mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for ZFP28

Gene summary

Basic gene Info.	Gene symbol	ZFP28
	Gene name	ZFP28 zinc finger protein
	Synonyms	mkr5
	Cytomap	UCSC genome browser: -
	Type of gene	protein-coding
	RefGenes	NM_020828.1,
	Description	krueppel-like zinc finger factor X6zfp-28zinc finger factor X6zinc finger protein 28 homolog
	Modification date	20141207
dbXrefs	HGNC : HGNC
	Ensembl : ENSG00000196867
	HPRD : 15725
	Vega : OTTHUMG00000181944
Protein	UniProt: Q8NHY6 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ZFP28
	BioGPS: 140612
Pathway	NCI Pathway Interaction Database: ZFP28
	KEGG: ZFP28
	REACTOME: ZFP28
	Pathway Commons: ZFP28
Context	iHOP: ZFP28
	ligand binding site mutation search in PubMed: ZFP28
	UCL Cancer Institute: ZFP28
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

Top

Ligand binding site mutations for ZFP28

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
H523	R525I	COAD	2
H779	R777I	UCEC	2
C507	D509N	COAD	1
H779	R777I	COAD	1
C425	K427T	COAD	1
C647	C647W	GBM	1
H723	T724A	HNSC	1
H523	H523N	KIRC	1
C453	N451S	LUAD	1
H723	G725R	SKCM	1
H523	R525I	UCEC	1
C507	D506G	UCEC	1
C650	K652E	UCEC	1
H719,H723	R721I	UCEC	1
H579,H583	R581I	UCEC	1
H494	R493H	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Top

Protein structure related information for ZFP28

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
H494	R493H	-1.5260291
C507	D506G	-1.4058978
H523	H523N	-1.2477252
C647	C647W	-1.2435087
H723	R721I	-0.981554
H719	R721I	-0.981554
H583	R581I	-0.98130085
H579	R581I	-0.98130085
C507	D509N	-0.93649482
H779	R777I	-0.8747528
C453	N451S	-0.78048398
H523	R525I	-0.78010028
C425	K427T	-0.66342694
H723	T724A	-0.65327106
C650	K652E	-0.367809
H723	G725R	-0.25270751

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ZFP28 from PDB

PDB ID	PDB title	PDB structure
2EM2	Solution structure of the C2H2 type zinc finger (region 584-616) of human Zinc finger protein 28 homolog

Top

Differential gene expression and gene-gene network for ZFP28

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of ZFP28 and the right PPI network was created from samples without mutations in the LBS of ZFP28. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

Top

Phenotype information for ZFP28

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin