mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DNMT1
Gene summary
Basic gene Info.Gene symbolDNMT1
Gene nameDNA (cytosine-5-)-methyltransferase 1
SynonymsADCADN|AIM|CXXC9|DNMT|HSN1E|MCMT
CytomapUCSC genome browser: 19p13.2
Type of geneprotein-coding
RefGenesNM_001130823.1,
NM_001379.2,
DescriptionCXXC-type zinc finger protein 9DNA (cytosine-5)-methyltransferase 1DNA MTase HsaIDNA methyltransferase HsaIm.HsaI
Modification date20141222
dbXrefs MIM : 126375
HGNC : HGNC
Ensembl : ENSG00000130816
HPRD : 00532
Vega : OTTHUMG00000180397
ProteinUniProt: P26358
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DNMT1
BioGPS: 1786
PathwayNCI Pathway Interaction Database: DNMT1
KEGG: DNMT1
REACTOME: DNMT1
Pathway Commons: DNMT1
ContextiHOP: DNMT1
ligand binding site mutation search in PubMed: DNMT1
UCL Cancer Institute: DNMT1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0010216maintenance of DNA methylation18754681


Top
Ligand binding site mutations for DNMT1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Q517Q517PCOAD1
E485E485KCOAD1
K697M696IKIRC1
G1223,P1225P1224SSKCM1
C353P351LSKCM1
H418,C414H416YSTAD1
N1233G1231CSTAD1
C353K352ESTAD1
N1233R1234LSTAD1
C1485D1486NUCEC1
S480F479LUCEC1
E485E485KUCEC1
C356Q358RUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for DNMT1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H418H416Y0.14640059
C414H416Y0.14640059
E485E485K-1.2758061
P1225P1224S-1.1483484
G1223P1224S-1.1483484
C353P351L-1.1442981
K697M696I-1.0753115
S480F479L-0.95484083
C356Q358R-0.89578841
Q517Q517P-0.66922584
N1233R1234L-0.52605997
N1233G1231C-0.50695197
C1485D1486N-0.47122844
C353K352E-0.4266461
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DNMT1 from PDB

Top
Differential gene expression and gene-gene network for DNMT1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DNMT1 and the right PPI network was created from samples without mutations in the LBS of DNMT1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for DNMT1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1858804Cerebellar Ataxia, Deafness, and Narcolepsy6Biomarker, GeneticVariation
umls:C1458155Breast Neoplasms4AlteredExpression, Biomarker, GeneticVariation
umls:C0038356Stomach Neoplasms4AlteredExpression, Biomarker, GeneticVariation
umls:C0497327Dementia4Biomarker
umls:C0007097Carcinoma4Biomarker
umls:C0001418Adenocarcinoma3AlteredExpression, Biomarker
umls:C0027889Hereditary Sensory and Autonomic Neuropathies3Biomarker
umls:C0033578Prostatic Neoplasms2AlteredExpression, Biomarker
umls:C0282612Prostatic Intraepithelial Neoplasia2Biomarker
umls:C0009375Colonic Neoplasms1Biomarker, Therapeutic
umls:C0003469Anxiety Disorders1Biomarker
umls:C0004096Asthma1Biomarker
umls:C1384666Hearing Loss1Biomarker
umls:C0025149Medulloblastoma1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for DNMT1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00928AzacitidineSmall molecule
ApprovedDB01035ProcainamideSmall molecule
ApprovedDB01099FlucytosineSmall molecule
Approved|investigationalDB01262DecitabineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DNMT1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)3ptaAC1485
ZNZINC(2+)3swrAC1485
ZNZINC(2+)4yocAC1485
ZNZINC(2+)4wxxAC1485
ZNZINC(2+)4wxxBC1485
ZNZINC(2+)3epzAC353 C356 C414 H418
ZNZINC(2+)3epzBC353 C356 C414 H418
ZNZINC(2+)4wxxAC353 C356 C414 H418
ZNZINC(2+)4wxxBC353 C356 C414 H418
SAHS-ADENOSYL-L-HOMOCYSTEINE4wxxBG1223
SAHS-ADENOSYL-L-HOMOCYSTEINE4wxxAG1223 P1225
NUCNucleic Acids3ptaAK697
NUCNucleic Acids3ptaAN1233
SAHS-ADENOSYL-L-HOMOCYSTEINE3ptaAP1225
SFGSINEFUNGIN3swrAP1225
BGCBETA-D-GLUCOSE3epzAS480 E485 Q517


Top
Conservation information for LBS of DNMT1
Multiple alignments for P26358 in multiple species
LBSAA sequence# speciesSpecies
A1579RQVGNAVPPPL5Homo sapiens, Gallus gallus, Mus musculus, Bos taurus, Arabidopsis thaliana
A1579RQIGNAVPPPL3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
A647-DKENAFKRRR2Homo sapiens, Bos taurus
A647DDKENAMKRRR1Gallus gallus
A647-DKENAMKRRR1Mus musculus
A647-DPLQATAAEN1Arabidopsis thaliana
A647-DPLEEIG---1Arabidopsis thaliana
A647-VPSEAINAEN1Arabidopsis thaliana
A647-VPSEAIH--E1Arabidopsis thaliana
A685-----------4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
A685GRSKQACQERR1Homo sapiens
A685GRSKQACLQRR1Gallus gallus
A685GRSKQACLKRR1Mus musculus
A685GRSKQACQKRR1Bos taurus
C1191VFTEDCNVLL-3Gallus gallus, Mus musculus, Bos taurus
C1191VFVDNCNVIL-3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
C1191VFTEDCNILL-1Homo sapiens
C1191VFVDNCNVILR1Arabidopsis thaliana
C1476-----------4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
C1476ALRGVCSCAE-2Gallus gallus, Mus musculus
C1476ALRGVCSCVEA1Homo sapiens
C1476ALRGVCSCVE-1Bos taurus
C1478-----------4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
C1478RGVCSCAE-GK2Gallus gallus, Mus musculus
C1478RGVCSCVEAGK1Homo sapiens
C1478RGVCSCVE-GK1Bos taurus
C1485-----------4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
C1485EAGKACDPAAR1Homo sapiens
C1485E-GKPCDPADR1Gallus gallus
C1485E-GKACDPESR1Mus musculus
C1485E-GKPCEPAAR1Bos taurus
C353INEDEIA----2Arabidopsis thaliana, Arabidopsis thaliana
C353THPPKCIQCGQ1Homo sapiens
C353TTPPKCVDCRQ1Gallus gallus
C353INSPKCPECGQ1Mus musculus
C353TNPPKCTECLQ1Bos taurus
C353ISEDEIA----1Arabidopsis thaliana
C353INEHEIA----1Arabidopsis thaliana
C356PKCIQCGQYLD1Homo sapiens
C356PKCVDCRQYLD1Gallus gallus
C356PKCPECGQHLD1Mus musculus
C356PKCTECLQYLD1Bos taurus
C356DEIA------N1Arabidopsis thaliana
C356DEIA------H1Arabidopsis thaliana
C356DEIA------D1Arabidopsis thaliana
C356HEIA------N1Arabidopsis thaliana
C414CFSVYCKHGHL1Homo sapiens
C414SFSVYDKRGHL1Gallus gallus
C414SFSVYCSRGHL1Mus musculus
C414CFSVYCKRGHL1Bos taurus
C414NWALYNSDLRF1Arabidopsis thaliana
C414NWALYNSDLML1Arabidopsis thaliana
C414NWTLYNSDSRM1Arabidopsis thaliana
C414NWALYNSDSRM1Arabidopsis thaliana
C653MKRRRCGVCEV2Gallus gallus, Mus musculus
C653FKRRRCGVCEV1Homo sapiens
C653FKRRRCGVCEI1Bos taurus
C653TAAEN-GEDEV1Arabidopsis thaliana
C653IG----AEEEF1Arabidopsis thaliana
C653INAENVEEEEL1Arabidopsis thaliana
C653IH--EVEEEEI1Arabidopsis thaliana
C656RRCGVCEVCQQ3Homo sapiens, Gallus gallus, Mus musculus
C656RRCGVCEICQQ1Bos taurus
C656EN-GEDEVEEE1Arabidopsis thaliana
C656---AEEEFEEV1Arabidopsis thaliana
C656ENVEEEELEEV1Arabidopsis thaliana
C656-EVEEEEIEED1Arabidopsis thaliana
C659GVCEVCQQPEC3Homo sapiens, Gallus gallus, Mus musculus
C659GVCEICQQPEC1Bos taurus
C659GEDEVEEEGGN1Arabidopsis thaliana
C659AEEEFEEVED-1Arabidopsis thaliana
C659EEEELEEVEE-1Arabidopsis thaliana
C659EEEEIEEDEE-1Arabidopsis thaliana
C664CQQPECGKCKA4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
C664EEEGGNGEEE-1Arabidopsis thaliana
C664EEVED------1Arabidopsis thaliana
C664EEVEE------1Arabidopsis thaliana
C664EEDEE------1Arabidopsis thaliana
C667PECGKCKACKD3Homo sapiens, Mus musculus, Bos taurus
C667EE---------2Arabidopsis thaliana, Arabidopsis thaliana
C667PECGKCKACQN1Gallus gallus
C667GGNGEEE----1Arabidopsis thaliana
C667ED---------1Arabidopsis thaliana
C670GKCKACKDMVK3Homo sapiens, Mus musculus, Bos taurus
C670-----------3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
C670GKCKACQNMVK1Gallus gallus
C670GEEE-------1Arabidopsis thaliana
C686-----------4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
C686RSKQACQERRC1Homo sapiens
C686RSKQACLQRRC1Gallus gallus
C686RSKQACLKRRC1Mus musculus
C686RSKQACQKRRC1Bos taurus
C691----------V2Arabidopsis thaliana, Arabidopsis thaliana
C691-----------2Arabidopsis thaliana, Arabidopsis thaliana
C691CQERRCPNMAM1Homo sapiens
C691CLQRRCPNLAV1Gallus gallus
C691CLKRRCPNLAV1Mus musculus
C691CQKRRCPNMAM1Bos taurus
C820FLVDECEDMQL3Homo sapiens, Gallus gallus, Bos taurus
C820FLTNECLTVQL2Arabidopsis thaliana, Arabidopsis thaliana
C820FLVGECENMQL1Mus musculus
C820FLTNECMTTQL1Arabidopsis thaliana
C820FLTNECLTVHL1Arabidopsis thaliana
C893S--GFCSSC--3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
C893NKFKFCVSCAR1Homo sapiens
C893NKYKFCLSCAR1Gallus gallus
C893NKHKFCLSCIR1Mus musculus
C893NKYKFCASCAR1Bos taurus
C893S--GFCTSC--1Arabidopsis thaliana
C896GFCSSC----K3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
C896KFCVSCARLAE1Homo sapiens
C896KFCLSCARLDE1Gallus gallus
C896KFCLSCIRLAE1Mus musculus
C896KFCASCARLAE1Bos taurus
C896GFCTSC----K1Arabidopsis thaliana
D1190TVFVDNCNVIL4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
D1190TVFTEDCNVLL3Gallus gallus, Mus musculus, Bos taurus
D1190TVFTEDCNILL1Homo sapiens
E1168TLWAIEMWDPA3Homo sapiens, Mus musculus, Bos taurus
E1168TKWAIEYEEPA3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
E1168TLWAIEMWEPA1Gallus gallus
E1168AKWAIEYEEPA1Arabidopsis thaliana
E1189TTVFTEDCNVL2Gallus gallus, Mus musculus
E1189ATVFVDNCNVI2Arabidopsis thaliana, Arabidopsis thaliana
E1189STVFTEDCNIL1Homo sapiens
E1189STVFTEDCNVL1Bos taurus
E1189STVFVDNCNVI1Arabidopsis thaliana
E1189TTVFVDNCNVI1Arabidopsis thaliana
E1266RFFLLENVRNF3Homo sapiens, Gallus gallus, Mus musculus
E1266KYFLLENVKKF2Arabidopsis thaliana, Arabidopsis thaliana
E1266RYFLLENVRNF1Bos taurus
E1266RYFLLENVRTF1Arabidopsis thaliana
E1266KYFLLENVKTF1Arabidopsis thaliana
E485RTDMAWYRLGK3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
E485STSFAEYILMD2Homo sapiens, Bos taurus
E485TTAFADYILME1Gallus gallus
E485STAFAEYILME1Mus musculus
E485RTDVAWYRLGK1Arabidopsis thaliana
E514SKIVVEFLQSN2Homo sapiens, Bos taurus
E514SKIVVEFLQNN2Gallus gallus, Mus musculus
E514GISILTFLRVE1Arabidopsis thaliana
E514GTSILALLKNE1Arabidopsis thaliana
E514GISIFNMLMRE1Arabidopsis thaliana
E514AISIFNMLMRE1Arabidopsis thaliana
F1145RTLDVFSGCGG4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
F1145-TLDIFAGCGG4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
F648DKENAFKRRRC2Homo sapiens, Bos taurus
F648DKENAMKRRRC2Gallus gallus, Mus musculus
F648DPLQATAAEN-1Arabidopsis thaliana
F648DPLEEIG----1Arabidopsis thaliana
F648VPSEAINAENV1Arabidopsis thaliana
F648VPSEAIH--EV1Arabidopsis thaliana
G1147LDVFSGCGGLS4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
G1147LDIFAGCGGLS4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G1149VFSGCGGLSEG4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
G1149IFAGCGGLSHG3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G1149IFAGCGGLSYG1Arabidopsis thaliana
G1150FSGCGGLSEGF4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
G1150FAGCGGLSHGL3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G1150FAGCGGLSYGL1Arabidopsis thaliana
G1223EMLCGGPPCQG4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
G1223DFINGGPPCQG2Arabidopsis thaliana, Arabidopsis thaliana
G1223DFISGGPPCQG2Arabidopsis thaliana, Arabidopsis thaliana
G665QQPECGKCKAC4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
G665EEGGNGEEE--1Arabidopsis thaliana
G665EVED-------1Arabidopsis thaliana
G665EVEE-------1Arabidopsis thaliana
G665EDEE-------1Arabidopsis thaliana
H1502PWCLPHTGNRH4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
H1502PLALSKTAKNH2Arabidopsis thaliana, Arabidopsis thaliana
H1502PFCLPNTAERH1Arabidopsis thaliana
H1502PNLL-NKAKDH1Arabidopsis thaliana
H418YNSDSRMISLE2Arabidopsis thaliana, Arabidopsis thaliana
H418YCKHGHLCPID1Homo sapiens
H418YDKRGHLCPFD1Gallus gallus
H418YCSRGHLCPVD1Mus musculus
H418YCKRGHLCPID1Bos taurus
H418YNSDLRFISLE1Arabidopsis thaliana
H418YNSDLMLISLE1Arabidopsis thaliana
H793NGQMFHAHWFC2Homo sapiens, Bos taurus
H793-GQMFHAHWFC1Gallus gallus
H793GQMMFHAHWFC1Mus musculus
H793HCKMLHGRFLQ1Arabidopsis thaliana
H793NSKKLHGKLLQ1Arabidopsis thaliana
H793HSKMLHGKLLQ1Arabidopsis thaliana
H793QCKMLHGKLLQ1Arabidopsis thaliana
K649KENAFKRRRCG2Homo sapiens, Bos taurus
K649KENAMKRRRCG2Gallus gallus, Mus musculus
K649PLQATAAEN-G1Arabidopsis thaliana
K649PLEEIG----A1Arabidopsis thaliana
K649PSEAINAENVE1Arabidopsis thaliana
K649PSEAIH--EVE1Arabidopsis thaliana
K683-----------4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
K683GSGRSKQACQE1Homo sapiens
K683GSGRSKQACLQ1Gallus gallus
K683GTGRSKQACLK1Mus musculus
K683GSGRSKQACQK1Bos taurus
K697PNMAMKEADDD2Homo sapiens, Bos taurus
K697-----EDENEE2Arabidopsis thaliana, Arabidopsis thaliana
K697PNLAVREADED1Gallus gallus
K697PNLAVKEADDD1Mus musculus
K697----VEEEGEN1Arabidopsis thaliana
K697----VEEEDEN1Arabidopsis thaliana
L1151SGCGGLSEGFH4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
L1151AGCGGLSHGLE2Arabidopsis thaliana, Arabidopsis thaliana
L1151AGCGGLSHGLK1Arabidopsis thaliana
L1151AGCGGLSYGLE1Arabidopsis thaliana
L1247KFKNSLVVSFL4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
L1247KVQCEMILAFL3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
L1247KNQCQMILAFL1Arabidopsis thaliana
M1169LWAIEMWDPAA3Homo sapiens, Mus musculus, Bos taurus
M1169KWAIEYEEPAG3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
M1169LWAIEMWEPAA1Gallus gallus
M1169KWAIEYEEPAA1Arabidopsis thaliana
M694RRCPNMAMKEA2Homo sapiens, Bos taurus
M694-------VEEE2Arabidopsis thaliana, Arabidopsis thaliana
M694--------EDE2Arabidopsis thaliana, Arabidopsis thaliana
M694RRCPNLAVREA1Gallus gallus
M694RRCPNLAVKEA1Mus musculus
N1233GFSGMNRFNSR4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
N1233GFSGMNRFNQS1Arabidopsis thaliana
N1233GFSRLNRFSDG1Arabidopsis thaliana
N1233GFSGMNRFSHG1Arabidopsis thaliana
N1233GFSGMNRFSDG1Arabidopsis thaliana
N1578HRQVGNAVPPP5Homo sapiens, Gallus gallus, Mus musculus, Bos taurus, Arabidopsis thaliana
N1578HRQIGNAVPPP3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
P1225LCGGPPCQGFS4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
P1225INGGPPCQGFS2Arabidopsis thaliana, Arabidopsis thaliana
P1225ISGGPPCQGFS2Arabidopsis thaliana, Arabidopsis thaliana
Q404TRDLPCRTLHN2Arabidopsis thaliana, Arabidopsis thaliana
Q404YEALPQHKLTC1Homo sapiens
Q404YEDLPQHKVTS1Gallus gallus
Q404YEDSPMHRFTS1Mus musculus
Q404YEDLPQHKLTC1Bos taurus
Q404SEHLPHRMLHN1Arabidopsis thaliana
Q404ARNLPCRTLHN1Arabidopsis thaliana
Q517IFNMLMRESRV2Arabidopsis thaliana, Arabidopsis thaliana
Q517VVEFLQSNS--1Homo sapiens
Q517VVEFLQNNR--1Gallus gallus
Q517VVEFLQNNP--1Mus musculus
Q517VVEFLQSNP--1Bos taurus
Q517ILTFLRVESRV1Arabidopsis thaliana
Q517ILALLKNETRM1Arabidopsis thaliana
Q684-----------4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
Q684SGRSKQACQER1Homo sapiens
Q684SGRSKQACLQR1Gallus gallus
Q684TGRSKQACLKR1Mus musculus
Q684SGRSKQACQKR1Bos taurus
R1276FVSFKRSMVLK3Homo sapiens, Gallus gallus, Bos taurus
R1276FVTYNKGRTFQ2Arabidopsis thaliana, Arabidopsis thaliana
R1276FVSYRRSMVLK1Mus musculus
R1276FVSFNKGQTFQ1Arabidopsis thaliana
R1276FVSFNEGHTFH1Arabidopsis thaliana
R650ENAFKRRRCGV2Homo sapiens, Bos taurus
R650ENAMKRRRCGV2Gallus gallus, Mus musculus
R650LQATAAEN-GE1Arabidopsis thaliana
R650LEEIG----AE1Arabidopsis thaliana
R650SEAINAENVEE1Arabidopsis thaliana
R650SEAIH--EVEE1Arabidopsis thaliana
R652AFKRRRCGVCE2Homo sapiens, Bos taurus
R652AMKRRRCGVCE2Gallus gallus, Mus musculus
R652ATAAEN-GEDE1Arabidopsis thaliana
R652EIG----AEEE1Arabidopsis thaliana
R652AINAENVEEEE1Arabidopsis thaliana
R652AIH--EVEEEE1Arabidopsis thaliana
R681-----------4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
R681FGGSGRSKQAC3Homo sapiens, Gallus gallus, Bos taurus
R681FGGTGRSKQAC1Mus musculus
S1146TLDVFSGCGGL4Homo sapiens, Gallus gallus, Mus musculus, Bos taurus
S1146TLDIFAGCGGL4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
S480IFVTLRTDMAW2Arabidopsis thaliana, Arabidopsis thaliana
S480ALIGFSTSFAE1Homo sapiens
S480ALIGFTTAFAD1Gallus gallus
S480VLIGFSTAFAE1Mus musculus
S480ALLGFSTSFAE1Bos taurus
S480ISISIRTDVAW1Arabidopsis thaliana
S480IFVLLRTDMAW1Arabidopsis thaliana
S682-----------4Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
S682GGSGRSKQACQ2Homo sapiens, Bos taurus
S682GGSGRSKQACL1Gallus gallus
S682GGTGRSKQACL1Mus musculus
V1580QVGNAVPPPLA5Homo sapiens, Gallus gallus, Mus musculus, Bos taurus, Arabidopsis thaliana
V1580QIGNAVPPPLA3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
W1170WAIEMWDPAAQ3Homo sapiens, Mus musculus, Bos taurus
W1170WAIEYEEPAGH2Arabidopsis thaliana, Arabidopsis thaliana
W1170WAIEMWEPAAQ1Gallus gallus
W1170WAIEYEEPAGQ1Arabidopsis thaliana
W1170WAIEYEEPAAQ1Arabidopsis thaliana


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas