mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PPM1K
Gene summary
Basic gene Info.Gene symbolPPM1K
Gene nameprotein phosphatase, Mg2+/Mn2+ dependent, 1K
CytomapUCSC genome browser: 4q22.1
Type of geneprotein-coding
DescriptionPP2C domain-containing protein phosphatase 1KPP2C-kappaPP2C-type mitochondrial phosphoprotein phosphatasebranched-chain alpha-ketoacid dehydrogenase phosphataseprotein phosphatase 1K, mitochondrialprotein phosphatase 2C kappa
Modification date20141211
dbXrefs MIM : 611065
Ensembl : ENSG00000163644
HPRD : 15167
Vega : OTTHUMG00000130952
ProteinUniProt: Q8N3J5
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PPM1K
BioGPS: 152926
PathwayNCI Pathway Interaction Database: PPM1K
Pathway Commons: PPM1K
ContextiHOP: PPM1K
ligand binding site mutation search in PubMed: PPM1K
UCL Cancer Institute: PPM1K
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for PPM1K
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for PPM1K
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PPM1K from PDB

Differential gene expression and gene-gene network for PPM1K
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PPM1K and the right PPI network was created from samples without mutations in the LBS of PPM1K. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for PPM1K
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for PPM1K
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PPM1K go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
MGMAGNESIUM(2+)4da1AD298 D337

Conservation information for LBS of PPM1K
Multiple alignments for Q8N3J5 in multiple species
LBSAA sequence# speciesSpecies
D112NEDRFGFAQLT2Mus musculus, Bos taurus
D112NEDRFDFAQLT1Homo sapiens
D112SMEDYHVAKFT1Arabidopsis thaliana
D112PMEDYHVSKFV1Arabidopsis thaliana
D112PMEDYHVANFI1Arabidopsis thaliana
D127YFAVYDGHGGP3Homo sapiens, Mus musculus, Bos taurus
D127LFAIFDGHKGD1Arabidopsis thaliana
D127LFAIYDGHLGE1Arabidopsis thaliana
D127LFAIYDGHMGD1Arabidopsis thaliana
D298LVLTTDGINFM3Homo sapiens, Mus musculus, Bos taurus
D298LILASDGISKV1Arabidopsis thaliana
D298LVLASDGLWKV1Arabidopsis thaliana
D298LLLASDGIWKV1Arabidopsis thaliana
D337QYGTEDNSTAV2Homo sapiens, Mus musculus
D337QYGTEDNTTAV1Bos taurus
D337KRNSKDDISCI1Arabidopsis thaliana
D337RRDSKDDISCI1Arabidopsis thaliana
D337RRESKDDISCV1Arabidopsis thaliana
E143LQKHLFSNILK2Arabidopsis thaliana, Arabidopsis thaliana
E143CHTHMEKCIMD1Homo sapiens
E143CHTHMEKCVMD1Mus musculus
E143CHTHMEKCILD1Bos taurus
E143LQKRLFSNILK1Arabidopsis thaliana
G128FAVYDGHGGPA3Homo sapiens, Mus musculus, Bos taurus
G128FAIFDGHKGDH1Arabidopsis thaliana
G128FAIYDGHLGER1Arabidopsis thaliana
G128FAIYDGHMGDS1Arabidopsis thaliana

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas