mutLBSgeneDB |
Gene summary for CTSG |
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Basic gene Info. | Gene symbol | CTSG |
Gene name | cathepsin G | |
Synonyms | CATG|CG | |
Cytomap | UCSC genome browser: 14q11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001911.2, | |
Description | - | |
Modification date | 20141207 | |
dbXrefs | MIM : 116830 | |
HGNC : HGNC | ||
Ensembl : ENSG00000100448 | ||
HPRD : 00289 | ||
Vega : OTTHUMG00000140182 | ||
Protein | UniProt: P08311 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CTSG | |
BioGPS: 1511 | ||
Pathway | NCI Pathway Interaction Database: CTSG | |
KEGG: CTSG | ||
REACTOME: CTSG | ||
Pathway Commons: CTSG | ||
Context | iHOP: CTSG | |
ligand binding site mutation search in PubMed: CTSG | ||
UCL Cancer Institute: CTSG | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0006508 | proteolysis | 11907569 |
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Ligand binding site mutations for CTSG |
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LBS | AAchange of nsSNV | Cancer type | # samples | C49 | R48T | BLCA | 1 | Y217 | Y217H | LUAD | 1 | D200 | D200N | LUSC | 1 | C49 | G51R | SKCM | 1 | D200 | D200N | SKCM | 1 | V215 | V215I | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CTSG |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D200 | D200N | -1.0879914 | C49 | R48T | -0.63979037 | Y217 | Y217H | -0.4783381 | V215 | V215I | -0.43586613 | C49 | G51R | -0.047270164 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for CTSG |
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Phenotype information for CTSG |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CTSG |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB02360 | Bis-Napthyl Beta-Ketophosphonic Acid | Small molecule | ![]() |
Experimental | DB04016 | 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid | Small molecule | ![]() |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of CTSG |
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LBS | AA sequence | # species | Species |
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