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mutLBSgeneDB |
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| Gene summary for DPEP1 |
 Gene summary |
| Basic gene Info. | Gene symbol | DPEP1 |
| Gene name | dipeptidase 1 (renal) | |
| Synonyms | MBD1|MDP|RDP | |
| Cytomap | UCSC genome browser: 16q24.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001128141.2, NM_004413.3, | |
| Description | dehydropeptidase-Idipeptidase 1hRDPmicrosomal dipeptidaserenal dipeptidase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 179780 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000015413 | ||
| HPRD : 01563 | ||
| Vega : OTTHUMG00000138052 | ||
| Protein | UniProt: P16444 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DPEP1 | |
| BioGPS: 1800 | ||
| Pathway | NCI Pathway Interaction Database: DPEP1 | |
| KEGG: DPEP1 | ||
| REACTOME: DPEP1 | ||
| Pathway Commons: DPEP1 | ||
| Context | iHOP: DPEP1 | |
| ligand binding site mutation search in PubMed: DPEP1 | ||
| UCL Cancer Institute: DPEP1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0016999 | antibiotic metabolic process | 8737157 | GO:0035690 | cellular response to drug | 20435919 | GO:0050667 | homocysteine metabolic process | 20031578 |
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| Ligand binding site mutations for DPEP1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H214 | H214Y | LUAD | 1 | G307 | D306Y | LUAD | 1 | R246 | V248M | PRAD | 1 | H214 | A213T | SKCM | 1 | V308 | V308A | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for DPEP1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | V308 | V308A | -1.626436 | H214 | A213T | -1.3696775 | R246 | V248M | -0.93344697 | H214 | H214Y | -0.67019495 | G307 | D306Y | -0.65479964 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DPEP1 from PDB |
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| Differential gene expression and gene-gene network for DPEP1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for DPEP1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for DPEP1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved | DB01597 | Cilastatin | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of DPEP1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of DPEP1 |
| Multiple alignments for P16444 in multiple species |
| LBS | AA sequence | # species | Species | D304 | VGLGGDYDGVT | 2 | Mus musculus, Rattus norvegicus | D304 | VGFGGDFDGVP | 1 | Homo sapiens | D304 | IGLGGDFDGID | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D304 | VGFGGDYDGVS | 1 | Bos taurus | D38 | IDGHNDLPWQL | 3 | Homo sapiens, Mus musculus, Bos taurus | D38 | IDGHNDLPIYL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D38 | IDGHNDLPWQM | 1 | Rattus norvegicus | E141 | SLIGVEGGHLI | 2 | Mus musculus, Rattus norvegicus | E141 | SLIGVEGGHSI | 1 | Homo sapiens | E141 | SMMGIEGLHQI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E141 | SLVGVEGGHSI | 1 | Bos taurus | G307 | GGDFDGVPRVP | 1 | Homo sapiens | G307 | GGDFDGIDMVP | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G307 | GGDYDGVTMLP | 1 | Mus musculus | G307 | GGDYDGVTNLP | 1 | Rattus norvegicus | G307 | GGDYDGVSRLP | 1 | Bos taurus | H168 | YLTLTHSCNTP | 2 | Homo sapiens, Bos taurus | H168 | YLTLTHNCNTP | 2 | Mus musculus, Rattus norvegicus | H168 | YATLAHNCDNV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H214 | MIDLSHVSVAT | 2 | Mus musculus, Rattus norvegicus | H214 | LIDLAHVSVAT | 1 | Homo sapiens | H214 | IVDLSHTTPET | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H214 | IIDLAHVSVAT | 1 | Bos taurus | H235 | PVIFSHSSAYS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | H235 | PAFFSHSSAKG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H36 | PVIDGHNDLPW | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | H36 | PLIDGHNDLPI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | P309 | DFDGVPRVPEG | 1 | Homo sapiens | P309 | DFDGIDMVPKG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | P309 | DYDGVTMLPVG | 1 | Mus musculus | P309 | DYDGVTNLPVG | 1 | Rattus norvegicus | P309 | DYDGVSRLPSG | 1 | Bos taurus | R246 | VCASRRNVPDD | 1 | Homo sapiens | R246 | VYDHPRNVPDD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R246 | LCPHRRNVPDD | 1 | Mus musculus | R246 | VCPHRRNVPDD | 1 | Rattus norvegicus | R246 | VCRHRRNVPDH | 1 | Bos taurus | V308 | GDFDGVPRVPE | 1 | Homo sapiens | V308 | GDFDGIDMVPK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V308 | GDYDGVTMLPV | 1 | Mus musculus | V308 | GDYDGVTNLPV | 1 | Rattus norvegicus | V308 | GDYDGVSRLPS | 1 | Bos taurus | W41 | HNDLPWQLLDM | 1 | Homo sapiens | W41 | HNDLPIYLREN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | W41 | HNDLPWQLLNL | 1 | Mus musculus | W41 | HNDLPWQMLTL | 1 | Rattus norvegicus | W41 | HNDLPWQLLKR | 1 | Bos taurus | Y268 | VMVNFYNNYIS | 1 | Homo sapiens | Y268 | VMVNFYPAFIS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y268 | VMVNFFSNFVS | 1 | Mus musculus | Y268 | VMVNFYNQFVS | 1 | Rattus norvegicus | Y268 | VMVNFYNDYVS | 1 | Bos taurus | Y271 | NFYNNYIS-CT | 1 | Homo sapiens | Y271 | NFYPAFISPHP | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y271 | NFFSNFVS-CS | 1 | Mus musculus | Y271 | NFYNQFVS-CS | 1 | Rattus norvegicus | Y271 | NFYNDYVS-CK | 1 | Bos taurus | Y84 | QFWSAYMPCDT | 2 | Mus musculus, Rattus norvegicus | Y84 | QFWSVYTPCDT | 1 | Homo sapiens | Y84 | QFWSVFVECPS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y84 | QFWSAYTPCDT | 1 | Bos taurus |
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