mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DYNLL2
Gene summary
Basic gene Info.Gene symbolDYNLL2
Gene namedynein, light chain, LC8-type 2
SynonymsDNCL1B|Dlc2|RSPH22
CytomapUCSC genome browser: 17q22
Type of geneprotein-coding
RefGenesNM_080677.2,
Description8 kDa dynein light chain bDLC8bdynein light chain 2, cytoplasmicradial spoke 22 homolog
Modification date20141207
dbXrefs MIM : 608942
HGNC : HGNC
HPRD : 06489
ProteinUniProt: Q96FJ2
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DYNLL2
BioGPS: 140735
PathwayNCI Pathway Interaction Database: DYNLL2
KEGG: DYNLL2
REACTOME: DYNLL2
Pathway Commons: DYNLL2
ContextiHOP: DYNLL2
ligand binding site mutation search in PubMed: DYNLL2
UCL Cancer Institute: DYNLL2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for DYNLL2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R60R60QSTAD1
H68H68YUCEC1
T70,H68E69KUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for DYNLL2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R60R60Q-1.1200512
H68E69K-0.91621198
T70E69K-0.91621198
H68H68Y-0.022543329
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DYNLL2 from PDB

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Differential gene expression and gene-gene network for DYNLL2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DYNLL2 and the right PPI network was created from samples without mutations in the LBS of DYNLL2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for DYNLL2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for DYNLL2
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DYNLL2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (SER,ARG,GLY,THR,GLN,THR,GLU)2xqqDH68
IIIPeptide ligand (SER,ARG,GLY,THR,GLN,THR,GLU)2xqqAR60 H68
IIIPeptide ligand (SER,ARG,GLY,THR,GLN,THR,GLU)2xqqBR60 H68
IIIPeptide ligand (SER,ARG,GLY,THR,GLN,THR,GLU)2xqqCR60 H68
IIIPeptide ligand (GLN,PRO,LYS,ASP,ASP,LYS,ASN,THR,MET,THR,ASP,SER)4d07AR60 H68 T70


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Conservation information for LBS of DYNLL2
Multiple alignments for Q96FJ2 in multiple species
LBSAA sequence# speciesSpecies
A82YLGQVAILLFK7Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
A82YLGTVAFLLFK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D12VIKNADMSEDM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D12VIKNADMSEEM2Drosophila melanogaster, Drosophila melanogaster
D12VIKAVDMSEKM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D12VIKNADMSDDM1Caenorhabditis elegans
E30ATQAMEKYNIE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E30ATQALEKYNIE3Caenorhabditis elegans, Drosophila melanogaster, Drosophila melanogaster
E30AVQAMEKFTIE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E35EKYNIEKDIAA7Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
E35EKFTIEKDIAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F62IVGRNFGSYVT7Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
F62IVGRNFGSFVT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F73HETKHFIYFYL5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
F73HETRHFIYFYL2Drosophila melanogaster, Drosophila melanogaster
F73HESRHFIYFYL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G63VGRNFGSYVTH7Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
G63VGRNFGSFVTH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H68GSYVTHETKHF5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
H68GSYVTHETRHF2Drosophila melanogaster, Drosophila melanogaster
H68GSFVTHESRHF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I34MEKYNIEKDIA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I34LEKYNIEKDIA3Caenorhabditis elegans, Drosophila melanogaster, Drosophila melanogaster
I34MEKFTIEKDIA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K36KYNIEKDIAAY6Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster
K36KFTIEKDIAAF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K36KYNIEKDIAAF1Drosophila melanogaster
K43IAAYIKKEFDK6Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster
K43IAAFIKREFDK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K43IAAFIKKEFDK1Drosophila melanogaster
K9RKAVIKNADMS7Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
K9-MAVIKAVDMS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M18Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
N10KAVIKNADMSE6Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
N10MAVIKAVDMSE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N10KAVIKNADMSD1Caenorhabditis elegans
N61CIVGRNFGSYV7Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
N61CIVGRNFGSFV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R60HCIVGRNFGSY7Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
R60HCIVGRNFGSF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S64GRNFGSYVTHE7Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
S64GRNFGSFVTHE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T67FGSYVTHETKH5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
T67FGSYVTHETRH2Drosophila melanogaster, Drosophila melanogaster
T67FGSFVTHESRH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T70YVTHETKHFIY5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
T70YVTHETRHFIY2Drosophila melanogaster, Drosophila melanogaster
T70FVTHESRHFIY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V66NFGSYVTHETK5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
V66NFGSYVTHETR2Drosophila melanogaster, Drosophila melanogaster
V66NFGSFVTHESR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y65RNFGSYVTHET7Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
Y65RNFGSFVTHES1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y75TKHFIYFYLGQ5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
Y75TRHFIYFYLGQ2Drosophila melanogaster, Drosophila melanogaster
Y75SRHFIYFYLGT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y77HFIYFYLGQVA7Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
Y77HFIYFYLGTVA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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