mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CYP3A4
Gene summary
Basic gene Info.Gene symbolCYP3A4
Gene namecytochrome P450, family 3, subfamily A, polypeptide 4
SynonymsCP33|CP34|CYP3A|CYP3A3|CYPIIIA3|CYPIIIA4|HLP|NF-25|P450C3|P450PCN1
CytomapUCSC genome browser: 7q21.1
Type of geneprotein-coding
RefGenesNM_001202855.2,
NM_017460.5,NM_001202856.1,NM_001202857.1,
Description1,8-cineole 2-exo-monooxygenaseP450-III, steroid induciblealbendazole monooxygenasealbendazole sulfoxidasecytochrome P450 3A3cytochrome P450 3A4cytochrome P450 HLpcytochrome P450 NF-25cytochrome P450, subfamily IIIA (niphedipine oxidase), polypept
Modification date20141207
dbXrefs MIM : 124010
HGNC : HGNC
HPRD : 00484
ProteinUniProt: P08684
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CYP3A4
BioGPS: 1576
PathwayNCI Pathway Interaction Database: CYP3A4
KEGG: CYP3A4
REACTOME: CYP3A4
Pathway Commons: CYP3A4
ContextiHOP: CYP3A4
ligand binding site mutation search in PubMed: CYP3A4
UCL Cancer Institute: CYP3A4
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0009822alkaloid catabolic process15039299
GO:0016098monoterpenoid metabolic process16401082
GO:0017144drug metabolic process15327587
GO:0036378calcitriol biosynthetic process from calciol15546903
GO:0042737drug catabolic process15039299
GO:0042738exogenous drug catabolic process18619574
GO:0046483heterocycle metabolic process15327587
GO:0055114oxidation-reduction process16401082
GO:0070989oxidative demethylation15039299


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Ligand binding site mutations for CYP3A4

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D217,F219P218LSKCM2
R440R439KBLCA1
I369A369VCOAD1
A448L448IHNSC1
V240F240LKIRC1
S119S119FSKCM1
H30G31RSKCM1
R130R130QSKCM1
I120E122KSKCM1
I369P367SSKCM1
M452M451ISKCM1
R212R212IUCEC1
M452M451IUCEC1
W126E125KUCEC1
F219F219LUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CYP3A4
Protein structure of wild type (WT) and mutant type (MT) of CYP3A4
Wild type CYP3A4
Mutant type CYP3A4

Free energy of binding of drugs to wild type and mutant tpye of CYP3A4
Gene symbolDrug nameFree energy of binding (kcal/mol) of wild typeFree energy of binding (kcal/mol) of mutant type
CYP3A4Azithromycin-7-7
CYP3A4Daclatasvir-11.4-10.3

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
W126E125K-1.7707443
I120E122K-1.2490953
R212R212I-0.79902669
F219P218L-0.69446249
D217P218L-0.69446249
F219F219L-0.63121168
R130R130Q-0.5771518
H30G31R-0.41190549
S119S119F-0.10643628
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CYP3A4 from PDB
PDB IDPDB titlePDB structure
4D75Cytochrome P450 3A4 bound to an inhibitor

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Differential gene expression and gene-gene network for CYP3A4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CYP3A4 and the right PPI network was created from samples without mutations in the LBS of CYP3A4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CYP3A4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1458155Breast Neoplasms10AlteredExpression, Biomarker, GeneticVariation
umls:C0033578Prostatic Neoplasms3Biomarker
umls:C0019196Hepatitis C3Biomarker
umls:C0029463Osteosarcoma1AlteredExpression, Biomarker
umls:C0040479Torsades de Pointes1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CYP3A4
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|vet_approvedDB00199ErythromycinSmall molecule
ApprovedDB00207AzithromycinSmall molecule
ApprovedDB00951IsoniazidSmall molecule
ApprovedDB01211ClarithromycinSmall molecule
ApprovedDB01267PaliperidoneSmall molecule
InvestigationalDB05478Pradefovir MesylateSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CYP3A4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
STRPROGESTERONE5a1pAD217 F219
STRPROGESTERONE5a1rAD217 F219
STRPROGESTERONE1w0fAD217 F219 V240
CITCITRIC ACID5a1pAH30
J9KTERT-BUTYL [(2S)-1-({3-OXO-3-[(PYRIDIN-3- YLMETHYL)AMINO]PROPYL}SULFANYL)-3-PHENYLPROPAN-2- YL]CARBAMATE4d78AI120 I369
1RDN~2~-(METHYL{[2-(PROPAN-2-YL)-1,3-THIAZOL-4- YL]METHYL}CARBAMOYL)-N-(4-{[(1,3-THIAZOL-5-YLMETHOXY) CARBONYL]AMINO}BUTYL)-L-VALINAMIDE4k9tAI120 V240
7AWN~2~-(METHYL{[2-(PROPAN-2-YL)-1,3-THIAZOL-4- YL]METHYL}CARBAMOYL)-N-[(2R,5S)-1-PHENYL-5-{[(1,3- THIAZOL-5-YLMETHOXY)CARBONYL]AMINO}OCTAN-2-YL]-L- VALINAMIDE4k9wBI369
MYTMETYRAPONE1w0gAS119
ERYERYTHROMYCIN A(1+)2j0dAS119
KLN1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAYL]METHOXY}PHENYL)PIPERAZINE2v0mAS119
KLN1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAYL]METHOXY}PHENYL)PIPERAZINE2v0mAS119
KLN1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAYL]METHOXY}PHENYL)PIPERAZINE2v0mBS119
KLN1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAYL]METHOXY}PHENYL)PIPERAZINE2v0mCS119
KLN1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAYL]METHOXY}PHENYL)PIPERAZINE2v0mCS119
KLN1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAYL]METHOXY}PHENYL)PIPERAZINE2v0mDS119
KLN1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAYL]METHOXY}PHENYL)PIPERAZINE2v0mDS119
6AW1,3-THIAZOL-5-YLMETHYL [(3S,6S)-6-{[N-(METHYL{[2- (PROPAN-2-YL)-1,3-THIAZOL-4-YL]METHYL}CARBAMOYL)-L- SERYL]AMINO}OCTAN-3-YL]CARBAMATE4k9vAS119
8AW1,3-THIAZOL-5-YLMETHYL [(2R,5R)-5-{[(2S)-2- METHYLBUTANOYL]AMINO}-1,6-DIPHENYLHEXAN-2-YL]CARBAMATE4k9xAS119
5AWN~2~-(METHYL{[2-(PROPAN-2-YL)-1,3-THIAZOL-4- YL]METHYL}CARBAMOYL)-N-[(2S,5S)-5-{[(1,3-THIAZOL-5- YLMETHOXY)CARBONYL]AMINO}HEXAN-2-YL]-D-VALINAMIDE4k9uAS119 D217
KLN1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAYL]METHOXY}PHENYL)PIPERAZINE2v0mBS119 I120
08YBROMOCRIPTINE3ua1AS119 I120
Z8ZN~2~-(METHYL{[2-(PROPAN-2-YL)-1,3-THIAZOL-4- YL]METHYL}CARBAMOYL)-N-[(2R,5R)-5-{[(1,3-OXAZOL-5- YLMETHOXY)CARBONYL]AMINO}-1,6-DIPHENYLHEXAN-2-YL]-L- VALINAMIDE4i4gAS119 I120
RITRITONAVIR3nxuAS119 I120 I369
RITRITONAVIR3nxuBS119 I120 I369
Z9ZPYRIDIN-3-YLMETHYL [(2R,5S)-5-{[N-(METHYL{[2-(PROPAN-2- YL)-1,3-THIAZOL-4-YL]METHYL}CARBAMOYL)-D-VALYL]AMINO}- 1,6-DIPHENYLHEXAN-2-YL]CARBAMATE4i4hAS119 I120 I369
D0RDESTHIAZOLYLMETHYLOXYCARBONYL RITONAVIR3tjsAS119 I369
7AWN~2~-(METHYL{[2-(PROPAN-2-YL)-1,3-THIAZOL-4- YL]METHYL}CARBAMOYL)-N-[(2R,5S)-1-PHENYL-5-{[(1,3- THIAZOL-5-YLMETHOXY)CARBONYL]AMINO}OCTAN-2-YL]-L- VALINAMIDE4k9wAS119 I369
7AWN~2~-(METHYL{[2-(PROPAN-2-YL)-1,3-THIAZOL-4- YL]METHYL}CARBAMOYL)-N-[(2R,5S)-1-PHENYL-5-{[(1,3- THIAZOL-5-YLMETHOXY)CARBONYL]AMINO}OCTAN-2-YL]-L- VALINAMIDE4k9wCS119 I369
7AWN~2~-(METHYL{[2-(PROPAN-2-YL)-1,3-THIAZOL-4- YL]METHYL}CARBAMOYL)-N-[(2R,5S)-1-PHENYL-5-{[(1,3- THIAZOL-5-YLMETHOXY)CARBONYL]AMINO}OCTAN-2-YL]-L- VALINAMIDE4k9wDS119 I369
PKTTERT-BUTYL [(2S)-1-(1H-INDOL-3-YL)-3-({3-OXO- 3-[(PYRIDIN-3-YLMETHYL)AMINO]PROPYL}SULFANYL) PROPAN-2-YL]CARBAMATE4d7dAS119 I369
2QH(8R)-3,3-DIFLUORO-8-[4-FLUORO-3-(PYRIDIN-3-YL)PHENYL]- 8-(4-METHOXY-3-METHYLPHENYL)-2,3,4,8- TETRAHYDROIMIDAZO[1,5-A]PYRIMIDIN-6-AMINE4ny4AS119 R212
PK9TERT-BUTYL {6-OXO-6-[(PYRIDIN-3-YLMETHYL) AMINO]HEXYL}CARBAMATE4d6zAS119 R212 I369
PK9TERT-BUTYL {6-OXO-6-[(PYRIDIN-3-YLMETHYL) AMINO]HEXYL}CARBAMATE4d75AS119 R212 I369
HEMHEME B1tqnAS119 W126 R130 I369 R440 A448 M452
HEMHEME B2v0mAS119 W126 R130 I369 R440 A448 M452
HEMHEME B2v0mCS119 W126 R130 I369 R440 A448 M452
HEMHEME B2v0mDS119 W126 R130 I369 R440 A448 M452
HEMHEME B3nxuAS119 W126 R130 I369 R440 A448 M452
HEMHEME B3nxuBS119 W126 R130 I369 R440 A448 M452
HEMHEME B3tjsAS119 W126 R130 I369 R440 A448 M452
HEMHEME B4i4hAS119 W126 R130 I369 R440 A448 M452
HEMHEME B4k9tAS119 W126 R130 I369 R440 A448 M452
HEMHEME B4k9vAS119 W126 R130 I369 R440 A448 M452
HEMHEME B4k9wBS119 W126 R130 I369 R440 A448 M452
HEMHEME B4k9wCS119 W126 R130 I369 R440 A448 M452
HEMHEME B4k9xAS119 W126 R130 I369 R440 A448 M452
HEMHEME B4ny4AS119 W126 R130 I369 R440 A448 M452
HEMHEME B5a1rAS119 W126 R130 I369 R440 A448 M452
HEMHEME B4d6zAS119 W126 R130 I369 R440 A448 M452
HEMHEME B4d75AS119 W126 R130 I369 R440 A448 M452
HEMHEME B4d78AS119 W126 R130 I369 R440 A448 M452
HEMHEME B4d7dAS119 W126 R130 I369 R440 A448 M452
HEMHEME B4i3qAS119 W126 R130 I369 R440 M452
HEMHEME B4i4gAS119 W126 R130 I369 R440 M452
HEMHEME B4k9wAS119 W126 R130 I369 R440 M452
HEMHEME B4k9wDS119 W126 R130 I369 R440 M452
HEMHEME B1w0fAS119 W126 R130 R440 A448
HEMHEME B1w0gAS119 W126 R130 R440 A448
HEMHEME B2j0dAS119 W126 R130 R440 A448
HEMHEME B3ua1AS119 W126 R130 R440 A448
HEMHEME B4k9uAS119 W126 R130 R440 A448
HEMHEME B1w0eAS119 W126 R130 R440 A448 M452
HEMHEME B2j0dBS119 W126 R130 R440 A448 M452
HEMHEME B5a1pAS119 W126 R130 R440 A448 M452
5AWN~2~-(METHYL{[2-(PROPAN-2-YL)-1,3-THIAZOL-4- YL]METHYL}CARBAMOYL)-N-[(2S,5S)-5-{[(1,3-THIAZOL-5- YLMETHOXY)CARBONYL]AMINO}HEXAN-2-YL]-D-VALINAMIDE4k9uAV240
HEMHEME B2v0mBW126 R130 R440 M452


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Conservation information for LBS of CYP3A4
Multiple alignments for P08684 in multiple species
LBSAA sequence# speciesSpecies
A305IIFIFAGYETT2Homo sapiens, Canis lupus familiaris
A305FVFFFAGFETS1Drosophila melanogaster
A305VIFIFAGYETT1Rattus norvegicus
A370RLFPIAMRLER1Homo sapiens
A370RKWPAAIAVDR1Drosophila melanogaster
A370RLYPIGNRLER1Rattus norvegicus
A370RLYPIAGRLER1Canis lupus familiaris
A448IGMRFALMNMK2Homo sapiens, Rattus norvegicus
A448IGSRFALLEAK1Drosophila melanogaster
A448IGMRFAIMNMK1Canis lupus familiaris
C442SGPRNCIGMRF1Homo sapiens
C442LGQRNCIGSRF1Drosophila melanogaster
C442NGPRNCIGMRF1Rattus norvegicus
C442TGPRNCIGMRF1Canis lupus familiaris
D214KLLRFDFLDPF1Homo sapiens
D214KLTTFTFLQS-1Drosophila melanogaster
D214KLLRFDFFDPL1Rattus norvegicus
D214KLLKFDFLDPF1Canis lupus familiaris
D217RFDFLDPFFLS1Homo sapiens
D217TFTFLQS--MK1Drosophila melanogaster
D217RFDFFDPLFLS1Rattus norvegicus
D217KFDFLDPFFFS1Canis lupus familiaris
D76VWGFYDGQQPV1Homo sapiens
D76FFGIFEQRQPL1Drosophila melanogaster
D76IWGLFDGQTPV1Rattus norvegicus
D76MWGFYDGRQPV1Canis lupus familiaris
E308IFAGYETTSSV1Homo sapiens
E308FFAGFETSAVL1Drosophila melanogaster
E308IFAGYETTSST1Rattus norvegicus
E308IFAGYETTSTS1Canis lupus familiaris
E374IAMRLERVCKK1Homo sapiens
E374AAIAVDRECNK1Drosophila melanogaster
E374IGNRLERVCKK1Rattus norvegicus
E374IAGRLERVCKK1Canis lupus familiaris
F108----PFGPVGF1Homo sapiens
F108SDDDPHDMSNL1Drosophila melanogaster
F108----DFGPVGI1Rattus norvegicus
F108----TLGPVGF1Canis lupus familiaris
F137LLSPTFTSGKL1Homo sapiens
F137TLSPAFTGSKM1Drosophila melanogaster
F137LLSPTFTSGRL1Rattus norvegicus
F137LLSPTFTTGKL1Canis lupus familiaris
F213KKLLRFDFLDP1Homo sapiens
F213KKLTTFTFLQS1Drosophila melanogaster
F213KKLLRFDFFDP1Rattus norvegicus
F213KKLLKFDFLDP1Canis lupus familiaris
F215LLRFDFLDPFF1Homo sapiens
F215LTTFTFLQS--1Drosophila melanogaster
F215LLRFDFFDPLF1Rattus norvegicus
F215LLKFDFLDPFF1Canis lupus familiaris
F219DFLDPFFLSIT1Homo sapiens
F219TFLQS--MKFM1Drosophila melanogaster
F219DFFDPLFLSVV1Rattus norvegicus
F219DFLDPFFFSIL1Canis lupus familiaris
F220FLDPFFLSITV1Homo sapiens
F220FLQS--MKFML1Drosophila melanogaster
F220FFDPLFLSVVL1Rattus norvegicus
F220FLDPFFFSILL1Canis lupus familiaris
F241LNICVFPREVT1Homo sapiens
F241LKVELFDRKST1Drosophila melanogaster
F241LNICMFPKDSI1Rattus norvegicus
F241LNIWLFPKKVT1Canis lupus familiaris
F271KHRVDFLQLMI2Homo sapiens, Canis lupus familiaris
F271IVRPDMINMLM1Drosophila melanogaster
F271KHRVDFLQLML1Rattus norvegicus
F302AQSIIFIFAGY2Homo sapiens, Canis lupus familiaris
F302AQCFVFFFAGF1Drosophila melanogaster
F302AQSVIFIFAGY1Rattus norvegicus
F304SIIFIFAGYET2Homo sapiens, Canis lupus familiaris
F304CFVFFFAGFET1Drosophila melanogaster
F304SVIFIFAGYET1Rattus norvegicus
F435YIYTPFGSGPR1Homo sapiens
F435FTYFPFGLGQR1Drosophila melanogaster
F435YVYLPFGNGPR1Rattus norvegicus
F435YTYLPFGTGPR1Canis lupus familiaris
F447CIGMRFALMNM2Homo sapiens, Rattus norvegicus
F447CIGSRFALLEA1Drosophila melanogaster
F447CIGMRFAIMNM1Canis lupus familiaris
F46PTPLPFLGNIL1Homo sapiens
F46EKPVLYFGNMA1Drosophila melanogaster
F46PKPLPFLGTVL1Rattus norvegicus
F46PTPLPFVGTAL1Canis lupus familiaris
F57-YHKGFCMFDM1Homo sapiens
F57MFLRKRAMFDI1Drosophila melanogaster
F57-YYKGLGRFDM1Rattus norvegicus
F57-YRNGFYVFDM1Canis lupus familiaris
G306IFIFAGYETTS3Homo sapiens, Rattus norvegicus, Canis lupus familiaris
G306VFFFAGFETSA1Drosophila melanogaster
G436IYTPFGSGPRN1Homo sapiens
G436TYFPFGLGQRN1Drosophila melanogaster
G436VYLPFGNGPRN1Rattus norvegicus
G436TYLPFGTGPRN1Canis lupus familiaris
G444PRNCIGMRFAL2Homo sapiens, Rattus norvegicus
G444QRNCIGSRFAL1Drosophila melanogaster
G444PRNCIGMRFAI1Canis lupus familiaris
G481KLSLGGL-LQP1Homo sapiens
G481ELITSGFQLSP1Drosophila melanogaster
G481KLSRQAI-LEP1Rattus norvegicus
G481KLNAQGI-IQP1Canis lupus familiaris
H28YLYGTHSHGLF1Homo sapiens
H28YRWASANNDFF1Drosophila melanogaster
H28YRLGTHRHGIF1Rattus norvegicus
H28YLYGTYTHGIF1Canis lupus familiaris
H30YGTHSHGLFKK1Homo sapiens
H30WASANNDFFKD1Drosophila melanogaster
H30LGTHRHGIFKK1Rattus norvegicus
H30YGTYTHGIFRK1Canis lupus familiaris
I118FMKSAISIAED1Homo sapiens
I118LFGSSLFSMRD1Drosophila melanogaster
I118IMGKAVSVAKD1Rattus norvegicus
I118FMKSAISLSED1Canis lupus familiaris
I120KSAISIAEDEE1Homo sapiens
I120GSSLFSMRDAR1Drosophila melanogaster
I120GKAVSVAKDEE1Rattus norvegicus
I120KSAISLSEDEE1Canis lupus familiaris
I301VAQSIIFIFAG2Homo sapiens, Canis lupus familiaris
I301VAQCFVFFFAG1Drosophila melanogaster
I301IAQSVIFIFAG1Rattus norvegicus
I369LRLFPIAMRLE1Homo sapiens
I369LRKWPAAIAVD1Drosophila melanogaster
I369LRLYPIGNRLE1Rattus norvegicus
I369LRLYPIAGRLE1Canis lupus familiaris
I443GPRNCIGMRFA3Homo sapiens, Rattus norvegicus, Canis lupus familiaris
I443GQRNCIGSRFA1Drosophila melanogaster
L210ENTKKLLRFDF1Homo sapiens
L210QMGKKLTTFTF1Drosophila melanogaster
L210EKTKKLLRFDF1Rattus norvegicus
L210ENTKKLLKFDF1Canis lupus familiaris
L211NTKKLLRFDFL1Homo sapiens
L211MGKKLTTFTFL1Drosophila melanogaster
L211KTKKLLRFDFF1Rattus norvegicus
L211NTKKLLKFDFL1Canis lupus familiaris
L216LRFDFLDPFFL1Homo sapiens
L216TTFTFLQS--M1Drosophila melanogaster
L216LRFDFFDPLFL1Rattus norvegicus
L216LKFDFLDPFFF1Canis lupus familiaris
L221LDPFFLSITVF1Homo sapiens
L221LQS--MKFMLF1Drosophila melanogaster
L221FDPLFLSVVLF1Rattus norvegicus
L221LDPFFFSILLF1Canis lupus familiaris
L364VLNETLRLYPI2Rattus norvegicus, Canis lupus familiaris
L364VVNETLRLFPI1Homo sapiens
L364VVNEVLRKWPA1Drosophila melanogaster
L373PIAMRLERVCK1Homo sapiens
L373PAAIAVDRECN1Drosophila melanogaster
L373PIGNRLERVCK1Rattus norvegicus
L373PIAGRLERVCK1Canis lupus familiaris
L482LSLGGL-LQPE1Homo sapiens
L482LITSGFQLSPK1Drosophila melanogaster
L482LSRQAI-LEPE1Rattus norvegicus
L482LNAQGI-IQPE1Canis lupus familiaris
M371LFPIAMRLERV1Homo sapiens
M371KWPAAIAVDRE1Drosophila melanogaster
M371LYPIGNRLERV1Rattus norvegicus
M371LYPIAGRLERV1Canis lupus familiaris
M452FALMNMKLALI1Homo sapiens
M452FALLEAKAVIY1Drosophila melanogaster
M452FALMNMKLALT1Rattus norvegicus
M452FAIMNMKLALV1Canis lupus familiaris
N441GSGPRNCIGMR1Homo sapiens
N441GLGQRNCIGSR1Drosophila melanogaster
N441GNGPRNCIGMR1Rattus norvegicus
N441GTGPRNCIGMR1Canis lupus familiaris
P107-----PFGPVG1Homo sapiens
P107SSDDDPHDMSN1Drosophila melanogaster
P107-----DFGPVG1Rattus norvegicus
P107-----TLGPVG1Canis lupus familiaris
P434PYIYTPFGSGP1Homo sapiens
P434PFTYFPFGLGQ1Drosophila melanogaster
P434PYVYLPFGNGP1Rattus norvegicus
P434PYTYLPFGTGP1Canis lupus familiaris
Q484GGL-LQPEKPV1Homo sapiens
Q484SGFQLSPKGGF1Drosophila melanogaster
Q484QAI-LEPEKPI1Rattus norvegicus
Q484QGI-IQPEKPI1Canis lupus familiaris
Q78GFYDGQQPVLA1Homo sapiens
Q78GIFEQRQPLLM1Drosophila melanogaster
Q78GLFDGQTPVFA1Rattus norvegicus
Q78GFYDGRQPVLA1Canis lupus familiaris
R105SVFTNRR----3Homo sapiens, Rattus norvegicus, Canis lupus familiaris
R105DHFINHRNVFA1Drosophila melanogaster
R106VFTNRR-----3Homo sapiens, Rattus norvegicus, Canis lupus familiaris
R106HFINHRNVFAT1Drosophila melanogaster
R130EWKRLRSLLSP1Homo sapiens
R130RWKDMRSTLSP1Drosophila melanogaster
R130EWKRYRALLSP1Rattus norvegicus
R130EWKRMRTLLSP1Canis lupus familiaris
R212TKKLLRFDFLD1Homo sapiens
R212GKKLTTFTFLQ1Drosophila melanogaster
R212TKKLLRFDFFD1Rattus norvegicus
R212TKKLLKFDFLD1Canis lupus familiaris
R372FPIAMRLERVC1Homo sapiens
R372WPAAIAVDREC1Drosophila melanogaster
R372YPIGNRLERVC1Rattus norvegicus
R372YPIAGRLERVC1Canis lupus familiaris
R375AMRLERVCKKD1Homo sapiens
R375AIAVDRECNKD1Drosophila melanogaster
R375GNRLERVCKKD1Rattus norvegicus
R375AGRLERVCKKD1Canis lupus familiaris
R440FGSGPRNCIGM1Homo sapiens
R440FGLGQRNCIGS1Drosophila melanogaster
R440FGNGPRNCIGM1Rattus norvegicus
R440FGTGPRNCIGM1Canis lupus familiaris
S119MKSAISIAEDE1Homo sapiens
S119FGSSLFSMRDA1Drosophila melanogaster
S119MGKAVSVAKDE1Rattus norvegicus
S119MKSAISLSEDE1Canis lupus familiaris
S29LYGTHSHGLFK1Homo sapiens
S29RWASANNDFFK1Drosophila melanogaster
S29RLGTHRHGIFK1Rattus norvegicus
S29LYGTYTHGIFR1Canis lupus familiaris
S437YTPFGSGPRNC1Homo sapiens
S437YFPFGLGQRNC1Drosophila melanogaster
S437YLPFGNGPRNC1Rattus norvegicus
S437YLPFGTGPRNC1Canis lupus familiaris
T224FFLSITVFPFL1Homo sapiens
T224--MKFMLFFAL1Drosophila melanogaster
T224LFLSVVLFPFL1Rattus norvegicus
T224FFFSILLFPFL1Canis lupus familiaris
T27LYLYGTHSHGL1Homo sapiens
T27FYRWASANNDF1Drosophila melanogaster
T27LYRLGTHRHGI1Rattus norvegicus
T27LYLYGTYTHGI1Canis lupus familiaris
T309FAGYETTSSVL1Homo sapiens
T309FAGFETSAVLM1Drosophila melanogaster
T309FAGYETTSSTL1Rattus norvegicus
T309FAGYETTSTSL1Canis lupus familiaris
T310AGYETTSSVLS1Homo sapiens
T310AGFETSAVLMC1Drosophila melanogaster
T310AGYETTSSTLS1Rattus norvegicus
T310AGYETTSTSLS1Canis lupus familiaris
V111-PFGPVGFMKS1Homo sapiens
V111DPHDMSNLFGS1Drosophila melanogaster
V111-DFGPVGIMGK1Rattus norvegicus
V111-TLGPVGFMKS1Canis lupus familiaris
V240VLNICVFPREV1Homo sapiens
V240ILKVELFDRKS1Drosophila melanogaster
V240MLNICMFPKDS1Rattus norvegicus
V240ILNIWLFPKKV1Canis lupus familiaris
V313ETTSSVLSFIM1Homo sapiens
V313ETSAVLMCFTA1Drosophila melanogaster
V313ETTSSTLSFVL1Rattus norvegicus
V313ETTSTSLSFLM1Canis lupus familiaris
W126AEDEEWKRLRS1Homo sapiens
W126MRDARWKDMRS1Drosophila melanogaster
W126AKDEEWKRYRA1Rattus norvegicus
W126SEDEEWKRMRT1Canis lupus familiaris
Y53NILS-YHKGFC1Homo sapiens
Y53NMAGMFLRKRA1Drosophila melanogaster
Y53TVLN-YYKGLG1Rattus norvegicus
Y53TALG-YRNGFY1Canis lupus familiaris


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