mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DPEP1
Gene summary
Basic gene Info.Gene symbolDPEP1
Gene namedipeptidase 1 (renal)
CytomapUCSC genome browser: 16q24.3
Type of geneprotein-coding
Descriptiondehydropeptidase-Idipeptidase 1hRDPmicrosomal dipeptidaserenal dipeptidase
Modification date20141207
dbXrefs MIM : 179780
Ensembl : ENSG00000015413
HPRD : 01563
Vega : OTTHUMG00000138052
ProteinUniProt: P16444
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DPEP1
BioGPS: 1800
PathwayNCI Pathway Interaction Database: DPEP1
Pathway Commons: DPEP1
ContextiHOP: DPEP1
ligand binding site mutation search in PubMed: DPEP1
UCL Cancer Institute: DPEP1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0016999antibiotic metabolic process8737157
GO:0035690cellular response to drug20435919
GO:0050667homocysteine metabolic process20031578

Ligand binding site mutations for DPEP1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for DPEP1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DPEP1 from PDB

Differential gene expression and gene-gene network for DPEP1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DPEP1 and the right PPI network was created from samples without mutations in the LBS of DPEP1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for DPEP1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for DPEP1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB01597CilastatinSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DPEP1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of DPEP1
Multiple alignments for P16444 in multiple species
LBSAA sequence# speciesSpecies
D304VGLGGDYDGVT2Mus musculus, Rattus norvegicus
D304VGFGGDFDGVP1Homo sapiens
D304IGLGGDFDGID1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D304VGFGGDYDGVS1Bos taurus
D38IDGHNDLPWQL3Homo sapiens, Mus musculus, Bos taurus
D38IDGHNDLPIYL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D38IDGHNDLPWQM1Rattus norvegicus
E141SLIGVEGGHLI2Mus musculus, Rattus norvegicus
E141SLIGVEGGHSI1Homo sapiens
E141SMMGIEGLHQI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E141SLVGVEGGHSI1Bos taurus
G307GGDFDGVPRVP1Homo sapiens
G307GGDFDGIDMVP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G307GGDYDGVTMLP1Mus musculus
G307GGDYDGVTNLP1Rattus norvegicus
G307GGDYDGVSRLP1Bos taurus
H168YLTLTHSCNTP2Homo sapiens, Bos taurus
H168YLTLTHNCNTP2Mus musculus, Rattus norvegicus
H168YATLAHNCDNV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H214MIDLSHVSVAT2Mus musculus, Rattus norvegicus
H214LIDLAHVSVAT1Homo sapiens
H214IVDLSHTTPET1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H214IIDLAHVSVAT1Bos taurus
H235PVIFSHSSAYS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H235PAFFSHSSAKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H36PVIDGHNDLPW4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H36PLIDGHNDLPI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P309DFDGVPRVPEG1Homo sapiens
P309DFDGIDMVPKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P309DYDGVTMLPVG1Mus musculus
P309DYDGVTNLPVG1Rattus norvegicus
P309DYDGVSRLPSG1Bos taurus
R246VCASRRNVPDD1Homo sapiens
R246VYDHPRNVPDD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R246LCPHRRNVPDD1Mus musculus
R246VCPHRRNVPDD1Rattus norvegicus
R246VCRHRRNVPDH1Bos taurus
V308GDFDGVPRVPE1Homo sapiens
V308GDFDGIDMVPK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V308GDYDGVTMLPV1Mus musculus
V308GDYDGVTNLPV1Rattus norvegicus
V308GDYDGVSRLPS1Bos taurus
W41HNDLPWQLLDM1Homo sapiens
W41HNDLPIYLREN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W41HNDLPWQLLNL1Mus musculus
W41HNDLPWQMLTL1Rattus norvegicus
Y268VMVNFYNNYIS1Homo sapiens
Y268VMVNFYPAFIS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y268VMVNFFSNFVS1Mus musculus
Y268VMVNFYNQFVS1Rattus norvegicus
Y268VMVNFYNDYVS1Bos taurus
Y271NFYNNYIS-CT1Homo sapiens
Y271NFYPAFISPHP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y271NFFSNFVS-CS1Mus musculus
Y271NFYNQFVS-CS1Rattus norvegicus
Y271NFYNDYVS-CK1Bos taurus
Y84QFWSAYMPCDT2Mus musculus, Rattus norvegicus
Y84QFWSVYTPCDT1Homo sapiens
Y84QFWSVFVECPS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)

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