mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DCK
Gene summary
Basic gene Info.Gene symbolDCK
Gene namedeoxycytidine kinase
Synonyms-
CytomapUCSC genome browser: 4q13.3-q21.1
Type of geneprotein-coding
RefGenesNM_000788.2,
Descriptiondeoxynucleoside kinase
Modification date20141207
dbXrefs MIM : 125450
HGNC : HGNC
Ensembl : ENSG00000156136
HPRD : 00507
Vega : OTTHUMG00000129908
ProteinUniProt: P27707
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DCK
BioGPS: 1633
PathwayNCI Pathway Interaction Database: DCK
KEGG: DCK
REACTOME: DCK
Pathway Commons: DCK
ContextiHOP: DCK
ligand binding site mutation search in PubMed: DCK
UCL Cancer Institute: DCK
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006220pyrimidine nucleotide metabolic process12808445
GO:0009157deoxyribonucleoside monophosphate biosynthetic process12808445


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Ligand binding site mutations for DCK
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
K207L208RCOAD1
E127F126LGBM1
R192R192LLUAD1
R104I105LLUAD1
F137I136VLUAD1
E90E90KUCEC1
R104S103GUCEC1
Y86E87DUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for DCK
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
F137I136V-1.1361919
K207L208R-1.0951971
E90E90K-1.0468122
Y86E87D-1.0276413
R104I105L-0.72098846
R104S103G-0.56033179
E127F126L-0.51077333
R192R192L-0.12758308
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DCK from PDB

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Differential gene expression and gene-gene network for DCK
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DCK and the right PPI network was created from samples without mutations in the LBS of DCK. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for DCK
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0031117Peripheral Nervous System Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for DCK
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB01073FludarabineSmall molecule
ExperimentalDB025942'-DeoxycytidineSmall molecule
InvestigationalDB05494CP-4055Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DCK go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
MGMAGNESIUM(2+)1p5zBE127
MGMAGNESIUM(2+)1p62BE127
MGMAGNESIUM(2+)2a2zAE127
MGMAGNESIUM(2+)2a2zBE127
MGMAGNESIUM(2+)2a2zCE127
MGMAGNESIUM(2+)2a2zDE127
MGMAGNESIUM(2+)2a7qAE127
MGMAGNESIUM(2+)2qrnAE127
MGMAGNESIUM(2+)2qrnBE127
MGMAGNESIUM(2+)2qrnCE127
MGMAGNESIUM(2+)2qrnDE127
MGMAGNESIUM(2+)2qroAE127
MGMAGNESIUM(2+)2qroBE127
MGMAGNESIUM(2+)2qroCE127
MGMAGNESIUM(2+)2qroDE127
MGMAGNESIUM(2+)2zi4AE127
MGMAGNESIUM(2+)3ipxAE127
ADPADP1p5zBE127 R192
ADPADP1p62BE127 R192
UDPURIDINE-DIPHOSPHATE2a2zAE127 R192
UDPURIDINE-DIPHOSPHATE2a2zBE127 R192
UDPURIDINE-DIPHOSPHATE2a2zCE127 R192
UDPURIDINE-DIPHOSPHATE2a2zDE127 R192
UDPURIDINE-DIPHOSPHATE2qrnAE127 R192
UDPURIDINE-DIPHOSPHATE2qrnBE127 R192
UDPURIDINE-DIPHOSPHATE2qrnCE127 R192
UDPURIDINE-DIPHOSPHATE2qrnDE127 R192
UDPURIDINE-DIPHOSPHATE2zi7AE127 R192
UDPURIDINE-DIPHOSPHATE2ziaBE127 R192
UDPURIDINE-DIPHOSPHATE3mjrCE127 R192
UDPURIDINE-DIPHOSPHATE4q19BE127 R192
UDPURIDINE-DIPHOSPHATE4q1eBE127 R192
UDPURIDINE-DIPHOSPHATE4q1bAE127 R192
AC29-HYROXYETHOXYMETHYLGUANINE3mjrAF137
1NO2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-METHYL-1, 3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE4jlkAF137
2Y8(R)-2-((1-(2-(3-(2-FLUOROETHOXY)-4-METHOXYPHENYL)-5- METHYLTHIAZOL-4-YL)ETHYL)THIO)PYRIMIDINE-4,6-DIAMINE2-{[(1R)-1-{2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5- METHYL-1,3-THIAZOL-4-YL}ETHYL]SULFANYL}PYRIMIDINE-4,6- DIAMINE4q1eAF137
2XJ1-(5-(4-(((2,6-DIAMINOPYRIMIDIN-4-YL)THIO)METHYL)-5- PROPYLTHIAZOL-2-YL)-2-METHOXYPHENOXY)-2-METHYLPROPAN- 2-OL1-[5-(4-{[(2,6-DIAMINOPYRIMIDIN-4-YL)SULFANYL]METHYL}- 5-PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOXY]-2- METHYLPROPAN-2-OL4q18BF137 K207
AC29-HYROXYETHOXYMETHYLGUANINE3mjrBR104 F137
ADPADP1p60AR192
ADPADP1p60BR192
ADPADP1p61BR192
ADPADP2no0AR192
ADPADP2no0BR192
ADPADP2no1AR192
ADPADP2no1BR192
ADPADP2no6AR192
ADPADP2no6BR192
ADPADP2no7AR192
ADPADP2no7BR192
ADPADP2no9AR192
ADPADP2no9BR192
ADPADP2noaAR192
ADPADP2noaBR192
UDPURIDINE-DIPHOSPHATE2qroAR192
UDPURIDINE-DIPHOSPHATE2qroBR192
UDPURIDINE-DIPHOSPHATE2qroCR192
UDPURIDINE-DIPHOSPHATE2qroDR192
ADPADP2zi3AR192
ADPADP2zi3BR192
ADPADP2zi4AR192
UDPURIDINE-DIPHOSPHATE2zi7BR192
ADPADP2zi9AR192
ADPADP2zi9BR192
UDPURIDINE-DIPHOSPHATE2ziaAR192
ADPADP3hp1AR192
ADPADP3ipxAR192
ADPADP3kfxAR192
ADPADP3kfxBR192
UDPURIDINE-DIPHOSPHATE3mjrAR192
UDPURIDINE-DIPHOSPHATE3mjrBR192
UDPURIDINE-DIPHOSPHATE3mjrDR192
UDPURIDINE-DIPHOSPHATE3qejAR192
UDPURIDINE-DIPHOSPHATE3qejBR192
UDPURIDINE-DIPHOSPHATE3qenAR192
UDPURIDINE-DIPHOSPHATE3qenBR192
UDPURIDINE-DIPHOSPHATE3qeoAR192
UDPURIDINE-DIPHOSPHATE3qeoBR192
UDPURIDINE-DIPHOSPHATE4jlkAR192
UDPURIDINE-DIPHOSPHATE4jlkBR192
UDPURIDINE-DIPHOSPHATE4l5bAR192
UDPURIDINE-DIPHOSPHATE4l5bBR192
UDPURIDINE-DIPHOSPHATE4jljAR192
UDPURIDINE-DIPHOSPHATE4jljBR192
UDPURIDINE-DIPHOSPHATE4jlmAR192
UDPURIDINE-DIPHOSPHATE4jlmBR192
UDPURIDINE-DIPHOSPHATE4jlnAR192
UDPURIDINE-DIPHOSPHATE4jlnBR192
UDPURIDINE-DIPHOSPHATE4kcgAR192
UDPURIDINE-DIPHOSPHATE4kcgBR192
UDPURIDINE-DIPHOSPHATE4q18AR192
UDPURIDINE-DIPHOSPHATE4q18BR192
UDPURIDINE-DIPHOSPHATE4q19AR192
UDPURIDINE-DIPHOSPHATE4q1cAR192
UDPURIDINE-DIPHOSPHATE4q1cBR192
UDPURIDINE-DIPHOSPHATE4q1eAR192
UDPURIDINE-DIPHOSPHATE4q1fAR192
UDPURIDINE-DIPHOSPHATE4q1fBR192
UDPURIDINE-DIPHOSPHATE4q1aAR192
UDPURIDINE-DIPHOSPHATE4q1aBR192
UDPURIDINE-DIPHOSPHATE4q1bBR192
UDPURIDINE-DIPHOSPHATE4q1dAR192
UDPURIDINE-DIPHOSPHATE4q1dBR192
B874-(1-BENZOTHIOPHEN-2-YL)-6-[4-(2-OXO-2-PYRROLIDIN-1-YLETHYL)PIPERAZIN-1-YL]PYRIMIDINE3ipyBY86
1NO2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-METHYL-1, 3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE4jlkAY86
1NO2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-METHYL-1, 3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE4jlkBY86
1NM2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1,3- THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE4jljAY86
1NM2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1,3- THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE4jljBY86
1NN2-[({5-ETHYL-2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1, 3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE4jlmAY86
2XJ1-(5-(4-(((2,6-DIAMINOPYRIMIDIN-4-YL)THIO)METHYL)-5- PROPYLTHIAZOL-2-YL)-2-METHOXYPHENOXY)-2-METHYLPROPAN- 2-OL1-[5-(4-{[(2,6-DIAMINOPYRIMIDIN-4-YL)SULFANYL]METHYL}- 5-PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOXY]-2- METHYLPROPAN-2-OL4q18AY86
2XJ1-(5-(4-(((2,6-DIAMINOPYRIMIDIN-4-YL)THIO)METHYL)-5- PROPYLTHIAZOL-2-YL)-2-METHOXYPHENOXY)-2-METHYLPROPAN- 2-OL1-[5-(4-{[(2,6-DIAMINOPYRIMIDIN-4-YL)SULFANYL]METHYL}- 5-PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOXY]-2- METHYLPROPAN-2-OL4q18BY86
2Y7(S)-2-((1-(2-(3-(2-FLUOROETHOXY)-4-METHOXYPHENYL)-5- METHYLTHIAZOL-4-YL)ETHYL)THIO)PYRIMIDINE-4,6-DIAMINE2-{[(1S)-1-{2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5- METHYL-1,3-THIAZOL-4-YL}ETHYL]SULFANYL}PYRIMIDINE-4,6- DIAMINE4q1eAY86
2Y7(S)-2-((1-(2-(3-(2-FLUOROETHOXY)-4-METHOXYPHENYL)-5- METHYLTHIAZOL-4-YL)ETHYL)THIO)PYRIMIDINE-4,6-DIAMINE2-{[(1S)-1-{2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5- METHYL-1,3-THIAZOL-4-YL}ETHYL]SULFANYL}PYRIMIDINE-4,6- DIAMINE4q1eBY86
D5MDAMP2qroAY86 E127 F137 R192
D5MDAMP2qroBY86 E127 F137 R192
D5MDAMP2qroCY86 E127 F137 R192
D5MDAMP2qroDY86 E127 F137 R192
B874-(1-BENZOTHIOPHEN-2-YL)-6-[4-(2-OXO-2-PYRROLIDIN-1-YLETHYL)PIPERAZIN-1-YL]PYRIMIDINE3ipyAY86 E90
AR3CYTARABINE1p5zBY86 F137
DCZ2'-DEOXYCYTIDINE1p60AY86 F137
DCZ2'-DEOXYCYTIDINE1p60BY86 F137
DCZ2'-DEOXYCYTIDINE1p61BY86 F137
GEOGEMCITABINE1p62BY86 F137
DCZ2'-DEOXYCYTIDINE2a2zAY86 F137
DCZ2'-DEOXYCYTIDINE2a2zBY86 F137
DCZ2'-DEOXYCYTIDINE2a2zCY86 F137
DCZ2'-DEOXYCYTIDINE2a2zDY86 F137
DCZ2'-DEOXYCYTIDINE2a30AY86 F137
DCZ2'-DEOXYCYTIDINE2a30BY86 F137
DCZ2'-DEOXYCYTIDINE2a30CY86 F137
DCZ2'-DEOXYCYTIDINE2a30DY86 F137
GEOGEMCITABINE2no0AY86 F137
GEOGEMCITABINE2no0BY86 F137
DCZ2'-DEOXYCYTIDINE2no1AY86 F137
DCZ2'-DEOXYCYTIDINE2no1BY86 F137
LDCL-2'-DEOXYCYTIDINE2no7AY86 F137
LDCL-2'-DEOXYCYTIDINE2no7BY86 F137
LTTTROXACITABINE2no9BY86 F137
3TCLAMIVUDINE2noaAY86 F137
3TCLAMIVUDINE2noaBY86 F137
3D12'-DEOXYADENOSINE2zi3AY86 F137
CL9CLADRIBINE2ziaAY86 F137
LLTTELBIVUDINE3hp1AY86 F137
B874-(1-BENZOTHIOPHEN-2-YL)-6-[4-(2-OXO-2-PYRROLIDIN-1-YLETHYL)PIPERAZIN-1-YL]PYRIMIDINE3ipyBY86 F137
LLTTELBIVUDINE3qeoAY86 F137
LLTTELBIVUDINE3qeoBY86 F137
1NO2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-METHYL-1, 3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE4jlkBY86 F137
1UX1-[5-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL)SULFANYL]METHYL}- 5-PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOXY]-2- METHYLPROPAN-2-OL4l5bAY86 F137
1UX1-[5-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL)SULFANYL]METHYL}- 5-PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOXY]-2- METHYLPROPAN-2-OL4l5bBY86 F137
1NM2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1,3- THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE4jljAY86 F137
1NM2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1,3- THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE4jljBY86 F137
1NN2-[({5-ETHYL-2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1, 3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE4jlmAY86 F137
1NN2-[({5-ETHYL-2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1, 3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE4jlmBY86 F137
18V2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-PROPYL-1, 3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE4jlnAY86 F137
18V2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-PROPYL-1, 3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE4jlnBY86 F137
1QCN-{2-[5-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL) SULFANYL]METHYL}-5-PROPYL-1,3-THIAZOL-2-YL)-2- METHOXYPHENOXY]ETHYL}METHANESULFONAMIDE4kcgBY86 F137
2XJ1-(5-(4-(((2,6-DIAMINOPYRIMIDIN-4-YL)THIO)METHYL)-5- PROPYLTHIAZOL-2-YL)-2-METHOXYPHENOXY)-2-METHYLPROPAN- 2-OL1-[5-(4-{[(2,6-DIAMINOPYRIMIDIN-4-YL)SULFANYL]METHYL}- 5-PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOXY]-2- METHYLPROPAN-2-OL4q18AY86 F137
2XL5-(4-(((4,6-DIAMINOPYRIMIDIN-2-YL)THIO)METHYL)-5- PROPYLTHIAZOL-2-YL)-2-METHOXYPHENOL5-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL)SULFANYL]METHYL}-5- PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOL4q19AY86 F137
2XL5-(4-(((4,6-DIAMINOPYRIMIDIN-2-YL)THIO)METHYL)-5- PROPYLTHIAZOL-2-YL)-2-METHOXYPHENOL5-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL)SULFANYL]METHYL}-5- PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOL4q19BY86 F137
2XM2,2'-((4-(4-(((4,6-DIAMINOPYRIMIDIN-2-YL)THIO)METHYL)- 5-PROPYLTHIAZOL-2-YL)-1,2-PHENYLENE)BIS(OXY)) BIS(ETHAN-1-OL)2,2'-{[4-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL) SULFANYL]METHYL}-5-PROPYL-1,3-THIAZOL-2-YL)BENZENE-1, 2-DIYL]BIS(OXY)}DIETHANOL4q1cAY86 F137
2XM2,2'-((4-(4-(((4,6-DIAMINOPYRIMIDIN-2-YL)THIO)METHYL)- 5-PROPYLTHIAZOL-2-YL)-1,2-PHENYLENE)BIS(OXY)) BIS(ETHAN-1-OL)2,2'-{[4-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL) SULFANYL]METHYL}-5-PROPYL-1,3-THIAZOL-2-YL)BENZENE-1, 2-DIYL]BIS(OXY)}DIETHANOL4q1cBY86 F137
2Y8(R)-2-((1-(2-(3-(2-FLUOROETHOXY)-4-METHOXYPHENYL)-5- METHYLTHIAZOL-4-YL)ETHYL)THIO)PYRIMIDINE-4,6-DIAMINE2-{[(1R)-1-{2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5- METHYL-1,3-THIAZOL-4-YL}ETHYL]SULFANYL}PYRIMIDINE-4,6- DIAMINE4q1eBY86 F137
2XNN-{2-[5-(4-{(1R)-1-[(4,6-DIAMINOPYRIMIDIN-2-YL) SULFANYL]ETHYL}-5-METHYL-1,3-THIAZOL-2-YL)-2- METHOXYPHENOXY]ETHYL}METHANESULFONAMIDE4q1fBY86 F137
2XZ2-(5-(4-(((4,6-DIAMINOPYRIMIDIN-2-YL)THIO)METHYL)-5- PROPYLTHIAZOL-2-YL)-2-METHOXYPHENOXY)ETHAN-1-OL2-[5-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL)SULFANYL]METHYL}- 5-PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOXY]ETHANOL4q1aAY86 F137
2XZ2-(5-(4-(((4,6-DIAMINOPYRIMIDIN-2-YL)THIO)METHYL)-5- PROPYLTHIAZOL-2-YL)-2-METHOXYPHENOXY)ETHAN-1-OL2-[5-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL)SULFANYL]METHYL}- 5-PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOXY]ETHANOL4q1aBY86 F137
2Y0N-(2-(3-(4-(((4,6-DIAMINOPYRIMIDIN-2-YL)THIO)METHYL)-5- PROPYLTHIAZOL-2-YL)PHENOXY)ETHYL)METHANESULFONAMIDEN-{2-[3-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL) SULFANYL]METHYL}-5-PROPYL-1,3-THIAZOL-2-YL) PHENOXY]ETHYL}METHANESULFONAMIDE4q1bBY86 F137
2Y1(R)-2-((1-(2-(3-(2-FLUOROETHOXY)-4-METHOXYPHENYL)-5- PROPYLTHIAZOL-4-YL)ETHYL)THIO)PYRIMIDINE-4,6-DIAMINE2-{[(1R)-1-{2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5- PROPYL-1,3-THIAZOL-4-YL}ETHYL]SULFANYL}PYRIMIDINE-4,6- DIAMINE4q1dAY86 F137
2Y1(R)-2-((1-(2-(3-(2-FLUOROETHOXY)-4-METHOXYPHENYL)-5- PROPYLTHIAZOL-4-YL)ETHYL)THIO)PYRIMIDINE-4,6-DIAMINE2-{[(1R)-1-{2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5- PROPYL-1,3-THIAZOL-4-YL}ETHYL]SULFANYL}PYRIMIDINE-4,6- DIAMINE4q1dBY86 F137
1QCN-{2-[5-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL) SULFANYL]METHYL}-5-PROPYL-1,3-THIAZOL-2-YL)-2- METHOXYPHENOXY]ETHYL}METHANESULFONAMIDE4kcgAY86 F137 K207
2XNN-{2-[5-(4-{(1R)-1-[(4,6-DIAMINOPYRIMIDIN-2-YL) SULFANYL]ETHYL}-5-METHYL-1,3-THIAZOL-2-YL)-2- METHOXYPHENOXY]ETHYL}METHANESULFONAMIDE4q1fAY86 F137 K207
2Y0N-(2-(3-(4-(((4,6-DIAMINOPYRIMIDIN-2-YL)THIO)METHYL)-5- PROPYLTHIAZOL-2-YL)PHENOXY)ETHYL)METHANESULFONAMIDEN-{2-[3-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL) SULFANYL]METHYL}-5-PROPYL-1,3-THIAZOL-2-YL) PHENOXY]ETHYL}METHANESULFONAMIDE4q1bAY86 F137 K207
DCMDCMP2qrnAY86 F137 R192
DCMDCMP2qrnBY86 F137 R192
DCMDCMP2qrnCY86 F137 R192
DCMDCMP2qrnDY86 F137 R192
CFBCLOFARABINE2a7qAY86 R104 F137
ETVEMTRICITABINE2no6AY86 R104 F137
ETVEMTRICITABINE2no6BY86 R104 F137
LTTTROXACITABINE2no9AY86 R104 F137
3D12'-DEOXYADENOSINE2zi3BY86 R104 F137
3L1L-2'-DEOXYADENOSINE2zi4AY86 R104 F137
GNGDEOXYGUANOSINE2zi7BY86 R104 F137
GNGDEOXYGUANOSINE2zi7AY86 R104 F137
CL9CLADRIBINE2zi9AY86 R104 F137
CL9CLADRIBINE2zi9BY86 R104 F137
CL9CLADRIBINE2ziaBY86 R104 F137
B862'-DEOXY-5-FLUOROCYTIDINE3ipxAY86 R104 F137
B874-(1-BENZOTHIOPHEN-2-YL)-6-[4-(2-OXO-2-PYRROLIDIN-1-YLETHYL)PIPERAZIN-1-YL]PYRIMIDINE3ipyAY86 R104 F137
MCY5-METHYL-2'-DEOXYCYTIDINE3kfxAY86 R104 F137
MCY5-METHYL-2'-DEOXYCYTIDINE3kfxBY86 R104 F137
AC29-HYROXYETHOXYMETHYLGUANINE3mjrDY86 R104 F137
5BTBRCDR3qenAY86 R104 F137
5BTBRCDR3qenBY86 R104 F137


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Conservation information for LBS of DCK
Multiple alignments for P27707 in multiple species
LBSAA sequence# speciesSpecies
A100TFQSYACLSRI2Bos taurus, Mus musculus
A100TFQTYACLSRI1Homo sapiens
A100IFQSYACLSRI1Rattus norvegicus
A31IEGNIAAGKST4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
A32EGNIAAGKSTF4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
C146LYESDCMNETE3Rattus norvegicus, Bos taurus, Mus musculus
C146LYESECMNETE1Homo sapiens
D133RSVYSDRYIFA4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
D241LDVNEDFKDKH2Bos taurus, Mus musculus
D241LDVNEDFKDKY1Homo sapiens
D241LDVNLDFKDKE1Rattus norvegicus
E127PVLFFERSVYS4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
E145NLYESDCMNET3Rattus norvegicus, Bos taurus, Mus musculus
E145NLYESECMNET1Homo sapiens
E196LRGRNEEQGIP3Homo sapiens, Bos taurus, Mus musculus
E196IRGRDEEQGIP1Rattus norvegicus
E197RGRNEEQGIPL3Homo sapiens, Bos taurus, Mus musculus
E197RGRDEEQGIPL1Rattus norvegicus
E240TLDVNEDFKDK3Homo sapiens, Bos taurus, Mus musculus
E240TLDVNLDFKDK1Rattus norvegicus
E53WEVVPEPVARW4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
E90MYEKPERWSFT3Homo sapiens, Bos taurus, Mus musculus
E90MYEKPERWSFI1Rattus norvegicus
F137SDRYIFASNLY4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
F242DVNEDFKDKYE1Homo sapiens
F242DVNLDFKDKEE1Rattus norvegicus
F242DVNEDFKDKHD1Bos taurus
F242DVNEDFKDKHE1Mus musculus
F96RWSFTFQSYAC2Bos taurus, Mus musculus
F96RWSFTFQTYAC1Homo sapiens
F96RWSFIFQSYAC1Rattus norvegicus
G199RNEEQGIPLEY3Homo sapiens, Bos taurus, Mus musculus
G199RDEEQGIPLEY1Rattus norvegicus
G33GNIAAGKSTFV4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
I200NEEQGIPLEYL3Homo sapiens, Bos taurus, Mus musculus
I200DEEQGIPLEYL1Rattus norvegicus
I30SIEGNIAAGKS4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
K207LEYLEKLHYKH4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
K243VNEDFKDKYES1Homo sapiens
K243VNLDFKDKEES1Rattus norvegicus
K243VNEDFKDKHDS1Bos taurus
K243VNEDFKDKHES1Mus musculus
K34NIAAGKSTFVN4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
L141IFASNLYESDC3Rattus norvegicus, Bos taurus, Mus musculus
L141IFASNLYESEC1Homo sapiens
L191LNRIYLRGRNE2Bos taurus, Mus musculus
L191LHRIYLRGRNE1Homo sapiens
L191LNRIYIRGRDE1Rattus norvegicus
L82SGGNVLQMMYE3Rattus norvegicus, Bos taurus, Mus musculus
L82NGGNVLQMMYE1Homo sapiens
M85NVLQMMYEKPE4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
N140YIFASNLYESD3Rattus norvegicus, Bos taurus, Mus musculus
N140YIFASNLYESE1Homo sapiens
N29ISIEGNIAAGK4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
P201EEQGIPLEYLE4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
P89MMYEKPERWSF4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
Q97WSFTFQSYACL2Bos taurus, Mus musculus
Q97WSFTFQTYACL1Homo sapiens
Q97WSFIFQSYACL1Rattus norvegicus
R104YACLSRIRAQL4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
R128VLFFERSVYSD4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
R188EKCLNRIYLRG2Bos taurus, Mus musculus
R188ETCLHRIYLRG1Homo sapiens
R188EKCLNRIYIRG1Rattus norvegicus
R192NRIYLRGRNEE2Bos taurus, Mus musculus
R192HRIYLRGRNEE1Homo sapiens
R192NRIYIRGRDEE1Rattus norvegicus
R194IYLRGRNEEQG3Homo sapiens, Bos taurus, Mus musculus
R194IYIRGRDEEQG1Rattus norvegicus
S144SNLYESDCMNE3Rattus norvegicus, Bos taurus, Mus musculus
S144SNLYESECMNE1Homo sapiens
S35IAAGKSTFVNI4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
T36AAGKSTFVNIL4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
V238ILTLDVNEDFK2Homo sapiens, Bos taurus
V238ILTLDVNLDFK1Rattus norvegicus
V238VLTLDVNEDFK1Mus musculus
V55VVPEPVARWCN4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
W58EPVARWCNVQS4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
Y204GIPLEYLEKLH4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus
Y86VLQMMYEKPER4Homo sapiens, Rattus norvegicus, Bos taurus, Mus musculus


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