mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DLD
Gene summary
Basic gene Info.Gene symbolDLD
Gene namedihydrolipoamide dehydrogenase
SynonymsDLDD|DLDH|E3|GCSL|LAD|PHE3
CytomapUCSC genome browser: 7q31-q32
Type of geneprotein-coding
RefGenesNM_000108.4,
NM_001289750.1,NM_001289751.1,NM_001289752.1,
DescriptionE3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complexdiaphorasedihydrolipoyl dehydrogenase, mitochondrialglycine cleavage system L proteinglycine cleavage system protein Llipoamide deh
Modification date20141207
dbXrefs MIM : 238331
HGNC : HGNC
Ensembl : ENSG00000091140
HPRD : 02006
Vega : OTTHUMG00000154813
ProteinUniProt: P09622
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DLD
BioGPS: 1738
PathwayNCI Pathway Interaction Database: DLD
KEGG: DLD
REACTOME: DLD
Pathway Commons: DLD
ContextiHOP: DLD
ligand binding site mutation search in PubMed: DLD
UCL Cancer Institute: DLD
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for DLD

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
H364H364YGBM1
S203G205CKIRC1
N73E74GKIRC1
L245G246AKIRC1
F318K320MLUAD1
S203G205ALUAD1
T276T276KLUAD1
C80C80FLUAD1
R334P333SLUSC1
I47V46GSTAD1
C85I86MSTAD1
G154G154EUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for DLD
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
F318K320M0.3022431
S203G205C0.20899461
R334P333S-1.5629161
T276T276K-1.4660034
I47V46G-1.3693325
L245G246A-0.88870557
H364H364Y-0.76693008
C85I86M-0.74744994
N73E74G-0.68260041
C80C80F-0.45612064
G154G154E-0.36205276
S203G205A-0.074921653
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DLD from PDB

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Differential gene expression and gene-gene network for DLD
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DLD and the right PPI network was created from samples without mutations in the LBS of DLD. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for DLD
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0268193NADH cytochrome B5 reductase deficiency12Biomarker, GeneticVariation
umls:C0023264Leigh Disease3Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for DLD
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
NutraceuticalDB00157NADHSmall molecule
ApprovedDB03147Flavin adenine dinucleotideSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DLD go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of DLD
Multiple alignments for P09622 in multiple species
LBSAA sequence# speciesSpecies
A182KNILIATGSEV3Homo sapiens, Canis lupus familiaris, Rattus norvegicus
A182KHIIVATGSDV2Arabidopsis thaliana, Arabidopsis thaliana
A182RNILIASGSEV1Caenorhabditis elegans
A182KNILVATGSEV1Mus musculus
A182KNFIIATGSEV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A182KNIIVATGSEV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A363AGPMLAHKAED4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
A363PGPMLAHKAEE2Arabidopsis thaliana, Arabidopsis thaliana
A363EGPMLAHKAED1Caenorhabditis elegans
A363LGPMLAHKAED1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A363FGPMLAHKAEE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A366MLAHKAEDEGI6Homo sapiens, Caenorhabditis elegans, Canis lupus familiaris, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A366MLAHKAEEDGV2Arabidopsis thaliana, Arabidopsis thaliana
A366MLAHKAEEEGI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C312DVLLVCIGRRP4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
C312DVVLVSAGRTP2Arabidopsis thaliana, Arabidopsis thaliana
C312DTLLVSVGRRP1Caenorhabditis elegans
C312DVLLVAIGRVP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C312EVLLVAVGRRP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C80TLGGTCLNVGC6Homo sapiens, Caenorhabditis elegans, Canis lupus familiaris, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C80ALGGTCLNVGC2Arabidopsis thaliana, Arabidopsis thaliana
C80KLGGTCLNVGC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C85CLNVGCIPSKA9Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Caenorhabditis elegans, Canis lupus familiaris, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D355IYAIGDVVAGP3Homo sapiens, Canis lupus familiaris, Mus musculus
D355VYAIGDVIPGP2Arabidopsis thaliana, Arabidopsis thaliana
D355IFAIGDVIEGP1Caenorhabditis elegans
D355IFAIGDVVAGP1Rattus norvegicus
D355IRVIGDATLGP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D355IKVVGDVTFGP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E227GVIGVELGSVW4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
E227GYIGLEMGSVW2Arabidopsis thaliana, Arabidopsis thaliana
E227GVIGLELGSVW1Caenorhabditis elegans
E227GIIGLEMGSVW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E227GIIGLEMGSVY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E243DVTAVEFLGHV4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
E243EVTVVEFAGDI1Arabidopsis thaliana
E243EVTVVEFAADI1Arabidopsis thaliana
E243EVTAVEFLGHV1Caenorhabditis elegans
E243EVTVVEFLPAV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E243KVTVVEFQPQI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E71KTVCIEKNETL3Homo sapiens, Rattus norvegicus, Mus musculus
E71KTTCIEKRGAL2Arabidopsis thaliana, Arabidopsis thaliana
E71KTVCVEKNATL1Caenorhabditis elegans
E71KTVCVEKNETL1Canis lupus familiaris
E71KTICVEKRGTL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E71NTACVEKRGKL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F190SEVTPFPGITI5Homo sapiens, Caenorhabditis elegans, Canis lupus familiaris, Rattus norvegicus, Mus musculus
F190SDVKSLPGITI2Arabidopsis thaliana, Arabidopsis thaliana
F190SEVKPFPGVTI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F190SEVTPFPGIEI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F244VTAVEFLGHVG5Homo sapiens, Caenorhabditis elegans, Canis lupus familiaris, Rattus norvegicus, Mus musculus
F244VTVVEFAGDIV1Arabidopsis thaliana
F244VTVVEFAADIV1Arabidopsis thaliana
F244VTVVEFLPAVG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F244VTVVEFQPQIG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F318IGRRPFTQNLG3Canis lupus familiaris, Rattus norvegicus, Mus musculus
F318AGRTPFTSGLD2Arabidopsis thaliana, Arabidopsis thaliana
F318IGRRPFTKNLG1Homo sapiens
F318VGRRPYTEGLG1Caenorhabditis elegans
F318IGRVPYTEGLG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F318VGRRPYIAGLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G152VVHVNGYGKIT2Homo sapiens, Canis lupus familiaris
G152VVHVNGFGKIT2Rattus norvegicus, Mus musculus
G152VTYVKGYGKFI1Arabidopsis thaliana
G152VNYVKGYGKFL1Arabidopsis thaliana
G152VGHVEGFATIV1Caenorhabditis elegans
G152VEYAKGTGSFI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G152VTYYKGNGSFE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G154HVNGYGKITGK2Homo sapiens, Canis lupus familiaris
G154HVNGFGKITGK2Rattus norvegicus, Mus musculus
G154YVKGYGKFISP1Arabidopsis thaliana
G154YVKGYGKFLSP1Arabidopsis thaliana
G154HVEGFATIVGP1Caenorhabditis elegans
G154YAKGTGSFIDP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G154YYKGNGSFEDE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G184ILIATGSEVTP3Homo sapiens, Canis lupus familiaris, Rattus norvegicus
G184IIVATGSDVKS2Arabidopsis thaliana, Arabidopsis thaliana
G184ILIASGSEVTP1Caenorhabditis elegans
G184ILVATGSEVTP1Mus musculus
G184FIIATGSEVKP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G184IIVATGSEVTP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G220KMVVIGAGVIG3Homo sapiens, Caenorhabditis elegans, Canis lupus familiaris
G220KLIVIGAGYIG2Arabidopsis thaliana, Arabidopsis thaliana
G220KLVVIGAGVIG2Rattus norvegicus, Mus musculus
G220KMTVLGGGIIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G220RLTIIGGGIIG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G222VVIGAGVIGVE4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
G222IVIGAGYIGLE2Arabidopsis thaliana, Arabidopsis thaliana
G222VVIGAGVIGLE1Caenorhabditis elegans
G222TVLGGGIIGLE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G222TIIGGGIIGLE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G250LGHVGGVGIDM2Homo sapiens, Canis lupus familiaris
G250LGHVGGIGIDM2Rattus norvegicus, Mus musculus
G250AGDIVP-SMDG1Arabidopsis thaliana
G250AADIVP-AMDG1Arabidopsis thaliana
G250LGHVGGMGIDG1Caenorhabditis elegans
G250LPAVGG-PMDA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G250QPQIGA-SMDG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G314LLVCIGRRPFT4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
G314VLVSAGRTPFT2Arabidopsis thaliana, Arabidopsis thaliana
G314LLVSVGRRPYT1Caenorhabditis elegans
G314LLVAIGRVPYT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G314LLVAVGRRPYI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G354NIYAIGDVVAG3Homo sapiens, Canis lupus familiaris, Mus musculus
G354GVYAIGDVIPG2Arabidopsis thaliana, Arabidopsis thaliana
G354SIFAIGDVIEG1Caenorhabditis elegans
G354NIFAIGDVVAG1Rattus norvegicus
G354HIRVIGDATLG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G354HIKVVGDVTFG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G48DVTVIGSGPGG4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
G48DVVIIGGGPGG2Arabidopsis thaliana, Arabidopsis thaliana
G48DLVVIGGGPGG1Caenorhabditis elegans
G48DLCVIGGGPGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G48DVVIIGGGPAG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G50TVIGSGPGGYV4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
G50VIIGGGPGGYV2Arabidopsis thaliana, Arabidopsis thaliana
G50VVIGGGPGGYV1Caenorhabditis elegans
G50CVIGGGPGGYV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G50VIIGGGPAGYV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G52IGSGPGGYVAA4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
G52IGGGPGGYVAA4Arabidopsis thaliana, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G52IGGGPAGYVAA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G78NETLGGTCLNV4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
G78RGALGGTCLNV2Arabidopsis thaliana, Arabidopsis thaliana
G78NATLGGTCLNV1Caenorhabditis elegans
G78RGTLGGTCLNV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G78RGKLGGTCLNV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G84TCLNVGCIPSK9Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Caenorhabditis elegans, Canis lupus familiaris, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H364GPMLAHKAEDE6Homo sapiens, Caenorhabditis elegans, Canis lupus familiaris, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H364GPMLAHKAEED2Arabidopsis thaliana, Arabidopsis thaliana
H364GPMLAHKAEEE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H487RVCHAHPTLSE6Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H487RVCHAHPTMSE2Arabidopsis thaliana, Arabidopsis thaliana
H487RVCHPHPTLSE1Caenorhabditis elegans
I219EKMVVIGAGVI2Homo sapiens, Canis lupus familiaris
I219KKLIVIGAGYI2Arabidopsis thaliana, Arabidopsis thaliana
I219EKLVVIGAGVI2Rattus norvegicus, Mus musculus
I219KKMVVIGAGVI1Caenorhabditis elegans
I219KKMTVLGGGII1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I219KRLTIIGGGII1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I224IGAGVIGVELG4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
I224IGAGYIGLEMG2Arabidopsis thaliana, Arabidopsis thaliana
I224IGAGVIGLELG1Caenorhabditis elegans
I224LGGGIIGLEMG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I224IGGGIIGLEMG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I313VLLVCIGRRPF4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
I313VVLVSAGRTPF2Arabidopsis thaliana, Arabidopsis thaliana
I313TLLVSVGRRPY1Caenorhabditis elegans
I313VLLVAIGRVPY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I313VLLVAVGRRPY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I47-DVTVIGSGPG4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
I47-DVVIIGGGPG2Arabidopsis thaliana, Arabidopsis thaliana
I47-DLVVIGGGPG1Caenorhabditis elegans
I47YDLCVIGGGPG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I47-DVVIIGGGPA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I70FKTVCIEKNET3Homo sapiens, Rattus norvegicus, Mus musculus
I70LKTTCIEKRGA2Arabidopsis thaliana, Arabidopsis thaliana
I70MKTVCVEKNAT1Caenorhabditis elegans
I70FKTVCVEKNET1Canis lupus familiaris
I70LKTICVEKRGT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I70FNTACVEKRGK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K277FKLNTKVTGAT4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
K277FMLKTKVVSVD1Arabidopsis thaliana
K277FMLKTKVVGVD1Arabidopsis thaliana
K277FLLNTKVMGAS1Caenorhabditis elegans
K277FKTSTKLLSAK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K277FKLSTKVISAK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K72TVCIEKNETLG3Homo sapiens, Rattus norvegicus, Mus musculus
K72TTCIEKRGALG2Arabidopsis thaliana, Arabidopsis thaliana
K72TVCVEKNATLG1Caenorhabditis elegans
K72TVCVEKNETLG1Canis lupus familiaris
K72TICVEKRGTLG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K72TACVEKRGKLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K89GCIPSKALLNN7Homo sapiens, Caenorhabditis elegans, Canis lupus familiaris, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K89GCIPSKALLHS2Arabidopsis thaliana, Arabidopsis thaliana
L245TAVEFLGHVGG5Homo sapiens, Caenorhabditis elegans, Canis lupus familiaris, Rattus norvegicus, Mus musculus
L245TVVEFAGDIVP1Arabidopsis thaliana
L245TVVEFAADIVP1Arabidopsis thaliana
L245TVVEFLPAVGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L245TVVEFQPQIGA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L362VAGPMLAHKAE4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
L362IPGPMLAHKAE2Arabidopsis thaliana, Arabidopsis thaliana
L362IEGPMLAHKAE1Caenorhabditis elegans
L362TLGPMLAHKAE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L362TFGPMLAHKAE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M361VVAGPMLAHKA4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
M361VIPGPMLAHKA2Arabidopsis thaliana, Arabidopsis thaliana
M361VIEGPMLAHKA1Caenorhabditis elegans
M361ATLGPMLAHKA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M361VTFGPMLAHKA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N73VCIEKNETLGG3Homo sapiens, Rattus norvegicus, Mus musculus
N73TCIEKRGALGG2Arabidopsis thaliana, Arabidopsis thaliana
N73VCVEKNATLGG1Caenorhabditis elegans
N73VCVEKNETLGG1Canis lupus familiaris
N73ICVEKRGTLGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N73ACVEKRGKLGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P488VCHAHPTLSEA6Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P488VCHAHPTMSEA2Arabidopsis thaliana, Arabidopsis thaliana
P488VCHPHPTLSEA1Caenorhabditis elegans
P51VIGSGPGGYVA4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
P51IIGGGPGGYVA2Arabidopsis thaliana, Arabidopsis thaliana
P51VIGGGPGGYVA2Caenorhabditis elegans, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P51IIGGGPAGYVA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R315LVCIGRRPFTQ3Canis lupus familiaris, Rattus norvegicus, Mus musculus
R315LVSAGRTPFTS2Arabidopsis thaliana, Arabidopsis thaliana
R315LVCIGRRPFTK1Homo sapiens
R315LVSVGRRPYTE1Caenorhabditis elegans
R315LVAIGRVPYTE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R315LVAVGRRPYIA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R334IELDPRGRIPV2Homo sapiens, Canis lupus familiaris
R334IELDPKGRIPV2Rattus norvegicus, Mus musculus
R334VETDKAGRILV1Arabidopsis thaliana
R334VETDKGGRILV1Arabidopsis thaliana
R334IDLDNRGRVPV1Caenorhabditis elegans
R334ISMDKSNRVIM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R334LEVDKRGRLVI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S185LIATGSEVTPF3Homo sapiens, Canis lupus familiaris, Rattus norvegicus
S185IVATGSDVKSL2Arabidopsis thaliana, Arabidopsis thaliana
S185LIASGSEVTPF1Caenorhabditis elegans
S185LVATGSEVTPF1Mus musculus
S185IIATGSEVKPF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S185IVATGSEVTPF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S203DTIVSSTGALS4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
S203KKIVSSTGALS3Arabidopsis thaliana, Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S203KQIVSSTGALS1Caenorhabditis elegans
S203EKIVSSTGALS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S49VTVIGSGPGGY4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
S49VVIIGGGPGGY2Arabidopsis thaliana, Arabidopsis thaliana
S49LVVIGGGPGGY1Caenorhabditis elegans
S49LCVIGGGPGGY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S49VVIIGGGPAGY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S88VGCIPSKALLN7Homo sapiens, Caenorhabditis elegans, Canis lupus familiaris, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S88VGCIPSKALLH2Arabidopsis thaliana, Arabidopsis thaliana
T183NILIATGSEVT3Homo sapiens, Canis lupus familiaris, Rattus norvegicus
T183HIIVATGSDVK2Arabidopsis thaliana, Arabidopsis thaliana
T183NILIASGSEVT1Caenorhabditis elegans
T183NILVATGSEVT1Mus musculus
T183NFIIATGSEVK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T183NIIVATGSEVT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T276KFKLNTKVTGA4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
T276KFMLKTKVVSV1Arabidopsis thaliana
T276KFMLKTKVVGV1Arabidopsis thaliana
T276KFLLNTKVMGA1Caenorhabditis elegans
T276KFKTSTKLLSA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T276DFKLSTKVISA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T79ETLGGTCLNVG4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
T79GALGGTCLNVG2Arabidopsis thaliana, Arabidopsis thaliana
T79ATLGGTCLNVG1Caenorhabditis elegans
T79GTLGGTCLNVG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T79GKLGGTCLNVG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V223VIGAGVIGVEL4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
V223VIGAGYIGLEM2Arabidopsis thaliana, Arabidopsis thaliana
V223VIGAGVIGLEL1Caenorhabditis elegans
V223VLGGGIIGLEM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V223IIGGGIIGLEM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V242ADVTAVEFLGH4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
V242SEVTVVEFAGD1Arabidopsis thaliana
V242SEVTVVEFAAD1Arabidopsis thaliana
V242AEVTAVEFLGH1Caenorhabditis elegans
V242AEVTVVEFLPA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V242SKVTVVEFQPQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V251GHVGGVGIDME2Homo sapiens, Canis lupus familiaris
V251GHVGGIGIDME2Rattus norvegicus, Mus musculus
V251GDIVP-SMDGE1Arabidopsis thaliana
V251ADIVP-AMDGE1Arabidopsis thaliana
V251GHVGGMGIDGE1Caenorhabditis elegans
V251PAVGG-PMDAD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V251PQIGA-SMDGE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V278KLNTKVTGATK4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
V278MLKTKVVSVDS1Arabidopsis thaliana
V278MLKTKVVGVDS1Arabidopsis thaliana
V278LLNTKVMGASQ1Caenorhabditis elegans
V278KTSTKLLSAKV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V278KLSTKVISAKR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V392NCVPSVIYTHP4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
V392DKVPGVVYTHP1Arabidopsis thaliana
V392DKVPGVVYTYP1Arabidopsis thaliana
V392NCVPSVVYTHP1Caenorhabditis elegans
V392NCIPAVMYTHP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V392NNIPSVMYSHP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V83GTCLNVGCIPS9Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Caenorhabditis elegans, Canis lupus familiaris, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y153VHVNGYGKITG2Homo sapiens, Canis lupus familiaris
Y153VHVNGFGKITG2Rattus norvegicus, Mus musculus
Y153TYVKGYGKFIS1Arabidopsis thaliana
Y153NYVKGYGKFLS1Arabidopsis thaliana
Y153GHVEGFATIVG1Caenorhabditis elegans
Y153EYAKGTGSFID1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y153TYYKGNGSFED1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y394VPSVIYTHPEV4Homo sapiens, Canis lupus familiaris, Rattus norvegicus, Mus musculus
Y394VPGVVYTHPEV1Arabidopsis thaliana
Y394VPGVVYTYPEV1Arabidopsis thaliana
Y394VPSVVYTHPEV1Caenorhabditis elegans
Y394IPAVMYTHPEV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y394IPSVMYSHPEV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)


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