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mutLBSgeneDB |
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| Gene summary for DTYMK |
 Gene summary |
| Basic gene Info. | Gene symbol | DTYMK |
| Gene name | deoxythymidylate kinase (thymidylate kinase) | |
| Synonyms | CDC8|PP3731|TMPK|TYMK | |
| Cytomap | UCSC genome browser: 2q37.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001165031.1, NM_012145.3,NR_033255.1, | |
| Description | dTMP kinasethymidylate kinase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 188345 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000168393 | ||
| HPRD : 01773 | ||
| Vega : OTTHUMG00000133409 | ||
| Protein | UniProt: P23919 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DTYMK | |
| BioGPS: 1841 | ||
| Pathway | NCI Pathway Interaction Database: DTYMK | |
| KEGG: DTYMK | ||
| REACTOME: DTYMK | ||
| Pathway Commons: DTYMK | ||
| Context | iHOP: DTYMK | |
| ligand binding site mutation search in PubMed: DTYMK | ||
| UCL Cancer Institute: DTYMK | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0046939 | nucleotide phosphorylation | 8845311 |
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| Ligand binding site mutations for DTYMK |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R143 | R143L | LUAD | 1 | H148 | H148N | THCA | 1 | R150 | R150H | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for DTYMK |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R143 | R143L | 0.36612139 | R150 | R150H | -1.7241738 | H148 | H148N | -0.23225454 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DTYMK from PDB |
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| Differential gene expression and gene-gene network for DTYMK |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for DTYMK |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for DTYMK |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB01643 | Thymidine-5'-Phosphate | Small molecule |  |
| Experimental | DB03150 | 2',3'-Dideoxythymidine-5'-Monophosphate | Small molecule |  |
| Experimental | DB03195 | Phosphoric Acid Mono-[3-Fluoro-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahyro-Furan-2-Ylmethyl] Ester | Small molecule |  |
| Experimental | DB03233 | Phosphoric Acid Mono-[3-Amino-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahydro-Furan-2-Ylmethyl] Ester | Small molecule |  |
| Experimental | DB03280 | P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate | Small molecule |  |
| Experimental | DB03666 | 3'-Azido-3'-Deoxythymidine-5'-Monophosphate | Small molecule |  |
| Experimental | DB03845 | P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate | Small molecule |  |
| Experimental | DB04395 | Phosphoaminophosphonic Acid-Adenylate Ester | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of DTYMK go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | TAE | N1-[(E)-4-DIHYDROXYPHOSPHONYL-BUT-2-ENYL]-THYMINE | 2xx3 | A | H148 R150 | ADP | ADP | 1e2d | A | R143 | ADP | ADP | 1e2e | A | R143 | ANP | AMP-PNP | 1e2f | A | R143 | ADP | ADP | 1e2f | A | R143 | ADP | ADP | 1e2g | A | R143 | ATP | ATP | 1e2q | A | R143 | ADP | ADP | 1e98 | A | R143 | ADP | ADP | 1e99 | A | R143 | Z5A | P1-(5'-ADENOSYL)P5-(5'-(3'AZIDO-3'-DEOXYTHYMIDYL))PENTAPHOSPHATE | 1e9a | A | R143 | ADP | ADP | 1e9b | A | R143 | ANP | AMP-PNP | 1e9b | A | R143 | ADP | ADP | 1e9c | A | R143 | ANP | AMP-PNP | 1e9c | A | R143 | ADP | ADP | 1e9d | A | R143 | ADP | ADP | 1e9e | A | R143 | ADP | ADP | 1e9f | A | R143 | ADP | ADP | 1nmx | A | R143 | ADP | ADP | 1nmy | A | R143 | ANP | AMP-PNP | 1nmy | A | R143 | ANP | AMP-PNP | 1nmz | A | R143 | ADP | ADP | 1nn0 | A | R143 | ANP | AMP-PNP | 1nn1 | A | R143 | ADP | ADP | 1nn3 | A | R143 | ANP | AMP-PNP | 1nn5 | A | R143 | ADP | ADP | 2xx3 | A | R143 |
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| Conservation information for LBS of DTYMK |
| Multiple alignments for P23919 in multiple species |
| LBS | AA sequence | # species | Species | A145 | AAKRGAFGHER | 1 | Homo sapiens | A145 | AAQRGGFGEER | 1 | Caenorhabditis elegans | A145 | NAEKSGFGDER | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A145 | AATRGQYGEER | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A145 | AAARGEFGLER | 1 | Mus musculus | A17 | EGLDRSGKSTQ | 2 | Caenorhabditis elegans, Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A17 | EGVDRAGKSTQ | 1 | Homo sapiens | A17 | EGLDRTGKTTQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A17 | EGVDRAGKTTQ | 1 | Mus musculus | D15 | VLEGVDRAGKS | 1 | Homo sapiens | D15 | VFEGLDRSGKS | 1 | Caenorhabditis elegans | D15 | LIEGLDRTGKT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D15 | VIEGLDRSGKS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D15 | VLEGVDRAGKT | 1 | Mus musculus | F105 | FSGVAFTGAK- | 2 | Homo sapiens, Mus musculus | F105 | YSGVAYSLAK- | 1 | Caenorhabditis elegans | F105 | YSGVAYSAAKG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F105 | FSGIAFSAAK- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F42 | AELLRFPERST | 2 | Homo sapiens, Mus musculus | F42 | AVLQAFPDRSS | 1 | Caenorhabditis elegans | F42 | CKLLKFPERST | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F42 | AELFKFPDRTT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F72 | SVHLLFSANRW | 2 | Homo sapiens, Mus musculus | F72 | ALHLLFSADRF | 1 | Caenorhabditis elegans | F72 | AIHLLFSANRW | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F72 | VIHLLFSANRW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G102 | RYAFSGVAFTG | 2 | Homo sapiens, Mus musculus | G102 | RYCYSGVAYSL | 1 | Caenorhabditis elegans | G102 | RYVYSGVAYSA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G102 | RYAFSGIAFSA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G144 | -AAKRGAFGHE | 1 | Homo sapiens | G144 | -AAQRGGFGEE | 1 | Caenorhabditis elegans | G144 | NNAEKSGFGDE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G144 | -AATRGQYGEE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G144 | -AAARGEFGLE | 1 | Mus musculus | G18 | GVDRAGKSTQS | 1 | Homo sapiens | G18 | GLDRSGKSTQA | 1 | Caenorhabditis elegans | G18 | GLDRTGKTTQC | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G18 | GLDRSGKSTQC | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G18 | GVDRAGKTTQG | 1 | Mus musculus | H148 | RGAFGHERYEN | 1 | Homo sapiens | H148 | RGGFGEERLET | 1 | Caenorhabditis elegans | H148 | KSGFGDERYET | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H148 | RGQYGEERYEK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H148 | RGEFGLERYET | 1 | Mus musculus | I184 | -ASKSIEAVHE | 1 | Homo sapiens | I184 | -ADGDLDSVEK | 1 | Caenorhabditis elegans | I184 | VTNKGIQEVEA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I184 | -ASSSLEDVHS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I184 | -ASKSIEEVHK | 1 | Mus musculus | K182 | VD-ASKSIEAV | 1 | Homo sapiens | K182 | VN-ADGDLDSV | 1 | Caenorhabditis elegans | K182 | VDVTNKGIQEV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K182 | LD-ASSSLEDV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K182 | VD-ASKSIEEV | 1 | Mus musculus | K19 | VDRAGKSTQSR | 1 | Homo sapiens | K19 | LDRSGKSTQAK | 1 | Caenorhabditis elegans | K19 | LDRTGKTTQCN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K19 | LDRSGKSTQCQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K19 | VDRAGKTTQGL | 1 | Mus musculus | L57 | LLSSYLQKKS- | 1 | Homo sapiens | L57 | LIDQYLRKEI- | 1 | Caenorhabditis elegans | L57 | LINEYLTDDSF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L57 | KIDDYLKESV- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L57 | LLNSYLEKKT- | 1 | Mus musculus | P43 | ELLRFPERSTE | 2 | Homo sapiens, Mus musculus | P43 | VLQAFPDRSSS | 1 | Caenorhabditis elegans | P43 | KLLKFPERSTR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P43 | ELFKFPDRTTA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q157 | ENGAFQERALR | 1 | Homo sapiens | Q157 | ETATIQQKVAA | 1 | Caenorhabditis elegans | Q157 | ETVKFQEKVKQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q157 | EKIEMQEKVLK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q157 | ETGTFQKQVLL | 1 | Mus musculus | R143 | D-AAKRGAFGH | 1 | Homo sapiens | R143 | V-AAQRGGFGE | 1 | Caenorhabditis elegans | R143 | DNNAEKSGFGD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R143 | I-AATRGQYGE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R143 | D-AAARGEFGL | 1 | Mus musculus | R150 | AFGHERYENGA | 1 | Homo sapiens | R150 | GFGEERLETAT | 1 | Caenorhabditis elegans | R150 | GFGDERYETVK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R150 | QYGEERYEKIE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R150 | EFGLERYETGT | 1 | Mus musculus | R16 | LEGVDRAGKST | 1 | Homo sapiens | R16 | FEGLDRSGKST | 1 | Caenorhabditis elegans | R16 | IEGLDRTGKTT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R16 | IEGLDRSGKST | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R16 | LEGVDRAGKTT | 1 | Mus musculus | R45 | LRFPERSTEIG | 2 | Homo sapiens, Mus musculus | R45 | QAFPDRSSSIG | 1 | Caenorhabditis elegans | R45 | LKFPERSTRIG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R45 | FKFPDRTTAIG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R76 | LFSANRWEQVP | 2 | Homo sapiens, Mus musculus | R76 | LFSADRFSKNQ | 1 | Caenorhabditis elegans | R76 | LFSANRWEIVD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R76 | LFSANRWETIQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R97 | TLVVDRYAFSG | 1 | Homo sapiens | R97 | DVICDRYCYSG | 1 | Caenorhabditis elegans | R97 | NIVMDRYVYSG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R97 | TCILDRYAFSG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R97 | TLVLDRYAFSG | 1 | Mus musculus | S101 | DRYAFSGVAFT | 2 | Homo sapiens, Mus musculus | S101 | DRYCYSGVAYS | 1 | Caenorhabditis elegans | S101 | DRYVYSGVAYS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S101 | DRYAFSGIAFS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S183 | D-ASKSIEAVH | 1 | Homo sapiens | S183 | N-ADGDLDSVE | 1 | Caenorhabditis elegans | S183 | DVTNKGIQEVE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S183 | D-ASSSLEDVH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S183 | D-ASKSIEEVH | 1 | Mus musculus | S20 | DRAGKSTQSRK | 1 | Homo sapiens | S20 | DRSGKSTQAKR | 1 | Caenorhabditis elegans | S20 | DRTGKTTQCNI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S20 | DRSGKSTQCQL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S20 | DRAGKTTQGLK | 1 | Mus musculus | T21 | RAGKSTQSRKL | 1 | Homo sapiens | T21 | RSGKSTQAKRL | 1 | Caenorhabditis elegans | T21 | RTGKTTQCNIL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T21 | RSGKSTQCQLL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T21 | RAGKTTQGLKL | 1 | Mus musculus | Y151 | FGHERYENGAF | 1 | Homo sapiens | Y151 | FGEERLETATI | 1 | Caenorhabditis elegans | Y151 | FGDERYETVKF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y151 | YGEERYEKIEM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y151 | FGLERYETGTF | 1 | Mus musculus |
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