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mutLBSgeneDB |
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| Gene summary for REM2 |
 Gene summary |
| Basic gene Info. | Gene symbol | REM2 |
| Gene name | RAS (RAD and GEM)-like GTP binding 2 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 14q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_173527.2, | |
| Description | GTP-binding protein REM 2Rad and Gem-related 2 (rat homolog)rad and Gem-like GTP-binding protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000139890 | ||
| HPRD : 08248 | ||
| Vega : OTTHUMG00000170277 | ||
| Protein | UniProt: Q8IYK8 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_REM2 | |
| BioGPS: 161253 | ||
| Pathway | NCI Pathway Interaction Database: REM2 | |
| KEGG: REM2 | ||
| REACTOME: REM2 | ||
| Pathway Commons: REM2 | ||
| Context | iHOP: REM2 | |
| ligand binding site mutation search in PubMed: REM2 | ||
| UCL Cancer Institute: REM2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for REM2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | A261 | H263Y | COAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for REM2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | A261 | H263Y | -0.36284128 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for REM2 from PDB |
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| Differential gene expression and gene-gene network for REM2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for REM2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for REM2 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of REM2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GDP | GUANOSINE-5'-DIPHOSPHATE | 3cbq | A | A261 |
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| Conservation information for LBS of REM2 |
| Multiple alignments for Q8IYK8 in multiple species |
| LBS | AA sequence | # species | Species | A260 | HIETSAALHHN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A261 | IETSAALHHNT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D232 | VGNKSDLARSR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G124 | LVGESGVGKST | 2 | Homo sapiens, Mus musculus | G124 | LLGESGVGKST | 1 | Rattus norvegicus | G126 | GESGVGKSTLA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K127 | ESGVGKSTLAG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K230 | ILVGNKSDLAR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L233 | GNKSDLARSRE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N229 | VILVGNKSDLA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S128 | SGVGKSTLAGT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S259 | KHIETSAALHH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T129 | GVGKSTLAGTF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V125 | VGESGVGKSTL | 2 | Homo sapiens, Mus musculus | V125 | LGESGVGKSTL | 1 | Rattus norvegicus |
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