mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DTYMK
Gene summary
Basic gene Info.Gene symbolDTYMK
Gene namedeoxythymidylate kinase (thymidylate kinase)
SynonymsCDC8|PP3731|TMPK|TYMK
CytomapUCSC genome browser: 2q37.3
Type of geneprotein-coding
RefGenesNM_001165031.1,
NM_012145.3,NR_033255.1,
DescriptiondTMP kinasethymidylate kinase
Modification date20141207
dbXrefs MIM : 188345
HGNC : HGNC
Ensembl : ENSG00000168393
HPRD : 01773
Vega : OTTHUMG00000133409
ProteinUniProt: P23919
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DTYMK
BioGPS: 1841
PathwayNCI Pathway Interaction Database: DTYMK
KEGG: DTYMK
REACTOME: DTYMK
Pathway Commons: DTYMK
ContextiHOP: DTYMK
ligand binding site mutation search in PubMed: DTYMK
UCL Cancer Institute: DTYMK
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0046939nucleotide phosphorylation8845311


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Ligand binding site mutations for DTYMK

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R143R143LLUAD1
H148H148NTHCA1
R150R150HUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for DTYMK
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R143R143L0.36612139
R150R150H-1.7241738
H148H148N-0.23225454
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DTYMK from PDB

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Differential gene expression and gene-gene network for DTYMK
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DTYMK and the right PPI network was created from samples without mutations in the LBS of DTYMK. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for DTYMK
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for DTYMK
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB01643Thymidine-5'-PhosphateSmall molecule
ExperimentalDB031502',3'-Dideoxythymidine-5'-MonophosphateSmall molecule
ExperimentalDB03195Phosphoric Acid Mono-[3-Fluoro-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahyro-Furan-2-Ylmethyl] EsterSmall molecule
ExperimentalDB03233Phosphoric Acid Mono-[3-Amino-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahydro-Furan-2-Ylmethyl] EsterSmall molecule
ExperimentalDB03280P1-(5'-Adenosyl)P5-(5'-Thymidyl)PentaphosphateSmall molecule
ExperimentalDB036663'-Azido-3'-Deoxythymidine-5'-MonophosphateSmall molecule
ExperimentalDB03845P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))PentaphosphateSmall molecule
ExperimentalDB04395Phosphoaminophosphonic Acid-Adenylate EsterSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DTYMK go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
TAEN1-[(E)-4-DIHYDROXYPHOSPHONYL-BUT-2-ENYL]-THYMINE2xx3AH148 R150
ADPADP1e2dAR143
ADPADP1e2eAR143
ANPAMP-PNP1e2fAR143
ADPADP1e2fAR143
ADPADP1e2gAR143
ATPATP1e2qAR143
ADPADP1e98AR143
ADPADP1e99AR143
Z5AP1-(5'-ADENOSYL)P5-(5'-(3'AZIDO-3'-DEOXYTHYMIDYL))PENTAPHOSPHATE1e9aAR143
ADPADP1e9bAR143
ANPAMP-PNP1e9bAR143
ADPADP1e9cAR143
ANPAMP-PNP1e9cAR143
ADPADP1e9dAR143
ADPADP1e9eAR143
ADPADP1e9fAR143
ADPADP1nmxAR143
ADPADP1nmyAR143
ANPAMP-PNP1nmyAR143
ANPAMP-PNP1nmzAR143
ADPADP1nn0AR143
ANPAMP-PNP1nn1AR143
ADPADP1nn3AR143
ANPAMP-PNP1nn5AR143
ADPADP2xx3AR143


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Conservation information for LBS of DTYMK
Multiple alignments for P23919 in multiple species
LBSAA sequence# speciesSpecies
A145AAKRGAFGHER1Homo sapiens
A145AAQRGGFGEER1Caenorhabditis elegans
A145NAEKSGFGDER1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A145AATRGQYGEER1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A145AAARGEFGLER1Mus musculus
A17EGLDRSGKSTQ2Caenorhabditis elegans, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A17EGVDRAGKSTQ1Homo sapiens
A17EGLDRTGKTTQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A17EGVDRAGKTTQ1Mus musculus
D15VLEGVDRAGKS1Homo sapiens
D15VFEGLDRSGKS1Caenorhabditis elegans
D15LIEGLDRTGKT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D15VIEGLDRSGKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D15VLEGVDRAGKT1Mus musculus
F105FSGVAFTGAK-2Homo sapiens, Mus musculus
F105YSGVAYSLAK-1Caenorhabditis elegans
F105YSGVAYSAAKG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F105FSGIAFSAAK-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F42AELLRFPERST2Homo sapiens, Mus musculus
F42AVLQAFPDRSS1Caenorhabditis elegans
F42CKLLKFPERST1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F42AELFKFPDRTT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F72SVHLLFSANRW2Homo sapiens, Mus musculus
F72ALHLLFSADRF1Caenorhabditis elegans
F72AIHLLFSANRW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F72VIHLLFSANRW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G102RYAFSGVAFTG2Homo sapiens, Mus musculus
G102RYCYSGVAYSL1Caenorhabditis elegans
G102RYVYSGVAYSA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G102RYAFSGIAFSA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G144-AAKRGAFGHE1Homo sapiens
G144-AAQRGGFGEE1Caenorhabditis elegans
G144NNAEKSGFGDE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G144-AATRGQYGEE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G144-AAARGEFGLE1Mus musculus
G18GVDRAGKSTQS1Homo sapiens
G18GLDRSGKSTQA1Caenorhabditis elegans
G18GLDRTGKTTQC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G18GLDRSGKSTQC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G18GVDRAGKTTQG1Mus musculus
H148RGAFGHERYEN1Homo sapiens
H148RGGFGEERLET1Caenorhabditis elegans
H148KSGFGDERYET1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H148RGQYGEERYEK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H148RGEFGLERYET1Mus musculus
I184-ASKSIEAVHE1Homo sapiens
I184-ADGDLDSVEK1Caenorhabditis elegans
I184VTNKGIQEVEA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I184-ASSSLEDVHS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I184-ASKSIEEVHK1Mus musculus
K182VD-ASKSIEAV1Homo sapiens
K182VN-ADGDLDSV1Caenorhabditis elegans
K182VDVTNKGIQEV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K182LD-ASSSLEDV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K182VD-ASKSIEEV1Mus musculus
K19VDRAGKSTQSR1Homo sapiens
K19LDRSGKSTQAK1Caenorhabditis elegans
K19LDRTGKTTQCN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K19LDRSGKSTQCQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K19VDRAGKTTQGL1Mus musculus
L57LLSSYLQKKS-1Homo sapiens
L57LIDQYLRKEI-1Caenorhabditis elegans
L57LINEYLTDDSF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L57KIDDYLKESV-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L57LLNSYLEKKT-1Mus musculus
P43ELLRFPERSTE2Homo sapiens, Mus musculus
P43VLQAFPDRSSS1Caenorhabditis elegans
P43KLLKFPERSTR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P43ELFKFPDRTTA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q157ENGAFQERALR1Homo sapiens
Q157ETATIQQKVAA1Caenorhabditis elegans
Q157ETVKFQEKVKQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q157EKIEMQEKVLK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q157ETGTFQKQVLL1Mus musculus
R143D-AAKRGAFGH1Homo sapiens
R143V-AAQRGGFGE1Caenorhabditis elegans
R143DNNAEKSGFGD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R143I-AATRGQYGE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R143D-AAARGEFGL1Mus musculus
R150AFGHERYENGA1Homo sapiens
R150GFGEERLETAT1Caenorhabditis elegans
R150GFGDERYETVK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R150QYGEERYEKIE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R150EFGLERYETGT1Mus musculus
R16LEGVDRAGKST1Homo sapiens
R16FEGLDRSGKST1Caenorhabditis elegans
R16IEGLDRTGKTT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R16IEGLDRSGKST1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R16LEGVDRAGKTT1Mus musculus
R45LRFPERSTEIG2Homo sapiens, Mus musculus
R45QAFPDRSSSIG1Caenorhabditis elegans
R45LKFPERSTRIG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R45FKFPDRTTAIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R76LFSANRWEQVP2Homo sapiens, Mus musculus
R76LFSADRFSKNQ1Caenorhabditis elegans
R76LFSANRWEIVD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R76LFSANRWETIQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R97TLVVDRYAFSG1Homo sapiens
R97DVICDRYCYSG1Caenorhabditis elegans
R97NIVMDRYVYSG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R97TCILDRYAFSG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R97TLVLDRYAFSG1Mus musculus
S101DRYAFSGVAFT2Homo sapiens, Mus musculus
S101DRYCYSGVAYS1Caenorhabditis elegans
S101DRYVYSGVAYS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S101DRYAFSGIAFS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S183D-ASKSIEAVH1Homo sapiens
S183N-ADGDLDSVE1Caenorhabditis elegans
S183DVTNKGIQEVE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S183D-ASSSLEDVH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S183D-ASKSIEEVH1Mus musculus
S20DRAGKSTQSRK1Homo sapiens
S20DRSGKSTQAKR1Caenorhabditis elegans
S20DRTGKTTQCNI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S20DRSGKSTQCQL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S20DRAGKTTQGLK1Mus musculus
T21RAGKSTQSRKL1Homo sapiens
T21RSGKSTQAKRL1Caenorhabditis elegans
T21RTGKTTQCNIL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T21RSGKSTQCQLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T21RAGKTTQGLKL1Mus musculus
Y151FGHERYENGAF1Homo sapiens
Y151FGEERLETATI1Caenorhabditis elegans
Y151FGDERYETVKF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y151YGEERYEKIEM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y151FGLERYETGTF1Mus musculus


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