mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PTGR2
Gene summary
Basic gene Info.Gene symbolPTGR2
Gene nameprostaglandin reductase 2
SynonymsHEL-S-298|PGR2|ZADH1
CytomapUCSC genome browser: 14q24.3
Type of geneprotein-coding
RefGenesNM_001146154.1,
NM_001146155.1,NM_152444.2,
Description15-oxoprostaglandin 13-reductase15-oxoprostaglandin-delta13-reductasePRG-2epididymis secretory protein Li 298zinc binding alcohol dehydrogenase, domain containing 1zinc-binding alcohol dehydrogenase domain-containing protein 1
Modification date20141207
dbXrefs MIM : 608642
HGNC : HGNC
Ensembl : ENSG00000140043
HPRD : 09782
Vega : OTTHUMG00000171255
ProteinUniProt: Q8N8N7
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PTGR2
BioGPS: 145482
PathwayNCI Pathway Interaction Database: PTGR2
KEGG: PTGR2
REACTOME: PTGR2
Pathway Commons: PTGR2
ContextiHOP: PTGR2
ligand binding site mutation search in PubMed: PTGR2
UCL Cancer Institute: PTGR2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006693prostaglandin metabolic process19000823


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Ligand binding site mutations for PTGR2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C253L252MCOAD1
V232G233VLUAD1
I236D238HSKCM1
E115E115KTHCA1
I300L301IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PTGR2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
E115E115K-1.7017215
C253L252M-1.3389282
I236D238H-0.97293591
V232G233V-0.52449425
I300L301I-0.095304842
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PTGR2 from PDB

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Differential gene expression and gene-gene network for PTGR2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PTGR2 and the right PPI network was created from samples without mutations in the LBS of PTGR2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PTGR2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PTGR2

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00328IndomethacinSmall molecule
ExperimentalDB07177(5E,13E)-11-HYDROXY-9,15-DIOXOPROSTA-5,13-DIEN-1-OIC ACIDSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PTGR2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NAPNADP ZWITTERION2vnaAC253
CBW(3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC ACID2w4qAC253
P1ZPHENYLBUTAZONE2w98AC253
CBW(3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC ACID2w4qAE115
P1ZPHENYLBUTAZONE2w98BE115
P1ZPHENYLBUTAZONE2w98AE115 I300
NAPNADP ZWITTERION2w4qAV232 C253
NAPNADP ZWITTERION2w98AV232 I236 C253
NAPNADP ZWITTERION2w98BV232 I236 C253
NAPNADP ZWITTERION2zb4AV232 I236 C253
NDPNADPH2zb7AV232 I236 C253
NAPNADP ZWITTERION2zb8AV232 I236 C253


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Conservation information for LBS of PTGR2
Multiple alignments for Q8N8N7 in multiple species
LBSAA sequence# speciesSpecies
A166SGAAGACGSLA3Mus musculus, Rattus norvegicus, Bos taurus
A166SGAAGACGSVA1Homo sapiens
A166SGAAGAVGTVC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C167GAAGACGSLAG3Mus musculus, Rattus norvegicus, Bos taurus
C167GAAGACGSVAG1Homo sapiens
C167GAAGAVGTVCI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C187RVVGICGTHEK2Homo sapiens, Rattus norvegicus
C187KVIAIAGGPEK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C187RVVGICGTQEK1Mus musculus
C187RVVGICGTPEK1Bos taurus
C253SHIILCGQISQ4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
C253AMLIACGAISA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C54DPYMRCRMNED2Homo sapiens, Bos taurus
C54DPAQKFWIS-S1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C54DPYMRCKMNED1Mus musculus
C54DPYMRCKMNEE1Rattus norvegicus
D294VLNYKDKFEPG2Homo sapiens, Mus musculus
D294VTDNIDDFPKA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D294VLNYKDRFEPG1Rattus norvegicus
D294VLNYKDKFEFG1Bos taurus
E115DGNGLEKVDPQ2Mus musculus, Rattus norvegicus
E115DGNSLEKVDPQ1Homo sapiens
E115NVQGLRKLDKN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E115DGNILEKVDPQ1Bos taurus
E297YKDKFEPGILQ2Homo sapiens, Mus musculus
E297NIDDFPKALDK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E297YKDRFEPGILQ1Rattus norvegicus
E297YKDKFEFGILQ1Bos taurus
F129GHLSYFLGAIG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F129GKLWWYLSVLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F287ITRERFLVLNY2Homo sapiens, Bos taurus
F287VVKG-VLVTDN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F287ITRERFTVLNY1Mus musculus
F287ITRERFMVLNY1Rattus norvegicus
F296NYKDKFEPGIL2Homo sapiens, Mus musculus
F296DNIDDFPKALD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F296NYKDRFEPGIL1Rattus norvegicus
F296NYKDKFEFGIL1Bos taurus
F99DFVTSFYWPWQ4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F99DYVSAVT-GWT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G165VSGAAGACGSL3Mus musculus, Rattus norvegicus, Bos taurus
G165VSGAAGACGSV1Homo sapiens
G165ISGAAGAVGTV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G188VVGICGTHEKC2Homo sapiens, Rattus norvegicus
G188VIAIAGGPEKV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G188VVGICGTQEKC1Mus musculus
G188VVGICGTPEKC1Bos taurus
G254HIILCGQISQY4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G254MLIACGAISAY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G335QSMMTGGNIGK3Homo sapiens, Rattus norvegicus, Bos taurus
G335KGLFSGVNKGK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G335QSMMTGGNVGK1Mus musculus
I236NVGGDISNAVI2Mus musculus, Rattus norvegicus
I236NVGGNISDTVI1Homo sapiens
I236NVGSNVLEAGV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I236NVGGDISDTVI1Bos taurus
I256ILCGQISQYNK3Homo sapiens, Rattus norvegicus, Bos taurus
I256IACGAISAYND1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I256ILCGQISQYSN1Mus musculus
I300KFEPGILQLSQ2Homo sapiens, Mus musculus
I300DFPKALDKLGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I300RFEPGILQLSQ1Rattus norvegicus
I300KFEFGILQLSQ1Bos taurus
I65TGTDYITPWQL1Homo sapiens
I65MDKNYAKGVQP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I65TGTDYLAPWQL1Mus musculus
I65TGADYLAPWQL1Rattus norvegicus
I65TGSDYITPWQL1Bos taurus
K116GNGLEKVDPQL2Mus musculus, Rattus norvegicus
K116GNSLEKVDPQL1Homo sapiens
K116VQGLRKLDKNK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K116GNILEKVDPQL1Bos taurus
K192CGTHEKCILLT1Homo sapiens
K192AGGPEKVAFVE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K192CGTQEKCLFLT1Mus musculus
K192CGTHEKCLFLT1Rattus norvegicus
K192CGTPEKCLFLT1Bos taurus
K293LVLNYKDKFEP1Homo sapiens
K293LVTDNIDDFPK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K293TVLNYKDKFEP1Mus musculus
K293MVLNYKDRFEP1Rattus norvegicus
K293LVLNYKDKFEF1Bos taurus
L138IGMPGLTSLI-4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L138LGGTSLTAYFI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L288TRERFLVLNYK2Homo sapiens, Bos taurus
L288VKG-VLVTDNI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L288TRERFTVLNYK1Mus musculus
L288TRERFMVLNYK1Rattus norvegicus
L290ERFLVLNYKDK2Homo sapiens, Bos taurus
L290G-VLVTDNIDD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L290ERFTVLNYKDK1Mus musculus
L290ERFMVLNYKDR1Rattus norvegicus
M135LGAIGMPGLTS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M135LSVLGGTSLTA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M332AAFQSMMTGGN2Homo sapiens, Bos taurus
M332VAFQSMMTGGN2Mus musculus, Rattus norvegicus
M332LIWKGLFSGVN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M333AFQSMMTGGNI3Homo sapiens, Rattus norvegicus, Bos taurus
M333IWKGLFSGVNK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M333AFQSMMTGGNV1Mus musculus
N231DVYFDNVGGDI3Mus musculus, Rattus norvegicus, Bos taurus
N231DVYFDNVGGNI1Homo sapiens
N231DYFIDNVGSNV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N291RFLVLNYKDKF2Homo sapiens, Bos taurus
N291-VLVTDNIDDF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N291RFTVLNYKDKF1Mus musculus
N291RFMVLNYKDRF1Rattus norvegicus
N337MMTGGNIGKQI3Homo sapiens, Rattus norvegicus, Bos taurus
N337LFSGVNKGKLI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N337MMTGGNVGKQI1Mus musculus
P50YLSVDPYMRCR2Homo sapiens, Bos taurus
P50YLSVDPYMRCK2Mus musculus, Rattus norvegicus
P50YLSNDPAQKFW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q255IILCGQISQYN3Homo sapiens, Rattus norvegicus, Bos taurus
Q255LIACGAISAYN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q255IILCGQISQYS1Mus musculus
S257LCGQISQYNKD3Homo sapiens, Rattus norvegicus, Bos taurus
S257ACGAISAYNDP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S257LCGQISQYSND1Mus musculus
T139GMPGLTSLI--4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T139GGTSLTAYFIF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T97KGDFVTSFYWP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T97PGDYVSAVT-G1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V117NGLEKVDPQLV2Mus musculus, Rattus norvegicus
V117NSLEKVDPQLV1Homo sapiens
V117QGLRKLDKNKV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V117NILEKVDPQLV1Bos taurus
V232VYFDNVGGDIS3Mus musculus, Rattus norvegicus, Bos taurus
V232VYFDNVGGNIS1Homo sapiens
V232YFIDNVGSNVL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V289RERFLVLNYKD2Homo sapiens, Bos taurus
V289KG-VLVTDNID1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V289RERFTVLNYKD1Mus musculus
V289RERFMVLNYKD1Rattus norvegicus
Y100FVTSFYWPWQT4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y100YVSAVT-GWTT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y208DAAVNYKTGNV2Mus musculus, Rattus norvegicus
Y208DAAINYKKDNV1Homo sapiens
Y208VVGVDYKDPSF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y208DAAINYKEGNV1Bos taurus
Y259GQISQYNKDVP3Homo sapiens, Rattus norvegicus, Bos taurus
Y259GAISAYNDPSK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y259GQISQYSNDVP1Mus musculus
Y265NKDVPYPPPLP2Rattus norvegicus, Bos taurus
Y265NKDVPYPPPLS1Homo sapiens
Y265NDPSKF---VF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y265SNDVPYPPPLP1Mus musculus
Y51LSVDPYMRCRM2Homo sapiens, Bos taurus
Y51LSVDPYMRCKM2Mus musculus, Rattus norvegicus
Y51LSNDPAQKFWI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y64DTGTDYITPWQ1Homo sapiens
Y64SMDKNYAKGVQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y64DTGTDYLAPWQ1Mus musculus
Y64ETGADYLAPWQ1Rattus norvegicus
Y64DTGSDYITPWQ1Bos taurus


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