mutLBSgeneDB |
Gene summary for DHX9 |
Gene summary |
Basic gene Info. | Gene symbol | DHX9 |
Gene name | DEAH (Asp-Glu-Ala-His) box helicase 9 | |
Synonyms | DDX9|LKP|NDH2|NDHII|RHA | |
Cytomap | UCSC genome browser: 1q25 | |
Type of gene | protein-coding | |
RefGenes | NM_001357.4, NR_033302.1,NM_030588.1, | |
Description | ATP-dependent RNA helicase ADEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9DEAH (Asp-Glu-Ala-His) box polypeptide 9DEAH box protein 9RNA helicase Aleukophysinnuclear DNA helicase II | |
Modification date | 20141222 | |
dbXrefs | MIM : 603115 | |
HGNC : HGNC | ||
Ensembl : ENSG00000135829 | ||
HPRD : 04386 | ||
Vega : OTTHUMG00000035337 | ||
Protein | UniProt: Q08211 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DHX9 | |
BioGPS: 1660 | ||
Pathway | NCI Pathway Interaction Database: DHX9 | |
KEGG: DHX9 | ||
REACTOME: DHX9 | ||
Pathway Commons: DHX9 | ||
Context | iHOP: DHX9 | |
ligand binding site mutation search in PubMed: DHX9 | ||
UCL Cancer Institute: DHX9 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0001649 | osteoblast differentiation | 16210410 |
Top |
Ligand binding site mutations for DHX9 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | K54 | D56H | OV | 1 | A183 | R184C | SKCM | 1 | D511 | I509S | UCEC | 1 | K236 | L237M | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for DHX9 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D511 | I509S | -1.1534479 | A183 | R184C | -1.076715 | K236 | L237M | -0.89017612 | K54 | D56H | -0.7894905 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for DHX9 from PDB |
Top |
Differential gene expression and gene-gene network for DHX9 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for DHX9 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for DHX9 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of DHX9 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3vyx | A | A183 K236 | MN | MANGANESE(2+) | 3llm | A | D511 | MN | MANGANESE(2+) | 3llm | B | D511 | NUC | Nucleic Acids | 3vyy | A | K54 | NUC | Nucleic Acids | 3vyy | B | K54 |
Top |
Conservation information for LBS of DHX9 |
Multiple alignments for Q08211 in multiple species |
LBS | AA sequence | # species | Species | A183 | LENAKARLNQY | 3 | Homo sapiens, Mus musculus, Bos taurus | A183 | MENSKKALNEF | 1 | Caenorhabditis elegans | A183 | IENAKERLNIY | 1 | Drosophila melanogaster | C415 | RGATGCGKTTQ | 3 | Homo sapiens, Mus musculus, Bos taurus | C415 | KGETGCGKSTQ | 1 | Caenorhabditis elegans | C415 | RGNTGCGKTTQ | 1 | Drosophila melanogaster | D511 | SHVIVDEIHER | 3 | Homo sapiens, Mus musculus, Bos taurus | D511 | SHVIIDEIHER | 1 | Caenorhabditis elegans | D511 | SHIIVDEIHER | 1 | Drosophila melanogaster | E179 | GNWTLENAKAR | 3 | Homo sapiens, Mus musculus, Bos taurus | E179 | GGWTMENSKKA | 1 | Caenorhabditis elegans | E179 | GNWTIENAKER | 1 | Drosophila melanogaster | E512 | HVIVDEIHERD | 3 | Homo sapiens, Mus musculus, Bos taurus | E512 | HVIIDEIHERD | 1 | Caenorhabditis elegans | E512 | HIIVDEIHERD | 1 | Drosophila melanogaster | F34 | KNRQKFMCEVR | 2 | Mus musculus, Bos taurus | F34 | KNRQKFMCEVQ | 1 | Homo sapiens | F34 | SGRQRFKCELR | 1 | Caenorhabditis elegans | F34 | KNRQRFLCEVR | 1 | Drosophila melanogaster | G414 | IRGATGCGKTT | 3 | Homo sapiens, Mus musculus, Bos taurus | G414 | IKGETGCGKST | 1 | Caenorhabditis elegans | G414 | IRGNTGCGKTT | 1 | Drosophila melanogaster | G416 | GATGCGKTTQV | 3 | Homo sapiens, Mus musculus, Bos taurus | G416 | GETGCGKSTQV | 1 | Caenorhabditis elegans | G416 | GNTGCGKTTQI | 1 | Drosophila melanogaster | K182 | TLENAKARLNQ | 3 | Homo sapiens, Mus musculus, Bos taurus | K182 | TMENSKKALNE | 1 | Caenorhabditis elegans | K182 | TIENAKERLNI | 1 | Drosophila melanogaster | K191 | NQYFQKEKI-Q | 3 | Homo sapiens, Mus musculus, Bos taurus | K191 | NEFLQKMRLPQ | 1 | Caenorhabditis elegans | K191 | NIYKQTNNI-R | 1 | Drosophila melanogaster | K236 | HGSNKKLAAQS | 3 | Homo sapiens, Mus musculus, Bos taurus | K236 | TGSNKKVSEAA | 1 | Caenorhabditis elegans | K236 | SGSNKKSASKS | 1 | Drosophila melanogaster | K29 | RAVGNKNRQKF | 3 | Homo sapiens, Mus musculus, Bos taurus | K29 | KSETRSGRQRF | 1 | Caenorhabditis elegans | K29 | RQTGPKNRQRF | 1 | Drosophila melanogaster | K417 | ATGCGKTTQVP | 3 | Homo sapiens, Mus musculus, Bos taurus | K417 | ETGCGKSTQVA | 1 | Caenorhabditis elegans | K417 | NTGCGKTTQIA | 1 | Drosophila melanogaster | K54 | GNSTNKKDAQS | 3 | Homo sapiens, Mus musculus, Bos taurus | K54 | GNSTNKKDAAT | 1 | Caenorhabditis elegans | K54 | GNSTNKKDAEK | 1 | Drosophila melanogaster | L388 | QERELLPVKKF | 3 | Homo sapiens, Mus musculus, Bos taurus | L388 | AQRGELPVAQY | 1 | Caenorhabditis elegans | L388 | EFREKLPIAAM | 1 | Drosophila melanogaster | N186 | AKARLNQYFQK | 3 | Homo sapiens, Mus musculus, Bos taurus | N186 | SKKALNEFLQK | 1 | Caenorhabditis elegans | N186 | AKERLNIYKQT | 1 | Drosophila melanogaster | N30 | AVGNKNRQKFM | 3 | Homo sapiens, Mus musculus, Bos taurus | N30 | SETRSGRQRFK | 1 | Caenorhabditis elegans | N30 | QTGPKNRQRFL | 1 | Drosophila melanogaster | N53 | MGNSTNKKDAQ | 3 | Homo sapiens, Mus musculus, Bos taurus | N53 | FGNSTNKKDAA | 1 | Caenorhabditis elegans | N53 | VGNSTNKKDAE | 1 | Drosophila melanogaster | Q187 | KARLNQYFQKE | 3 | Homo sapiens, Mus musculus, Bos taurus | Q187 | KKALNEFLQKM | 1 | Caenorhabditis elegans | Q187 | KERLNIYKQTN | 1 | Drosophila melanogaster | Q190 | LNQYFQKEKI- | 3 | Homo sapiens, Mus musculus, Bos taurus | Q190 | LNEFLQKMRLP | 1 | Caenorhabditis elegans | Q190 | LNIYKQTNNI- | 1 | Drosophila melanogaster | Q240 | KKLAAQSCALS | 3 | Homo sapiens, Mus musculus, Bos taurus | Q240 | KKVSEAACAMN | 1 | Caenorhabditis elegans | Q240 | KKSASKSCALS | 1 | Drosophila melanogaster | R456 | VSVAERVAFER | 1 | Homo sapiens | R456 | ISLAERVANER | 1 | Caenorhabditis elegans | R456 | ISVAERVARER | 1 | Drosophila melanogaster | R456 | VAVAERVAYER | 1 | Mus musculus | R456 | VSVAERVAYER | 1 | Bos taurus | T413 | IIRGATGCGKT | 3 | Homo sapiens, Mus musculus, Bos taurus | T413 | LIKGETGCGKS | 1 | Caenorhabditis elegans | T413 | IIRGNTGCGKT | 1 | Drosophila melanogaster | T418 | TGCGKTTQVPQ | 3 | Homo sapiens, Mus musculus, Bos taurus | T418 | TGCGKSTQVAQ | 1 | Caenorhabditis elegans | T418 | TGCGKTTQIAQ | 1 | Drosophila melanogaster | T419 | GCGKTTQVPQF | 2 | Homo sapiens, Bos taurus | T419 | GCGKSTQVAQF | 1 | Caenorhabditis elegans | T419 | GCGKTTQIAQY | 1 | Drosophila melanogaster | T419 | GCGKTTQVPQY | 1 | Mus musculus | T52 | GMGNSTNKKDA | 3 | Homo sapiens, Mus musculus, Bos taurus | T52 | AFGNSTNKKDA | 1 | Caenorhabditis elegans | T52 | GVGNSTNKKDA | 1 | Drosophila melanogaster |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |