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mutLBSgeneDB |
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| Gene summary for LPAR1 |
 Gene summary |
| Basic gene Info. | Gene symbol | LPAR1 |
| Gene name | lysophosphatidic acid receptor 1 | |
| Synonyms | EDG2|GPR26|Gpcr26|LPA1|Mrec1.3|VZG1|edg-2|rec.1.3|vzg-1 | |
| Cytomap | UCSC genome browser: 9q31.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001401.3, NM_057159.2, | |
| Description | LPA receptor 1LPA-1endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2lysophosphatidic acid receptor Edg-2ventricular zone gene 1 | |
| Modification date | 20141209 | |
| dbXrefs | MIM : 602282 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000198121 | ||
| HPRD : 03790 | ||
| Vega : OTTHUMG00000020486 | ||
| Protein | UniProt: Q92633 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LPAR1 | |
| BioGPS: 1902 | ||
| Pathway | NCI Pathway Interaction Database: LPAR1 | |
| KEGG: LPAR1 | ||
| REACTOME: LPAR1 | ||
| Pathway Commons: LPAR1 | ||
| Context | iHOP: LPAR1 | |
| ligand binding site mutation search in PubMed: LPAR1 | ||
| UCL Cancer Institute: LPAR1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for LPAR1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | S183 | V184M | COAD | 1 | L207 | Y206H | COAD | 1 | R124 | R124H | COAD | 1 | E293 | E293D | COAD | 1 | G179 | V177I | GBM | 1 | M198 | M198T | HNSC | 1 | T113 | T113A | LUAD | 1 | M198 | N197S | SKCM | 1 | L297 | L299I | SKCM | 1 | R124 | R124C | SKCM | 1 | S183 | G185A | STAD | 1 | Y34 | R36Q | UCEC | 1 | T113 | N112S | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for LPAR1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | L207 | Y206H | -1.2914453 | Y34 | R36Q | -1.0321587 | E293 | E293D | -1.0244833 | S183 | G185A | -1.0240518 | R124 | R124H | -0.93577838 | M198 | M198T | -0.90179389 | M198 | N197S | -0.74993138 | T113 | T113A | -0.66806329 | L297 | L299I | -0.65884026 | G179 | V177I | -0.65866147 | R124 | R124C | -0.61677292 | S183 | V184M | -0.44642227 | T113 | N112S | -0.16160217 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for LPAR1 from PDB |
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| Differential gene expression and gene-gene network for LPAR1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for LPAR1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1458155 | Breast Neoplasms | 3 | AlteredExpression, Biomarker |
| umls:C0033578 | Prostatic Neoplasms | 3 | AlteredExpression, Biomarker |
| umls:C0376634 | Craniofacial Abnormalities | 1 | Biomarker |
| umls:C0015927 | Fetal Death | 1 | Biomarker |
| umls:C0018273 | Growth Disorders | 1 | Biomarker |
| umls:C0023467 | Leukemia, Myeloid, Acute | 1 | Biomarker |
| umls:C0553757 | Olfaction Disorders | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for LPAR1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of LPAR1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 1WV | (2S)-2,3-DIHYDROXYPROPYL (7Z)-TETRADEC-7-ENOATE | 4z34 | A | G179 | 1WV | (2S)-2,3-DIHYDROXYPROPYL (7Z)-TETRADEC-7-ENOATE | 4z35 | A | G179 S183 | 1WV | (2S)-2,3-DIHYDROXYPROPYL (7Z)-TETRADEC-7-ENOATE | 4z36 | A | G179 S183 | ON3 | ONO-3080573 | 1-(4-{[(2S,3R)-2-(2,3-DIHYDRO-1H-INDEN-2-YLOXY)-3-(3,5- DIMETHOXY-4-METHYLPHENYL)-3-HYDROXYPROPYL]OXY}PHENYL) CYCLOPROPANECARBOXYLIC ACID | 4z36 | A | M198 L207 E293 L297 | ON7 | ONO9780307 | {1-[(2S,3S)-2-(2,3-DIHYDRO-1H-INDEN-2-YLMETHYL)-3-(3,5- DIMETHOXY-4-METHYLPHENYL)-3-HYDROXYPROPYL]-4- (METHOXYCARBONYL)-1H-PYRROL-3-YL}ACETIC ACID | 4z34 | A | T113 M198 L207 E293 L297 | ON9 | ONO-9910539 | 3-{1-[(2S,3S)-3-(4-ACETYL-3,5-DIMETHOXYPHENYL)-2-(2,3- DIHYDRO-1H-INDEN-2-YLMETHYL)-3-HYDROXYPROPYL]-4- (METHOXYCARBONYL)-1H-PYRROL-3-YL}PROPANOIC ACID | 4z35 | A | Y34 T113 R124 M198 L207 E293 L297 |
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| Conservation information for LBS of LPAR1 |
| Multiple alignments for Q92633 in multiple species |
| LBS | AA sequence | # species | Species | D129 | RQGLIDTSLTA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D129 | RQGLIDTSLTV | 1 | Bos taurus | E293 | DVLAYEKFFLL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F296 | AYEKFFLLLAE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F97 | AAADFFAGLAY | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G179 | MAIVMGAIPSV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G274 | ICWTPGLVLLL | 2 | Homo sapiens, Bos taurus | G274 | VCWTPGLVLLL | 2 | Mus musculus, Rattus norvegicus | H40 | NRSGKYLATEW | 3 | Bos taurus, Mus musculus, Rattus norvegicus | H40 | NRSGKHLATEW | 1 | Homo sapiens | I128 | LRQGLIDTSLT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K294 | VLAYEKFFLLL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K39 | YNRSGKYLATE | 3 | Bos taurus, Mus musculus, Rattus norvegicus | K39 | YNRSGKHLATE | 1 | Homo sapiens | L122 | TVSTWLLRQGL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L123 | VSTWLLRQGLI | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L132 | LIDTSLTASVA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L132 | LIDTSLTVSVA | 1 | Bos taurus | L207 | YSDSYLVFWAI | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L277 | TPGLVLLLLDV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L278 | PGLVLLLLDVC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L297 | YEKFFLLLAEF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | M106 | AYFYLMFNTGP | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | M198 | ENCSNMAPLYS | 2 | Homo sapiens, Bos taurus | M198 | DHCSNMAPLYS | 2 | Mus musculus, Rattus norvegicus | Q125 | TWLLRQGLIDT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R124 | STWLLRQGLID | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S183 | MGAIPSVGWNC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T109 | YLMFNTGPNTR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T113 | NTGPNTRRLTV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T130 | QGLIDTSLTAS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T130 | QGLIDTSLTVS | 1 | Bos taurus | V52 | TVSKLVMGLGI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V52 | TVTKLVMGLGI | 1 | Bos taurus | W210 | SYLVFWAIFNL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | W271 | AFIICWTPGLV | 2 | Homo sapiens, Bos taurus | W271 | AFIVCWTPGLV | 2 | Mus musculus, Rattus norvegicus | Y34 | SIAFFYNRSGK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus |
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