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mutLBSgeneDB |
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| Gene summary for DDX10 |
 Gene summary |
| Basic gene Info. | Gene symbol | DDX10 |
| Gene name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | |
| Synonyms | HRH-J8 | |
| Cytomap | UCSC genome browser: 11q22-q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004398.3, | |
| Description | DDX10-NUP98 fusion protein type 2DEAD box protein 10DEAD box-10DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase)probable ATP-dependent RNA helicase DDX10 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601235 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000178105 | ||
| HPRD : 03138 | ||
| Vega : OTTHUMG00000166540 | ||
| Protein | UniProt: Q13206 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DDX10 | |
| BioGPS: 1662 | ||
| Pathway | NCI Pathway Interaction Database: DDX10 | |
| KEGG: DDX10 | ||
| REACTOME: DDX10 | ||
| Pathway Commons: DDX10 | ||
| Context | iHOP: DDX10 | |
| ligand binding site mutation search in PubMed: DDX10 | ||
| UCL Cancer Institute: DDX10 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for DDX10 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Y89,L91 | R90H | HNSC | 1 | T115 | A113T | KIRC | 1 | K119 | K119R | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for DDX10 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K119 | K119R | 0.03608083 | T115 | A113T | -0.96459836 | Y89 | R90H | -0.96152977 | L91 | R90H | -0.96152977 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DDX10 from PDB |
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| Differential gene expression and gene-gene network for DDX10 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for DDX10 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for DDX10 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of DDX10 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ADP | ADP | 2pl3 | A | Y89 L91 T115 K119 |
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| Conservation information for LBS of DDX10 |
| Multiple alignments for Q13206 in multiple species |
| LBS | AA sequence | # species | Species | E223 | MLVLDEADRIL | 2 | Homo sapiens, Mus musculus | E223 | MLILDEADRIL | 1 | Gallus gallus | F71 | NEITRFSDFPL | 2 | Homo sapiens, Mus musculus | F71 | NEIQRFSDFPL | 1 | Gallus gallus | G116 | GAAKTGSGKTL | 3 | Homo sapiens, Gallus gallus, Mus musculus | G118 | AKTGSGKTLAF | 3 | Homo sapiens, Gallus gallus, Mus musculus | K119 | KTGSGKTLAFL | 2 | Homo sapiens, Mus musculus | K119 | KTGSGKTLAFI | 1 | Gallus gallus | L91 | EAQYRLVTEIQ | 2 | Homo sapiens, Mus musculus | L91 | EAQYRMVTEIQ | 1 | Gallus gallus | Q96 | LVTEIQKQTIG | 2 | Homo sapiens, Mus musculus | Q96 | MVTEIQRQTIG | 1 | Gallus gallus | S117 | AAKTGSGKTLA | 3 | Homo sapiens, Gallus gallus, Mus musculus | T115 | LGAAKTGSGKT | 3 | Homo sapiens, Gallus gallus, Mus musculus | T120 | TGSGKTLAFLV | 2 | Homo sapiens, Mus musculus | T120 | TGSGKTLAFIV | 1 | Gallus gallus | T93 | QYRLVTEIQKQ | 2 | Homo sapiens, Mus musculus | T93 | QYRMVTEIQRQ | 1 | Gallus gallus | Y89 | LQEAQYRLVTE | 2 | Homo sapiens, Mus musculus | Y89 | LQEAQYRMVTE | 1 | Gallus gallus |
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