | -0.56353365 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for NEK7 from PDB |
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| Differential gene expression and gene-gene network for NEK7 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for NEK7 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0043094 | Weight Gain | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for NEK7 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of NEK7 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ADP | ADP | 2wqn | A | E112 A114 | III | Peptide ligand (GLY,TRP,LEU,ARG,LYS,GLU,LEU,GLU,ASN) | 5de2 | B | I169 | III | Peptide ligand (GLY,TRP,LEU,ARG,LYS,GLU,LEU,GLU,ASN,ALA,GLU,PHE,ILE,PRO,MET,PRO) | 5de2 | A | P134 I169 |
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| Conservation information for LBS of NEK7 |
| Multiple alignments for Q8TDX7 in multiple species |
| LBS | AA sequence | # species | Species | A114 | IVLELADAGDL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A114 | IVLELAEAGDM | 1 | Caenorhabditis elegans | A116 | LELADAGDLSR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A116 | LELAEAGDMSR | 1 | Caenorhabditis elegans | A171 | NVFITATGVVK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A171 | NVFITGNGIVK | 1 | Caenorhabditis elegans | A61 | DGVPVALKKVQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A61 | VDLHVALKKIQ | 1 | Caenorhabditis elegans | D118 | LADAGDLSRMI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D118 | LAEAGDMSRMI | 1 | Caenorhabditis elegans | E112 | LNIVLELADAG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E112 | LNIVLELAEAG | 1 | Caenorhabditis elegans | F126 | RMIKHFKKQKR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F126 | RMIKHFKKGGR | 1 | Caenorhabditis elegans | F45 | IGRGQFSEVYR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F45 | IGKGQFSEVFR | 1 | Caenorhabditis elegans | G117 | ELADAGDLSRM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G117 | ELAEAGDMSRM | 1 | Caenorhabditis elegans | G43 | KKIGRGQFSEV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G43 | KKIGKGQFSEV | 1 | Caenorhabditis elegans | H125 | SRMIKHFKKQK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H125 | SRMIKHFKKGG | 1 | Caenorhabditis elegans | H262 | PLPSDHYSEEL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H262 | PLPADIYSTQL | 1 | Caenorhabditis elegans | I169 | PANVFITATGV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I169 | PANVFITGNGI | 1 | Caenorhabditis elegans | I40 | RIEKKIGRGQF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I40 | IIEKKIGKGQF | 1 | Caenorhabditis elegans | K130 | HFKKQKRLIPE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K130 | HFKKGGRLIPE | 1 | Caenorhabditis elegans | K140 | ERTVWKYFVQL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K140 | EKTIWKYFVQL | 1 | Caenorhabditis elegans | K63 | VPVALKKVQIF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K63 | LHVALKKIQVF | 1 | Caenorhabditis elegans | L132 | KKQKRLIPERT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L132 | KKGGRLIPEKT | 1 | Caenorhabditis elegans | L232 | YEMAALQSPFY | 4 | Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus | M122 | GDLSRMIKHFK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M122 | GDMSRMIKHFK | 1 | Caenorhabditis elegans | P134 | QKRLIPERTVW | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P134 | GGRLIPEKTIW | 1 | Caenorhabditis elegans | Q129 | KHFKKQKRLIP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q129 | KHFKKGGRLIP | 1 | Caenorhabditis elegans | Q44 | KIGRGQFSEVY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q44 | KIGKGQFSEVF | 1 | Caenorhabditis elegans | R131 | FKKQKRLIPER | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R131 | FKKGGRLIPEK | 1 | Caenorhabditis elegans | S46 | GRGQFSEVYRA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S46 | GKGQFSEVFRA | 1 | Caenorhabditis elegans | T137 | LIPERTVWKYF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T137 | LIPEKTIWKYF | 1 | Caenorhabditis elegans | T170 | ANVFITATGVV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T170 | ANVFITGNGIV | 1 | Caenorhabditis elegans | V48 | GQFSEVYRASC | 2 | Mus musculus, Rattus norvegicus | V48 | GQFSEVYRAAC | 1 | Homo sapiens | V48 | GQFSEVFRAQC | 1 | Caenorhabditis elegans | Y141 | RTVWKYFVQLC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y141 | KTIWKYFVQLA | 1 | Caenorhabditis elegans |
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