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mutLBSgeneDB |
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| Gene summary for PPM1K |
 Gene summary |
| Basic gene Info. | Gene symbol | PPM1K |
| Gene name | protein phosphatase, Mg2+/Mn2+ dependent, 1K | |
| Synonyms | BDP|MSUDMV|PP2Ckappa|PP2Cm|PTMP|UG0882E07 | |
| Cytomap | UCSC genome browser: 4q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_152542.4, | |
| Description | PP2C domain-containing protein phosphatase 1KPP2C-kappaPP2C-type mitochondrial phosphoprotein phosphatasebranched-chain alpha-ketoacid dehydrogenase phosphataseprotein phosphatase 1K, mitochondrialprotein phosphatase 2C kappa | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 611065 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000163644 | ||
| HPRD : 15167 | ||
| Vega : OTTHUMG00000130952 | ||
| Protein | UniProt: Q8N3J5 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PPM1K | |
| BioGPS: 152926 | ||
| Pathway | NCI Pathway Interaction Database: PPM1K | |
| KEGG: PPM1K | ||
| REACTOME: PPM1K | ||
| Pathway Commons: PPM1K | ||
| Context | iHOP: PPM1K | |
| ligand binding site mutation search in PubMed: PPM1K | ||
| UCL Cancer Institute: PPM1K | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PPM1K |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D337 | E336D | COAD | 1 | D337 | T335I | PRAD | 1 | D298 | I300S | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PPM1K |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D298 | I300S | -2.007663 | D337 | E336D | -0.74322487 | D337 | T335I | -0.65024964 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PPM1K from PDB |
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| Differential gene expression and gene-gene network for PPM1K |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PPM1K |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PPM1K |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PPM1K go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | MG | MAGNESIUM(2+) | 4da1 | A | D298 D337 |
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| Conservation information for LBS of PPM1K |
| Multiple alignments for Q8N3J5 in multiple species |
| LBS | AA sequence | # species | Species | D112 | NEDRFGFAQLT | 2 | Mus musculus, Bos taurus | D112 | NEDRFDFAQLT | 1 | Homo sapiens | D112 | SMEDYHVAKFT | 1 | Arabidopsis thaliana | D112 | PMEDYHVSKFV | 1 | Arabidopsis thaliana | D112 | PMEDYHVANFI | 1 | Arabidopsis thaliana | D127 | YFAVYDGHGGP | 3 | Homo sapiens, Mus musculus, Bos taurus | D127 | LFAIFDGHKGD | 1 | Arabidopsis thaliana | D127 | LFAIYDGHLGE | 1 | Arabidopsis thaliana | D127 | LFAIYDGHMGD | 1 | Arabidopsis thaliana | D298 | LVLTTDGINFM | 3 | Homo sapiens, Mus musculus, Bos taurus | D298 | LILASDGISKV | 1 | Arabidopsis thaliana | D298 | LVLASDGLWKV | 1 | Arabidopsis thaliana | D298 | LLLASDGIWKV | 1 | Arabidopsis thaliana | D337 | QYGTEDNSTAV | 2 | Homo sapiens, Mus musculus | D337 | QYGTEDNTTAV | 1 | Bos taurus | D337 | KRNSKDDISCI | 1 | Arabidopsis thaliana | D337 | RRDSKDDISCI | 1 | Arabidopsis thaliana | D337 | RRESKDDISCV | 1 | Arabidopsis thaliana | E143 | LQKHLFSNILK | 2 | Arabidopsis thaliana, Arabidopsis thaliana | E143 | CHTHMEKCIMD | 1 | Homo sapiens | E143 | CHTHMEKCVMD | 1 | Mus musculus | E143 | CHTHMEKCILD | 1 | Bos taurus | E143 | LQKRLFSNILK | 1 | Arabidopsis thaliana | G128 | FAVYDGHGGPA | 3 | Homo sapiens, Mus musculus, Bos taurus | G128 | FAIFDGHKGDH | 1 | Arabidopsis thaliana | G128 | FAIYDGHLGER | 1 | Arabidopsis thaliana | G128 | FAIYDGHMGDS | 1 | Arabidopsis thaliana |
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