mutLBSgeneDB |
Gene summary for PPM1K |
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Basic gene Info. | Gene symbol | PPM1K |
Gene name | protein phosphatase, Mg2+/Mn2+ dependent, 1K | |
Synonyms | BDP|MSUDMV|PP2Ckappa|PP2Cm|PTMP|UG0882E07 | |
Cytomap | UCSC genome browser: 4q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_152542.4, | |
Description | PP2C domain-containing protein phosphatase 1KPP2C-kappaPP2C-type mitochondrial phosphoprotein phosphatasebranched-chain alpha-ketoacid dehydrogenase phosphataseprotein phosphatase 1K, mitochondrialprotein phosphatase 2C kappa | |
Modification date | 20141211 | |
dbXrefs | MIM : 611065 | |
HGNC : HGNC | ||
Ensembl : ENSG00000163644 | ||
HPRD : 15167 | ||
Vega : OTTHUMG00000130952 | ||
Protein | UniProt: Q8N3J5 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PPM1K | |
BioGPS: 152926 | ||
Pathway | NCI Pathway Interaction Database: PPM1K | |
KEGG: PPM1K | ||
REACTOME: PPM1K | ||
Pathway Commons: PPM1K | ||
Context | iHOP: PPM1K | |
ligand binding site mutation search in PubMed: PPM1K | ||
UCL Cancer Institute: PPM1K | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for PPM1K |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | D337 | E336D | COAD | 1 | D337 | T335I | PRAD | 1 | D298 | I300S | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for PPM1K |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D298 | I300S | -2.007663 | D337 | E336D | -0.74322487 | D337 | T335I | -0.65024964 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for PPM1K |
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Phenotype information for PPM1K |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for PPM1K |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | MG | MAGNESIUM(2+) | 4da1 | A | D298 D337 |
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Conservation information for LBS of PPM1K |
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LBS | AA sequence | # species | Species | D112 | NEDRFGFAQLT | 2 | Mus musculus, Bos taurus | D112 | NEDRFDFAQLT | 1 | Homo sapiens | D112 | SMEDYHVAKFT | 1 | Arabidopsis thaliana | D112 | PMEDYHVSKFV | 1 | Arabidopsis thaliana | D112 | PMEDYHVANFI | 1 | Arabidopsis thaliana | D127 | YFAVYDGHGGP | 3 | Homo sapiens, Mus musculus, Bos taurus | D127 | LFAIFDGHKGD | 1 | Arabidopsis thaliana | D127 | LFAIYDGHLGE | 1 | Arabidopsis thaliana | D127 | LFAIYDGHMGD | 1 | Arabidopsis thaliana | D298 | LVLTTDGINFM | 3 | Homo sapiens, Mus musculus, Bos taurus | D298 | LILASDGISKV | 1 | Arabidopsis thaliana | D298 | LVLASDGLWKV | 1 | Arabidopsis thaliana | D298 | LLLASDGIWKV | 1 | Arabidopsis thaliana | D337 | QYGTEDNSTAV | 2 | Homo sapiens, Mus musculus | D337 | QYGTEDNTTAV | 1 | Bos taurus | D337 | KRNSKDDISCI | 1 | Arabidopsis thaliana | D337 | RRDSKDDISCI | 1 | Arabidopsis thaliana | D337 | RRESKDDISCV | 1 | Arabidopsis thaliana | E143 | LQKHLFSNILK | 2 | Arabidopsis thaliana, Arabidopsis thaliana | E143 | CHTHMEKCIMD | 1 | Homo sapiens | E143 | CHTHMEKCVMD | 1 | Mus musculus | E143 | CHTHMEKCILD | 1 | Bos taurus | E143 | LQKRLFSNILK | 1 | Arabidopsis thaliana | G128 | FAVYDGHGGPA | 3 | Homo sapiens, Mus musculus, Bos taurus | G128 | FAIFDGHKGDH | 1 | Arabidopsis thaliana | G128 | FAIYDGHLGER | 1 | Arabidopsis thaliana | G128 | FAIYDGHMGDS | 1 | Arabidopsis thaliana |
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