mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for DHPS

Gene summary

Basic gene Info.	Gene symbol	DHPS
	Gene name	deoxyhypusine synthase
	Synonyms	DHS\|DS\|MIG13
	Cytomap	UCSC genome browser: 19p13.2
	Type of gene	protein-coding
	RefGenes	NM_001206974.1, NM_001930.3,NM_013406.2,NR_038192.1,NM_013407.1,
	Description	migration-inducing gene 13
	Modification date	20141207
dbXrefs	MIM : 600944
	HGNC : HGNC
	Ensembl : ENSG00000095059
	HPRD : 02969
	Vega : OTTHUMG00000182618
Protein	UniProt: P49366 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_DHPS
	BioGPS: 1725
Pathway	NCI Pathway Interaction Database: DHPS
	KEGG: DHPS
	REACTOME: DHPS
	Pathway Commons: DHPS
Context	iHOP: DHPS
	ligand binding site mutation search in PubMed: DHPS
	UCL Cancer Institute: DHPS
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

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Ligand binding site mutations for DHPS

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
S109,L107	I108M	LUAD	1
D342	D342N	LUAD	1
E323	E323K	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for DHPS

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
E323	E323K	-1.0801659
L107	I108M	-1.0530122
S109	I108M	-1.0530122
D342	D342N	-0.63743793

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DHPS from PDB

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Differential gene expression and gene-gene network for DHPS

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of DHPS and the right PPI network was created from samples without mutations in the LBS of DHPS. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for DHPS

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for DHPS

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Experimental	DB03639	1-Guanidinium-7-Aminoheptane	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DHPS go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
GC7		N"-(7-AMINOHEPTYL)METHANETRIAMINE	1rqd	A	E323
GC7		N"-(7-AMINOHEPTYL)METHANETRIAMINE	1rqd	B	E323
NAD		NAD ZWITTERION	1rlz	A	L107 D342
NAD		NAD ZWITTERION	1roz	A	L107 D342
NAD		NAD ZWITTERION	1roz	B	L107 D342
NAD		NAD ZWITTERION	1dhs	A	L107 S109 D342
NAD		NAD ZWITTERION	1rqd	A	L107 S109 D342
NAD		NAD ZWITTERION	1rqd	B	L107 S109 D342

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Conservation information for LBS of DHPS

Multiple alignments for P49366 in multiple species

LBS	AA sequence	# species	Species
A132	VLVTTAGGVEE	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A132	CIVTSAGGIEE	1	Caenorhabditis elegans
A132	VIVTTTGGVEE	1	Arabidopsis thaliana
A132	VIVTTAGGVEE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A132	AIVTTAGGIEE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A132	AIVTTAGGVEE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A132	AVVTSAGGVEE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A132	AIVATAGGVEE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A132	CIVTTAGGVEE	1	Drosophila melanogaster
A309	VYINTAQEFDG	5	Homo sapiens, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Mus musculus, Rattus norvegicus, Bos taurus
A309	VYINTGQEFDG	3	Caenorhabditis elegans, Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A309	VFINTGQEFDG	1	Arabidopsis thaliana
A309	VYINSANEFDG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A309	VYINTGQEYDG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A309	VFINTASEFDG	1	Drosophila melanogaster
A319	GSDSGARPDEA	6	Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
A319	GSDAGARPDEA	5	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 2
A319	GSDSGAQPDEA	1	Caenorhabditis elegans
A341	PVKVYADASLV	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A341	AVKVHAEATLV	1	Caenorhabditis elegans
A341	TVKVYCDATIA	1	Arabidopsis thaliana
A341	KVKVYGEVSLL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A341	AVKVYMEATAA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A341	SVKVYADVTTV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A341	SVKLFADVTTV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A341	SVKVYADATVV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A341	PVKVYAEASLV	1	Drosophila melanogaster
A343	KVYADASLVFP	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A343	KVHAEATLVFP	1	Caenorhabditis elegans
A343	KVYCDATIAFP	1	Arabidopsis thaliana
A343	KVYGEVSLLFP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A343	KVYMEATAAFP	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A343	KVYADVTTVFP	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A343	KLFADVTTVLP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A343	KVYADATVVFP	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A343	KVYAEASLVFP	1	Drosophila melanogaster
D238	SPALTDGSLGD	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D238	CPALTDGSLGD	3	Caenorhabditis elegans, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Drosophila melanogaster
D238	CPGLTDGSLGD	1	Arabidopsis thaliana
D238	SPALTDGSIGD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D238	CPAITDGSIGD	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D238	CPSLTDGSIGD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D238	CPAVTDGSIGD	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D316	EFDGSDSGARP	6	Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
D316	EFDGSDAGARP	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585
D316	EFDGSDSGAQP	1	Caenorhabditis elegans
D316	EYDGSDAGARP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D342	VKVYADASLVF	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D342	VKVHAEATLVF	1	Caenorhabditis elegans
D342	VKVYCDATIAF	1	Arabidopsis thaliana
D342	VKVYGEVSLLF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D342	VKVYMEATAAF	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D342	VKVYADVTTVF	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D342	VKLFADVTTVL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D342	VKVYADATVVF	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D342	VKVYAEASLVF	1	Drosophila melanogaster
E137	AGGVEEDLIKC	4	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Mus musculus, Rattus norvegicus
E137	AGGVEEDIIKC	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E137	AGGVEEDFIKC	2	Drosophila melanogaster, Bos taurus
E137	AGGIEEDLIKC	1	Caenorhabditis elegans
E137	TGGVEEDLIKC	1	Arabidopsis thaliana
E137	AGGIEEDFIKC	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E323	GARPDEAVSWG	10	Homo sapiens, Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Sac
E323	GAQPDEAVSWG	1	Caenorhabditis elegans
E323	GARPDEAISWG	1	Drosophila melanogaster
G133	LVTTAGGVEED	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G133	IVTTAGGVEED	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Drosophila melanogaster
G133	IVTSAGGIEED	1	Caenorhabditis elegans
G133	IVTTTGGVEED	1	Arabidopsis thaliana
G133	IVTTAGGIEED	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G133	VVTSAGGVEED	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G133	IVATAGGVEED	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G282	GMIILGGGVVK	3	Homo sapiens, Mus musculus, Rattus norvegicus
G282	GMIILGGGLIK	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G282	GSIILGGGVVK	1	Caenorhabditis elegans
G282	GMIILGGGLPK	1	Arabidopsis thaliana
G282	GIIILGGGVVK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G282	GMIILGGGIVK	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G282	GMIIVGGGVIK	1	Drosophila melanogaster
G282	GMIILGGGMVK	1	Bos taurus
G283	MIILGGGVVKH	3	Homo sapiens, Mus musculus, Rattus norvegicus
G283	MIILGGGLIKH	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G283	SIILGGGVVKH	1	Caenorhabditis elegans
G283	MIILGGGLPKH	1	Arabidopsis thaliana
G283	IIILGGGVVKH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G283	MIILGGGIVKH	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G283	MIIVGGGVIKH	1	Drosophila melanogaster
G283	MIILGGGMVKH	1	Bos taurus
G314	AQEFDGSDSGA	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G314	GQEFDGSDSGA	2	Caenorhabditis elegans, Arabidopsis thaliana
G314	GQEFDGSDAGA	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G314	ANEFDGSDAGA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G314	AQEFDGSDAGA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G314	GQEYDGSDAGA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G314	ASEFDGSDSGA	1	Drosophila melanogaster
H288	GGVVKHHIANA	3	Homo sapiens, Mus musculus, Rattus norvegicus
H288	GGLIKHHIANA	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H288	GGVVKHHINNA	1	Caenorhabditis elegans
H288	GGLPKHHICNA	1	Arabidopsis thaliana
H288	GGVVKHHICNA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H288	GGIVKHHIANA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H288	GGVIKHHICNA	1	Drosophila melanogaster
H288	GGMVKHHIANA	1	Bos taurus
I166	NGINRIGNLLV	3	Homo sapiens, Rattus norvegicus, Bos taurus
I166	QGMNRIGNLLV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I166	NGMNRAGNVLI	1	Caenorhabditis elegans
I166	KGLNRIGNLLV	1	Arabidopsis thaliana
I166	KGLNRIGNLIV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I166	KGLNRIGNLVV	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I166	KGMNRIGNLLV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I166	RGINRIGNLLV	1	Drosophila melanogaster
I166	SGINRIGNLLV	1	Mus musculus
I306	DYAVYINTAQE	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I306	DYAVYINTGQE	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I306	DHTVYINTGQE	1	Caenorhabditis elegans
I306	DYAVFINTGQE	1	Arabidopsis thaliana
I306	EWSVYINSANE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I306	ESAVYINTAQE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I306	DYSVFINTASE	1	Drosophila melanogaster
K329	AVSWGKIRMDA	3	Mus musculus, Rattus norvegicus, Bos taurus
K329	AVSWGKIRVDA	1	Homo sapiens
K329	AVSWGKVKPSA	1	Caenorhabditis elegans
K329	AVSWGKIRGSA	1	Arabidopsis thaliana
K329	AVSWGKIRGDA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K329	AVSWGKIKVGA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K329	AVSWGKIKVEA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K329	AVSWGKIKAEA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K329	AVSWGKIKADA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K329	AISWGKIRKDA	1	Drosophila melanogaster
L107	GYTSNLISSGI	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L107	GYTSNLISSGL	3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM
L107	GYTSNLISSGV	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L107	GYTSNLVTSGL	1	Caenorhabditis elegans
L107	GFTSNLVSSGV	1	Arabidopsis thaliana
L107	GYTSNLVSSGL	1	Drosophila melanogaster
L295	IANANLMRNGA	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L295	IANACLMRNGA	4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 858
L295	ICNANLMRNGA	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
L295	INNANLMRNGA	1	Caenorhabditis elegans
L295	ICNANMMRNGA	1	Arabidopsis thaliana
N106	LGYTSNLISSG	7	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Mus musculus, Rattus norv
N106	MGYTSNLISSG	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N106	LGYTSNLVTSG	1	Caenorhabditis elegans
N106	LGFTSNLVSSG	1	Arabidopsis thaliana
N106	LGYTSNLVSSG	1	Drosophila melanogaster
N292	KHHIANANLMR	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N292	KHHIANACLMR	4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 858
N292	KHHICNANLMR	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
N292	KHHINNANLMR	1	Caenorhabditis elegans
N292	KHHICNANMMR	1	Arabidopsis thaliana
N307	YAVYINTAQEF	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N307	YAVYINTGQEF	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N307	HTVYINTGQEF	1	Caenorhabditis elegans
N307	YAVFINTGQEF	1	Arabidopsis thaliana
N307	WSVYINSANEF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N307	SAVYINTAQEF	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N307	YAVYINTGQEY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N307	YSVFINTASEF	1	Drosophila melanogaster
S105	FLGYTSNLISS	7	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Mus musculus, Rattus norv
S105	FMGYTSNLISS	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S105	FLGYTSNLVTS	1	Caenorhabditis elegans
S105	FLGFTSNLVSS	1	Arabidopsis thaliana
S105	FLGYTSNLVSS	1	Drosophila melanogaster
S109	TSNLISSGIRE	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S109	TSNLISSGVRE	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S109	TSNLISSGLRE	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S109	TSNLVTSGLRE	1	Caenorhabditis elegans
S109	TSNLVSSGVRD	1	Arabidopsis thaliana
S109	TSNLISSGLRG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S109	TSNLVSSGLRE	1	Drosophila melanogaster
S315	QEFDGSDSGAR	5	Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus, Bos taurus
S315	QEFDGSDAGAR	3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM
S315	QEFDGSDSGAQ	1	Caenorhabditis elegans
S315	NEFDGSDAGAR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S315	QEYDGSDAGAR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S315	SEFDGSDSGAR	1	Drosophila melanogaster
T104	IFLGYTSNLIS	7	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Mus musculus, Rattus norv
T104	IFMGYTSNLIS	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T104	IFLGYTSNLVT	1	Caenorhabditis elegans
T104	IFLGFTSNLVS	1	Arabidopsis thaliana
T104	VFLGYTSNLVS	1	Drosophila melanogaster
T131	DVLVTTAGGVE	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T131	DCIVTSAGGIE	1	Caenorhabditis elegans
T131	DVIVTTTGGVE	1	Arabidopsis thaliana
T131	DVIVTTAGGVE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T131	SAIVTTAGGIE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T131	SAIVTTAGGVE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T131	DAVVTSAGGVE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T131	DAIVATAGGVE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T131	DCIVTTAGGVE	1	Drosophila melanogaster
T308	AVYINTAQEFD	5	Homo sapiens, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Mus musculus, Rattus norvegicus, Bos taurus
T308	AVYINTGQEFD	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T308	TVYINTGQEFD	1	Caenorhabditis elegans
T308	AVFINTGQEFD	1	Arabidopsis thaliana
T308	SVYINSANEFD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T308	AVYINTGQEYD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T308	SVFINTASEFD	1	Drosophila melanogaster
W327	DEAVSWGKIRM	3	Mus musculus, Rattus norvegicus, Bos taurus
W327	DEAVSWGKIRG	2	Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W327	DEAVSWGKIKV	2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
W327	DEAVSWGKIKA	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
W327	DEAVSWGKIRV	1	Homo sapiens
W327	DEAVSWGKVKP	1	Caenorhabditis elegans
W327	DEAISWGKIRK	1	Drosophila melanogaster