mutLBSgeneDB |
Gene summary for ZCWPW2 |
Gene summary |
Basic gene Info. | Gene symbol | ZCWPW2 |
Gene name | zinc finger, CW type with PWWP domain 2 | |
Synonyms | ZCW2 | |
Cytomap | UCSC genome browser: 3p24.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001040432.1, | |
Description | zinc finger CW-type PWWP domain protein 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000206559 | ||
Vega : OTTHUMG00000155705 | ||
Protein | UniProt: Q504Y3 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZCWPW2 | |
BioGPS: 152098 | ||
Pathway | NCI Pathway Interaction Database: ZCWPW2 | |
KEGG: ZCWPW2 | ||
REACTOME: ZCWPW2 | ||
Pathway Commons: ZCWPW2 | ||
Context | iHOP: ZCWPW2 | |
ligand binding site mutation search in PubMed: ZCWPW2 | ||
UCL Cancer Institute: ZCWPW2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for ZCWPW2 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | S46 | S46G | COAD | 5 | S45 | S45L | COAD | 1 | E56 | E56A | COAD | 1 | C71 | N70Y | LUAD | 1 | W30 | W30C | LUSC | 1 | S46 | S46I | OV | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ZCWPW2 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | E56 | E56A | -1.2287137 | W30 | W30C | -1.0852168 | S46 | S46G | -0.76135418 | C71 | N70Y | -0.39452449 | S45 | S45L | -0.39252141 | S46 | S46I | -0.13527907 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ZCWPW2 from PDB |
PDB ID | PDB title | PDB structure | 4Z0O | CW-type zinc finger of ZCWPW2 with F78D mutation |
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Differential gene expression and gene-gene network for ZCWPW2 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for ZCWPW2 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ZCWPW2 |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ZCWPW2 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4o62 | A | C71 | ZN | ZINC(2+) | 4o62 | B | C71 | ZN | ZINC(2+) | 4o62 | C | C71 | ZN | ZINC(2+) | 4z0o | A | C71 | ZN | ZINC(2+) | 4z0r | A | C71 | ZN | ZINC(2+) | 4z0r | B | C71 | ZN | ZINC(2+) | 4z0r | C | C71 | III | Peptide ligand (ALA,ARG,THR,LYS,GLN,THR) | 4o62 | B | W30 E56 | III | Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG,LYS,SER) | 4z0r | B | W30 S45 S46 E56 |
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Conservation information for LBS of ZCWPW2 |
Multiple alignments for Q504Y3 in multiple species |
LBS | AA sequence | # species | Species |
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