mutLBSgeneDB |
Gene summary for CTSE |
Gene summary |
Basic gene Info. | Gene symbol | CTSE |
Gene name | cathepsin E | |
Synonyms | CATE | |
Cytomap | UCSC genome browser: 1q31 | |
Type of gene | protein-coding | |
RefGenes | NM_001910.3, NM_148964.2, | |
Description | erythrocyte membrane aspartic proteinaseslow-moving proteinase | |
Modification date | 20141207 | |
dbXrefs | MIM : 116890 | |
HGNC : HGNC | ||
Ensembl : ENSG00000196188 | ||
HPRD : 00294 | ||
Vega : OTTHUMG00000036121 | ||
Protein | UniProt: P14091 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CTSE | |
BioGPS: 1510 | ||
Pathway | NCI Pathway Interaction Database: CTSE | |
KEGG: CTSE | ||
REACTOME: CTSE | ||
Pathway Commons: CTSE | ||
Context | iHOP: CTSE | |
ligand binding site mutation search in PubMed: CTSE | ||
UCL Cancer Institute: CTSE | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | 8765029 |
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Ligand binding site mutations for CTSE |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | G240,D242 | F241L | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CTSE |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CTSE from PDB |
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Differential gene expression and gene-gene network for CTSE |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CTSE |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CTSE |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CTSE go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of CTSE |
Multiple alignments for P14091 in multiple species |
LBS | AA sequence | # species | Species | D216 | AQNLVALPMFS | 2 | Mus musculus, Rattus norvegicus | D216 | AQNLVDLPMFS | 1 | Homo sapiens | D242 | TFGGYDPSHFS | 2 | Mus musculus, Rattus norvegicus | D242 | IFGGYDHSHFS | 1 | Homo sapiens | E161 | FATQVEGLTVV | 1 | Homo sapiens | E161 | ----VEGLTVD | 1 | Mus musculus | E161 | ----VEGLTVE | 1 | Rattus norvegicus | E235 | GGSGSELTFGG | 2 | Mus musculus, Rattus norvegicus | E235 | GGAGSELIFGG | 1 | Homo sapiens | F238 | GSELTFGGYDP | 2 | Mus musculus, Rattus norvegicus | F238 | GSELIFGGYDH | 1 | Homo sapiens | F79 | LDMEYFGTISI | 2 | Homo sapiens, Mus musculus | F79 | LDMEYFGTVSI | 1 | Rattus norvegicus | F95 | NFTVIFDTGSS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G231 | SDPQGGSGSEL | 2 | Mus musculus, Rattus norvegicus | G231 | SNPEGGAGSEL | 1 | Homo sapiens | G240 | ELTFGGYDPSH | 2 | Mus musculus, Rattus norvegicus | G240 | ELIFGGYDHSH | 1 | Homo sapiens | I237 | SGSELTFGGYD | 2 | Mus musculus, Rattus norvegicus | I237 | AGSELIFGGYD | 1 | Homo sapiens | L163 | TQVEGLTVVGQ | 1 | Homo sapiens | L163 | --VEGLTVDGQ | 1 | Mus musculus | L163 | --VEGLTVEGQ | 1 | Rattus norvegicus | L236 | GSGSELTFGGY | 2 | Mus musculus, Rattus norvegicus | L236 | GAGSELIFGGY | 1 | Homo sapiens | S234 | QGGSGSELTFG | 2 | Mus musculus, Rattus norvegicus | S234 | EGGAGSELIFG | 1 | Homo sapiens | V160 | -----VEGLTV | 2 | Mus musculus, Rattus norvegicus | V160 | AFATQVEGLTV | 1 | Homo sapiens | Y78 | YLDMEYFGTIS | 2 | Homo sapiens, Mus musculus | Y78 | YLDMEYFGTVS | 1 | Rattus norvegicus |
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