mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DAPK1
Gene summary
Basic gene Info.Gene symbolDAPK1
Gene namedeath-associated protein kinase 1
SynonymsDAPK
CytomapUCSC genome browser: 9q21.33
Type of geneprotein-coding
RefGenesNM_001288729.1,
NM_001288730.1,NM_001288731.1,NM_004938.3,
DescriptionDAP kinase 1
Modification date20141207
dbXrefs MIM : 600831
HGNC : HGNC
Ensembl : ENSG00000196730
HPRD : 02902
Vega : OTTHUMG00000020150
ProteinUniProt: P53355
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DAPK1
BioGPS: 1612
PathwayNCI Pathway Interaction Database: DAPK1
KEGG: DAPK1
REACTOME: DAPK1
Pathway Commons: DAPK1
ContextiHOP: DAPK1
ligand binding site mutation search in PubMed: DAPK1
UCL Cancer Institute: DAPK1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006468protein phosphorylation10629061
GO:0017148negative regulation of translation18995835
GO:0035556intracellular signal transduction10629061
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process16132846
GO:0046777protein autophosphorylation10629061
GO:0071346cellular response to interferon-gamma18995835


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Ligand binding site mutations for DAPK1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
K29R31HCOAD1
F183A185TCOAD1
V96V96ICOAD1
P181T180ISKCM1
K42,A40A41SSTAD1
G16G16RUCEC1
F183F183CUCEC1
K29R31HUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for DAPK1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
A40A41S-1.683053
K42A41S-1.683053
F183F183C-1.5054834
K29R31H-1.2585989
V96V96I-0.90753522
F183A185T-0.81484589
P181T180I-0.45656135
G16G16R-0.013812536
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DAPK1 from PDB

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Differential gene expression and gene-gene network for DAPK1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DAPK1 and the right PPI network was created from samples without mutations in the LBS of DAPK1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for DAPK1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007131Carcinoma, Non-Small-Cell Lung8Biomarker
umls:C0023467Leukemia, Myeloid, Acute7AlteredExpression, Biomarker
umls:C0001418Adenocarcinoma6Biomarker
umls:C0026986Myelodysplastic Syndromes6Biomarker
umls:C0007134Carcinoma, Renal Cell5Biomarker
umls:C0007138Carcinoma, Transitional Cell5Biomarker
umls:C0024121Lung Neoplasms4Biomarker
umls:C0027627Neoplasm Metastasis4Biomarker
umls:C0010606Carcinoma, Adenoid Cystic2Biomarker
umls:C0036095Salivary Gland Neoplasms2Biomarker
umls:C0006118Brain Neoplasms1Biomarker
umls:C0009759Conjunctival Diseases1Biomarker
umls:C0085183Neoplasms, Second Primary1Biomarker
umls:C0031117Peripheral Nervous System Diseases1Biomarker
umls:C0035242Respiratory Tract Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for DAPK1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB040695,6-Dihydro-Benzo[H]Cinnolin-3-YlamineSmall molecule
ExperimentalDB04395Phosphoaminophosphonic Acid-Adenylate EsterSmall molecule
ExperimentalDB074446-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DAPK1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ANPAMP-PNP1ig1AA40 K42 V96
ANPAMP-PNP1jkkAA40 K42 V96
ANPAMP-PNP1jklAA40 K42 V96
DRG5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE1p4fAA40 K42 V96
STUSTAUROSPORINE1wvyAA40 K42 V96
ADPADP2w4jAA40 K42 V96
ADPADP2w4kAA40 K42 V96
ADPADP2xuuAA40 K42 V96
OSVRUTHENIUM OCTASPORINE 42yakAA40 K42 V96
ANPAMP-PNP3dfcBA40 K42 V96
ADPADP3eh9AA40 K42 V96
ANPAMP-PNP3ehaAA40 K42 V96
ADPADP3f5gAA40 K42 V96
ANPAMP-PNP3f5uAA40 K42 V96
ANPAMP-PNP3gu4AA40 K42 V96
ANPAMP-PNP3gu5AA40 K42 V96
ADPADP3gu6AA40 K42 V96
ADPADP3gu7AA40 K42 V96
3GUN6-CYCLOPENTYLADENOSINE3gu8AA40 K42 V96
GUB9-ALPHA-L-LYXOFURANOSYL-N-(2-PHENYLETHYL)-9H-PURIN-6-AMINE3gubAA40 K42 V96
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE3zxtAA40 K42 V96
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE3zxtBA40 K42 V96
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE3zxtCA40 K42 V96
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE3zxtDA40 K42 V96
38G4-(3-{3-[(R)-{[2-(DIMETHYLAMINO)ETHYL]AMINO}(HYDROXY) METHYL]PHENYL}IMIDAZO[1,2-B]PYRIDAZIN-6-YL)-2- METHOXYPHENOL4txcAA40 K42 V96
2AN8-ANILINO-1-NAPHTHALENE SULFONATE5autAA40 K42 V96
LU2LUTEOLIN5auuAA40 K42 V96
AGIAPIGENIN5auvAA40 K42 V96
QUEQUERCETIN5auwAA40 K42 V96
KMPKAEMPFEROL5auxAA40 K42 V96
MRIMORIN2-[2,4-BIS(OXIDANYL)PHENYL]-3,5,7-TRIS(OXIDANYL) CHROMEN-4-ONE5auyAA40 K42 V96
GENGENISTEIN5auzAA40 K42 V96
KMPKAEMPFEROL5av2AA40 K42 V96
KMPKAEMPFEROL5av3AA40 K42 V96
GENGENISTEIN5av4AA40 K42 V96
BD46-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE1wvxAA40 V96
4FTPHTHALAZINE4yo4AA40 V96
DKG4-METHYLPYRIDAZINE4ypdAA40 V96
47X3',4',7-TRIHYDROXYISOFLAVONE5av0AA40 V96
IODIODIDE5av3AF183
IODIODIDE5av3AF183
BRBROMIDE5av1AG16 K29
BRBROMIDE5av2AG16 K29
BRBROMIDE5av4AG16 K29
MGMAGNESIUM(2+)4pf4AK42
MGMAGNESIUM(2+)4tl0AK42
CLCHLORIDE5auvAK42
CLCHLORIDE5auxAK42
BRBROMIDE5av1AK42
BRBROMIDE5av2AK42
IODIODIDE5av3AK42
IODIODIDE5av3AK42
BRBROMIDE5av4AK42
BRBROMIDE5av1AP181
IODIODIDE5av3AP181


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Conservation information for LBS of DAPK1
Multiple alignments for P53355 in multiple species
LBSAA sequence# speciesSpecies
A25GSGQFAVVKKC2Homo sapiens, Mus musculus
A25GSGQFAVVRRV1Caenorhabditis elegans
A40TGLQYAAKFIK2Homo sapiens, Mus musculus
A40TGEKYAAKFIK1Caenorhabditis elegans
A97ILELVAGGELF2Homo sapiens, Mus musculus
A97VLELVSGGELF1Caenorhabditis elegans
D139QIAHFDLKPEN2Homo sapiens, Mus musculus
D139HIVHLDIKPEN1Caenorhabditis elegans
D161RIKIIDFGLAH2Homo sapiens, Mus musculus
D161QIKIIDFGLSR1Caenorhabditis elegans
E100LVAGGELFDFL2Homo sapiens, Mus musculus
E100LVSGGELFDHV1Caenorhabditis elegans
E143FDLKPENIMLL2Homo sapiens, Mus musculus
E143LDIKPENVMLK1Caenorhabditis elegans
E17YYDTGEELGSG2Homo sapiens, Mus musculus
E17VYEIETELGSG1Caenorhabditis elegans
E64EDIEREVSILK2Homo sapiens, Mus musculus
E64QNIEREVRVLQ1Caenorhabditis elegans
E94VILILELVAGG2Homo sapiens, Mus musculus
E94VIIVLELVSGG1Caenorhabditis elegans
F102AGGELFDFLAE2Homo sapiens, Mus musculus
F102SGGELFDHVCA1Caenorhabditis elegans
F162IKIIDFGLAHK2Homo sapiens, Mus musculus
F162IKIIDFGLSRE1Caenorhabditis elegans
F183FGTPEFVAPEI2Homo sapiens, Mus musculus
F183VGTPEFVAPEV1Caenorhabditis elegans
F24LGSGQFAVVKK2Homo sapiens, Mus musculus
F24LGSGQFAVVRR1Caenorhabditis elegans
G16DYYDTGEELGS2Homo sapiens, Mus musculus
G16DVYEIETELGS1Caenorhabditis elegans
G20TGEELGSGQFA2Homo sapiens, Mus musculus
G20IETELGSGQFA1Caenorhabditis elegans
G22EELGSGQFAVV2Homo sapiens, Mus musculus
G22TELGSGQFAVV1Caenorhabditis elegans
H131GVYYLHSLQIA2Homo sapiens, Mus musculus
H131AVRHLHSLHIV1Caenorhabditis elegans
I160PRIKIIDFGLA2Homo sapiens, Mus musculus
I160SQIKIIDFGLS1Caenorhabditis elegans
I209GVITYILLSGA2Homo sapiens, Mus musculus
I209GVVTYILLSGG1Caenorhabditis elegans
I266KKRMTIQDSLQ2Homo sapiens, Mus musculus
I266DQRATVEECLQ1Caenorhabditis elegans
I77-HPNVITLHEV2Homo sapiens, Mus musculus
I77GNSNVVELHAV1Caenorhabditis elegans
K141AHFDLKPENIM2Homo sapiens, Mus musculus
K141VHLDIKPENVM1Caenorhabditis elegans
K222FLGDTKQETLA2Homo sapiens, Mus musculus
K222FLGDNRDETFS1Caenorhabditis elegans
K29FAVVKKCREKS2Homo sapiens, Mus musculus
K29FAVVRRVRDRK1Caenorhabditis elegans
K42LQYAAKFIKKR2Homo sapiens, Mus musculus
K42EKYAAKFIKKR1Caenorhabditis elegans
L19DTGEELGSGQF2Homo sapiens, Mus musculus
L19EIETELGSGQF1Caenorhabditis elegans
L196YEPLGLEADMW2Homo sapiens, Mus musculus
L196YEALSPATDMW1Caenorhabditis elegans
L218GASPFLGDTKQ2Homo sapiens, Mus musculus
L218GGSPFLGDNRD1Caenorhabditis elegans
L68REVSILKEIQ-1Homo sapiens
L68REVRVLQKIRG1Caenorhabditis elegans
L68REVSILKEIR-1Mus musculus
L79PNVITLHEVYE2Homo sapiens, Mus musculus
L79SNVVELHAVYE1Caenorhabditis elegans
L91KTDVILILELV2Homo sapiens, Mus musculus
L91ASDVIIVLELV1Caenorhabditis elegans
L93DVILILELVAG2Homo sapiens, Mus musculus
L93DVIIVLELVSG1Caenorhabditis elegans
L95ILILELVAGGE2Homo sapiens, Mus musculus
L95IIVLELVSGGE1Caenorhabditis elegans
M146KPENIMLLDRN2Homo sapiens, Mus musculus
M146KPENVMLKQRG1Caenorhabditis elegans
M200GLEADMWSIGV2Homo sapiens, Mus musculus
M200SPATDMWAVGV1Caenorhabditis elegans
N144DLKPENIMLLD2Homo sapiens, Mus musculus
N144DIKPENVMLKQ1Caenorhabditis elegans
P142HFDLKPENIML2Homo sapiens, Mus musculus
P142HLDIKPENVML1Caenorhabditis elegans
P181NIFGTPEFVAP2Homo sapiens, Mus musculus
P181DMVGTPEFVAP1Caenorhabditis elegans
Q23ELGSGQFAVVK2Homo sapiens, Mus musculus
Q23ELGSGQFAVVR1Caenorhabditis elegans
Q267KRMTIQDSLQH2Homo sapiens, Mus musculus
Q267QRATVEECLQH1Caenorhabditis elegans
S132VYYLHSLQIAH2Homo sapiens, Mus musculus
S132VRHLHSLHIVH1Caenorhabditis elegans
S21GEELGSGQFAV2Homo sapiens, Mus musculus
S21ETELGSGQFAV1Caenorhabditis elegans
T225DTKQETLANVS2Homo sapiens, Mus musculus
T225DNRDETFSNIT1Caenorhabditis elegans
T265PKKRMTIQDSL2Homo sapiens, Mus musculus
T265VDQRATVEECL1Caenorhabditis elegans
T78HPNVITLHEVY2Homo sapiens, Mus musculus
T78NSNVVELHAVY1Caenorhabditis elegans
V26SGQFAVVKKCR2Homo sapiens, Mus musculus
V26SGQFAVVRRVR1Caenorhabditis elegans
V27GQFAVVKKCRE2Homo sapiens, Mus musculus
V27GQFAVVRRVRD1Caenorhabditis elegans
V96LILELVAGGEL2Homo sapiens, Mus musculus
V96IVLELVSGGEL1Caenorhabditis elegans
Y128ILNGVYYLHSL1Homo sapiens
Y128ILLAVRHLHSL1Caenorhabditis elegans
Y128ILSGVYYLHSL1Mus musculus


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