mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DPYSL3
Gene summary
Basic gene Info.Gene symbolDPYSL3
Gene namedihydropyrimidinase-like 3
CytomapUCSC genome browser: 5q32
Type of geneprotein-coding
Descriptioncollapsin response mediator protein 4 longdihydropyrimidinase-related protein 3unc-33-like phosphoprotein 1
Modification date20141207
dbXrefs MIM : 601168
Ensembl : ENSG00000113657
HPRD : 03104
Vega : OTTHUMG00000163437
ProteinUniProt: Q14195
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DPYSL3
BioGPS: 1809
PathwayNCI Pathway Interaction Database: DPYSL3
Pathway Commons: DPYSL3
ContextiHOP: DPYSL3
ligand binding site mutation search in PubMed: DPYSL3
UCL Cancer Institute: DPYSL3
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for DPYSL3

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for DPYSL3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DPYSL3 from PDB

Differential gene expression and gene-gene network for DPYSL3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DPYSL3 and the right PPI network was created from samples without mutations in the LBS of DPYSL3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for DPYSL3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for DPYSL3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DPYSL3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
MGMAGNESIUM(2+)4cnsAD128 G464
MGMAGNESIUM(2+)4cnsBD128 G464
MGMAGNESIUM(2+)4cnsCD128 G464
MGMAGNESIUM(2+)4cnsDD128 G464

Conservation information for LBS of DPYSL3
Multiple alignments for Q14195 in multiple species
LBSAA sequence# speciesSpecies
D128WREWADGKSCC3Homo sapiens, Mus musculus, Rattus norvegicus
D128WSKWADEKACC1Danio rerio
D128WREWADGKTCC1Xenopus tropicalis
G464LHVTQGAGRFI3Homo sapiens, Mus musculus, Rattus norvegicus
G464LHATSGTGRFI1Danio rerio
G464LHVTQGTGRFI1Xenopus tropicalis
G466VTQGAGRFIPC3Homo sapiens, Mus musculus, Rattus norvegicus
G466ATSGTGRFIPC1Danio rerio
G466VTQGTGRFIPC1Xenopus tropicalis
I279VFGEPITASLG5Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus, Rattus norvegicus
K254PLYVTKVMSKS4Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus
K254PLYVTRVMSKS1Danio rerio
T303AAAFVTSPPLS4Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus
T303AASFVTSPPLS1Danio rerio

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas