mutLBSgeneDB |
Gene summary for CTNND1 |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CTNND1 |
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LBS | AAchange of nsSNV | Cancer type | # samples | A381,F377 | L379V | COAD | 1 | N362 | P361H | COAD | 1 | G474 | T475P | COAD | 1 | H392 | H392Y | LUAD | 1 | F377 | R378L | LUAD | 1 | G474 | I472S | LUSC | 1 | K486 | M487K | STAD | 1 | K444 | K444T | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CTNND1 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | G474 | I472S | -1.320874 | K444 | K444T | -1.2420726 | N362 | P361H | -1.1831193 | F377 | L379V | -1.1304552 | A381 | L379V | -1.1304552 | G474 | T475P | -1.0871957 | K486 | M487K | -1.0652412 | H392 | H392Y | -0.76135143 | F377 | R378L | -0.20012637 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for CTNND1 |
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Phenotype information for CTNND1 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CTNND1 |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ASP,GLU,GLU,GLY,GLY,GLY,GLU,GLU,ASP,GLN,ASP,PHE,ASP,LEU,SER,GLN,LEU,HIS) | 3l6y | E | N362 F377 A381 H392 K444 G474 K486 | III | Peptide ligand (ASP,GLU,GLU,GLY,GLY,GLY,GLU,GLU,ASP,GLN,ASP,PHE,ASP,LEU,SER,GLN,LEU,HIS) | 3l6y | C | N362 F377 H392 K444 G474 K486 | III | Peptide ligand (ASP,GLU,GLU,GLY,GLY,GLY,GLU,GLU,ASP,GLN,ASP,PHE,ASP,LEU,SER,GLN,LEU,HIS) | 3l6x | A | N362 H392 K444 G474 K486 | III | Peptide ligand (ASP,GLU,GLU,GLY,GLY,GLY,GLU,GLU,ASP,GLN,ASP,PHE,ASP,LEU,SER,GLN,LEU,HIS) | 3l6y | A | N362 H392 K444 G474 K486 |
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Conservation information for LBS of CTNND1 |
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LBS | AA sequence | # species | Species |
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