mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PARP1
Gene summary
Basic gene Info.Gene symbolPARP1
Gene namepoly (ADP-ribose) polymerase 1
SynonymsADPRT|ADPRT 1|ADPRT1|ARTD1|PARP|PARP-1|PPOL|pADPRT-1
CytomapUCSC genome browser: 1q41-q42
Type of geneprotein-coding
RefGenesNM_001618.3,
DescriptionADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)ADP-ribosyltransferase NAD(+)ADP-ribosyltransferase diphtheria toxin-like 1NAD(+) ADP-ribosyltransferase 1poly (ADP-ribose) polymerase family, member 1poly [ADP-ribose] polymerase 1poly(ADP-
Modification date20141222
dbXrefs MIM : 173870
HGNC : HGNC
Ensembl : ENSG00000143799
HPRD : 01435
Vega : OTTHUMG00000037556
ProteinUniProt: P09874
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PARP1
BioGPS: 142
PathwayNCI Pathway Interaction Database: PARP1
KEGG: PARP1
REACTOME: PARP1
Pathway Commons: PARP1
ContextiHOP: PARP1
ligand binding site mutation search in PubMed: PARP1
UCL Cancer Institute: PARP1
Assigned class in mutLBSgeneDBA: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for PARP1.1. Timinszky, G., Till, S., Hassa, P. O., Hothorn, M., Kustatscher, G., Nijmeijer, B., ... & Hottiger, M. O. (2009). A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nature structural & molecular biology, 16(9), 923-929. 19680243

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006471protein ADP-ribosylation17396150
GO:0032869cellular response to insulin stimulus19303849
GO:0070212protein poly-ADP-ribosylation15674325


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Ligand binding site mutations for PARP1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D766D766NBLCA1
C24E26QBLCA1
W589R591HCOAD1
Y710A709TGBM1
P881P881LHNSC1
R587F586LHNSC1
I895I895TKIRC1
A898D899NOV1
I895I895VOV1
Y570S568FSKCM1
F638Y639CUCEC1
W589R591CUCEC1
W589R591SUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PARP1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
I895I895T-1.8214331
I895I895V-1.6446674
W589R591S-1.4907548
W589R591H-1.4745051
A898D899N-1.2832507
W589R591C-1.2545946
Y710A709T-1.0071355
F638Y639C-0.84968293
C24E26Q-0.81142247
R587F586L-0.56867448
P881P881L-0.44804855
Y570S568F-0.3012442
D766D766N-0.25005371
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PARP1 from PDB

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Differential gene expression and gene-gene network for PARP1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PARP1 and the right PPI network was created from samples without mutations in the LBS of PARP1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PARP1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1458155Breast Neoplasms9Biomarker, GeneticVariation
umls:C0026764Multiple Myeloma7Biomarker
umls:C0004096Asthma5Biomarker, GeneticVariation
umls:C0021368Inflammation3Biomarker
umls:C0033578Prostatic Neoplasms3Biomarker
umls:C0004153Atherosclerosis2Biomarker
umls:C0007786Brain Ischemia2Biomarker
umls:C0019158Hepatitis2Biomarker
umls:C0028754Obesity2Biomarker
umls:C0032285Pneumonia2Biomarker
umls:C0022658Kidney Diseases2Biomarker
umls:C0002170Alopecia1Biomarker
umls:C0002871Anemia1Biomarker
umls:C0270611Brain Injuries1Biomarker
umls:C0878544Cardiomyopathies1Biomarker
umls:C2931673Ceroid lipofuscinosis, neuronal 1, infantile1Biomarker
umls:C0011603Dermatitis1Biomarker
umls:C3714756Intellectual Disability1Biomarker
umls:C0022821Kyphosis1Biomarker
umls:C0242422Parkinsonian Disorders1Biomarker
umls:C0031117Peripheral Nervous System Diseases1Biomarker
umls:C2936350Plaque, Atherosclerotic1Biomarker
umls:C0042842Vitamin A Deficiency1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PARP1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB02498Carba-Nicotinamide-Adenine-DinucleotideSmall molecule
ExperimentalDB02690NU1025Small molecule
ApprovedDB02701NicotinamideSmall molecule
ExperimentalDB030722-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-QuinazolinoneSmall molecule
ExperimentalDB030733-MethoxybenzamideSmall molecule
ExperimentalDB035092-(4-Chlorophenyl)-5-QuinoxalinecarboxamideSmall molecule
ExperimentalDB037223,4-Dihydro-5-Methyl-IsoquinolinoneSmall molecule
ExperimentalDB040102-(3'-Methoxyphenyl) Benzimidazole-4-CarboxamideSmall molecule
ExperimentalDB070966-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONESmall molecule
InvestigationalDB07232VeliparibSmall molecule
ExperimentalDB07330trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidiniumSmall molecule
ExperimentalDB077875-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONESmall molecule
ApprovedDB09074OlaparibSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PARP1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
2UR(2R)-5-FLUORO-2-METHYL-2,3-DIHYDRO-1-BENZOFURAN-7- CARBOXAMIDE4opxCA898
2US(2Z)-2-(2,4-DIHYDROXYBENZYLIDENE)-3-OXO-2,3-DIHYDRO-1- BENZOFURAN-7-CARBOXAMIDE4oqaCA898
2YQ(8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2, 4-TRIAZOL-5-YL)-2,7,8,9-TETRAHYDRO-3H-PYRIDO[4,3,2- DE]PHTHALAZIN-3-ONE4pjtAA898
2YQ(8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2, 4-TRIAZOL-5-YL)-2,7,8,9-TETRAHYDRO-3H-PYRIDO[4,3,2- DE]PHTHALAZIN-3-ONE4pjtBA898
2YQ(8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2, 4-TRIAZOL-5-YL)-2,7,8,9-TETRAHYDRO-3H-PYRIDO[4,3,2- DE]PHTHALAZIN-3-ONE4pjtCA898
2YQ(8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2, 4-TRIAZOL-5-YL)-2,7,8,9-TETRAHYDRO-3H-PYRIDO[4,3,2- DE]PHTHALAZIN-3-ONE4pjtDA898
FSU2-(3-METHOXYPROPYL)-3-OXO-2,3-DIHYDRO-1H- ISOINDOLE-4-CARBOXAMIDE4zzzBA898
D7N2-[1-(4,4-DIFLUOROCYCLOHEXYL)-PIPERIDIN-4-YL] -6-FLUORO-3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4- CARBOXAMIDE5a00AA898
P34N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE4uxbBA898
RPBRUCAPARIB4rv6AA898
RPBRUCAPARIB4rv6BA898
ZNZINC(2+)2l30AC24
ZNZINC(2+)3od8AC24
ZNZINC(2+)3od8BC24
ZNZINC(2+)3od8CC24
ZNZINC(2+)3od8DC24
ZNZINC(2+)3od8EC24
ZNZINC(2+)3od8FC24
ZNZINC(2+)3od8GC24
ZNZINC(2+)3od8HC24
ZNZINC(2+)3odaAC24
ZNZINC(2+)3odaBC24
ZNZINC(2+)3odaCC24
ZNZINC(2+)3odaDC24
ZNZINC(2+)3odaEC24
ZNZINC(2+)3odaFC24
ZNZINC(2+)3odaGC24
ZNZINC(2+)3odaHC24
ZNZINC(2+)4av1AC24
ZNZINC(2+)4av1CC24
ZNZINC(2+)4dqyAC24
ZNZINC(2+)4dqyDC24
ZNZINC(2+)4opxAC24
ZNZINC(2+)4opxDC24
ZNZINC(2+)4oqaAC24
ZNZINC(2+)4oqaDC24
ZNZINC(2+)4oqbAC24
ZNZINC(2+)4oqbDC24
ZNZINC(2+)2n8aAC24
CNQ3-(4-CHLOROPHENYL)QUINOXALINE-5-CARBOXAMIDE1wokAD766
CNQ3-(4-CHLOROPHENYL)QUINOXALINE-5-CARBOXAMIDE1wokBD766
CNQ3-(4-CHLOROPHENYL)QUINOXALINE-5-CARBOXAMIDE1wokCD766
1WQ(2S)-6-{[4-(4-CHLOROPHENYL)-3,6-DIHYDROPYRIDIN-1(2H)- YL]METHYL}-2-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE4l6sAD766
1WQ(2S)-6-{[4-(4-CHLOROPHENYL)-3,6-DIHYDROPYRIDIN-1(2H)- YL]METHYL}-2-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE4l6sBD766
XAV2-[4-(TRIFLUOROMETHYL)PHENYL]-7,8-DIHYDRO-5H-THIOPYRANO[4,3-D]PYRIMIDIN-4-OL4r5wBD766
3JDNIRAPARIB2-{4-[(3S)-PIPERIDIN-3-YL]PHENYL}-2H-INDAZOLE-7- CARBOXAMIDE4r6eAD766
3JDNIRAPARIB2-{4-[(3S)-PIPERIDIN-3-YL]PHENYL}-2H-INDAZOLE-7- CARBOXAMIDE4r6eBD766
3JDNIRAPARIB2-{4-[(3S)-PIPERIDIN-3-YL]PHENYL}-2H-INDAZOLE-7- CARBOXAMIDE4r6eCD766
CACALCIUM(2+)4xhuAD766
FRQ5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE1uk1AD766 A898
FRQ5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE1uk1BD766 A898
CNQ3-(4-CHLOROPHENYL)QUINOXALINE-5-CARBOXAMIDE1wokDD766 A898
2UT(2Z)-2-{4-[2-(MORPHOLIN-4-YL)ETHOXY]BENZYLIDENE}-3-OXO- 2,3-DIHYDRO-1-BENZOFURAN-7-CARBOXAMIDE4oqbCD766 A898
XAV2-[4-(TRIFLUOROMETHYL)PHENYL]-7,8-DIHYDRO-5H-THIOPYRANO[4,3-D]PYRIMIDIN-4-OL4r5wAD766 A898
3JDNIRAPARIB2-{4-[(3S)-PIPERIDIN-3-YL]PHENYL}-2H-INDAZOLE-7- CARBOXAMIDE4r6eDD766 A898
2YQ(8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1- METHYL-1H-1,2,4-TRIAZOL-5-YL)-2,7,8,9-TETRAHYDRO- 3H-PYRIDO[4,3,2-DE]PHTHALAZIN-3-ONE4undAI895 A898
NUCNucleic Acids4dqyCY570 R587 W589
NUCNucleic Acids4dqyFY570 R587 W589 F638
NUCNucleic Acids4opxCY570 R587 W589 F638
NUCNucleic Acids4oqaCY570 R587 W589 F638
NUCNucleic Acids4oqbCY570 R587 W589 F638
NUCNucleic Acids4oqbFY570 R587 W589 F638
NUCNucleic Acids4opxFY570 W589 F638
NUCNucleic Acids4oqaFY570 W589 F638


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Conservation information for LBS of PARP1
Multiple alignments for P09874 in multiple species
LBSAA sequence# speciesSpecies
A19AKSGRASCKKC3Homo sapiens, Bos taurus, Rattus norvegicus
A19AKSGRSNCKTC1Caenorhabditis elegans
A19AKSSRSSCKTC1Arabidopsis thaliana
A19AKSGRSSCKSC1Oryza sativa subsp. japonica
A19ARTGRATCKGC1Drosophila melanogaster
A880QGLRIAPPEAP6Homo sapiens, Caenorhabditis elegans, Arabidopsis thaliana, Oryza sativa subsp. japonica, Bos taurus, Rattus norvegicus
A880HGLRIAPPEAP1Drosophila melanogaster
A898KGIYFADMVSK4Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus
A898KGVYFADMFSK1Caenorhabditis elegans
A898KGIYFADLVSK1Arabidopsis thaliana
A898KGLYFADLVSK1Oryza sativa subsp. japonica
C125SNRSTCKGCME2Homo sapiens, Rattus norvegicus
C125SNRGKCGKCGQ1Caenorhabditis elegans
C125TSRAGCRKCSE1Arabidopsis thaliana
C125SARTSCRRCGE1Oryza sativa subsp. japonica
C125SSRSTCRGCEQ1Drosophila melanogaster
C125SNRSTCKSCME1Bos taurus
C128STCKGCMEKIE2Homo sapiens, Rattus norvegicus
C128GKCGKCGQNFE1Caenorhabditis elegans
C128AGCRKCSEKIL1Arabidopsis thaliana
C128TSCRRCGEKIK1Oryza sativa subsp. japonica
C128STCRGCEQKIN1Drosophila melanogaster
C128STCKSCMEKID1Bos taurus
C162WYHPGCFVKNR1Homo sapiens
C162ANHFKCFLQEF1Caenorhabditis elegans
C162WHHAKCFLEMS1Arabidopsis thaliana
C162WYHASCFLEMS1Oryza sativa subsp. japonica
C162WHHLECFAQLR1Drosophila melanogaster
C162WYHPKCFVQKR1Bos taurus
C162WYHPTCFVKNR1Rattus norvegicus
C21SGRASCKKCSE2Homo sapiens, Rattus norvegicus
C21SGRSNCKTCKK1Caenorhabditis elegans
C21SSRSSCKTCKS1Arabidopsis thaliana
C21SGRSSCKSCRS1Oryza sativa subsp. japonica
C21TGRATCKGCKS1Drosophila melanogaster
C21SGRASCKKCKE1Bos taurus
C24ASCKKCSESIP2Homo sapiens, Rattus norvegicus
C24SNCKTCKKNIA1Caenorhabditis elegans
C24SSCKTCKSVIN1Arabidopsis thaliana
C24SSCKSCRSPIG1Oryza sativa subsp. japonica
C24ATCKGCKSTIS1Drosophila melanogaster
C24ASCKKCKESIP1Bos taurus
C295GALLPCEEC-S2Homo sapiens, Bos taurus
C295GCPIICQTCSN1Caenorhabditis elegans
C295GPLALCPMC-S1Arabidopsis thaliana
C295GALGTCPVC-S1Oryza sativa subsp. japonica
C295GAIESCSECNS1Drosophila melanogaster
C295GALLPCKEC-S1Rattus norvegicus
C298LPCEEC-SGQL2Homo sapiens, Bos taurus
C298IICQTCSNGKI1Caenorhabditis elegans
C298ALCPMC-SGHL1Arabidopsis thaliana
C298GTCPVC-SSFL1Oryza sativa subsp. japonica
C298ESCSECNSCQF1Drosophila melanogaster
C298LPCKEC-SGQL1Rattus norvegicus
C311--AYYCTGDVT3Homo sapiens, Bos taurus, Rattus norvegicus
C311CRTYVCTGYAT1Caenorhabditis elegans
C311--LYRCHGYIS1Arabidopsis thaliana
C311--QYHCSGYVS1Oryza sativa subsp. japonica
C311--GYICNGNHS1Drosophila melanogaster
C321TAWTKCMVKTQ3Homo sapiens, Bos taurus, Rattus norvegicus
C321TEYSKCTYESK1Caenorhabditis elegans
C321SEWSKCSHSTL1Arabidopsis thaliana
C321SEWSKCTYSTT1Oryza sativa subsp. japonica
C321SEWTKCNKLLK1Drosophila melanogaster
C56WYHFSCFW-KV2Homo sapiens, Rattus norvegicus
C56WFHYNCFWIKM1Caenorhabditis elegans
C56WNHASCIL-KK1Arabidopsis thaliana
C56WNHASCIL-SK1Oryza sativa subsp. japonica
C56WFHKTCFF-K-1Drosophila melanogaster
C56WYHLSCFW-KV1Bos taurus
D145SKKMVDPEKP-1Homo sapiens
D145HNK--------1Caenorhabditis elegans
D145FSK---PEGPG1Arabidopsis thaliana
D145SSKLEGQG---1Oryza sativa subsp. japonica
D145RKTVYDTEVGM1Drosophila melanogaster
D145SKKVVYPDKP-1Bos taurus
D145SKKMLDPEKP-1Rattus norvegicus
D766KVEMLDNLLDI3Homo sapiens, Bos taurus, Rattus norvegicus
D766KVKMLEALQDI2Arabidopsis thaliana, Oryza sativa subsp. japonica
D766KNNMLNALLDI1Caenorhabditis elegans
D766LRQMLDSLAEI1Drosophila melanogaster
D770LDNLLDIEVAY3Homo sapiens, Bos taurus, Rattus norvegicus
D770LEALQDIEIAS2Arabidopsis thaliana, Oryza sativa subsp. japonica
D770LNALLDIKFAY1Caenorhabditis elegans
D770LDSLAEIEVAY1Drosophila melanogaster
E763VQAKVEMLDNL3Homo sapiens, Bos taurus, Rattus norvegicus
E763IKEKNNMLNAL1Caenorhabditis elegans
E763FKSKVKMLEAL1Arabidopsis thaliana
E763LMVKVKMLEAL1Oryza sativa subsp. japonica
E763IEDLRQMLDSL1Drosophila melanogaster
E988SLLYNEYIVYD2Homo sapiens, Drosophila melanogaster
E988CLLYNEYIVYD2Bos taurus, Rattus norvegicus
E988HLLYNEFIVYD1Caenorhabditis elegans
E988ELMYNEYIVYD1Arabidopsis thaliana
E988ELMYNEYIVYN1Oryza sativa subsp. japonica
F44VQSPMFDGKVP2Homo sapiens, Rattus norvegicus
F44RPSTFFDGNMD1Caenorhabditis elegans
F44VQSTHFDGIMP1Arabidopsis thaliana
F44VQATQFDGLMP1Oryza sativa subsp. japonica
F44VQSAFHDAKVP1Drosophila melanogaster
F44VESPMFDGKIP1Bos taurus
F638KYPKKFYPLEI2Homo sapiens, Rattus norvegicus
F638KMPGMFSYVET1Caenorhabditis elegans
F638KQPGKFLPLDI1Arabidopsis thaliana
F638KQPGKFYPLDI1Oryza sativa subsp. japonica
F638KRTGRMYPIEI1Drosophila melanogaster
F638KHPKKFYPLEI1Bos taurus
F897GKGIYFADMVS4Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus
F897GKGVYFADMFS1Caenorhabditis elegans
F897GKGIYFADLVS1Arabidopsis thaliana
F897GKGLYFADLVS1Oryza sativa subsp. japonica
G275QQVPSGE--SA2Homo sapiens, Rattus norvegicus
G275QDIPEGHDPTA1Caenorhabditis elegans
G275QSTRGSE--LD1Arabidopsis thaliana
G275QDTSGPE--RH1Oryza sativa subsp. japonica
G275QQPVTGD--TE1Drosophila melanogaster
G275QEVPSGE--SA1Bos taurus
G863RLLWHGSRTTN3Homo sapiens, Bos taurus, Rattus norvegicus
G863MLLWHGSRLTN2Arabidopsis thaliana, Oryza sativa subsp. japonica
G863RLLWHGSGKMN1Caenorhabditis elegans
G863KLLWHGSRLTN1Drosophila melanogaster
G888EAPVTGYMFGK4Homo sapiens, Oryza sativa subsp. japonica, Bos taurus, Rattus norvegicus
G888EAPVSGYMFGK1Caenorhabditis elegans
G888EAPATGYMFGK1Arabidopsis thaliana
G888EAPPTGYMFGK1Drosophila melanogaster
G894YMFGKGIYFAD5Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Bos taurus, Rattus norvegicus
G894YMFGKGVYFAD1Caenorhabditis elegans
G894YMFGKGLYFAD1Oryza sativa subsp. japonica
H159IDRWYHPGCFV1Homo sapiens
H159-GKANHFKCFL1Caenorhabditis elegans
H159M--WHHAKCFL1Arabidopsis thaliana
H159---WYHASCFL1Oryza sativa subsp. japonica
H159QPLWHHLECFA1Drosophila melanogaster
H159VDCWYHPKCFV1Bos taurus
H159IDRWYHPTCFV1Rattus norvegicus
H53VPHWYHFSCFW2Homo sapiens, Rattus norvegicus
H53MPMWNHASCIL2Arabidopsis thaliana, Oryza sativa subsp. japonica
H53MDSWFHYNCFW1Caenorhabditis elegans
H53VPNWFHKTCFF1Drosophila melanogaster
H53IPHWYHLSCFW1Bos taurus
H862RRLLWHGSRTT3Homo sapiens, Bos taurus, Rattus norvegicus
H862KMLLWHGSRLT2Arabidopsis thaliana, Oryza sativa subsp. japonica
H862RRLLWHGSGKM1Caenorhabditis elegans
H862RKLLWHGSRLT1Drosophila melanogaster
I154-QLGMIDRWYH2Homo sapiens, Rattus norvegicus
I154------GKANH1Caenorhabditis elegans
I154GNKGLM--WHH1Arabidopsis thaliana
I154--------WYH1Oryza sativa subsp. japonica
I154MKYGGQPLWHH1Drosophila melanogaster
I154-QLGMVDCWYH1Bos taurus
I879SQGLRIAPPEA4Homo sapiens, Oryza sativa subsp. japonica, Bos taurus, Rattus norvegicus
I879GQGLRIAPPEA1Caenorhabditis elegans
I879NQGLRIAPPEA1Arabidopsis thaliana
I879SHGLRIAPPEA1Drosophila melanogaster
I895MFGKGIYFADM4Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus
I895MFGKGVYFADM1Caenorhabditis elegans
I895MFGKGIYFADL1Arabidopsis thaliana
I895MFGKGLYFADL1Oryza sativa subsp. japonica
K119AAEYAKSNRST2Homo sapiens, Rattus norvegicus
K119KTEKSLSNRGK1Caenorhabditis elegans
K119GIEVSQTSRAG1Arabidopsis thaliana
K119-IEVAKSARTS1Oryza sativa subsp. japonica
K119GIEYAKSSRST1Drosophila melanogaster
K119GAGYAKSNRST1Bos taurus
K126NRSTCKGCMEK2Homo sapiens, Rattus norvegicus
K126NRGKCGKCGQN1Caenorhabditis elegans
K126SRAGCRKCSEK1Arabidopsis thaliana
K126ARTSCRRCGEK1Oryza sativa subsp. japonica
K126SRSTCRGCEQK1Drosophila melanogaster
K126NRSTCKSCMEK1Bos taurus
K134MEKIEKGQVRL1Homo sapiens
K134GQNFERGEIKA1Caenorhabditis elegans
K134SEKILKGEVRI1Arabidopsis thaliana
K134GEKIKKGTVRV1Oryza sativa subsp. japonica
K134EQKINKDLVRL1Drosophila melanogaster
K134MEKIDKGQVRL1Bos taurus
K134MEKIEKGQMRL1Rattus norvegicus
K148MVDPEKP-QLG1Homo sapiens
K148-----------1Caenorhabditis elegans
K148---PEGPGNKG1Arabidopsis thaliana
K148LEGQG------1Oryza sativa subsp. japonica
K148VYDTEVGMKYG1Drosophila melanogaster
K148VVYPDKP-QLG1Bos taurus
K148MLDPEKP-QLG1Rattus norvegicus
K15RVEYAKSGRAS3Homo sapiens, Bos taurus, Rattus norvegicus
K15AIEYAKSGRSN1Caenorhabditis elegans
K15RAEYAKSSRSS1Arabidopsis thaliana
K15KAEYAKSGRSS1Oryza sativa subsp. japonica
K15LAEYARTGRAT1Drosophila melanogaster
K22GRASCKKCSES2Homo sapiens, Rattus norvegicus
K22GRSNCKTCKKN1Caenorhabditis elegans
K22SRSSCKTCKSV1Arabidopsis thaliana
K22GRSSCKSCRSP1Oryza sativa subsp. japonica
K22GRATCKGCKST1Drosophila melanogaster
K22GRASCKKCKES1Bos taurus
K600-IGSNKLEQMP3Homo sapiens, Bos taurus, Rattus norvegicus
K600-VGGNKHESYS1Caenorhabditis elegans
K600KIGGNKVEEM-1Arabidopsis thaliana
K600KIGGTKLEEM-1Oryza sativa subsp. japonica
K600-IGNSKLEEFD1Drosophila melanogaster
K621KLYEEKTGN--3Homo sapiens, Bos taurus, Rattus norvegicus
K621DVFHEKTKN--1Caenorhabditis elegans
K621RLFLEKTGNTW1Arabidopsis thaliana
K621RLFLEKTGNPW1Oryza sativa subsp. japonica
K621EIYADKTGN--1Drosophila melanogaster
K903ADMVSKSANYC4Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus
K903ADLVSKSAQYC2Arabidopsis thaliana, Oryza sativa subsp. japonica
K903ADMFSKSFFYC1Caenorhabditis elegans
L151EKP-QLGMIDR2Homo sapiens, Rattus norvegicus
L151---------GK1Caenorhabditis elegans
L151EGPGNKGLM--1Arabidopsis thaliana
L151G----------1Oryza sativa subsp. japonica
L151EVGMKYGGQPL1Drosophila melanogaster
L151DKP-QLGMVDC1Bos taurus
L769MLDNLLDIEVA3Homo sapiens, Bos taurus, Rattus norvegicus
L769MLEALQDIEIA2Arabidopsis thaliana, Oryza sativa subsp. japonica
L769MLNALLDIKFA1Caenorhabditis elegans
L769MLDSLAEIEVA1Drosophila melanogaster
M43MVQSPMFDGKV2Homo sapiens, Rattus norvegicus
M43NRPSTFFDGNM1Caenorhabditis elegans
M43LVQSTHFDGIM1Arabidopsis thaliana
M43MVQATQFDGLM1Oryza sativa subsp. japonica
M43MVQSAFHDAKV1Drosophila melanogaster
M43MVESPMFDGKI1Bos taurus
N767VEMLDNLLDIE3Homo sapiens, Bos taurus, Rattus norvegicus
N767VKMLEALQDIE2Arabidopsis thaliana, Oryza sativa subsp. japonica
N767NNMLNALLDIK1Caenorhabditis elegans
N767RQMLDSLAEIE1Drosophila melanogaster
N868GSRTTNFAGIL3Homo sapiens, Bos taurus, Rattus norvegicus
N868GSRLTNFVGIL2Arabidopsis thaliana, Drosophila melanogaster
N868GSGKMNFAGIL1Caenorhabditis elegans
N868GSRLTNYVGIL1Oryza sativa subsp. japonica
P49FDGKVPHWYHF2Homo sapiens, Rattus norvegicus
P49FDGNMDSWFHY1Caenorhabditis elegans
P49FDGIMPMWNHA1Arabidopsis thaliana
P49FDGLMPMWNHA1Oryza sativa subsp. japonica
P49HDAKVPNWFHK1Drosophila melanogaster
P49FDGKIPHWYHL1Bos taurus
P881GLRIAPPEAPV5Homo sapiens, Caenorhabditis elegans, Oryza sativa subsp. japonica, Bos taurus, Rattus norvegicus
P881GLRIAPPEAPA1Arabidopsis thaliana
P881GLRIAPPEAPP1Drosophila melanogaster
Q150PEKP-QLGMID2Homo sapiens, Rattus norvegicus
Q150----------G1Caenorhabditis elegans
Q150PEGPGNKGLM-1Arabidopsis thaliana
Q150QG---------1Oryza sativa subsp. japonica
Q150TEVGMKYGGQP1Drosophila melanogaster
Q150PDKP-QLGMVD1Bos taurus
Q759NADSVQAKVEM1Homo sapiens
Q759SFHKIKEKNNM1Caenorhabditis elegans
Q759DEDDFKSKVKM1Arabidopsis thaliana
Q759DEDDLMVKVKM1Oryza sativa subsp. japonica
Q759THQQIEDLRQM1Drosophila melanogaster
Q759NANSVQAKVEM1Bos taurus
Q759NTDSVQAKVEM1Rattus norvegicus
R122YAKSNRSTCKG2Homo sapiens, Rattus norvegicus
R122KSLSNRGKCGK1Caenorhabditis elegans
R122VSQTSRAGCRK1Arabidopsis thaliana
R122VAKSARTSCRR1Oryza sativa subsp. japonica
R122YAKSSRSTCRG1Drosophila melanogaster
R122YAKSNRSTCKS1Bos taurus
R138EKGQVRLSKKM1Homo sapiens
R138ERGEIKAHNK-1Caenorhabditis elegans
R138LKGEVRIFSK-1Arabidopsis thaliana
R138KKGTVRVSSKL1Oryza sativa subsp. japonica
R138NKDLVRLRKTV1Drosophila melanogaster
R138DKGQVRLSKKV1Bos taurus
R138EKGQMRLSKKM1Rattus norvegicus
R18YAKSGRASCKK3Homo sapiens, Bos taurus, Rattus norvegicus
R18YAKSGRSNCKT1Caenorhabditis elegans
R18YAKSSRSSCKT1Arabidopsis thaliana
R18YAKSGRSSCKS1Oryza sativa subsp. japonica
R18YARTGRATCKG1Drosophila melanogaster
R34PKDSLRMAIMV2Homo sapiens, Rattus norvegicus
R34ALDQLRMSMNR1Caenorhabditis elegans
R34NKENFRLGKLV1Arabidopsis thaliana
R34GKDQLRLGKMV1Oryza sativa subsp. japonica
R34SKDTLRIAVMV1Drosophila melanogaster
R34PKDSIRMAFMV1Bos taurus
R587RYWIFRSWGRV3Homo sapiens, Bos taurus, Rattus norvegicus
R587DCYVFRKWGRV2Arabidopsis thaliana, Oryza sativa subsp. japonica
R587NYYVFRSWGRV1Caenorhabditis elegans
R587KYWIFRSWGRI1Drosophila melanogaster
R878LSQGLRIAPPE4Homo sapiens, Oryza sativa subsp. japonica, Bos taurus, Rattus norvegicus
R878LGQGLRIAPPE1Caenorhabditis elegans
R878LNQGLRIAPPE1Arabidopsis thaliana
R878LSHGLRIAPPE1Drosophila melanogaster
S120AEYAKSNRSTC2Homo sapiens, Rattus norvegicus
S120TEKSLSNRGKC1Caenorhabditis elegans
S120IEVSQTSRAGC1Arabidopsis thaliana
S120IEVAKSARTSC1Oryza sativa subsp. japonica
S120IEYAKSSRSTC1Drosophila melanogaster
S120AGYAKSNRSTC1Bos taurus
S123AKSNRSTCKGC2Homo sapiens, Rattus norvegicus
S123SLSNRGKCGKC1Caenorhabditis elegans
S123SQTSRAGCRKC1Arabidopsis thaliana
S123AKSARTSCRRC1Oryza sativa subsp. japonica
S123AKSSRSTCRGC1Drosophila melanogaster
S123AKSNRSTCKSC1Bos taurus
S16VEYAKSGRASC3Homo sapiens, Bos taurus, Rattus norvegicus
S16IEYAKSGRSNC1Caenorhabditis elegans
S16AEYAKSSRSSC1Arabidopsis thaliana
S16AEYAKSGRSSC1Oryza sativa subsp. japonica
S16AEYARTGRATC1Drosophila melanogaster
S20KSGRASCKKCS2Homo sapiens, Rattus norvegicus
S20KSGRSNCKTCK1Caenorhabditis elegans
S20KSSRSSCKTCK1Arabidopsis thaliana
S20KSGRSSCKSCR1Oryza sativa subsp. japonica
S20RTGRATCKGCK1Drosophila melanogaster
S20KSGRASCKKCK1Bos taurus
S274KQQVPSGE--S1Homo sapiens
S274EQDIPEGHDPT1Caenorhabditis elegans
S274EQSTRGSE--L1Arabidopsis thaliana
S274GQDTSGPE--R1Oryza sativa subsp. japonica
S274NQQPVTGD--T1Drosophila melanogaster
S274KQEVPSGE--S1Bos taurus
S274QQQVPSGE--S1Rattus norvegicus
S864LLWHGSRTTNF3Homo sapiens, Bos taurus, Rattus norvegicus
S864LLWHGSRLTNF2Arabidopsis thaliana, Drosophila melanogaster
S864LLWHGSGKMNF1Caenorhabditis elegans
S864LLWHGSRLTNY1Oryza sativa subsp. japonica
S904DMVSKSANYCH3Homo sapiens, Bos taurus, Rattus norvegicus
S904DLVSKSAQYCY2Arabidopsis thaliana, Oryza sativa subsp. japonica
S904DMFSKSFFYCR1Caenorhabditis elegans
S904DMVSKSANYCC1Drosophila melanogaster
T124KSNRSTCKGCM2Homo sapiens, Rattus norvegicus
T124LSNRGKCGKCG1Caenorhabditis elegans
T124QTSRAGCRKCS1Arabidopsis thaliana
T124KSARTSCRRCG1Oryza sativa subsp. japonica
T124KSSRSTCRGCE1Drosophila melanogaster
T124KSNRSTCKSCM1Bos taurus
T887PEAPVTGYMFG4Homo sapiens, Oryza sativa subsp. japonica, Bos taurus, Rattus norvegicus
T887PEAPVSGYMFG1Caenorhabditis elegans
T887PEAPATGYMFG1Arabidopsis thaliana
T887PEAPPTGYMFG1Drosophila melanogaster
V48MFDGKVPHWYH2Homo sapiens, Rattus norvegicus
V48FFDGNMDSWFH1Caenorhabditis elegans
V48HFDGIMPMWNH1Arabidopsis thaliana
V48QFDGLMPMWNH1Oryza sativa subsp. japonica
V48FHDAKVPNWFH1Drosophila melanogaster
V48MFDGKIPHWYH1Bos taurus
V762SVQAKVEMLDN3Homo sapiens, Bos taurus, Rattus norvegicus
V762KIKEKNNMLNA1Caenorhabditis elegans
V762DFKSKVKMLEA1Arabidopsis thaliana
V762DLMVKVKMLEA1Oryza sativa subsp. japonica
V762QIEDLRQMLDS1Drosophila melanogaster
V773LLDIEVAYSLL3Homo sapiens, Bos taurus, Rattus norvegicus
V773LLDIKFAYDQI1Caenorhabditis elegans
V773LQDIEIASRIV1Arabidopsis thaliana
V773LQDIEIASKLV1Oryza sativa subsp. japonica
V773LAEIEVAYSII1Drosophila melanogaster
W157GMIDRWYHPGC1Homo sapiens
W157---GKANHFKC1Caenorhabditis elegans
W157GLM--WHHAKC1Arabidopsis thaliana
W157-----WYHASC1Oryza sativa subsp. japonica
W157GGQPLWHHLEC1Drosophila melanogaster
W157GMVDCWYHPKC1Bos taurus
W157GMIDRWYHPTC1Rattus norvegicus
W51GKVPHWYHFSC2Homo sapiens, Rattus norvegicus
W51GNMDSWFHYNC1Caenorhabditis elegans
W51GIMPMWNHASC1Arabidopsis thaliana
W51GLMPMWNHASC1Oryza sativa subsp. japonica
W51AKVPNWFHKTC1Drosophila melanogaster
W51GKIPHWYHLSC1Bos taurus
W589WIFRSWGRVGT3Homo sapiens, Bos taurus, Rattus norvegicus
W589YVFRKWGRVGN2Arabidopsis thaliana, Oryza sativa subsp. japonica
W589YVFRSWGRVGT1Caenorhabditis elegans
W589WIFRSWGRIGT1Drosophila melanogaster
Y570GTNSYYKLQLL3Homo sapiens, Bos taurus, Rattus norvegicus
Y570NKNSYYKIQLL1Caenorhabditis elegans
Y570GINSYYILQII1Arabidopsis thaliana
Y570GVNSYYILQVI1Oryza sativa subsp. japonica
Y570NKNSYYKVQLL1Drosophila melanogaster
Y710QIQAAYSILSE3Homo sapiens, Bos taurus, Rattus norvegicus
Y710NIQKGFEALTE2Arabidopsis thaliana, Oryza sativa subsp. japonica
Y710QINLAFEVLND1Caenorhabditis elegans
Y710QIQSAYRVVKE1Drosophila melanogaster
Y889APVTGYMFGKG4Homo sapiens, Oryza sativa subsp. japonica, Bos taurus, Rattus norvegicus
Y889APVSGYMFGKG1Caenorhabditis elegans
Y889APATGYMFGKG1Arabidopsis thaliana
Y889APPTGYMFGKG1Drosophila melanogaster
Y896FGKGIYFADMV4Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus
Y896FGKGVYFADMF1Caenorhabditis elegans
Y896FGKGIYFADLV1Arabidopsis thaliana
Y896FGKGLYFADLV1Oryza sativa subsp. japonica
Y907SKSANYCHTSQ3Homo sapiens, Bos taurus, Rattus norvegicus
Y907SKSFFYCRANA1Caenorhabditis elegans
Y907SKSAQYCYTCK1Arabidopsis thaliana
Y907SKSAQYCYVDR1Oryza sativa subsp. japonica
Y907SKSANYCCTSQ1Drosophila melanogaster


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