mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DHFR
Gene summary
Basic gene Info.Gene symbolDHFR
Gene namedihydrofolate reductase
SynonymsDHFRP1|DYR
CytomapUCSC genome browser: 5q11.2-q13.2
Type of geneprotein-coding
RefGenesNM_000791.3,
NM_001290354.1,NM_001290357.1,NR_110936.1,
Description-
Modification date20141207
dbXrefs MIM : 126060
HGNC : HGNC
Ensembl : ENSG00000228716
HPRD : 00519
Vega : OTTHUMG00000162529
ProteinUniProt: P00374
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DHFR
BioGPS: 1719
PathwayNCI Pathway Interaction Database: DHFR
KEGG: DHFR
REACTOME: DHFR
Pathway Commons: DHFR
ContextiHOP: DHFR
ligand binding site mutation search in PubMed: DHFR
UCL Cancer Institute: DHFR
Assigned class in mutLBSgeneDBA: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for DHFR.1. "Smiley RD, Stinnett LG, Saxton AM, Howell EE. Breaking symmetry: mutations engineered into R67 dihydrofolate reductase, a D2 symmetric homotetramer possessing a single active site pore. Biochemistry. 2002 Dec 31;41(52):15664-75. PubMed PMID: 12501195." 12501195
2. "Strader MB, Chopra S, Jackson M, Smiley RD, Stinnett L, Wu J, Howell EE. Defining the binding site of homotetrameric R67 dihydrofolate reductase and correlating binding enthalpy with catalysis. Biochemistry. 2004 Jun 15;43(23):7403-12. PubMed PMID: 15182183. " 15182183

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0046653tetrahydrofolate metabolic process12096917


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Ligand binding site mutations for DHFR

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L76L76ICOAD1
Q171E172DHNSC1
R78R78KHNSC1
K133L134IHNSC1
H131H131YLUAD1
S120S120YUCEC1
S168L167IUCEC1
L76L76IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for DHFR
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S120S120Y0.27642604
K133L134I-1.3770913
Q171E172D-0.82182869
L76L76I-0.79966498
H131H131Y-0.65977425
S168L167I-0.40692822
R78R78K-0.35796145
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DHFR from PDB

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Differential gene expression and gene-gene network for DHFR
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DHFR and the right PPI network was created from samples without mutations in the LBS of DHFR. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for DHFR
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0029463Osteosarcoma5AlteredExpression, Biomarker
umls:C3151205Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency2GeneticVariation
umls:C0016412Folic Acid Deficiency2Biomarker, GeneticVariation
umls:C0027627Neoplasm Metastasis2Biomarker
umls:C0002888Anemia, Megaloblastic2Biomarker
umls:C0009404Colorectal Neoplasms2Biomarker
umls:C0027765Nervous System Diseases2Biomarker, GeneticVariation
umls:C0025521Metabolism, Inborn Errors2Biomarker
umls:C0004352Autistic Disorder1Biomarker, GeneticVariation
umls:C0000786Abortion, Spontaneous1Biomarker
umls:C3658338Drug-Related Side Effects and Adverse Reactions1Biomarker
umls:C0021361Infertility, Female1Therapeutic
umls:C0030312Pancytopenia1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for DHFR
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
NutraceuticalDB00157NADHSmall molecule
Approved|vet_approvedDB00205PyrimethamineSmall molecule
Approved|vet_approvedDB00440TrimethoprimSmall molecule
ApprovedDB00563MethotrexateSmall molecule
Approved|investigationalDB00642PemetrexedSmall molecule
Approved|vet_approvedDB00798GentamicinSmall molecule
ApprovedDB01131ProguanilSmall molecule
Approved|investigationalDB01157TrimetrexateSmall molecule
ExperimentalDB021042,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]PyrimidineSmall molecule
ExperimentalDB024272,4-Diamino-6-[N-(2',5'-Dimethoxybenzyl)-N-Methylamino]QuinazolineSmall molecule
ExperimentalDB025596-(Octahydro-1h-Indol-1-Ylmethyl)Decahydroquinazoline-2,4-DiamineSmall molecule
ExperimentalDB02583N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3-D]Pyrimidine-2,4,6-TriamineSmall molecule
ExperimentalDB029192,4-Diamino-6-[N-(3',4',5'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]PyrimidineSmall molecule
ExperimentalDB03060Sri-9662Small molecule
ExperimentalDB031252,4-Diamino-5-(3,4,5-Trimethoxy-Benzyl)-Pyrimidin-1-IumSmall molecule
ExperimentalDB03351Sri-9439Small molecule
ExperimentalDB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall molecule
ExperimentalDB036956-(2,5-Dimethoxy-Benzyl)-5-Methyl-Pyrido[2,3-D]Pyrimidine-2,4-DiamineSmall molecule
ExperimentalDB03886BiopterinSmall molecule
ExperimentalDB039872,4-Diamino-6-[N-(3',5'-Dimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]PyrimidineSmall molecule
ApprovedDB06813PralatrexateSmall molecule
ExperimentalDB071405-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineSmall molecule
ExperimentalDB071415-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineSmall molecule
ExperimentalDB071425-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineSmall molecule
ExperimentalDB071445-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineSmall molecule
ExperimentalDB082345-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamineSmall molecule
ExperimentalDB08406[N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINESmall molecule
ExperimentalDB08448(4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-olSmall molecule
ExperimentalDB08642(2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DHFR go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of DHFR
Multiple alignments for P00374 in multiple species
LBSAA sequence# speciesSpecies
A10LNCIVAVSQ-N4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A10LTMIVAVSSPN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A10MNLIVAMDA-E1Caenorhabditis elegans
A10FNLIVAVCE-N1Drosophila melanogaster
D111---KVDMVWIV2Homo sapiens, Mus musculus
D111SDIQVGKVFII1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D111---SIETIWNI1Caenorhabditis elegans
D111---EVENIWIV1Drosophila melanogaster
D111---KVDVVWIV1Bos taurus
D111---KVDMVWVV1Rattus norvegicus
D146QEFESDTFFP-2Mus musculus, Rattus norvegicus
D146QDFESDTFFP-1Homo sapiens
D146KEYPCDSFFPF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D146KNFEADVHLK-1Caenorhabditis elegans
D146QKFDCDTFFP-1Drosophila melanogaster
D146QEFESDAFFP-1Bos taurus
D169PGVLSDVQEEK1Homo sapiens
D169GRLKAASSNKE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D169SSENSEIFEEN1Caenorhabditis elegans
D169SDMPLGVQEEN1Drosophila melanogaster
D169PGVPLDVQEEK1Bos taurus
D169PGVLSEVQEEK1Mus musculus
D169PGVLSEIQEEK1Rattus norvegicus
D22IGKNGDLPWPP3Homo sapiens, Bos taurus, Mus musculus
D22IGKKNSMPWH-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D22IGKNGVLPWR-1Caenorhabditis elegans
D22IGIRGDLPWR-1Drosophila melanogaster
D22IGKNGDLPWPL1Rattus norvegicus
E124SSVYQEAMNQP2Mus musculus, Rattus norvegicus
E124SSVYKEAMNHP1Homo sapiens
E124SFLYGSALYHP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E124AEIYDLALREN1Caenorhabditis elegans
E124SGVYEEAMASP1Drosophila melanogaster
E124SSVYKEAMNKP1Bos taurus
E144IMQEFESDTFF2Mus musculus, Rattus norvegicus
E144IMQDFESDTFF1Homo sapiens
E144IHKEYPCDSFF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E144IFKNFEADVHL1Caenorhabditis elegans
E144IMQKFDCDTFF1Drosophila melanogaster
E144IMQEFESDAFF1Bos taurus
E184--EVYEKKD--2Mus musculus, Rattus norvegicus
E184--EVYEKND--1Homo sapiens
E184--ELYGKNDDV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E184KWKVVENH---1Caenorhabditis elegans
E184--KILEKHS--1Drosophila melanogaster
E184--EVYEKNN--1Bos taurus
E31PPLRNEFRYFQ1Homo sapiens
E31H-IKQEMAYFA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E31R-IKKDMQYFA1Caenorhabditis elegans
E31R-IKSELKYFS1Drosophila melanogaster
E31PPLRNEFQYFQ1Bos taurus
E31PPLRNEFKYFQ1Mus musculus
E31PLLRNEFKYFQ1Rattus norvegicus
E79IVLSRE-----3Bos taurus, Mus musculus, Rattus norvegicus
E79LVLSRE-----1Homo sapiens
E79IVITRNSNYNF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E79IVLSRQ-----1Caenorhabditis elegans
E79IVLSTT-----1Drosophila melanogaster
F32PLRNEFRYFQR1Homo sapiens
F32-IKQEMAYFAN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F32-IKKDMQYFAS1Caenorhabditis elegans
F32-IKSELKYFSR1Drosophila melanogaster
F32PLRNEFQYFQR1Bos taurus
F32PLRNEFKYFQR1Mus musculus
F32LLRNEFKYFQR1Rattus norvegicus
F35NEFKYFQRMTT2Mus musculus, Rattus norvegicus
F35NEFRYFQRMTT1Homo sapiens
F35QEMAYFANVTS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F35KDMQYFASVTK1Caenorhabditis elegans
F35SELKYFSRTTK1Drosophila melanogaster
F35NEFQYFQRMTT1Bos taurus
G117MVWIVGGSSVY2Homo sapiens, Mus musculus
G117KVFIIGGSFLY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G117TIWNIGGAEIY1Caenorhabditis elegans
G117NIWIVGGSGVY1Drosophila melanogaster
G117VVWIVGGSSVY1Bos taurus
G117MVWVVGGSSVY1Rattus norvegicus
G118VWIVGGSSVYK2Homo sapiens, Bos taurus
G118VFIIGGSFLYG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G118IWNIGGAEIYD1Caenorhabditis elegans
G118IWIVGGSGVYE1Drosophila melanogaster
G118VWIVGGSSVYQ1Mus musculus
G118VWVVGGSSVYQ1Rattus norvegicus
G18-NMGIGKNGDL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G18PNLGIGKKNSM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G18-EGGIGKNGVL1Caenorhabditis elegans
G18-NFGIGIRGDL1Drosophila melanogaster
G21GIGKNGDLPWP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G21GIGKKNSMPWH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G21GIGKNGVLPWR1Caenorhabditis elegans
G21GIGIRGDLPWR1Drosophila melanogaster
G54NLVIMGRKTWF3Bos taurus, Mus musculus, Rattus norvegicus
G54NLVIMGKKTWF1Homo sapiens
G54NVVIMGRSCYD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G54NAVLMGRKCWE1Caenorhabditis elegans
G54NAVVMGRKTYF1Drosophila melanogaster
G70NRPLKDRINIV4Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus
G70NRPLKGRINLV1Homo sapiens
G70RRPLAGRLNIV1Caenorhabditis elegans
G70KRPLPDRLNIV1Drosophila melanogaster
H131MNQPGHLRLFV2Mus musculus, Rattus norvegicus
H131MNHPGHLKLFV1Homo sapiens
H131LYHPLTKNLLF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H131LRENLVDEIHL1Caenorhabditis elegans
H131MASPRCHRLYI1Drosophila melanogaster
H131MNKPGHVRLFV1Bos taurus
I139LFVTRIMQEFE3Bos taurus, Mus musculus, Rattus norvegicus
I139LFVTRIMQDFE1Homo sapiens
I139LLFTRIHKEYP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I139IHLTRIFKNFE1Caenorhabditis elegans
I139LYITKIMQKFD1Drosophila melanogaster
I17Q-NMGIGKNGD4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I17SPNLGIGKKNS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I17A-EGGIGKNGV1Caenorhabditis elegans
I17E-NFGIGIRGD1Drosophila melanogaster
I61KTWFSIPEKNR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I61SCYDSLPKKNR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I61KCWESIPVTRR1Caenorhabditis elegans
I61KTYFGVPESKR1Drosophila melanogaster
I8RPLNCIVAVSQ3Bos taurus, Mus musculus, Rattus norvegicus
I8GSLNCIVAVSQ1Homo sapiens
I8RDLTMIVAVSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I8RKMNLIVAMDA1Caenorhabditis elegans
I8R-FNLIVAVCE1Drosophila melanogaster
K133QPGHLRLFVTR2Mus musculus, Rattus norvegicus
K133HPGHLKLFVTR1Homo sapiens
K133HPLTKNLLFTR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K133ENLVDEIHLTR1Caenorhabditis elegans
K133SPRCHRLYITK1Drosophila melanogaster
K133KPGHVRLFVTR1Bos taurus
K158DLEKYKLLP--2Homo sapiens, Rattus norvegicus
K158ELEKFVGIP-V1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K158DFSKMEKVQNA1Caenorhabditis elegans
K158P-DSFREVA--1Drosophila melanogaster
K158DFEKYKLLP--1Bos taurus
K158DLGKYKLLP--1Mus musculus
K19NMGIGKNGDLP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K19NLGIGKKNSMP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K19EGGIGKNGVLP1Caenorhabditis elegans
K19NFGIGIRGDLP1Drosophila melanogaster
K55LVIMGRKTWFS3Bos taurus, Mus musculus, Rattus norvegicus
K55LVIMGKKTWFS1Homo sapiens
K55VVIMGRSCYDS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K55AVLMGRKCWES1Caenorhabditis elegans
K55AVVMGRKTYFG1Drosophila melanogaster
K56VIMGRKTWFSI3Bos taurus, Mus musculus, Rattus norvegicus
K56VIMGKKTWFSI1Homo sapiens
K56VIMGRSCYDSL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K56VLMGRKCWESI1Caenorhabditis elegans
K56VVMGRKTYFGV1Drosophila melanogaster
K69KNRPLKDRINI4Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus
K69KNRPLKGRINL1Homo sapiens
K69TRRPLAGRLNI1Caenorhabditis elegans
K69SKRPLPDRLNI1Drosophila melanogaster
L154--EIDLEKYKL2Homo sapiens, Rattus norvegicus
L154KAHPELEKFVG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L154--SLDFSKMEK1Caenorhabditis elegans
L154--AIP-DSFRE1Drosophila melanogaster
L154--EIDFEKYKL1Bos taurus
L154--EIDLGKYKL1Mus musculus
L23GKNGDLPWPPL3Homo sapiens, Bos taurus, Mus musculus
L23GKKNSMPWH-I1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L23GKNGVLPWR-I1Caenorhabditis elegans
L23GIRGDLPWR-I1Drosophila melanogaster
L23GKNGDLPWPLL1Rattus norvegicus
L68EKNRPLKDRIN3Bos taurus, Mus musculus, Rattus norvegicus
L68EKNRPLKGRIN1Homo sapiens
L68KKNRPLKDRIN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L68VTRRPLAGRLN1Caenorhabditis elegans
L68ESKRPLPDRLN1Drosophila melanogaster
L76RINIVLSRE--3Bos taurus, Mus musculus, Rattus norvegicus
L76RINLVLSRE--1Homo sapiens
L76RINIVITRNSN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L76RLNIVLSRQ--1Caenorhabditis elegans
L76RLNIVLSTT--1Drosophila melanogaster
L94FLSRSLDDALK1Homo sapiens
L94YAADCIDSALD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L94IVVNSLEAAMK1Caenorhabditis elegans
L94LLCPNLETAMK1Drosophila melanogaster
L94FLAKSLDDALE1Bos taurus
L94FLAKSLDDALR1Mus musculus
L94FLAKSLDDALK1Rattus norvegicus
M112--KVDMVWIVG2Homo sapiens, Mus musculus
M112DIQVGKVFIIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M112--SIETIWNIG1Caenorhabditis elegans
M112--EVENIWIVG1Drosophila melanogaster
M112--KVDVVWIVG1Bos taurus
M112--KVDMVWVVG1Rattus norvegicus
M15VSQ-NMGIGKN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M15VSSPNLGIGKK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M15MDA-EGGIGKN1Caenorhabditis elegans
M15VCE-NFGIGIR1Drosophila melanogaster
N20MGIGKNGDLPW4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N20LGIGKKNSMPW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N20GGIGKNGVLPW1Caenorhabditis elegans
N20FGIGIRGDLPW1Drosophila melanogaster
N6MVRPLNCIVAV3Bos taurus, Mus musculus, Rattus norvegicus
N6MVGSLNCIVAV1Homo sapiens
N6HPRDLTMIVAV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N6-MRKMNLIVAM1Caenorhabditis elegans
N6MLR-FNLIVAV1Drosophila melanogaster
N65SIPEKNRPLKD3Bos taurus, Mus musculus, Rattus norvegicus
N65SIPEKNRPLKG1Homo sapiens
N65SLPKKNRPLKD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N65SIPVTRRPLAG1Caenorhabditis elegans
N65GVPESKRPLPD1Drosophila melanogaster
P161KYKLLP--EYP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
P161KFVGIP-VEEG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P161KMEKVQNAEVS1Caenorhabditis elegans
P161SFREVA--PDS1Drosophila melanogaster
P24KNGDLPWPPLR3Homo sapiens, Bos taurus, Mus musculus
P24KKNSMPWH-IK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P24KNGVLPWR-IK1Caenorhabditis elegans
P24IRGDLPWR-IK1Drosophila melanogaster
P24KNGDLPWPLLR1Rattus norvegicus
P27DLPWPPLRNEF3Homo sapiens, Bos taurus, Mus musculus
P27SMPWH-IKQEM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P27VLPWR-IKKDM1Caenorhabditis elegans
P27DLPWR-IKSEL1Drosophila melanogaster
P27DLPWPLLRNEF1Rattus norvegicus
P62TWFSIPEKNRP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
P62CYDSLPKKNRP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P62CWESIPVTRRP1Caenorhabditis elegans
P62TYFGVPESKRP1Drosophila melanogaster
P67PEKNRPLKDRI3Bos taurus, Mus musculus, Rattus norvegicus
P67PEKNRPLKGRI1Homo sapiens
P67PKKNRPLKDRI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P67PVTRRPLAGRL1Caenorhabditis elegans
P67PESKRPLPDRL1Drosophila melanogaster
Q13IVAVSQ-NMGI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q13IVAVSSPNLGI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q13IVAMDA-EGGI1Caenorhabditis elegans
Q13IVAVCE-NFGI1Drosophila melanogaster
Q171VLSDVQEEKGI1Homo sapiens
Q171LKAASSNKEEV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q171ENSEIFEENGL1Caenorhabditis elegans
Q171MPLGVQEENGI1Drosophila melanogaster
Q171VPLDVQEEKGI1Bos taurus
Q171VLSEVQEEKGI1Mus musculus
Q171VLSEIQEEKGI1Rattus norvegicus
Q36EFKYFQRMTTT2Mus musculus, Rattus norvegicus
Q36EFRYFQRMTTT1Homo sapiens
Q36EMAYFANVTSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q36DMQYFASVTKN1Caenorhabditis elegans
Q36ELKYFSRTTKR1Drosophila melanogaster
Q36EFQYFQRMTTV1Bos taurus
Q48-----QNLVIM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q48GKSKIMNVVIM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q48-----RNAVLM1Caenorhabditis elegans
Q48-----QNAVVM1Drosophila melanogaster
R138RLFVTRIMQEF3Bos taurus, Mus musculus, Rattus norvegicus
R138KLFVTRIMQDF1Homo sapiens
R138NLLFTRIHKEY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R138EIHLTRIFKNF1Caenorhabditis elegans
R138RLYITKIMQKF1Drosophila melanogaster
R29PWPPLRNEFRY1Homo sapiens
R29PWH-IKQEMAY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R29PWR-IKKDMQY1Caenorhabditis elegans
R29PWR-IKSELKY1Drosophila melanogaster
R29PWPPLRNEFQY1Bos taurus
R29PWPPLRNEFKY1Mus musculus
R29PWPLLRNEFKY1Rattus norvegicus
R33LRNEFKYFQRM2Mus musculus, Rattus norvegicus
R33LRNEFRYFQRM1Homo sapiens
R33IKQEMAYFANV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R33IKKDMQYFASV1Caenorhabditis elegans
R33IKSELKYFSRT1Drosophila melanogaster
R33LRNEFQYFQRM1Bos taurus
R37FKYFQRMTTTS2Mus musculus, Rattus norvegicus
R37FRYFQRMTTTS1Homo sapiens
R37MAYFANVTSST1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R37MQYFASVTKNV1Caenorhabditis elegans
R37LKYFSRTTKRT1Drosophila melanogaster
R37FQYFQRMTTVS1Bos taurus
R71RPLKDRINIVL3Bos taurus, Mus musculus, Rattus norvegicus
R71RPLKGRINLVL1Homo sapiens
R71RPLKDRINIVI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R71RPLAGRLNIVL1Caenorhabditis elegans
R71RPLPDRLNIVL1Drosophila melanogaster
R78NIVLSRE----3Bos taurus, Mus musculus, Rattus norvegicus
R78NLVLSRE----1Homo sapiens
R78NIVITRNSNYN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R78NIVLSRQ----1Caenorhabditis elegans
R78NIVLSTT----1Drosophila melanogaster
R92AHFLAKSLDDA3Bos taurus, Mus musculus, Rattus norvegicus
R92AHFLSRSLDDA1Homo sapiens
R92NLYAADCIDSA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R92DYIVVNSLEAA1Caenorhabditis elegans
R92V-LLCPNLETA1Drosophila melanogaster
S119WIVGGSSVYKE2Homo sapiens, Bos taurus
S119FIIGGSFLYGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S119WNIGGAEIYDL1Caenorhabditis elegans
S119WIVGGSGVYEE1Drosophila melanogaster
S119WIVGGSSVYQE1Mus musculus
S119WVVGGSSVYQE1Rattus norvegicus
S12CIVAVSQ-NMG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S12MIVAVSSPNLG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S12LIVAMDA-EGG1Caenorhabditis elegans
S12LIVAVCE-NFG1Drosophila melanogaster
S120IVGGSSVYKEA2Homo sapiens, Bos taurus
S120IIGGSFLYGSA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S120NIGGAEIYDLA1Caenorhabditis elegans
S120IVGGSGVYEEA1Drosophila melanogaster
S120IVGGSSVYQEA1Mus musculus
S120VVGGSSVYQEA1Rattus norvegicus
S168YPGVLSDVQEE1Homo sapiens
S168EGRLKAASSNK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S168VSSENSEIFEE1Caenorhabditis elegans
S168DSDMPLGVQEE1Drosophila melanogaster
S168YPGVPLDVQEE1Bos taurus
S168YPGVLSEVQEE1Mus musculus
S168YPGVLSEIQEE1Rattus norvegicus
S4--MVRPLNCIV3Bos taurus, Mus musculus, Rattus norvegicus
S4--MVGSLNCIV1Homo sapiens
S4TKHPRDLTMIV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S4---MRKMNLIV1Caenorhabditis elegans
S4--MLR-FNLIV1Drosophila melanogaster
S42RMTTTSSVEGK3Homo sapiens, Mus musculus, Rattus norvegicus
S42NVTSSTESSGQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S42SVTKNVSDQSK1Caenorhabditis elegans
S42RTTKRTSDPTK1Drosophila melanogaster
S42RMTTVSSVEGK1Bos taurus
S60RKTWFSIPEKN3Bos taurus, Mus musculus, Rattus norvegicus
S60KKTWFSIPEKN1Homo sapiens
S60RSCYDSLPKKN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S60RKCWESIPVTR1Caenorhabditis elegans
S60RKTYFGVPESK1Drosophila melanogaster
S77INIVLSRE---3Bos taurus, Mus musculus, Rattus norvegicus
S77INLVLSRE---1Homo sapiens
S77INIVITRNSNY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S77LNIVLSRQ---1Caenorhabditis elegans
S77LNIVLSTT---1Drosophila melanogaster
S93HFLAKSLDDAL3Bos taurus, Mus musculus, Rattus norvegicus
S93HFLSRSLDDAL1Homo sapiens
S93LYAADCIDSAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S93YIVVNSLEAAM1Caenorhabditis elegans
S93-LLCPNLETAM1Drosophila melanogaster
T137LRLFVTRIMQE2Mus musculus, Rattus norvegicus
T137LKLFVTRIMQD1Homo sapiens
T137KNLLFTRIHKE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T137DEIHLTRIFKN1Caenorhabditis elegans
T137HRLYITKIMQK1Drosophila melanogaster
T137VRLFVTRIMQE1Bos taurus
T147EFESDTFFP--2Mus musculus, Rattus norvegicus
T147DFESDTFFP--1Homo sapiens
T147EYPCDSFFPFE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T147NFEADVHLK--1Caenorhabditis elegans
T147KFDCDTFFP--1Drosophila melanogaster
T147EFESDAFFP--1Bos taurus
T41QRMTTTSSVEG3Homo sapiens, Mus musculus, Rattus norvegicus
T41ANVTSSTESSG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T41ASVTKNVSDQS1Caenorhabditis elegans
T41SRTTKRTSDPT1Drosophila melanogaster
T41QRMTTVSSVEG1Bos taurus
T57IMGRKTWFSIP3Bos taurus, Mus musculus, Rattus norvegicus
T57IMGKKTWFSIP1Homo sapiens
T57IMGRSCYDSLP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T57LMGRKCWESIP1Caenorhabditis elegans
T57VMGRKTYFGVP1Drosophila melanogaster
V11NCIVAVSQ-NM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
V11TMIVAVSSPNL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V11NLIVAMDA-EG1Caenorhabditis elegans
V11NLIVAVCE-NF1Drosophila melanogaster
V116DMVWIVGGSSV2Homo sapiens, Mus musculus
V116GKVFIIGGSFL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V116ETIWNIGGAEI1Caenorhabditis elegans
V116ENIWIVGGSGV1Drosophila melanogaster
V116DVVWIVGGSSV1Bos taurus
V116DMVWVVGGSSV1Rattus norvegicus
V121VGGSSVYKEAM2Homo sapiens, Bos taurus
V121VGGSSVYQEAM2Mus musculus, Rattus norvegicus
V121IGGSFLYGSAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V121IGGAEIYDLAL1Caenorhabditis elegans
V121VGGSGVYEEAM1Drosophila melanogaster
V170GVLSDVQEEKG1Homo sapiens
V170RLKAASSNKEE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V170SENSEIFEENG1Caenorhabditis elegans
V170DMPLGVQEENG1Drosophila melanogaster
V170GVPLDVQEEKG1Bos taurus
V170GVLSEVQEEKG1Mus musculus
V170GVLSEIQEEKG1Rattus norvegicus
V44TTTSSVEGK--3Homo sapiens, Mus musculus, Rattus norvegicus
V44TSSTESSGQLE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V44TKNVSDQSK--1Caenorhabditis elegans
V44TKRTSDPTK--1Drosophila melanogaster
V44TTVSSVEGK--1Bos taurus
V9PLNCIVAVSQ-3Bos taurus, Mus musculus, Rattus norvegicus
V9SLNCIVAVSQ-1Homo sapiens
V9DLTMIVAVSSP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V9KMNLIVAMDA-1Caenorhabditis elegans
V9-FNLIVAVCE-1Drosophila melanogaster
W25NGDLPWPPLRN3Homo sapiens, Bos taurus, Mus musculus
W25KNSMPWH-IKQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W25NGVLPWR-IKK1Caenorhabditis elegans
W25RGDLPWR-IKS1Drosophila melanogaster
W25NGDLPWPLLRN1Rattus norvegicus
Y122GGSSVYKEAMN2Homo sapiens, Bos taurus
Y122GGSSVYQEAMN2Mus musculus, Rattus norvegicus
Y122GGSFLYGSALY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y122GGAEIYDLALR1Caenorhabditis elegans
Y122GGSGVYEEAMA1Drosophila melanogaster
Y157IDLEKYKLLP-2Homo sapiens, Rattus norvegicus
Y157PELEKFVGIP-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y157LDFSKMEKVQN1Caenorhabditis elegans
Y157IP-DSFREVA-1Drosophila melanogaster
Y157IDFEKYKLLP-1Bos taurus
Y157IDLGKYKLLP-1Mus musculus
Y163LP--EYPGVLS3Homo sapiens, Mus musculus, Rattus norvegicus
Y163IP-VEEGRLKA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y163VQNAEVSSENS1Caenorhabditis elegans
Y163VA--PDSDMPL1Drosophila melanogaster
Y163LP--EYPGVPL1Bos taurus


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