mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CTNNB1
Gene summary
Basic gene Info.Gene symbolCTNNB1
Gene namecatenin (cadherin-associated protein), beta 1, 88kDa
SynonymsCTNNB|MRD19|armadillo
CytomapUCSC genome browser: 3p21
Type of geneprotein-coding
RefGenesNM_001098209.1,
NM_001098210.1,NM_001904.3,
Descriptioncatenin beta-1
Modification date20141222
dbXrefs MIM : 116806
HGNC : HGNC
Ensembl : ENSG00000168036
HPRD : 00286
Vega : OTTHUMG00000131393
ProteinUniProt: P35222
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CTNNB1
BioGPS: 1499
PathwayNCI Pathway Interaction Database: CTNNB1
KEGG: CTNNB1
REACTOME: CTNNB1
Pathway Commons: CTNNB1
ContextiHOP: CTNNB1
ligand binding site mutation search in PubMed: CTNNB1
UCL Cancer Institute: CTNNB1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0008285negative regulation of cell proliferation12970740
GO:0016055Wnt signaling pathway10644691
GO:0030997regulation of centriole-centriole cohesion18086858
GO:0032355response to estradiol15304487
GO:0033234negative regulation of protein sumoylation22155184
GO:0043065positive regulation of apoptotic process12970740
GO:0045893positive regulation of transcription, DNA-templated12970740
GO:0045944positive regulation of transcription from RNA polymerase II promoter11751639
GO:0060070canonical Wnt signaling pathway12937339
GO:0071681cellular response to indole-3-methanol10868478
GO:0090279regulation of calcium ion import19996314
GO:2000008regulation of protein localization to cell surface19996314


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Ligand binding site mutations for CTNNB1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
I303I303MCOAD2
C619C619YCOAD2
W383W383RCOAD1
K292K292TCOAD1
T257T257ICOAD1
N387N387KCOAD1
D162D162ECOAD1
R582R582QCOAD1
Y333,K335E334KCOAD1
N516L517FCOAD1
R515R515QCOAD1
W383W383GCOAD1
T257I256TCOAD1
Y333,K335E334ACOAD1
E568E568KCOAD1
H176,L178Q177RCOAD1
R212T214ACOAD1
L159L159PCOAD1
H176,L178Q177HCOAD1
R185H186LCOAD1
N426N426DKIRC1
R212C213FLUAD1
D164,V166Q165HLUSC1
C429C429GSKCM1
K292K292ESKCM1
P606P606LSKCM1
V166V166GSTAD1
W338T339NSTAD1
K170K170MUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for CTNNB1 from My Cancer Genome.
CTNNB1 is the gene which encodes the ß-catenin protein. ß-catenin is part of a complex of proteins that form adherens junctions, which are important for the establishment and maintenance of epithelial cell layers by regulating cell growth and adhesion between adjacent cells (Hartsock and Nelson 2008). ß-catenin is also part of the canonical Wnt signaling pathway. In the absence of Wnt signaling, glycogen synthase kinase-3 (GSK-3) phosphorylates ß-catenin, thereby targeting ß-catenin for degradation via the ubiquitin-proteasome system. When Wnt binds to its receptor, Frizzled, ß-catenin phosphorylation and ubiquitin-mediated degradation are blocked. ß-catenin is then free to translocate to the cell nucleus where it acts as a co-factor for the T-cell factor/lymphoid enhancing factor (TCF/LEF) transcription factors. The ß-catenin-TCF/LEF complex results in the activation of targets including c-MYC and Cyclin-D1 (for review, see Giles, van Es, and Clevers 2003). Mutant CTNNB1 (ß-catenin) has been implicated in the pathogenesis of several cancers including melanoma, colorectal cancer, hepatocelluar carcinoma, and ovarian cancer (Giles, van Es, and Clevers 2003). Related Pathways: β-catenin/Wnt signaling Lovly, C.M., Sosman, J., Pao, W. 2015. CTNNB1. My Cancer Genomehttps://www.mycancergenome.org/content/gene/ctnnb1/ (Updated December 2015)

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Protein structure related information for CTNNB1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
T257T257I0.43670365
R185H186L0.36567022
C619C619Y0.26645544
K292K292E0.094113074
H176Q177R0.081956105
L178Q177R0.081956105
V166V166G-2.0374723
L159L159P-1.696064
R582R582Q-1.4860601
C429C429G-1.4079344
I303I303M-1.2940518
T257I256T-1.1866771
E568E568K-1.157738
W338T339N-1.081749
V166Q165H-1.0522164
D164Q165H-1.0522164
R212T214A-0.97330001
N387N387K-0.89999124
N426N426D-0.76856947
W383W383G-0.7253223
K335E334A-0.70914599
Y333E334A-0.70914599
Y333E334K-0.66008153
K335E334K-0.66008153
R515R515Q-0.61239023
P606P606L-0.3911711
N516L517F-0.38918475
K170K170M-0.29473306
W383W383R-0.29416079
L178Q177H-0.27441165
H176Q177H-0.27441165
R212C213F-0.26639689
K292K292T-0.13768036
D162D162E-0.080315953
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CTNNB1 from PDB
PDB IDPDB titlePDB structure
1JDHCRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4

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Differential gene expression and gene-gene network for CTNNB1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CTNNB1 and the right PPI network was created from samples without mutations in the LBS of CTNNB1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CTNNB1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C2239176Carcinoma, Hepatocellular52AlteredExpression, Biomarker, GeneticVariation
umls:C1527249Colorectal Cancer36Biomarker, GeneticVariation
umls:C0009404Colorectal Neoplasms31AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0009375Colonic Neoplasms26AlteredExpression, Biomarker, GeneticVariation
umls:C0001430Adenoma21AlteredExpression, Biomarker, GeneticVariation
umls:C0206624Hepatoblastoma17Biomarker, GeneticVariation
umls:C0025149Medulloblastoma16Biomarker, GeneticVariation
umls:C0001418Adenocarcinoma16AlteredExpression, Biomarker, GeneticVariation
umls:C0699790Colon Carcinoma15Biomarker, GeneticVariation
umls:C0027708Wilms Tumor11Biomarker, GeneticVariation
umls:C0033578Prostatic Neoplasms9AlteredExpression, Biomarker
umls:C1458155Breast Neoplasms9AlteredExpression, Biomarker
umls:C0023903Liver Neoplasms9Biomarker, GeneticVariation
umls:C0206711Pilomatrixoma6Biomarker, GeneticVariation
umls:C0024121Lung Neoplasms5AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0030297Pancreatic Neoplasms5AlteredExpression, Biomarker, GeneticVariation
umls:C0010276Craniopharyngioma5Biomarker, GeneticVariation
umls:C0023890Liver Cirrhosis4Biomarker
umls:C0206669Adenoma, Liver Cell3Biomarker
umls:C0206686Adrenocortical Carcinoma3Biomarker
umls:C0021841Intestinal Neoplasms3Biomarker
umls:C0919267Ovarian Neoplasms3Biomarker
umls:C1879526Aberrant Crypt Foci3Biomarker
umls:C0023904Liver Neoplasms, Experimental3Biomarker
umls:C1140680Malignant neoplasm of ovary2Biomarker, GeneticVariation
umls:C0001624Adrenal Gland Neoplasms2Biomarker
umls:C0007873Uterine Cervical Neoplasms2Biomarker
umls:C0334634Lymphoma, Mantle-Cell1AlteredExpression, Biomarker
umls:C0000772Abnormalities, Multiple1Biomarker
umls:C0007528Cecal Neoplasms1Biomarker
umls:C0376634Craniofacial Abnormalities1Biomarker
umls:C0860207Drug-Induced Liver Injury1Therapeutic
umls:C0018923Hemangiosarcoma1Biomarker
umls:C0026846Muscular Atrophy1Therapeutic
umls:C0027626Neoplasm Invasiveness1Biomarker
umls:C0027746Nerve Degeneration1Biomarker
umls:C0232347No-Reflow Phenomenon1Therapeutic

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CTNNB1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB03904UreaSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CTNNB1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (SER,SER,SER,LEU,SER,ALA,LEU,SER,LEU,ASP,GLU,PRO,PHE,ILE,GLN,LYS,ASP,VAL,GLU,LEU,ARG,ILE,MET,PRO,PRO,VAL,GLN)1th1AH176 R185 T257 K292 Y333 K335
IIIPeptide ligand (SER,SER,LEU,SER,ALA,LEU,SER,LEU,ASP,GLU,PRO,PHE,ILE,GLN,LYS,ASP,VAL,GLU,LEU,ARG,ILE,MET,PRO,PRO,VAL,GLN)1th1BH176 R185 T257 K292 Y333 K335
IIIPeptide ligand (LEU,GLY,ALA,ASN,ASP,GLU,LEU,ILE,SER,PHE,LYS,ASP,GLU,GLY,GLU,GLN,GLU)2gl7DI303 N387 N426 C429 N516 R582
IIIPeptide ligand (ASP,LEU,ALA,ASP,VAL,LYS,SER,SER,LEU,VAL,ASN)1jpwAK292 Y333 K335
IIIPeptide ligand (GLU,ARG,ASP,LEU,ALA,ASP,VAL,LYS,SER,SER,LEU,VAL,ASN)2gl7AK292 Y333 K335
IIIPeptide ligand (ASP,LEU,ALA,ASP,VAL,LYS,SER,SER,LEU,VAL,ASN)2gl7DK292 Y333 K335 W338
IIIPeptide ligand (SER,GLN,GLU,GLN,LEU,GLU,HIS,ARG,GLU,ARG,SER,LEU,GLN,THR,LEU,ARG,ASP,ILE,GLN,ARG)3sl9GL159 D162 D164 V166
IIIPeptide ligand (GLN,LEU,GLU,HIS,ARG,GLU,ARG,SER,LEU,GLN,THR,LEU,ARG,ASP,ILE,GLN,ARG)2gl7DL159 D162 D164 V166 K170
IIIPeptide ligand (PRO,ASP,GLY,LEU,SER,GLN,GLU,GLN,LEU,GLU,HIS,ARG,GLU,ARG,SER,LEU,GLN,THR,LEU,ARG,ASP,ILE,GLN,ARG,MET,LEU,PHE)3sl9AL159 D162 D164 V166 K170
IIIPeptide ligand (ASP,GLY,LEU,SER,GLN,GLU,GLN,LEU,GLU,HIS,ARG,GLU,ARG,SER,LEU,GLN,THR,LEU,ARG,ASP,ILE,GLN,ARG,MET,LEU,PHE,PRO)3sl9EL159 D162 D164 V166 K170 L178
IIIPeptide ligand (SER,GLN,GLU,GLN,LEU,GLU,HIS,ARG,GLU,ARG,SER,LEU,GLN,THR,LEU,ARG,ASP,ILE,GLN,ARG,MET,LEU,PHE)2gl7AL159 D162 D164 V166 L178
IIIPeptide ligand (SER,GLN,GLU,GLN,LEU,GLU,HIS,ARG,GLU,ARG,SER,LEU,GLN,THR,LEU,ARG,ASP,ILE,GLN,ARG,MET,LEU,PHE)3sl9BL159 D162 D164 V166 L178
IIIPeptide ligand (GLY,ALA,ASN,ASP,GLU,LEU,ILE,SER,PHE,LYS,ASP,GLU,GLY)1jpwAN387 N426 C429
IIIPeptide ligand (GLY,ALA,ASN,ASP,GLU,LEU,ILE,SER,PHE,LYS,ASP,GLU,GLY)1jpwBN387 N426 C429
IIIPeptide ligand (GLY,ALA,ASN,ASP,GLU,LEU,ILE,SER,PHE,LYS,ASP,GLU,GLY)1jpwCN387 N426 C429
IIIPeptide ligand (LEU,GLY,ALA,ASN,ASP,GLU,LEU,ILE,SER,PHE,LYS,ASP,GLU,GLY,GLU,GLN,GLU)2gl7AN387 N426 C429 N516
IIIPeptide ligand (LYS,GLN,ALA,ALA,VAL,ASN,ALA,ALA,VAL,GLN,ARG,VAL,GLN,VAL,LEU,PRO,ASP,ALA,ASP,THR,LEU,LEU,HIS,PHE,ALA,THR,GLU,SER,THR)1th1AN387 N426 C429 R515 N516 C619
IIIPeptide ligand (PRO,GLN,LEU,ASN,SER,GLY,GLY,GLY,ASP,GLU,LEU,GLY,ALA,ASN,ASP,GLU,LEU,ILE,ARG,PHE,LYS,ASP,GLU,GLY,GLU,GLN,GLU,GLU)1g3jAN387 N426 C429 R515 N516 E568 R582 P606
IIIPeptide ligand (PRO,GLN,LEU,ASN,SER,GLY,GLY,GLY,ASP,GLU,LEU,GLY,ALA,ASN,ASP,GLU,LEU,ILE,ARG,PHE,LYS,ASP,GLU)1g3jCN387 N426 C429 R515 N516 E568 R582 P606
IIIPeptide ligand (ASP,LEU,ALA,ASP,VAL,LYS,SER,SER,LEU,VAL,ASN,GLU,SER)1g3jAR212 T257 K292 Y333 K335
IIIPeptide ligand (ASP,LEU,ALA,ASP,VAL,LYS,SER,SER,LEU,VAL,ASN)1g3jCT257 K292
IIIPeptide ligand (ASP,LEU,ALA,ASP,VAL,LYS,SER,SER,LEU,VAL,ASN)1jpwBT257 K292 K335
IIIPeptide ligand (ASP,LEU,ALA,ASP,VAL,LYS,SER,SER,LEU,VAL,ASN)1jpwCT257 K292 K335
IIIPeptide ligand (GLU,GLU,ASN,PRO,GLU,SER,ILE,LEU,ASP,GLU,HIS,VAL,GLN,ARG,VAL,MET,LYS)1qz7AT257 K292 K335 W338
IIIPeptide ligand (ARG,TRP,PRO,GLN,LEU,ILE,LEU,ASP,LEU,HIS,VAL,ARG,ARG,VAL,TRP)4djsAT257 K292 K335 W338
IIIPeptide ligand (ASP,ALA,ASP,THR,LEU,LEU,HIS,PHE,ALA,THR,GLU,SER,THR,PRO,ASP)1t08AW383 N387 N426 C429
IIIPeptide ligand (GLN,ALA,ALA,VAL,ASN,ALA,ALA,VAL,GLN,ARG,VAL,GLN,VAL,LEU,PRO,ASP,ALA,ASP,THR,LEU,LEU,HIS,PHE,ALA,THR,GLU,SER,THR)1th1BW383 N387 N426 C429 R515 C619


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Conservation information for LBS of CTNNB1
Multiple alignments for P35222 in multiple species
LBSAA sequence# speciesSpecies
A152ELATRAIPELT5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
A152DMSGLSLPDLV1Caenorhabditis elegans
A152ELATRAIPELI1Drosophila melanogaster
A152DLATRAIPELI1Anopheles gambiae
A295NVKFLAITTDC5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
A295NVKFLAIVTDC2Drosophila melanogaster, Anopheles gambiae
A295NPKLLAQVADG1Caenorhabditis elegans
A657ATYAAAVLFRM6Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster
A657VTYANGVL---1Caenorhabditis elegans
A657ATYAAAVLFKM1Anopheles gambiae
C429LSNLTCNNYKN5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
C429LSNLTCNNQRN2Drosophila melanogaster, Anopheles gambiae
C429LSNLTCNNTRN1Caenorhabditis elegans
C466TEPAICALRHL5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
C466TEPAVCALRHL2Drosophila melanogaster, Anopheles gambiae
C466TEPALCALRHC1Caenorhabditis elegans
C619AAGVLCELAQD5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
C619ILGLLYQLSKR1Caenorhabditis elegans
C619AAGVLCELAAD1Drosophila melanogaster
C619AAGVLCELAVD1Anopheles gambiae
D162TKLLNDEDQVV5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
D162IKLLNDEDQVV2Drosophila melanogaster, Anopheles gambiae
D162VKLMCDHDESV1Caenorhabditis elegans
D164LLNDEDQVVVN5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
D164LLNDEDQVVVS2Drosophila melanogaster, Anopheles gambiae
D164LMCDHDESVVA1Caenorhabditis elegans
D299LAITTDCLQIL5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
D299LAIVTDCLQIL2Drosophila melanogaster, Anopheles gambiae
D299LAQVADGLYFL1Caenorhabditis elegans
D390LRNLSDAATKQ5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
D390LRNLSDAATKV2Drosophila melanogaster, Anopheles gambiae
D390MRNLSDSATNE1Caenorhabditis elegans
E155TRAIPELTKLL5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
E155TRAIPELIKLL2Drosophila melanogaster, Anopheles gambiae
E155GLSLPDLVKLM1Caenorhabditis elegans
E568GVRMEEIVEGC5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
E568GVRMEEIVEGT2Drosophila melanogaster, Anopheles gambiae
E568GVPMWGVIEGA1Caenorhabditis elegans
E571MEEIVEGCTGA5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
E571MEEIVEGTVGA2Drosophila melanogaster, Anopheles gambiae
E571MWGVIEGAVSA1Caenorhabditis elegans
E608-----ENIQRV7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
E608GSMDDEVLERE1Caenorhabditis elegans
E620AGVLCELAQDK5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
E620LGLLYQLSKRP1Caenorhabditis elegans
E620AGVLCELAADK1Drosophila melanogaster
E620AGVLCELAVDK1Anopheles gambiae
F253VDSVLFYAITT5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
F253VESVLFYAITT2Drosophila melanogaster, Anopheles gambiae
F253LESVVHYAVTT1Caenorhabditis elegans
F293KTNVKFLAITT5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
F293RNNVKFLAIVT2Drosophila melanogaster, Anopheles gambiae
F293KTNPKLLAQVA1Caenorhabditis elegans
F660AAAVLFRMSED6Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster
F660ANGVL------1Caenorhabditis elegans
F660AAAVLFKMSED1Anopheles gambiae
G307QILAYGNQESK7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
G307YFLLIDDAPSK1Caenorhabditis elegans
G422VTCAAGILSNL7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
G422TACACGTLSNL1Caenorhabditis elegans
G512IKATVGLIRNL5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
G512IKAVIGLIRNL2Drosophila melanogaster, Anopheles gambiae
G512IKAALGVIRNS1Caenorhabditis elegans
G650HSRNEGVATYA6Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster
G650GSQYKSVVTYA1Caenorhabditis elegans
G650NSANEGVATYA1Anopheles gambiae
H176AAVMVHQLSKK5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
H176AAMMVHQLSKK2Drosophila melanogaster, Anopheles gambiae
H176AVHRAYMLSRE1Caenorhabditis elegans
H219TAGTLHNLSHH5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
H219AVGTLHNLSHH2Drosophila melanogaster, Anopheles gambiae
H219AIGALSHMSEQ1Caenorhabditis elegans
H223LHNLSHHREGL5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
H223LHNLSHHRQGL2Drosophila melanogaster, Anopheles gambiae
H223LSHMSEQRGGP1Caenorhabditis elegans
H224HNLSHHREGLL5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
H224HNLSHHRQGLL2Drosophila melanogaster, Anopheles gambiae
H224SHMSEQRGGPL1Caenorhabditis elegans
H260AITTLHNLLLH7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
H260AVTTLRNLLMH1Caenorhabditis elegans
H265HNLLLHQEGAK5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
H265HNLLLHQDGSK2Drosophila melanogaster, Anopheles gambiae
H265RNLLMHVSDSR1Caenorhabditis elegans
H470ICALRHLTSRH5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
H470VCALRHLTSRH2Drosophila melanogaster, Anopheles gambiae
H470LCALRHCTARH1Caenorhabditis elegans
H578CTGALHILARD5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
H578AVSALHQLANH1Caenorhabditis elegans
H578TVGALHILARE1Drosophila melanogaster
H578TVGALHILAKE1Anopheles gambiae
I296VKFLAITTDCL5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
I296VKFLAIVTDCL2Drosophila melanogaster, Anopheles gambiae
I296PKLLAQVADGL1Caenorhabditis elegans
I303TDCLQILAYGN7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
I303ADGLYFLLIDD1Caenorhabditis elegans
I607L-YSPI-----5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
I607L-HRLLAHPRL1Caenorhabditis elegans
I607L-FNEI-----1Drosophila melanogaster
I607LFYNDI-----1Anopheles gambiae
K170QVVVNKAAVMV5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
K170QVVVSQAAMMV2Drosophila melanogaster, Anopheles gambiae
K170ESVVARAVHRA1Caenorhabditis elegans
K180VHQLSKKEASR7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
K180AYMLSREDPN-1Caenorhabditis elegans
K181HQLSKKEASRH7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
K181YMLSREDPN--1Caenorhabditis elegans
K270HQEGAKMAVRL5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
K270HQDGSKMAVRL2Drosophila melanogaster, Anopheles gambiae
K270HVSDSRAQARA1Caenorhabditis elegans
K292NKTNVKFLAIT5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
K292QRNNVKFLAIV2Drosophila melanogaster, Anopheles gambiae
K292HKTNPKLLAQV1Caenorhabditis elegans
K312GNQESKLIILA7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
K312DDAPSKITFLS1Caenorhabditis elegans
K335Y-TYEKLLWTT5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
K335Y-DYEKLLWTT2Drosophila melanogaster, Anopheles gambiae
K335YSDHRKLIYTV1Caenorhabditis elegans
K345TSRVLKVLSVC7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
K345VVRCIRSLSVC1Caenorhabditis elegans
K435NNYKNKMMVCQ5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
K435NNTRNKQTVCS1Caenorhabditis elegans
K435NNQRNKATVCQ1Drosophila melanogaster
K435NNQRNKVTVCQ1Anopheles gambiae
K508HWPLIKATVGL5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
K508RWPLIKAVIGL2Drosophila melanogaster, Anopheles gambiae
K508T-PVIKAALGV1Caenorhabditis elegans
L148QDDAELATRAI6Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster
L148EGSNDMSGLSL1Caenorhabditis elegans
L148QDDADLATRAI1Anopheles gambiae
L156RAIPELTKLLN5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
L156RAIPELIKLLN2Drosophila melanogaster, Anopheles gambiae
L156LSLPDLVKLMC1Caenorhabditis elegans
L159PELTKLLNDED5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
L159PELIKLLNDED2Drosophila melanogaster, Anopheles gambiae
L159PDLVKLMCDHD1Caenorhabditis elegans
L178VMVHQLSKKEA5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
L178MMVHQLSKKEA2Drosophila melanogaster, Anopheles gambiae
L178HRAYMLSREDP1Caenorhabditis elegans
L264LHNLLLHQEGA5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
L264LHNLLLHQDGS2Drosophila melanogaster, Anopheles gambiae
L264LRNLLMHVSDS1Caenorhabditis elegans
L519IRNLALCPANH6Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster
L519IRNSALLQTNL1Caenorhabditis elegans
L519IRNLALCPANA1Anopheles gambiae
M174NKAAVMVHQLS5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
M174SQAAMMVHQLS2Drosophila melanogaster, Anopheles gambiae
M174ARAVHRAYMLS1Caenorhabditis elegans
N220AGTLHNLSHHR5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
N220VGTLHNLSHHR2Drosophila melanogaster, Anopheles gambiae
N220IGALSHMSEQR1Caenorhabditis elegans
N261ITTLHNLLLHQ7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
N261VTTLRNLLMHV1Caenorhabditis elegans
N290LLNKTNVKFLA5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
N290LLQRNNVKFLA2Drosophila melanogaster, Anopheles gambiae
N290HLHKTNPKLLA1Caenorhabditis elegans
N387LWTLRNLSDAA7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
N387LVAMRNLSDSA1Caenorhabditis elegans
N426AGILSNLTCNN7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
N426CGTLSNLTCNN1Caenorhabditis elegans
N430SNLTCNNYKNK5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
N430SNLTCNNQRNK2Drosophila melanogaster, Anopheles gambiae
N430SNLTCNNTRNK1Caenorhabditis elegans
N516VGLIRNLALCP5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
N516IGLIRNLALCP2Drosophila melanogaster, Anopheles gambiae
N516LGVIRNSALLQ1Caenorhabditis elegans
N609----ENIQRVA7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
N609SMDDEVLEREI1Caenorhabditis elegans
P463EDITEPAICAL5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
P463EEITEPAVCAL2Drosophila melanogaster, Anopheles gambiae
P463EEVTEPALCAL1Caenorhabditis elegans
P606LL-YSPI----5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
P606LL-HRLLAHPR1Caenorhabditis elegans
P606LL-FNEI----1Drosophila melanogaster
P606LLFYNDI----1Anopheles gambiae
Q302TTDCLQILAYG5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
Q302VTDCLQILAYG2Drosophila melanogaster, Anopheles gambiae
Q302VADGLYFLLID1Caenorhabditis elegans
R185KKEASRHAIMR5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
R185KKEASRHAIMN2Drosophila melanogaster, Anopheles gambiae
R185REDPN---FFN1Caenorhabditis elegans
R212DVETARCTAGT5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
R212-VNVRRNAIGA1Caenorhabditis elegans
R212DLESTKAAVGT1Drosophila melanogaster
R212DLETTKGAVGT1Anopheles gambiae
R225NLSHHREGLLA5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
R225NLSHHRQGLLA2Drosophila melanogaster, Anopheles gambiae
R225HMSEQRGGPLL1Caenorhabditis elegans
R342LWTTSRVLKVL7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
R342IYTVVRCIRSL1Caenorhabditis elegans
R376TDPSQRLVQNC5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
R376TAKDERSQTAI1Caenorhabditis elegans
R376GNMSPRLVQNC1Drosophila melanogaster
R376GNPSQRLVQNC1Anopheles gambiae
R386CLWTLRNLSDA7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
R386ILVAMRNLSDS1Caenorhabditis elegans
R469AICALRHLTSR5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
R469AVCALRHLTSR2Drosophila melanogaster, Anopheles gambiae
R469ALCALRHCTAR1Caenorhabditis elegans
R474RHLTSRHQEAE5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
R474RHCTARHSLAE1Caenorhabditis elegans
R474RHLTSRHVDSE1Drosophila melanogaster
R474RHLTSRHPESE1Anopheles gambiae
R515TVGLIRNLALC5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
R515VIGLIRNLALC2Drosophila melanogaster, Anopheles gambiae
R515ALGVIRNSALL1Caenorhabditis elegans
R565FVEGVRMEEIV5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
R565YADGVRMEEIV2Drosophila melanogaster, Anopheles gambiae
R565AVDGVPMWGVI1Caenorhabditis elegans
R582LHILARD----5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
R582LHQLANHPAVA1Caenorhabditis elegans
R582LHILARE----1Drosophila melanogaster
R582LHILAKE----1Anopheles gambiae
R612-ENIQRVAAGV7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
R612DEVLEREILGL1Caenorhabditis elegans
R661AAVLFRMSEDK6Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster
R661NGVL-------1Caenorhabditis elegans
R661AAVLFKMSEDK1Anopheles gambiae
S250GSPVDSVLFYA5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
S250SSPVESVLFYA2Drosophila melanogaster, Anopheles gambiae
S250YDSLESVVHYA1Caenorhabditis elegans
S425AAGILSNLTCN7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
S425ACGTLSNLTCN1Caenorhabditis elegans
S473LRHLTSRHQEA5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
S473LRHCTARHSLA1Caenorhabditis elegans
S473LRHLTSRHVDS1Drosophila melanogaster
S473LRHLTSRHPES1Anopheles gambiae
T257LFYAITTLHNL7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
T257VHYAVTTLRNL1Caenorhabditis elegans
T393LSDAATKQEGM5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
T393LSDSATNEENL1Caenorhabditis elegans
T393LSDAATKVEGL1Drosophila melanogaster
T393LSDAATKVDGL1Anopheles gambiae
T653NEGVATYAAAV7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
T653YKSVVTYANGV1Caenorhabditis elegans
V166NDEDQVVVNKA5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
V166NDEDQVVVSQA2Drosophila melanogaster, Anopheles gambiae
V166CDHDESVVARA1Caenorhabditis elegans
V167DEDQVVVNKAA5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
V167DEDQVVVSQAA2Drosophila melanogaster, Anopheles gambiae
V167DHDESVVARAV1Caenorhabditis elegans
V346SRVLKVLSVCS7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
V346VRCIRSLSVCP1Caenorhabditis elegans
V349LKVLSVCSSNK7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
V349IRSLSVCPSNK1Caenorhabditis elegans
V613ENIQRVAAGVL7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
V613EVLEREILGLL1Caenorhabditis elegans
W338YEKLLWTTSRV7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
W338HRKLIYTVVRC1Caenorhabditis elegans
W383VQNCLWTLRNL7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
W383QTAILVAMRNL1Caenorhabditis elegans
Y254DSVLFYAITTL5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
Y254ESVLFYAITTL2Drosophila melanogaster, Anopheles gambiae
Y254ESVVHYAVTTL1Caenorhabditis elegans
Y306LQILAYGNQES7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
Y306LYFLLIDDAPS1Caenorhabditis elegans
Y333RTY-TYEKLLW5Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus
Y333RSY-DYEKLLW2Drosophila melanogaster, Anopheles gambiae
Y333REYSDHRKLIY1Caenorhabditis elegans
Y654EGVATYAAAVL7Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus, Drosophila melanogaster, Anopheles gambiae
Y654KSVVTYANGVL1Caenorhabditis elegans


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