mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CYP1A1
Gene summary
Basic gene Info.Gene symbolCYP1A1
Gene namecytochrome P450, family 1, subfamily A, polypeptide 1
CytomapUCSC genome browser: 15q24.1
Type of geneprotein-coding
DescriptionCYPIA1aryl hydrocarbon hydroxylasecytochrome P1-450, dioxin-induciblecytochrome P450 1A1cytochrome P450 form 6cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1cytochrome P450-Ccytochrome P450-P1flavoprotein-linked monooxyge
Modification date20141222
dbXrefs MIM : 108330
Ensembl : ENSG00000140465
HPRD : 00148
Vega : OTTHUMG00000142812
ProteinUniProt: P04798
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CYP1A1
BioGPS: 1543
PathwayNCI Pathway Interaction Database: CYP1A1
Pathway Commons: CYP1A1
ContextiHOP: CYP1A1
ligand binding site mutation search in PubMed: CYP1A1
UCL Cancer Institute: CYP1A1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0017144drug metabolic process19219744
GO:0055114oxidation-reduction process19219744
GO:0071407cellular response to organic cyclic compound23275542

Ligand binding site mutations for CYP1A1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for CYP1A1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CYP1A1 from PDB

Differential gene expression and gene-gene network for CYP1A1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CYP1A1 and the right PPI network was created from samples without mutations in the LBS of CYP1A1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for CYP1A1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C2239176Carcinoma, Hepatocellular31Biomarker, GeneticVariation
umls:C1458155Breast Neoplasms21AlteredExpression, Biomarker, GeneticVariation
umls:C0033578Prostatic Neoplasms9Biomarker, GeneticVariation
umls:C0021364Infertility, Male8Biomarker, GeneticVariation
umls:C0020538Hypertension7Biomarker, GeneticVariation
umls:C0024117Pulmonary Disease, Chronic Obstructive6Biomarker, GeneticVariation
umls:C0011853Diabetes Mellitus, Experimental2Biomarker
umls:C0000786Abortion, Spontaneous2Biomarker, GeneticVariation
umls:C0020517Hypersensitivity2Biomarker, GeneticVariation
umls:C0022665Kidney Neoplasms2Biomarker, GeneticVariation
umls:C0028797Occupational Diseases2Biomarker, GeneticVariation
umls:C0162820Dermatitis, Allergic Contact1Biomarker
umls:C0011609Drug Eruptions1Biomarker
umls:C0273115Lung Injury1Biomarker
umls:C0085096Peripheral Vascular Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for CYP1A1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
InvestigationalDB023422-MethoxyestradiolSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CYP1A1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
HEMHEME B4i8vAR106 R135 V382 H388 G459
HEMHEME B4i8vBR106 R135 V382 H388 G459
HEMHEME B4i8vCR106 R135 V382 H388 G459
HEMHEME B4i8vDR106 V382 H388 G459

Conservation information for LBS of CYP1A1
Multiple alignments for P04798 in multiple species
LBSAA sequence# speciesSpecies
A317LDLFGAGFDTV3Homo sapiens, Macaca mulatta, Mus musculus
A317FDLFGAGFDTI1Rattus norvegicus
A317NDIFGAGFDTV1Gallus gallus
A317NDLFGAGFDTV1Gallus gallus
A463IGETIARWEVF2Homo sapiens, Macaca mulatta
A463IGETIGRSEVF1Mus musculus
A463IGETIGRLEVF1Rattus norvegicus
A463IGENIGKWEVF1Gallus gallus
A463IGESIGRWEVF1Gallus gallus
C457LGKRKCIGETI3Macaca mulatta, Mus musculus, Rattus norvegicus
C457MGKRKCIGETI1Homo sapiens
C457LGKRRCIGENI1Gallus gallus
C457LGKRRCIGESI1Gallus gallus
D313INIVLDLFGAG1Homo sapiens
D313VNVVLDLFGAG1Macaca mulatta
D313ITIVLDLFGAG1Mus musculus
D313ITIVFDLFGAG1Rattus norvegicus
D313INLVNDIFGAG1Gallus gallus
D313ISIVNDLFGAG1Gallus gallus
D320FGAGFDTVTTA5Homo sapiens, Macaca mulatta, Mus musculus, Gallus gallus, Gallus gallus
D320FGAGFDTITTA1Rattus norvegicus
F224NLSNEFGEVTG2Mus musculus, Rattus norvegicus
F224NLNNNFGEVVG1Homo sapiens
F224NLSNNFGEVVG1Macaca mulatta
F224NVVDEFVDVTA1Gallus gallus
F224NMNTEFGDVAA1Gallus gallus
F258DLNEKFYSFMQ1Homo sapiens
F258DLNEKFHSFMQ1Macaca mulatta
F258DLNDKFYSFMK1Mus musculus
F258DLNKKFYSFMK1Rattus norvegicus
F258DFNKRFMKLLQ1Gallus gallus
F258DVNARFSAFVQ1Gallus gallus
F319LFGAGFDTVTT4Homo sapiens, Macaca mulatta, Mus musculus, Gallus gallus
F319LFGAGFDTITT1Rattus norvegicus
F319IFGAGFDTVTT1Gallus gallus
F381FRHSSFVPFTI4Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus
F381FRHSSFMPFTI1Gallus gallus
F381FRHSSLLPFTI1Gallus gallus
F450EKVILFGLGKR2Macaca mulatta, Rattus norvegicus
F450EKVIIFGMGKR1Homo sapiens
F450EKVTLFGLGKR1Mus musculus
F450EKVMTFGLGKR1Gallus gallus
F450DKVLIFGLGKR1Gallus gallus
G316VLDLFGAGFDT3Homo sapiens, Macaca mulatta, Mus musculus
G316VFDLFGAGFDT1Rattus norvegicus
G316VNDIFGAGFDT1Gallus gallus
G316VNDLFGAGFDT1Gallus gallus
G318DLFGAGFDTVT4Homo sapiens, Macaca mulatta, Mus musculus, Gallus gallus
G318DLFGAGFDTIT1Rattus norvegicus
G318DIFGAGFDTVT1Gallus gallus
G459KRKCIGETIAR2Homo sapiens, Macaca mulatta
G459KRKCIGETIGR2Mus musculus, Rattus norvegicus
G459KRRCIGENIGK1Gallus gallus
G459KRRCIGESIGR1Gallus gallus
H388PFTIPHSTTRD4Homo sapiens, Macaca mulatta, Mus musculus, Gallus gallus
H388PFTIPHSTIRD1Rattus norvegicus
H388PFTIPHCTTKD1Gallus gallus
I115YTFTLISNGQS1Homo sapiens
I115YSFTLISNGQS1Macaca mulatta
I115YSFTLITNGKS1Mus musculus
I115YSFTLIANGQS1Rattus norvegicus
I115YSFRHITDGQS1Gallus gallus
I115PSWQYVSNGHS1Gallus gallus
I198SVANVICAICF5Macaca mulatta, Mus musculus, Rattus norvegicus, Gallus gallus, Gallus gallus
I198SVTNVICAICF1Homo sapiens
I386FVPFTIPHSTT3Homo sapiens, Macaca mulatta, Mus musculus
I386FVPFTIPHSTI1Rattus norvegicus
I386FMPFTIPHSTT1Gallus gallus
I386LLPFTIPHCTT1Gallus gallus
I449SEKVILFGLGK2Macaca mulatta, Rattus norvegicus
I449SEKVIIFGMGK1Homo sapiens
I449SEKVTLFGLGK1Mus musculus
I449AEKVMTFGLGK1Gallus gallus
I449ADKVLIFGLGK1Gallus gallus
I458GKRKCIGETIA2Homo sapiens, Macaca mulatta
I458GKRKCIGETIG2Mus musculus, Rattus norvegicus
I458GKRRCIGENIG1Gallus gallus
I458GKRRCIGESIG1Gallus gallus
L312IINIVLDLFGA1Homo sapiens
L312IVNVVLDLFGA1Macaca mulatta
L312VITIVLDLFGA1Mus musculus
L312VITIVFDLFGA1Rattus norvegicus
L312IINLVNDIFGA1Gallus gallus
L312IISIVNDLFGA1Gallus gallus
L314NIVLDLFGAGF1Homo sapiens
L314NVVLDLFGAGF1Macaca mulatta
L314TIVLDLFGAGF1Mus musculus
L314TIVFDLFGAGF1Rattus norvegicus
L314NLVNDIFGAGF1Gallus gallus
L314SIVNDLFGAGF1Gallus gallus
L496TPIYGLTMKHA2Homo sapiens, Macaca mulatta
L496TPTYGLTLKHA1Mus musculus
L496TPAYGLTLKHA1Rattus norvegicus
L496TPIYGLSMKHK1Gallus gallus
L496TPQYGLTMKYK1Gallus gallus
N255AFKDLNEKFYS1Homo sapiens
N255GFKDLNEKFHS1Macaca mulatta
N255AFKDLNDKFYS1Mus musculus
N255AFKDLNKKFYS1Rattus norvegicus
N255SFLDFNKRFMK1Gallus gallus
N255AFKDVNARFSA1Gallus gallus
Q411CVFVNQWQINH2Homo sapiens, Macaca mulatta
Q411CVFVNQWQVNH2Mus musculus, Rattus norvegicus
Q411CVFINQWQVNH1Gallus gallus
Q411CVFINQWQANH1Gallus gallus
R106DDFKGRPDLYS2Mus musculus, Rattus norvegicus
R106DDFKGRPDLYT1Homo sapiens
R106DDFKGRPNLYS1Macaca mulatta
R106EDFMGRPDLYS1Gallus gallus
R106EDFMGRPDLPS1Gallus gallus
R135VWAARRRLAQN3Homo sapiens, Macaca mulatta, Mus musculus
R135LWAARRRLAQN1Rattus norvegicus
R135MWKARRKLAQN1Gallus gallus
R135AWKARRKLAQN1Gallus gallus
R455FGLGKRKCIGE3Macaca mulatta, Mus musculus, Rattus norvegicus
R455FGLGKRRCIGE2Gallus gallus, Gallus gallus
R455FGMGKRKCIGE1Homo sapiens
S116TFTLISNGQSM1Homo sapiens
S116SFTLISNGQSM1Macaca mulatta
S116SFTLITNGKSM1Mus musculus
S116SFTLIANGQSM1Rattus norvegicus
S116SFRHITDGQSL1Gallus gallus
S116SWQYVSNGHSL1Gallus gallus
S122NGQSMSFSPDS1Homo sapiens
S122NGQSMSFGPDS1Macaca mulatta
S122NGKSMTFNPDS1Mus musculus
S122NGQSMTFNPDS1Rattus norvegicus
S122DGQSLTFSTDT1Gallus gallus
S122NGHSLAFSYEC1Gallus gallus
T321GAGFDTVTTAI3Homo sapiens, Macaca mulatta, Mus musculus
T321GAGFDTVTTAL2Gallus gallus, Gallus gallus
T321GAGFDTITTAI1Rattus norvegicus
T385SFVPFTIPHST4Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus
T385SFMPFTIPHST1Gallus gallus
T385SLLPFTIPHCT1Gallus gallus
V322AGFDTVTTAIS3Homo sapiens, Macaca mulatta, Mus musculus
V322AGFDTVTTALS2Gallus gallus, Gallus gallus
V322AGFDTITTAIS1Rattus norvegicus
V382RHSSFVPFTIP4Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus
V382RHSSFMPFTIP1Gallus gallus
V382RHSSLLPFTIP1Gallus gallus
W131DSGPVWAARRR3Homo sapiens, Macaca mulatta, Mus musculus
W131DSGPLWAARRR1Rattus norvegicus
W131DTGEMWKARRK1Gallus gallus
W131ECGDAWKARRK1Gallus gallus

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