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mutLBSgeneDB |
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| Gene summary for CSNK2B |
 Gene summary |
| Basic gene Info. | Gene symbol | CSNK2B |
| Gene name | casein kinase 2, beta polypeptide | |
| Synonyms | CK2B|CK2N|CSK2B|G5A | |
| Cytomap | UCSC genome browser: 6p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001282385.1, NM_001320.6, | |
| Description | CK II betaCSNK2B-LY6G5B-532CSNK2B-LY6G5B-560Casein kinase II beta subunitalternative name: G5a, phosvitincasein kinase II b subunit splicing isoform 318casein kinase II b subunit splicing isoform 660casein kinase II b subunit splicing isoform 806c | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 115441 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000204435 | ||
| HPRD : 00278 | ||
| Vega : OTTHUMG00000177888 | ||
| Protein | UniProt: P67870 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CSNK2B | |
| BioGPS: 1460 | ||
| Pathway | NCI Pathway Interaction Database: CSNK2B | |
| KEGG: CSNK2B | ||
| REACTOME: CSNK2B | ||
| Pathway Commons: CSNK2B | ||
| Context | iHOP: CSNK2B | |
| ligand binding site mutation search in PubMed: CSNK2B | ||
| UCL Cancer Institute: CSNK2B | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 19592636 | GO:0033211 | adiponectin-activated signaling pathway | 19233263 | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 19592636 |
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| Ligand binding site mutations for CSNK2B |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Y144 | P143H | OV | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CSNK2B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CSNK2B from PDB |
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| Differential gene expression and gene-gene network for CSNK2B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CSNK2B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0007137 | Carcinoma, Squamous Cell | 1 | Biomarker |
| umls:C0037286 | Skin Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CSNK2B |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CSNK2B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 1jwh | D | Y144 |
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| Conservation information for LBS of CSNK2B |
| Multiple alignments for P67870 in multiple species |
| LBS | AA sequence | # species | Species | C109 | GDFGYCPRVYC | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio | C109 | ADFGRCPRVYC | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C109 | ADFGKCPRVMC | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | C109 | CDFGHCPRVLC | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C109 | YDFGRCPRVFC | 1 | Arabidopsis thaliana | C109 | CDFGRCPRVFC | 1 | Arabidopsis thaliana | C109 | HDFGVCPRVYC | 1 | Caenorhabditis elegans | C109 | GDFGHCPRVYC | 1 | Drosophila melanogaster | C114 | CPRVYCENQPM | 6 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio | C114 | CPRVFCCGQSC | 2 | Arabidopsis thaliana, Arabidopsis thaliana | C114 | CPRVYCNLQQL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C114 | CPRVMCSSHPL | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | C114 | CPRVLCNGQPM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C114 | CPRVYCESQPM | 1 | Drosophila melanogaster | C137 | MVKLYCPKCMD | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio | C137 | TVKIYCPKCED | 2 | Arabidopsis thaliana, Arabidopsis thaliana | C137 | CVKLYCPSCED | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C137 | PVKLYCARCED | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | C137 | SVKLYCPRCED | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C137 | MVKLYCPRCND | 1 | Caenorhabditis elegans | C137 | MVKTYCPKCID | 1 | Drosophila melanogaster | C140 | LYCPKCMDVYT | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio | C140 | LYCPSCEDLYI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C140 | LYCARCEDIYN | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | C140 | LYCPRCEDVYT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C140 | IYCPKCEDIYY | 1 | Arabidopsis thaliana | C140 | IYCPKCEDISY | 1 | Arabidopsis thaliana | C140 | LYCPRCNDVFV | 1 | Caenorhabditis elegans | C140 | TYCPKCIDVYT | 1 | Drosophila melanogaster | Y144 | KCMDVYTPKSS | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio | Y144 | SCEDLYIPKSS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y144 | RCEDIYNPKSS | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | Y144 | RCEDVYTPKSQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y144 | KCEDIYYPRSK | 1 | Arabidopsis thaliana | Y144 | KCEDISYPRSK | 1 | Arabidopsis thaliana | Y144 | RCNDVFVPRSS | 1 | Caenorhabditis elegans | Y144 | KCIDVYTPKSS | 1 | Drosophila melanogaster |
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