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mutLBSgeneDB |
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| Gene summary for ADPRH |
 Gene summary |
| Basic gene Info. | Gene symbol | ADPRH |
| Gene name | ADP-ribosylarginine hydrolase | |
| Synonyms | ARH1 | |
| Cytomap | UCSC genome browser: 3q13.31-q13.33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001125.3, NM_001291949.1,NM_001291950.1, | |
| Description | ADP-ribose-L-arginine cleaving enzyme[Protein ADP-ribosylarginine] hydrolase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603081 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000144843 | ||
| HPRD : 04359 | ||
| Vega : OTTHUMG00000159420 | ||
| Protein | UniProt: P54922 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ADPRH | |
| BioGPS: 141 | ||
| Pathway | NCI Pathway Interaction Database: ADPRH | |
| KEGG: ADPRH | ||
| REACTOME: ADPRH | ||
| Pathway Commons: ADPRH | ||
| Context | iHOP: ADPRH | |
| ligand binding site mutation search in PubMed: ADPRH | ||
| UCL Cancer Institute: ADPRH | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for ADPRH |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D304 | T306A | LUSC | 1 | H125 | H125Y | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ADPRH |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D304 | T306A | -0.99421066 | H125 | H125Y | -0.268013 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ADPRH from PDB |
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| Differential gene expression and gene-gene network for ADPRH |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ADPRH |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ADPRH |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ADPRH go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | MG | MAGNESIUM(2+) | 3hfw | A | D304 | ADP | ADP | 3hfw | A | H125 |
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| Conservation information for LBS of ADPRH |
| Multiple alignments for P54922 in multiple species |
| LBS | AA sequence | # species | Species | A102 | RAPGGACMQNA | 2 | Mus musculus, Rattus norvegicus | A102 | RAPGGASVHNA | 1 | Homo sapiens | A102 | RAPGGASVQNA | 1 | Bos taurus | C129 | SHEGGCGAAMR | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D304 | HGGDSDSTAAI | 3 | Homo sapiens, Mus musculus, Bos taurus | D304 | HGGDSDSTATI | 1 | Rattus norvegicus | D55 | RWRVSDDTVMH | 3 | Homo sapiens, Mus musculus, Bos taurus | D55 | QWRVSDDTIMH | 1 | Rattus norvegicus | D56 | WRVSDDTVMHL | 3 | Homo sapiens, Mus musculus, Bos taurus | D56 | WRVSDDTIMHL | 1 | Rattus norvegicus | G100 | DGRAPGGACMQ | 2 | Mus musculus, Rattus norvegicus | G100 | DGRAPGGASVH | 1 | Homo sapiens | G100 | DGRAPGGASVQ | 1 | Bos taurus | G101 | GRAPGGACMQN | 2 | Mus musculus, Rattus norvegicus | G101 | GRAPGGASVHN | 1 | Homo sapiens | G101 | GRAPGGASVQN | 1 | Bos taurus | G127 | FNSHEGGCGAA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G128 | NSHEGGCGAAM | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G130 | HEGGCGAAMRA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | H125 | IPFNSHEGGCG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | H163 | SGRMTHHHPTG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | H165 | RMTHHHPTGYL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S103 | APGGACMQNAM | 2 | Mus musculus, Rattus norvegicus | S103 | APGGASVHNAM | 1 | Homo sapiens | S103 | APGGASVQNAM | 1 | Bos taurus | S124 | RIPFNSHEGGC | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S264 | TSLSYSGWGGS | 1 | Homo sapiens | S264 | IDVSYSGWGGS | 1 | Mus musculus | S264 | IEVSYSGWGGS | 1 | Rattus norvegicus | S264 | SSVSYSGWGGS | 1 | Bos taurus | S269 | SGWGGSSGHDA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S270 | GWGGSSGHDAP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S54 | GRWRVSDDTVM | 1 | Homo sapiens | S54 | ARWRVSDDTVM | 1 | Mus musculus | S54 | AQWRVSDDTIM | 1 | Rattus norvegicus | S54 | ERWRVSDDTVM | 1 | Bos taurus | T167 | THHHPTGYLGA | 2 | Homo sapiens, Bos taurus | T167 | THHHPTGYLGS | 2 | Mus musculus, Rattus norvegicus | Y263 | YTSLSYSGWGG | 1 | Homo sapiens | Y263 | YIDVSYSGWGG | 1 | Mus musculus | Y263 | YIEVSYSGWGG | 1 | Rattus norvegicus | Y263 | YSSVSYSGWGG | 1 | Bos taurus |
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