mutLBSgeneDB |
Gene summary for CTNND1 |
Gene summary |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for CTNND1 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | A381,F377 | L379V | COAD | 1 | N362 | P361H | COAD | 1 | G474 | T475P | COAD | 1 | H392 | H392Y | LUAD | 1 | F377 | R378L | LUAD | 1 | G474 | I472S | LUSC | 1 | K486 | M487K | STAD | 1 | K444 | K444T | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for CTNND1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | G474 | I472S | -1.320874 | K444 | K444T | -1.2420726 | N362 | P361H | -1.1831193 | F377 | L379V | -1.1304552 | A381 | L379V | -1.1304552 | G474 | T475P | -1.0871957 | K486 | M487K | -1.0652412 | H392 | H392Y | -0.76135143 | F377 | R378L | -0.20012637 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CTNND1 from PDB |
Top |
Differential gene expression and gene-gene network for CTNND1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for CTNND1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for CTNND1 |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CTNND1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ASP,GLU,GLU,GLY,GLY,GLY,GLU,GLU,ASP,GLN,ASP,PHE,ASP,LEU,SER,GLN,LEU,HIS) | 3l6y | E | N362 F377 A381 H392 K444 G474 K486 | III | Peptide ligand (ASP,GLU,GLU,GLY,GLY,GLY,GLU,GLU,ASP,GLN,ASP,PHE,ASP,LEU,SER,GLN,LEU,HIS) | 3l6y | C | N362 F377 H392 K444 G474 K486 | III | Peptide ligand (ASP,GLU,GLU,GLY,GLY,GLY,GLU,GLU,ASP,GLN,ASP,PHE,ASP,LEU,SER,GLN,LEU,HIS) | 3l6x | A | N362 H392 K444 G474 K486 | III | Peptide ligand (ASP,GLU,GLU,GLY,GLY,GLY,GLU,GLU,ASP,GLN,ASP,PHE,ASP,LEU,SER,GLN,LEU,HIS) | 3l6y | A | N362 H392 K444 G474 K486 |
Top |
Conservation information for LBS of CTNND1 |
Multiple alignments for O60716 in multiple species |
LBS | AA sequence | # species | Species |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |