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mutLBSgeneDB |
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| Gene summary for DPYSL3 |
 Gene summary |
| Basic gene Info. | Gene symbol | DPYSL3 |
| Gene name | dihydropyrimidinase-like 3 | |
| Synonyms | CRMP-4|CRMP4|DRP-3|DRP3|LCRMP|ULIP|ULIP-1 | |
| Cytomap | UCSC genome browser: 5q32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001197294.1, NM_001387.2, | |
| Description | collapsin response mediator protein 4 longdihydropyrimidinase-related protein 3unc-33-like phosphoprotein 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601168 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000113657 | ||
| HPRD : 03104 | ||
| Vega : OTTHUMG00000163437 | ||
| Protein | UniProt: Q14195 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DPYSL3 | |
| BioGPS: 1809 | ||
| Pathway | NCI Pathway Interaction Database: DPYSL3 | |
| KEGG: DPYSL3 | ||
| REACTOME: DPYSL3 | ||
| Pathway Commons: DPYSL3 | ||
| Context | iHOP: DPYSL3 | |
| ligand binding site mutation search in PubMed: DPYSL3 | ||
| UCL Cancer Institute: DPYSL3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for DPYSL3 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G464 | G464W | SKCM | 1 | D128 | A127V | STAD | 1 | D128 | A127D | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for DPYSL3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D128 | A127D | -0.91984078 | G464 | G464W | -0.74893545 | D128 | A127V | -0.61164111 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DPYSL3 from PDB |
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| Differential gene expression and gene-gene network for DPYSL3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for DPYSL3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for DPYSL3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of DPYSL3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | MG | MAGNESIUM(2+) | 4cns | A | D128 G464 | MG | MAGNESIUM(2+) | 4cns | B | D128 G464 | MG | MAGNESIUM(2+) | 4cns | C | D128 G464 | MG | MAGNESIUM(2+) | 4cns | D | D128 G464 |
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| Conservation information for LBS of DPYSL3 |
| Multiple alignments for Q14195 in multiple species |
| LBS | AA sequence | # species | Species | D128 | WREWADGKSCC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D128 | WSKWADEKACC | 1 | Danio rerio | D128 | WREWADGKTCC | 1 | Xenopus tropicalis | G464 | LHVTQGAGRFI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G464 | LHATSGTGRFI | 1 | Danio rerio | G464 | LHVTQGTGRFI | 1 | Xenopus tropicalis | G466 | VTQGAGRFIPC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G466 | ATSGTGRFIPC | 1 | Danio rerio | G466 | VTQGTGRFIPC | 1 | Xenopus tropicalis | I279 | VFGEPITASLG | 5 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus, Rattus norvegicus | K254 | PLYVTKVMSKS | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | K254 | PLYVTRVMSKS | 1 | Danio rerio | T303 | AAAFVTSPPLS | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | T303 | AASFVTSPPLS | 1 | Danio rerio |
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