mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DDX10
Gene summary
Basic gene Info.Gene symbolDDX10
Gene nameDEAD (Asp-Glu-Ala-Asp) box polypeptide 10
CytomapUCSC genome browser: 11q22-q23
Type of geneprotein-coding
DescriptionDDX10-NUP98 fusion protein type 2DEAD box protein 10DEAD box-10DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase)probable ATP-dependent RNA helicase DDX10
Modification date20141207
dbXrefs MIM : 601235
Ensembl : ENSG00000178105
HPRD : 03138
Vega : OTTHUMG00000166540
ProteinUniProt: Q13206
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DDX10
BioGPS: 1662
PathwayNCI Pathway Interaction Database: DDX10
Pathway Commons: DDX10
ContextiHOP: DDX10
ligand binding site mutation search in PubMed: DDX10
UCL Cancer Institute: DDX10
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for DDX10
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for DDX10
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DDX10 from PDB

Differential gene expression and gene-gene network for DDX10
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DDX10 and the right PPI network was created from samples without mutations in the LBS of DDX10. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for DDX10
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for DDX10
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DDX10 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ADPADP2pl3AY89 L91 T115 K119

Conservation information for LBS of DDX10
Multiple alignments for Q13206 in multiple species
LBSAA sequence# speciesSpecies
E223MLVLDEADRIL2Homo sapiens, Mus musculus
E223MLILDEADRIL1Gallus gallus
F71NEITRFSDFPL2Homo sapiens, Mus musculus
F71NEIQRFSDFPL1Gallus gallus
G116GAAKTGSGKTL3Homo sapiens, Gallus gallus, Mus musculus
G118AKTGSGKTLAF3Homo sapiens, Gallus gallus, Mus musculus
K119KTGSGKTLAFL2Homo sapiens, Mus musculus
K119KTGSGKTLAFI1Gallus gallus
L91EAQYRLVTEIQ2Homo sapiens, Mus musculus
L91EAQYRMVTEIQ1Gallus gallus
Q96LVTEIQKQTIG2Homo sapiens, Mus musculus
Q96MVTEIQRQTIG1Gallus gallus
S117AAKTGSGKTLA3Homo sapiens, Gallus gallus, Mus musculus
T115LGAAKTGSGKT3Homo sapiens, Gallus gallus, Mus musculus
T120TGSGKTLAFLV2Homo sapiens, Mus musculus
T120TGSGKTLAFIV1Gallus gallus
T93QYRLVTEIQKQ2Homo sapiens, Mus musculus
T93QYRMVTEIQRQ1Gallus gallus
Y89LQEAQYRLVTE2Homo sapiens, Mus musculus
Y89LQEAQYRMVTE1Gallus gallus

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