mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CSNK2B
Gene summary
Basic gene Info.Gene symbolCSNK2B
Gene namecasein kinase 2, beta polypeptide
CytomapUCSC genome browser: 6p21.3
Type of geneprotein-coding
DescriptionCK II betaCSNK2B-LY6G5B-532CSNK2B-LY6G5B-560Casein kinase II beta subunitalternative name: G5a, phosvitincasein kinase II b subunit splicing isoform 318casein kinase II b subunit splicing isoform 660casein kinase II b subunit splicing isoform 806c
Modification date20141207
dbXrefs MIM : 115441
Ensembl : ENSG00000204435
HPRD : 00278
Vega : OTTHUMG00000177888
ProteinUniProt: P67870
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CSNK2B
BioGPS: 1460
PathwayNCI Pathway Interaction Database: CSNK2B
Pathway Commons: CSNK2B
ContextiHOP: CSNK2B
ligand binding site mutation search in PubMed: CSNK2B
UCL Cancer Institute: CSNK2B
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation19592636
GO:0033211adiponectin-activated signaling pathway19233263
GO:0043537negative regulation of blood vessel endothelial cell migration19592636

Ligand binding site mutations for CSNK2B

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for CSNK2B
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CSNK2B from PDB

Differential gene expression and gene-gene network for CSNK2B
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CSNK2B and the right PPI network was created from samples without mutations in the LBS of CSNK2B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for CSNK2B
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007137Carcinoma, Squamous Cell1Biomarker
umls:C0037286Skin Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for CSNK2B
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CSNK2B go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of CSNK2B
Multiple alignments for P67870 in multiple species
LBSAA sequence# speciesSpecies
C109GDFGYCPRVYC5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
C109ADFGRCPRVYC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C109ADFGKCPRVMC1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C109CDFGHCPRVLC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C109YDFGRCPRVFC1Arabidopsis thaliana
C109CDFGRCPRVFC1Arabidopsis thaliana
C109HDFGVCPRVYC1Caenorhabditis elegans
C109GDFGHCPRVYC1Drosophila melanogaster
C114CPRVYCENQPM6Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
C114CPRVFCCGQSC2Arabidopsis thaliana, Arabidopsis thaliana
C114CPRVYCNLQQL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C114CPRVMCSSHPL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C114CPRVLCNGQPM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C114CPRVYCESQPM1Drosophila melanogaster
C137MVKLYCPKCMD5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
C137TVKIYCPKCED2Arabidopsis thaliana, Arabidopsis thaliana
C137CVKLYCPSCED1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C137PVKLYCARCED1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C137SVKLYCPRCED1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C137MVKLYCPRCND1Caenorhabditis elegans
C137MVKTYCPKCID1Drosophila melanogaster
C140LYCPKCMDVYT5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
C140LYCPSCEDLYI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C140LYCARCEDIYN1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C140LYCPRCEDVYT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C140IYCPKCEDIYY1Arabidopsis thaliana
C140IYCPKCEDISY1Arabidopsis thaliana
C140LYCPRCNDVFV1Caenorhabditis elegans
C140TYCPKCIDVYT1Drosophila melanogaster
Y144KCMDVYTPKSS5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
Y144SCEDLYIPKSS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y144RCEDIYNPKSS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y144RCEDVYTPKSQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y144KCEDIYYPRSK1Arabidopsis thaliana
Y144KCEDISYPRSK1Arabidopsis thaliana
Y144RCNDVFVPRSS1Caenorhabditis elegans
Y144KCIDVYTPKSS1Drosophila melanogaster

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