mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CYP2A13
Gene summary
Basic gene Info.Gene symbolCYP2A13
Gene namecytochrome P450, family 2, subfamily A, polypeptide 13
SynonymsCPAD|CYP2A|CYPIIA13
CytomapUCSC genome browser: 19q13.2
Type of geneprotein-coding
RefGenesNM_000766.4,
Descriptioncytochrome P450 2A13cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 13
Modification date20141207
dbXrefs MIM : 608055
HGNC : HGNC
Ensembl : ENSG00000197838
HPRD : 07454
Vega : OTTHUMG00000182762
ProteinUniProt: Q16696
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CYP2A13
BioGPS: 1553
PathwayNCI Pathway Interaction Database: CYP2A13
KEGG: CYP2A13
REACTOME: CYP2A13
Pathway Commons: CYP2A13
ContextiHOP: CYP2A13
ligand binding site mutation search in PubMed: CYP2A13
UCL Cancer Institute: CYP2A13
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for CYP2A13

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F392P393SSKCM2
A445R446KBRCA1
L395L395MBRCA1
R437R437WKIRC1
F392P393LLUAD1
R128R129GOV1
R101G102SSKCM1
Q104E103KSKCM1
R437,S433G435RSKCM1
G441G441ESKCM1
N297L296PTHCA1
L444G443DUCEC1
L395L395MUCEC1
T309R311HUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CYP2A13
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R101G102S0.2467006
T309R311H-1.9003934
R128R129G-1.5661849
A445R446K-1.2313605
Q104E103K-1.1487635
F392P393S-0.92449448
L395L395M-0.90097515
R437R437W-0.83616749
N297L296P-0.70054863
R437G435R-0.68274272
S433G435R-0.68274272
L444G443D-0.51722157
F392P393L-0.248467
G441G441E-0.01427856
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CYP2A13 from PDB
PDB IDPDB titlePDB structure
2P85Structure of Human Lung Cytochrome P450 2A13 with indole bound in two alternate conformations

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Differential gene expression and gene-gene network for CYP2A13
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CYP2A13 and the right PPI network was created from samples without mutations in the LBS of CYP2A13. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CYP2A13
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CYP2A13
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CYP2A13 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
INDINDOLE2p85AN297
INDINDOLE2p85BN297
INDINDOLE2p85CN297
INDINDOLE2p85DN297
INDINDOLE2p85EN297
INDINDOLE2p85FN297
9PL(+)-PILOCARPINE3t3sAN297
9PL(+)-PILOCARPINE3t3sBN297
9PL(+)-PILOCARPINE3t3sCN297
9PL(+)-PILOCARPINE3t3sDN297
9PL(+)-PILOCARPINE3t3sEN297
9PL(+)-PILOCARPINE3t3sFN297
NCT(S)-NICOTINE4ejgBN297
NCT(S)-NICOTINE4ejgCN297
NCT(S)-NICOTINE4ejgDN297
0QA4-[METHYL(NITROSO)AMINO]-1-(PYRIDIN-3-YL)BUTAN-1-ONE4ejhAN297
0QA4-[METHYL(NITROSO)AMINO]-1-(PYRIDIN-3-YL)BUTAN-1-ONE4ejhBN297
0QA4-[METHYL(NITROSO)AMINO]-1-(PYRIDIN-3-YL)BUTAN-1-ONE4ejhCN297
0QA4-[METHYL(NITROSO)AMINO]-1-(PYRIDIN-3-YL)BUTAN-1-ONE4ejhDN297
0QA4-[METHYL(NITROSO)AMINO]-1-(PYRIDIN-3-YL)BUTAN-1-ONE4ejhEN297
0QA4-[METHYL(NITROSO)AMINO]-1-(PYRIDIN-3-YL)BUTAN-1-ONE4ejhFN297
0QA4-[METHYL(NITROSO)AMINO]-1-(PYRIDIN-3-YL)BUTAN-1-ONE4ejiAN297
0QA4-[METHYL(NITROSO)AMINO]-1-(PYRIDIN-3-YL)BUTAN-1-ONE4ejiAQ104 F392
HEMHEME B3t3sFR101 L395 S433 R437 G441 L444 A445
HEMHEME B2p85FR101 R128 L395 S433 R437 A445
HEMHEME B4ejgBR101 R128 L395 S433 R437 A445
HEMHEME B2pg5BR101 R128 L395 S433 R437 G441
HEMHEME B3t3sBR101 R128 L395 S433 R437 G441
HEMHEME B3t3sHR101 R128 L395 S433 R437 G441
HEMHEME B4ejhAR101 R128 L395 S433 R437 G441
HEMHEME B4ejhFR101 R128 L395 S433 R437 G441
HEMHEME B2pg6BR101 R128 L395 S433 R437 G441 A445
HEMHEME B2pg7CR101 R128 L395 S433 R437 G441 A445
HEMHEME B4ejgCR101 R128 L395 S433 R437 G441 A445
HEMHEME B4ejgDR101 R128 L395 S433 R437 G441 A445
HEMHEME B4ejhCR101 R128 L395 S433 R437 G441 A445
HEMHEME B4ejhDR101 R128 L395 S433 R437 G441 A445
HEMHEME B4ejiAR101 R128 L395 S433 R437 G441 A445
HEMHEME B3t3sAR101 R128 L395 S433 R437 G441 L444
HEMHEME B3t3sCR101 R128 L395 S433 R437 G441 L444
HEMHEME B3t3sDR101 R128 L395 S433 R437 G441 L444
HEMHEME B3t3sGR101 R128 L395 S433 R437 G441 L444
HEMHEME B4ejgGR101 R128 L395 S433 R437 G441 L444 A445
HEMHEME B2p85CR101 R128 T309 L395 S433 R437
HEMHEME B2pg5AR101 R128 T309 L395 S433 R437 G441
HEMHEME B2pg5CR101 R128 T309 L395 S433 R437 G441
HEMHEME B2pg6AR101 R128 T309 L395 S433 R437 G441
HEMHEME B4ejgER101 R128 T309 L395 S433 R437 G441
HEMHEME B2p85AR101 R128 T309 L395 S433 R437 G441 A445
HEMHEME B2p85DR101 R128 T309 L395 S433 R437 G441 A445
HEMHEME B2p85ER101 R128 T309 L395 S433 R437 G441 A445
HEMHEME B2pg6CR101 R128 T309 L395 S433 R437 G441 A445
HEMHEME B2pg6DR101 R128 T309 L395 S433 R437 G441 A445
HEMHEME B4ejgAR101 R128 T309 L395 S433 R437 G441 A445
HEMHEME B4ejgFR101 R128 T309 L395 S433 R437 G441 A445
HEMHEME B4ejhBR101 R128 T309 L395 S433 R437 G441 A445
HEMHEME B4ejhER101 R128 T309 L395 S433 R437 G441 A445
HEMHEME B4ejhHR101 R128 T309 L395 S433 R437 G441 L444
HEMHEME B2p85BR101 R128 T309 L395 S433 R437 G441 L444 A445
HEMHEME B2pg5DR101 R128 T309 L395 S433 R437 G441 L444 A445
HEMHEME B2pg7AR101 R128 T309 L395 S433 R437 G441 L444 A445
HEMHEME B2pg7BR101 R128 T309 L395 S433 R437 G441 L444 A445
HEMHEME B2pg7DR101 R128 T309 L395 S433 R437 G441 L444 A445
HEMHEME B3t3sER101 R128 T309 L395 S433 R437 G441 L444 A445
HEMHEME B4ejhGR101 R128 T309 L395 S433 R437 G441 L444 A445
HEMHEME B4ejgHR101 R128 T309 S433 R437 G441


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Conservation information for LBS of CYP2A13
Multiple alignments for Q16696 in multiple species
LBSAA sequence# speciesSpecies
A117G-YGVAFSNGE2Homo sapiens, Homo sapiens
A117GNYGLFFMENN1Caenorhabditis elegans
A117G-YGIAFSSGE1Mus musculus
A117G-YGVAFSSGE1Rattus norvegicus
A117G-YGVVFSNGE1Homo sapiens
A301LNLFFAGTETV3Homo sapiens, Mus musculus, Rattus norvegicus
A301YDLYSAGMETI1Caenorhabditis elegans
A301LNLFIGGTETV1Homo sapiens
A301LNLFIAGTETV1Homo sapiens
A371IPMGLARRVTK2Mus musculus, Rattus norvegicus
A371IPMSLARRVKK2Homo sapiens, Homo sapiens
A371LPMGLAHRVNK1Homo sapiens
A371LPVNFLRCTLT1Caenorhabditis elegans
A445FGEGLARMELF5Homo sapiens, Mus musculus, Rattus norvegicus, Homo sapiens, Homo sapiens
A445LGENLARMEVF1Caenorhabditis elegans
C439IGKRYCFGEGL3Homo sapiens, Mus musculus, Rattus norvegicus
C439IGKRNCFGEGL2Homo sapiens, Homo sapiens
C439MGKRSCLGENL1Caenorhabditis elegans
E221TGQLYEMFSSV4Homo sapiens, Rattus norvegicus, Homo sapiens, Homo sapiens
E221KTQLLDAWPW-1Caenorhabditis elegans
E221MGQVYEMFSSV1Mus musculus
F107GEQATFDWLFK3Homo sapiens, Mus musculus, Rattus norvegicus
F107GEQATFDWVFK2Homo sapiens, Homo sapiens
F107PDTFIMDMLVQ1Caenorhabditis elegans
F111TFDWLFKG-YG3Homo sapiens, Mus musculus, Rattus norvegicus
F111TFDWVFKG-YG2Homo sapiens, Homo sapiens
F111IMDMLVQGNYG1Caenorhabditis elegans
F118-YGVAFSNGER2Homo sapiens, Homo sapiens
F118NYGLFFMENNW1Caenorhabditis elegans
F118-YGIAFSSGER1Mus musculus
F118-YGVAFSSGER1Rattus norvegicus
F118-YGVVFSNGER1Homo sapiens
F209MMLGSFQFTAT2Homo sapiens, Rattus norvegicus
F209MMLGIFQFTST2Homo sapiens, Homo sapiens
F209AINDVLEHFTS1Caenorhabditis elegans
F209MMLGSLQFTAT1Mus musculus
F300TLNLFFAGTET3Homo sapiens, Mus musculus, Rattus norvegicus
F300IYDLYSAGMET1Caenorhabditis elegans
F300TLNLFIGGTET1Homo sapiens
F300TLNLFIAGTET1Homo sapiens
F392KGTEVFPMLGS5Homo sapiens, Mus musculus, Rattus norvegicus, Homo sapiens, Homo sapiens
F392AGTRVIAQFQS1Caenorhabditis elegans
F432DAFVPFSIGKR5Homo sapiens, Mus musculus, Rattus norvegicus, Homo sapiens, Homo sapiens
F432DRVNPFSMGKR1Caenorhabditis elegans
F440GKRYCFGEGLA3Homo sapiens, Mus musculus, Rattus norvegicus
F440GKRNCFGEGLA2Homo sapiens, Homo sapiens
F440GKRSCLGENLA1Caenorhabditis elegans
F480PKHVGFATIPR2Homo sapiens, Homo sapiens
F480--ITSSLRAPK1Caenorhabditis elegans
F480PRLVGFVTIPP1Mus musculus
F480PRLVGFATIPP1Rattus norvegicus
F480PKHVVFATIPR1Homo sapiens
G302NLFFAGTETVS3Homo sapiens, Mus musculus, Rattus norvegicus
G302DLYSAGMETII1Caenorhabditis elegans
G302NLFIGGTETVS1Homo sapiens
G302NLFIAGTETVS1Homo sapiens
G369DVIPMSLARRV2Homo sapiens, Homo sapiens
G369DMLPMGLAHRV1Homo sapiens
G369YVLPVNFLRCT1Caenorhabditis elegans
G369DLIPMGLARRV1Mus musculus
G369DMIPMGLARRV1Rattus norvegicus
G441KRYCFGEGLAR3Homo sapiens, Mus musculus, Rattus norvegicus
G441KRNCFGEGLAR2Homo sapiens, Homo sapiens
G441KRSCLGENLAR1Caenorhabditis elegans
H372PMGLARRVTKD2Mus musculus, Rattus norvegicus
H372PMSLARRVKKD2Homo sapiens, Homo sapiens
H372PMGLAHRVNKD1Homo sapiens
H372PVNFLRCTLTD1Caenorhabditis elegans
I182TVSNVISSIVF5Homo sapiens, Mus musculus, Rattus norvegicus, Homo sapiens, Homo sapiens
I182VVGNVIHKHLF1Caenorhabditis elegans
L298LTTLNLFFAGT2Mus musculus, Rattus norvegicus
L298MTTLNLFFAGT1Homo sapiens
L298VAIYDLYSAGM1Caenorhabditis elegans
L298MTTLNLFIGGT1Homo sapiens
L298MSTLNLFIAGT1Homo sapiens
L366RFGDVIPMSLA2Homo sapiens, Homo sapiens
L366RFGDMLPMGLA1Homo sapiens
L366RLGYVLPVNFL1Caenorhabditis elegans
L366RFADLIPMGLA1Mus musculus
L366RFADMIPMGLA1Rattus norvegicus
L370VIPMSLARRVK2Homo sapiens, Homo sapiens
L370MLPMGLAHRVN1Homo sapiens
L370VLPVNFLRCTL1Caenorhabditis elegans
L370LIPMGLARRVT1Mus musculus
L370MIPMGLARRVT1Rattus norvegicus
L395EVFPMLGSVLR3Homo sapiens, Homo sapiens, Homo sapiens
L395EVFPMLGSVLK2Mus musculus, Rattus norvegicus
L395RVIAQFQSVHV1Caenorhabditis elegans
L444CFGEGLARMEL5Homo sapiens, Mus musculus, Rattus norvegicus, Homo sapiens, Homo sapiens
L444CLGENLARMEV1Caenorhabditis elegans
L449LARMELFLFFT3Homo sapiens, Homo sapiens, Homo sapiens
L449LARMELFLFLT2Mus musculus, Rattus norvegicus
L449LARMEVFLYFC1Caenorhabditis elegans
M365QRFGDVIPMSL2Homo sapiens, Homo sapiens
M365QRFGDMLPMGL1Homo sapiens
M365YRLGYVLPVNF1Caenorhabditis elegans
M365QRFADLIPMGL1Mus musculus
M365QRFADMIPMGL1Rattus norvegicus
N297VLTTLNLFFAG2Mus musculus, Rattus norvegicus
N297VMTTLNLFFAG1Homo sapiens
N297IVAIYDLYSAG1Caenorhabditis elegans
N297VMTTLNLFIGG1Homo sapiens
N297MMSTLNLFIAG1Homo sapiens
P431SDAFVPFSIGK5Homo sapiens, Mus musculus, Rattus norvegicus, Homo sapiens, Homo sapiens
P431DDRVNPFSMGK1Caenorhabditis elegans
Q104SGRGEQATFDW5Homo sapiens, Mus musculus, Rattus norvegicus, Homo sapiens, Homo sapiens
Q104SGRPDTFIMDM1Caenorhabditis elegans
Q360VIHEIQRFGDV2Homo sapiens, Homo sapiens
Q360VIHEIQRFGDM1Homo sapiens
Q360FLQEVYRLGYV1Caenorhabditis elegans
Q360VIHEIQRFADL1Mus musculus
Q360VIHEIQRFADM1Rattus norvegicus
R101EEFSGRGEQAT5Homo sapiens, Mus musculus, Rattus norvegicus, Homo sapiens, Homo sapiens
R101ESFSGRPDTFI1Caenorhabditis elegans
R128RAKQLRRFSIA3Homo sapiens, Rattus norvegicus, Homo sapiens
R128WWKAQRRFTTH1Caenorhabditis elegans
R128RAKQLRRFSIT1Mus musculus
R128RAKQLLRFAIA1Homo sapiens
R437FSIGKRYCFGE3Homo sapiens, Mus musculus, Rattus norvegicus
R437FSIGKRNCFGE2Homo sapiens, Homo sapiens
R437FSMGKRSCLGE1Caenorhabditis elegans
S433AFVPFSIGKRY3Homo sapiens, Mus musculus, Rattus norvegicus
S433AFVPFSIGKRN2Homo sapiens, Homo sapiens
S433RVNPFSMGKRS1Caenorhabditis elegans
T212GSFQFTATSTG2Homo sapiens, Rattus norvegicus
T212GIFQFTSTSTG2Homo sapiens, Homo sapiens
T212DVLEHFTSPKT1Caenorhabditis elegans
T212GSLQFTATSMG1Mus musculus
T305FAGTETVSTTL3Homo sapiens, Mus musculus, Rattus norvegicus
T305SAGMETIIIVL1Caenorhabditis elegans
T305IGGTETVSTTL1Homo sapiens
T305IAGTETVSTTL1Homo sapiens
T309ETVSTTLRYGF5Homo sapiens, Mus musculus, Rattus norvegicus, Homo sapiens, Homo sapiens
T309ETIIIVLRFAF1Caenorhabditis elegans
V116KG-YGVAFSNG2Homo sapiens, Homo sapiens
V116QGNYGLFFMEN1Caenorhabditis elegans
V116KG-YGIAFSSG1Mus musculus
V116KG-YGVAFSSG1Rattus norvegicus
V116KG-YGVVFSNG1Homo sapiens
V306AGTETVSTTLR4Homo sapiens, Mus musculus, Rattus norvegicus, Homo sapiens
V306AGMETIIIVLR1Caenorhabditis elegans
V306GGTETVSTTLR1Homo sapiens


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