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mutLBSgeneDB |
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| Gene summary for PARP15 |
 Gene summary |
| Basic gene Info. | Gene symbol | PARP15 |
| Gene name | poly (ADP-ribose) polymerase family, member 15 | |
| Synonyms | ARTD7|BAL3|pART7 | |
| Cytomap | UCSC genome browser: 3q21.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001113523.1, NM_152615.1, | |
| Description | ADP-ribosyltransferase diphtheria toxin-like 7B-aggressive lymphoma 3B-aggressive lymphoma protein 3PARP-15poly [ADP-ribose] polymerase 15 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612066 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000173200 | ||
| HPRD : 08811 | ||
| Vega : OTTHUMG00000159523 | ||
| Protein | UniProt: Q460N3 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PARP15 | |
| BioGPS: 165631 | ||
| Pathway | NCI Pathway Interaction Database: PARP15 | |
| KEGG: PARP15 | ||
| REACTOME: PARP15 | ||
| Pathway Commons: PARP15 | ||
| Context | iHOP: PARP15 | |
| ligand binding site mutation search in PubMed: PARP15 | ||
| UCL Cancer Institute: PARP15 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PARP15 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G380 | P379S | SKCM | 1 | S324 | V322A | UCEC | 1 | L659 | K658T | UCEC | 1 | G334 | S333L | UCEC | 1 | G381 | G381E | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PARP15 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | S324 | V322A | -1.2835216 | G381 | G381E | -1.1303983 | L659 | K658T | -0.93386624 | G380 | P379S | -0.63081703 | G334 | S333L | -0.26915982 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PARP15 from PDB |
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| Differential gene expression and gene-gene network for PARP15 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PARP15 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PARP15 |
| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB08348 | N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PARP15 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of PARP15 |
| Multiple alignments for Q460N3 in multiple species |
| LBS | AA sequence | # species | Species |
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