mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for EGFR
Gene summary
Basic gene Info.Gene symbolEGFR
Gene nameepidermal growth factor receptor
SynonymsERBB|ERBB1|HER1|NISBD2|PIG61|mENA
CytomapUCSC genome browser: 7p12
Type of geneprotein-coding
RefGenesNM_005228.3,
NM_201282.1,NM_201283.1,NM_201284.1,
Descriptionavian erythroblastic leukemia viral (v-erb-b) oncogene homologcell growth inhibiting protein 40cell proliferation-inducing protein 61erb-b2 receptor tyrosine kinase 1proto-oncogene c-ErbB-1receptor tyrosine-protein kinase erbB-1
Modification date20141221
dbXrefs MIM : 131550
HGNC : HGNC
Ensembl : ENSG00000146648
HPRD : 00579
Vega : OTTHUMG00000023661
ProteinUniProt: P00533
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_EGFR
BioGPS: 1956
PathwayNCI Pathway Interaction Database: EGFR
KEGG: EGFR
REACTOME: EGFR
Pathway Commons: EGFR
ContextiHOP: EGFR
ligand binding site mutation search in PubMed: EGFR
UCL Cancer Institute: EGFR
Assigned class in mutLBSgeneDBA: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for EGFR.1. "Doss GP, Rajith B, Chakraborty C, NagaSundaram N, Ali SK, Zhu H. Structural signature of the G719S-T790M double mutation in the EGFR kinase domain and its response to inhibitors. Sci Rep. 2014 Aug 5;4:5868. doi: 10.1038/srep05868. PubMed PMID: 25091415; PubMed Central PMCID: PMC4121614. " 25091415
2. "Ruan Z, Kannan N. Mechanistic Insights into R776H Mediated Activation of Epidermal Growth Factor Receptor Kinase. Biochemistry. 2015 Jul 14;54(27):4216-25. doi: 10.1021/acs.biochem.5b00444. Epub 2015 Jul 6. PubMed PMID: 26101090. " 26101090
3. "Valley CC, Arndt-Jovin DJ, Karedla N, Steinkamp MP, Chizhik AI, Hlavacek WS, Wilson BS, Lidke KA, Lidke DS. Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer. Mol Biol Cell. 2015 Nov 5;26(22):4087-99. doi: 10.1091/mbc.E15-05-0269. Epub 2015 Sep 2. PubMed PMID: 26337388; PubMed Central PMCID: PMC4710239. " 26337388
4. "Bao YX, Zhao XD, Deng HB, Lu CL, Guo Y, Lu X, Deng LL. Schedule-dependent cytotoxicity of sunitinib and TRAIL in human non-small cell lung cancer cells with or without EGFR and KRAS mutations. Cell Oncol (Dordr). 2016 Mar 25. [Epub ahead of print] PubMed PMID: 27016208. " 27016208

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0001934positive regulation of protein phosphorylation20551055
GO:0007165signal transduction10572067
GO:0007166cell surface receptor signaling pathway7736574
GO:0007173epidermal growth factor receptor signaling pathway12435727
GO:0008283cell proliferation17115032
GO:0008284positive regulation of cell proliferation7736574
GO:0018108peptidyl-tyrosine phosphorylation17115032
GO:0031659positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle18483258
GO:0042177negative regulation of protein catabolic process17115032
GO:0042327positive regulation of phosphorylation15082764
GO:0043406positive regulation of MAP kinase activity10572067
GO:0045429positive regulation of nitric oxide biosynthetic process12828935
GO:0045739positive regulation of DNA repair17115032
GO:0045740positive regulation of DNA replication17115032
GO:0045944positive regulation of transcription from RNA polymerase II promoter20551055
GO:0050679positive regulation of epithelial cell proliferation10572067
GO:0050999regulation of nitric-oxide synthase activity12828935
GO:0070141response to UV-A18483258
GO:0070374positive regulation of ERK1 and ERK2 cascade20551055
GO:0071392cellular response to estradiol stimulus20551055


Top
Ligand binding site mutations for EGFR
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L858L858RLUAD9
G724G724SCOAD3
G721G721SCOAD2
Y801V802ACOAD2
Q701N700DCOAD2
D837L838MKIRC2
M766,D770S768ILUAD2
P848T847KBRCA1
N115E114KBRCA1
L799,C797L798PCOAD1
N842N842HCOAD1
M766,D770S768TCOAD1
E804E804GCOAD1
I759I759TCOAD1
I809G810DCOAD1
S885E884GCOAD1
L788V786MCOAD1
N115E114KCOAD1
A722A722TCOAD1
M766,D770S768GCOAD1
C775V774ACOAD1
D800D800GCOAD1
S885E884KCOAD1
L747R748GCOAD1
S885E884QCOAD1
N808D807ECOAD1
L777L777PCOAD1
F723F723LCOAD1
H805K806RCOAD1
M766M766VCOAD1
A743V742ACOAD1
S921S921GCOAD1
Y813L814PCOAD1
S720S720YCOAD1
P848,L844K846ECOAD1
Y813L814MCOAD1
P848T847ACOAD1
K728L730FCOAD1
Q701P699HCOAD1
Y915D916VCOAD1
Y801Y801CCOAD1
Y764Y764HCOAD1
Y813Y813CCOAD1
S921S921RCOAD1
L703L703PCOAD1
K745K745RCOAD1
V726,G724T725ACOAD1
K745K745MCOAD1
K745,L747E746GCOAD1
G721G721CCOAD1
G719G719DGBM1
C775V774MGBM1
N842,L844V843LGBM1
N808D807HGBM1
H805H805RKIRC1
D837L838PKIRC1
F856F856LLUAD1
G721G721VLUAD1
D770V769LLUAD1
T790T790MLUAD1
G719G719ALUAD1
T909,W905L907MLUAD1
S921S921RLUAD1
S720S720CLUSC1
N842,L844V843LLUSC1
R841,D837A839VOV1
P772P772ROV1
L718K716ROV1
D837D837VOV1
N115E114KSKCM1
N115S116FSKCM1
P934P934SSKCM1
S921E922KSKCM1
E762D761NSTAD1
P937P937LSTAD1
I918G917AUCEC1
A743V742IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for EGFR from My Cancer Genome.
Epidermal growth factor receptor (EGFR) belongs to a family of receptor tyrosine kinases (RTKs) that include EGFR/ERBB1, HER2/ERBB2/NEU, HER3/ERBB3, and HER4/ERBB4. The binding of ligands, such as epidermal growth factor (EGF), induces a conformational change that facilitates receptor homo- or heterodimer formation, thereby resulting in activation of EGFR tyrosine kinase activity. Activated EGFR then phosphorylates its substrates, resulting in activation of multiple downstream pathways within the cell, including the PI3K-AKT-mTOR pathway, which is involved in cell survival, and the RAS-RAF-MEK-ERK pathway, which is involved in cell proliferation. Lovly, C.M., Horn, L., Pao, W. 2015. EGFR. My Cancer Genomehttps://www.mycancergenome.org/content/gene/egfr/ (Updated December 2015)

Top
Protein structure related information for EGFR
Protein structure of wild type (WT) and mutant type (MT) of EGFR
Wild type EGFR
Mutant type EGFR

Free energy of binding of drugs to wild type and mutant tpye of EGFR
Gene symbolDrug nameFree energy of binding (kcal/mol) of wild typeFree energy of binding (kcal/mol) of mutant type
EGFRErlotinib-8-6.7
EGFRGefitinib-8.9-6.8
EGFRLapatinib-11.1-8.8

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K745K745M0.44879295
K745K745R0.3368265
G721G721V0.22997981
N842N842H0.21623342
F856F856L0.16624251
G721G721C0.05669569
Q701N700D0.056237136
T909L907M-1.7565121
W905L907M-1.7565121
D800D800G-1.6700382
Y801V802A-1.5671431
L777L777P-1.5452646
K728L730F-1.5337529
I759I759T-1.4762324
E804E804G-1.4516433
L703L703P-1.4263318
M766S768G-1.4139716
D770S768G-1.4139716
Y813L814P-1.3700938
P772P772R-1.3222071
H805H805R-1.2904294
D837L838P-1.2776912
A722A722T-1.2120122
Y813L814M-1.1758884
P848T847A-1.1203861
C775V774A-1.1098842
D837L838M-1.1074628
L747R748G-1.1020953
Y801Y801C-1.0649201
M766S768T-1.0556762
D770S768T-1.0556762
S921S921G-1.0201701
P848T847K-1.0010114
P934P934S-0.942478
I809G810D-0.91480702
Y813Y813C-0.91436493
A743V742A-0.91033929
Y764Y764H-0.87852462
L858L858R-0.84709482
Q701P699H-0.82041809
G719G719D-0.78396474
K745E746G-0.74217471
L747E746G-0.74217471
N115E114K-0.70335732
M766S768I-0.7023328
D770S768I-0.7023328
S720S720C-0.70137013
L799L798P-0.70096619
C797L798P-0.70096619
I918G917A-0.68713622
E762D761N-0.68617145
N808D807H-0.65924958
G719G719A-0.65148634
H805K806R-0.64936572
S720S720Y-0.62395267
V726T725A-0.61961348
G724T725A-0.61961348
C775V774M-0.61698588
L718K716R-0.61433615
S885E884G-0.60718676
L788V786M-0.59968719
A743V742I-0.5980602
S921S921R-0.51583141
L844V843L-0.45670905
N842V843L-0.45670905
P937P937L-0.45468141
G724G724S-0.42657259
D837D837V-0.40781255
N808D807E-0.40422461
R841A839V-0.39317114
D837A839V-0.39317114
S885E884Q-0.35222293
N115S116F-0.35106673
S885E884K-0.32310215
Y915D916V-0.31619068
T790T790M-0.30281911
M766M766V-0.27288781
D770V769L-0.25946645
F723F723L-0.25836025
S921E922K-0.2115096
G721G721S-0.14506434
P848K846E-0.11988031
L844K846E-0.11988031
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for EGFR from PDB
PDB IDPDB titlePDB structure
1IVOCrystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.

Top
Differential gene expression and gene-gene network for EGFR
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types
EGFR_COAD_DE
EGFR_LUAD_DE

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of EGFR and the right PPI network was created from samples without mutations in the LBS of EGFR. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

* In COAD

* In LUAD


Top

Top
Phenotype information for EGFR
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007131Carcinoma, Non-Small-Cell Lung1400AlteredExpression, Biomarker, GeneticVariation
umls:C0001418Adenocarcinoma543AlteredExpression, Biomarker, GeneticVariation
umls:C0017636Glioblastoma356AlteredExpression, Biomarker, GeneticVariation
umls:C0152013Adenocarcinoma of lung316Biomarker
umls:C0007097Carcinoma264AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0007137Carcinoma, Squamous Cell243AlteredExpression, Biomarker, GeneticVariation
umls:C0027627Neoplasm Metastasis242AlteredExpression, Biomarker, GeneticVariation
umls:C0024121Lung Neoplasms200AlteredExpression, Biomarker, GeneticVariation
umls:C1458155Breast Neoplasms84AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C2239176Carcinoma, Hepatocellular52AlteredExpression, Biomarker, GeneticVariation
umls:C0009404Colorectal Neoplasms39AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0149925Small Cell Lung Carcinoma27Biomarker, GeneticVariation
umls:C0279626Esophageal Squamous Cell Carcinoma26Biomarker, GeneticVariation
umls:C0919267Ovarian Neoplasms25AlteredExpression, Biomarker, GeneticVariation
umls:C0033578Prostatic Neoplasms25AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0014859Esophageal Neoplasms20Biomarker, GeneticVariation
umls:C0206698Cholangiocarcinoma18AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0029463Osteosarcoma14AlteredExpression, Biomarker, GeneticVariation
umls:C0009375Colonic Neoplasms13Biomarker, GeneticVariation
umls:C0005695Urinary Bladder Neoplasms13AlteredExpression, Biomarker
umls:C0038356Stomach Neoplasms10AlteredExpression, Biomarker, Therapeutic
umls:C0014175Endometriosis9Biomarker, GeneticVariation
umls:C0034885Rectal Neoplasms8Biomarker, GeneticVariation
umls:C0027643Neoplasm Recurrence, Local8Biomarker, GeneticVariation
umls:C0018671Head and Neck Neoplasms8AlteredExpression, Biomarker, GeneticVariation
umls:C0030354Papilloma8Biomarker
umls:C0007873Uterine Cervical Neoplasms7Biomarker, GeneticVariation
umls:C0025500Mesothelioma7AlteredExpression, Biomarker, GeneticVariation
umls:C0206686Adrenocortical Carcinoma4Biomarker
umls:C0007193Cardiomyopathy, Dilated3Biomarker, GeneticVariation
umls:C0027626Neoplasm Invasiveness3Biomarker, GeneticVariation
umls:C0011860Diabetes Mellitus, Type 22Biomarker
umls:C0085548Polycystic Kidney, Autosomal Recessive2Biomarker
umls:C0024668Mammary Neoplasms, Experimental2Biomarker
umls:C0263454Chloracne1Biomarker
umls:C2609414Acute Kidney Injury1Therapeutic
umls:C0993582Arthritis, Experimental1Therapeutic
umls:C0005396Bile Duct Neoplasms1Therapeutic
umls:C0376634Craniofacial Abnormalities1Biomarker
umls:C0242656Disease Progression1Biomarker
umls:C0016978Gallbladder Neoplasms1Biomarker
umls:C0021655Insulin Resistance1Biomarker
umls:C0024667Mammary Neoplasms, Animal1Biomarker
umls:C0027439Nasopharyngeal Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs
31648L858Rdrug responseSomaticMedGen:CN225347
54392G719APathogenicSomaticMedGen:C0007131
SNOMED CT:254637007
137765V742Inot providedGermlineMedGen:CN169374

Top
Pharmacological information for EGFR
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00002CetuximabBiotech
Approved|investigationalDB00072TrastuzumabBiotech
Approved|vet_approvedDB00281LidocaineSmall molecule
Approved|investigationalDB00317GefitinibSmall molecule
Approved|investigationalDB00530ErlotinibSmall molecule
Approved|investigationalDB01259LapatinibSmall molecule
Approved|investigationalDB01269PanitumumabBiotech
Experimental|investigationalDB03496FlavopiridolSmall molecule
InvestigationalDB04988IGN311Biotech
InvestigationalDB05101MatuzumabBiotech
ApprovedDB05294VandetanibSmall molecule
InvestigationalDB05324HuMax-EGFrBiotech
InvestigationalDB05374CDX-110Small molecule
InvestigationalDB05424CI-1033Small molecule
InvestigationalDB05774IMC-11F8Small molecule
InvestigationalDB05900INSM-18Small molecule
ExperimentalDB07602S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINESmall molecule
ExperimentalDB07662N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDESmall molecule
ApprovedDB08916AfatinibSmall molecule
ApprovedDB09330OsimertinibSmall molecule
ApprovedDB09559NecitumumabBiotech

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of EGFR go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ANPAMP-PNP2itxAA722 A743 T790 N842 L844
DJKN-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE2j5fAA743 K745 E762 M766 L788 T790 C797 D800 L844
IRE3-CHLORO-4-FLUORO-N-[(4Z)-7-METHOXY-6-(3-MORPHOLIN-4-YLPROPOXY)QUINAZOLIN-4(1H)-YLIDENE]ANILINE2itoAA743 K745 E762 M766 L788 T790 D800 L844
ANPAMP-PNP3vjnAA743 K745 L844
AEE6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE2j6mAA743 T790 E804 L844
IIIPeptide ligand (THR,HIS,TYR,TYR,LEU,LEU,PRO)4r3pAD837 R841
IIIPeptide ligand (ASP,GLU,GLU,ASP,TYR,TYR,GLU,ILE,PRO)5czhAD837 R841
IIIPeptide ligand (ASP,HIS,GLN,TYR,TYR,ASN,ASP)5cziAD837 R841
IIIPeptide ligand (THR,HIS,TYR,TYR,LEU,LEU,PRO)4r3rAD837 R841 N842
ANPAMP-PNP3vjoAF723 A743 K745
W2R1-{3-[2-CHLORO-4-({5-[2-(2-HYDROXYETHOXY)ETHYL]-5H- PYRROLO[3,2-D]PYRIMIDIN-4-YL}AMINO)PHENOXY]PHENYL}-3- CYCLOHEXYLUREA3w2rAF723 V726 A743 K745 L747 M766 C775 L788 R841 N842 L844 F856
W2R1-{3-[2-CHLORO-4-({5-[2-(2-HYDROXYETHOXY)ETHYL]-5H- PYRROLO[3,2-D]PYRIMIDIN-4-YL}AMINO)PHENOXY]PHENYL}-3- CYCLOHEXYLUREA3w2sAF723 V726 A743 K745 M766 L788 T790 R841 L844 F856
YUNN-{4-[(3-BROMOPHENYL)AMINO]QUINAZOLIN-6-YL}PROPANAMIDE4lrmDG719 A743 K745
03PTAK-2853w2oAG719 S720 G721 V726 A743 K745 I759 E762 M766 L788
W194-{[4-(1-BENZOTHIOPHEN-4-YLOXY)-3-CHLOROPHENYL]AMINO}- N-(2-HYDROXYETHYL)-8,9-DIHYDRO-7H-PYRIMIDO[4,5- B]AZEPINE-6-CARBOXAMIDE3w33AG719 V726 A743 K745 C775 L777 L788 T790 L844 F856 L858
0WNAFATINIB, BOUND FORMN-{4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-7-[(3S)- TETRAHYDROFURAN-3-YLOXY]QUINAZOLIN-6-YL}-4- (DIMETHYLAMINO)BUTANAMIDE4g5jAK728 A743 K745 E762 M766 L788 T790 C797 D800 L844
5Q44-[(2-METHOXYPHENYL)AMINO]-~{N}-[4-(4-METHYLPIPERAZIN- 1-YL)PHENYL]-2-OXIDANYLIDENE-1~{H}-PYRIDINE-3- CARBOXAMIDE5em7AL718 A743 E804 R841 N842 L844
YUNN-{4-[(3-BROMOPHENYL)AMINO]QUINAZOLIN-6-YL}PROPANAMIDE4lrmEL718 A743 K745
0WNAFATINIB, BOUND FORMN-{4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-7-[(3S)- TETRAHYDROFURAN-3-YLOXY]QUINAZOLIN-6-YL}-4- (DIMETHYLAMINO)BUTANAMIDE4g5pAL718 A743 K745 C797 D800 L844
DJKN-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE4lqmAL718 A743 K745 E762 L788 T790 C797 D800 L844
4ZJN-[2-[(3R,4S)-3-FLUORANYL-4-METHOXY-PIPERIDIN-1- YL]PYRIMIDIN-4-YL]-2-METHYL-1-PROPAN-2-YL-IMIDAZO[4,5- C]PYRIDIN-6-AMINE5caqAL718 A743 K745 E762 M766 C775 L844
5Q34-[(2-AZANYLPYRIMIDIN-4-YL)AMINO]-~{N}-[4-(4- METHYLPIPERAZIN-1-YL)PHENYL]-2-OXIDANYLIDENE-1~{H}- PYRIDINE-3-CARBOXAMIDE5em6AL718 A743 K745 E762 M766 C775 L844
FI3N-[4-({[(2,6-DICHLORO-3,5-DIMETHOXYPHENYL)CARBAMOYL](6- {[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}PYRIMIDIN-4- YL)AMINO}METHYL)PHENYL]PROPANAMIDE4r5sAL718 A743 K745 E762 M766 L788 T790 C797 D800
IRE3-CHLORO-4-FLUORO-N-[(4Z)-7-METHOXY-6-(3-MORPHOLIN-4-YLPROPOXY)QUINAZOLIN-4(1H)-YLIDENE]ANILINE4wkqAL718 A743 K745 E762 M766 L788 T790 C797 D800 L844
IRE3-CHLORO-4-FLUORO-N-[(4Z)-7-METHOXY-6-(3-MORPHOLIN-4-YLPROPOXY)QUINAZOLIN-4(1H)-YLIDENE]ANILINE2itzAL718 A743 K745 E762 M766 L788 T790 D800 L844
HKINERATINIB (HKI-272), BOUND FORMN-(4-{[3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)PHENYL]AMINO}-3- CYANO-7-ETHOXYQUINOLIN-6-YL)-4-(DIMETHYLAMINO) BUTANAMIDE3w2qAL718 A743 K745 I759 E762 M766 L788 C797 D800 R841 L844
1C9DACOMITINIB(2E)-N-{4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-7- METHOXYQUINAZOLIN-6-YL}-4-(PIPERIDIN-1-YL)BUT-2- ENAMIDE4i24AL718 A743 K745 L788 C797 D800 L844
1C9DACOMITINIB(2E)-N-{4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-7- METHOXYQUINAZOLIN-6-YL}-4-(PIPERIDIN-1-YL)BUT-2- ENAMIDE4i24BL718 A743 K745 L788 C797 D800 L844
FMMLAPATINIB1xkkAL718 A743 K745 M766 C775 L777 L788 T790 C797 L799 D800 L844 F856 L858
4ZB(3R)-3-METHYL-1-(4-{[2-METHYL-1-(PROPAN-2-YL)-1H- IMIDAZO[4,5-C]PYRIDIN-6-YL]AMINO}PYRIMIDIN-2-YL) PYRROLIDINE-3-CARBOXAMIDE5canAL718 A743 K745 M766 C775 N842 L844
1C9DACOMITINIB(2E)-N-{4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-7- METHOXYQUINAZOLIN-6-YL}-4-(PIPERIDIN-1-YL)BUT-2- ENAMIDE4i23AL718 A743 K745 M766 L788 T790
AEE6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE2itpAL718 A743 K745 M766 L788 T790 E804 L844
AEE6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE2ittAL718 A743 K745 M766 L788 T790 E804 L844
ANPAMP-PNP2itnAL718 A743 K745 T790 C797 L844
ANPAMP-PNP2itvAL718 A743 K745 T790 C797 N842 L844
STUSTAUROSPORINE2itqAL718 A743 K745 T790 C797 R841 N842 L844
5Q44-[(2-METHOXYPHENYL)AMINO]-~{N}-[4-(4-METHYLPIPERAZIN- 1-YL)PHENYL]-2-OXIDANYLIDENE-1~{H}-PYRIDINE-3- CARBOXAMIDE5em8AL718 A743 T790 E804 N842 L844
4ZGN~2~-[2-METHYL-2-(METHYLSULFONYL)PROPYL]-N~4~-[2- METHYL-1-(PROPAN-2-YL)-1H-IMIDAZO[4,5-C]PYRIDIN-6- YL]PYRIMIDINE-2,4-DIAMINE5caoAL718 F723 A743 K745 M766 C775 L844
4YW2-METHYL-N-{2-[4-(METHYLSULFONYL)PIPERIDIN-1- YL]PYRIMIDIN-4-YL}-1-(PROPAN-2-YL)-1H-IMIDAZO[4,5- C]PYRIDIN-6-AMINE5c8mAL718 F723 V726 A743 K745 C775 L844
4Z82,2-DIMETHYL-3-[(4-{[2-METHYL-1-(PROPAN-2-YL)-1H- IMIDAZO[4,5-C]PYRIDIN-6-YL]AMINO}PYRIMIDIN-2-YL) AMINO]PROPANAMIDE5calAL718 F723 V726 A743 K745 C775 N842 L844
4ZH2-METHYL-N-[2-(2-METHYL-2-METHYLSULFONYL-PROPOXY) PYRIMIDIN-4-YL]-1-PROPAN-2-YL-IMIDAZO[4,5-C]PYRIDIN-6- AMINE5capAL718 F723 V726 A743 K745 E762 C775 L844
3QWN-[2-(4-METHOXYPIPERIDIN-1-YL)PYRIMIDIN-4-YL]-1- (PROPAN-2-YL)-2-(1H-PYRAZOL-4-YL)-1H-PYRROLO[3,2- C]PYRIDIN-6-AMINE4rj4AL718 F723 V726 A743 K745 M766 C775 L844
4YXN-{2-[4-(2-AMINOETHYL)-4-METHOXYPIPERIDIN-1- YL]PYRIMIDIN-4-YL}-2-METHYL-1-(PROPAN-2-YL)-1H- IMIDAZO[4,5-C]PYRIDIN-6-AMINE5c8nAL718 F723 V726 A743 K745 M766 C775 L844
STUSTAUROSPORINE2ituAL718 G719 A743 K745 C797 D800 L844
3QYN-[2-(4-METHOXYPIPERIDIN-1-YL)PYRIMIDIN-4-YL]-2-(1H- PYRAZOL-4-YL)-1H-PYRROLO[3,2-C]PYRIDIN-6-AMINE4rj5AL718 G719 A743 K745 E762 L844
IRE3-CHLORO-4-FLUORO-N-[(4Z)-7-METHOXY-6-(3-MORPHOLIN-4-YLPROPOXY)QUINAZOLIN-4(1H)-YLIDENE]ANILINE2ityAL718 G719 A743 K745 E762 M766 L788 T790 L844
HYZN-[1-(3-FLUOROBENZYL)-1H-INDAZOL-5-YL]-5-[(PIPERIDIN-1-YLAMINO)METHYL]PYRIMIDINE-4,6-DIAMINE2rgpAL718 G719 A743 K745 M766 C775 L777 L788 T790 D800 L844 F856
4ZQ(1R)-1-{6-({2-[(3R,4S)-3-FLUORO-4-METHOXYPIPERIDIN-1- YL]PYRIMIDIN-4-YL}AMINO)-1-[(2S)-1,1,1- TRIFLUOROPROPAN-2-YL]-1H-IMIDAZO[4,5-C]PYRIDIN-2- YL}ETHANOL5cavAL718 G719 F723 V726 A743 K745 E762 C775 T790 L844
5N3~{N}-(7-CHLORANYL-1~{H}-INDAZOL-3-YL)-7,7-DIMETHYL-2- (1~{H}-PYRAZOL-4-YL)-5~{H}-FURO[3,4-D]PYRIMIDIN-4- AMINE5edqAL718 G719 F723 V726 A743 K745 E762 M766 L777 L788 L844
3R12,6-DICHLORO-N-{2-[(2-{[(2S)-1-HYDROXYPROPAN-2- YL]AMINO}-6-METHYLPYRIMIDIN-4-YL)AMINO]PYRIDIN-4- YL}BENZAMIDE4rj7AL718 G719 F723 V726 A743 K745 R841 N842 L844
1WYN-(3-{[5-CHLORO-4-(1H-INDOL-3-YL)PYRIMIDIN-2-YL]AMINO}- 4-METHOXYPHENYL)PROPANAMIDE4li5AL718 G719 F723 V726 A743 T790 C797 D800 L844
3R0N-[2-(4-METHOXYPIPERIDIN-1-YL)PYRIMIDIN-4-YL]-2-(1H- PYRAZOL-4-YL)-3H-IMIDAZO[4,5-C]PYRIDIN-6-AMINE4rj6AL718 G719 S720 A743 K745 E762 L844
STUSTAUROSPORINE2itwAL718 G719 S720 F723 V726 A743 K745 L844
YY3N-(2-{[2-(DIMETHYLAMINO)ETHYL](METHYL)AMINO}-4-METHOXY- 5-{[4-(1-METHYL-1H-INDOL-3-YL)PYRIMIDIN-2- YL]AMINO}PHENYL)PROP-2-ENAMIDE4zauAL718 G719 V726 A743 C797
0UNWZ40023ikaAL718 G719 V726 A743 C797 D800 R841 L844
3QS1-CYCLOPENTYL-N-[2-(4-METHOXYPIPERIDIN-1-YL)PYRIMIDIN- 4-YL]-1H-PYRROLO[3,2-C]PYRIDIN-6-AMINE4rj8AL718 G719 V726 A743 K745 E762 C775 L844
4YV1-CYCLOPENTYL-N-[2-(4-METHOXYPIPERIDIN-1-YL)PYRIMIDIN- 4-YL]-1H-IMIDAZO[4,5-C]PYRIDIN-6-AMINE5c8kAL718 G719 V726 A743 K745 E762 M766 C775 L844
4ZQ(1R)-1-{6-({2-[(3R,4S)-3-FLUORO-4-METHOXYPIPERIDIN-1- YL]PYRIMIDIN-4-YL}AMINO)-1-[(2S)-1,1,1- TRIFLUOROPROPAN-2-YL]-1H-IMIDAZO[4,5-C]PYRIDIN-2- YL}ETHANOL5casAL718 G719 V726 A743 K745 E762 M766 C775 L844
4ZR(1R)-1-{6-({2-[(3S,4R)-3-FLUORO-4-METHOXYPIPERIDIN-1- YL]PYRIMIDIN-4-YL}AMINO)-1-[(2S)-1,1,1- TRIFLUOROPROPAN-2-YL]-1H-IMIDAZO[4,5-C]PYRIDIN-2- YL}ETHANOL5cauAL718 G719 V726 A743 K745 E762 M766 C775 L844
YUNN-{4-[(3-BROMOPHENYL)AMINO]QUINAZOLIN-6-YL}PROPANAMIDE4ll0BL718 V726 A743 C797 D800 L844
YUNN-{4-[(3-BROMOPHENYL)AMINO]QUINAZOLIN-6-YL}PROPANAMIDE4lrmAL718 V726 A743 K745
5N4~{N}-(1~{H}-INDAZOL-3-YL)-7,7-DIMETHYL-2-(2- METHYLPYRAZOL-3-YL)-5~{H}-FURO[3,4-D]PYRIMIDIN-4-AMINE5edrAL718 V726 A743 K745 E762 M766 L788 L844
W2PN-{2-[4-({3-CHLORO-4-[3-(TRIFLUOROMETHYL) PHENOXY]PHENYL}AMINO)-5H-PYRROLO[3,2-D]PYRIMIDIN-5- YL]ETHYL}-4-(DIMETHYLAMINO)BUTANAMIDE3w2pAL718 V726 A743 K745 I759 E762 M766 L788 C797 D800 R841 L844
AEE6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE2jiuAL718 V726 A743 K745 L788 D800 E804 L844
IRE3-CHLORO-4-FLUORO-N-[(4Z)-7-METHOXY-6-(3-MORPHOLIN-4-YLPROPOXY)QUINAZOLIN-4(1H)-YLIDENE]ANILINE3ug2AL718 V726 A743 K745 L788 D800 L844
IRE3-CHLORO-4-FLUORO-N-[(4Z)-7-METHOXY-6-(3-MORPHOLIN-4-YLPROPOXY)QUINAZOLIN-4(1H)-YLIDENE]ANILINE4i22AL718 V726 A743 K745 L788 D800 L844
5Q24-[2-(4-CHLOROPHENYL)ETHYLAMINO]-~{N}-[4-(4- METHYLPIPERAZIN-1-YL)PHENYL]-2-OXIDANYLIDENE-1~{H}- PYRIDINE-3-CARBOXAMIDE5em5AL718 V726 A743 K745 L788 L844
ANPAMP-PNP2eb3AL718 V726 A743 K745 L844
POX4-AMINO-6-{[1-(3-FLUOROBENZYL)-1H-INDAZOL-5-YL]AMINO}PYRIMIDINE-5-CARBALDEHYDE O-(2-METHOXYETHYL)OXIME3belAL718 V726 A743 K745 M766 C775 L777 L788 T790 D800 L844 F856 L858
YUNN-{4-[(3-BROMOPHENYL)AMINO]QUINAZOLIN-6-YL}PROPANAMIDE4ll0AL718 V726 A743 L788 C797 D800 L844
0WMAFATINIB(2E)-N-{4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-7-[(3S)- TETRAHYDROFURAN-3-YLOXY]QUINAZOLIN-6-YL}-4- (DIMETHYLAMINO)BUT-2-ENAMIDE4g5jAN808
IIIPeptide ligand (LYS,VAL,CYS,SER,THR,HIS,TYR,TYR,LEU,LEU,PRO)4zjvAR841
W324-({3-CHLORO-4-[3-(TRIFLUOROMETHYL) PHENOXY]PHENYL}AMINO)-N-[2-(METHYLSULFONYL)ETHYL]-8,9- DIHYDRO-7H-PYRIMIDO[4,5-B]AZEPINE-6-CARBOXAMIDE3w32AS720 A743 K745 M766 C775 L777 L788 T790 L844 F856
IIIPeptide ligand (VAL,PRO,CYS,ILE,LEU,PRO,ILE,ILE,GLU,ASN,GLY)4zjvAS921
IIIPeptide ligand (SER,LEU,PRO,SER,TYR,LEU,ASN,GLY,VAL,MET,PRO,PRO,THR,GLN,SER,PHE,ALA,PRO,ASP,PRO,LYS,TYR,VAL,SER,SER,LYS)4i21BT909 Y915 P934 P937
YUNN-{4-[(3-BROMOPHENYL)AMINO]QUINAZOLIN-6-YL}PROPANAMIDE4lrmBV726 A743 K745
YUNN-{4-[(3-BROMOPHENYL)AMINO]QUINAZOLIN-6-YL}PROPANAMIDE4lrmCV726 A743 K745
03PTAK-2853pozAV726 A743 K745 M766 C775 L777 L788 T790 R841 L844 F856
IIIPeptide ligand (SER,LEU,PRO,SER,TYR,LEU,ASN,GLY,VAL,MET,PRO,PRO,THR,GLN,SER,PHE,ALA,PRO,ASP,PRO,LYS,TYR,VAL,SER,SER,LYS)4zjvBW905 I918 P934 P937
IIIPeptide ligand (LYS,SER,LEU,PRO,SER,TYR,LEU,ASN,GLY,VAL,MET,PRO,PRO,THR,GLN,SER,PHE,ALA,PRO,ASP,PRO,LYS,TYR,VAL,SER,SER)4zjvAW905 T909 Y915 I918 P934 P937
0WMAFATINIB(2E)-N-{4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-7-[(3S)- TETRAHYDROFURAN-3-YLOXY]QUINAZOLIN-6-YL}-4- (DIMETHYLAMINO)BUT-2-ENAMIDE4g5jAY801 H805 N808 I809 Y813 P848


Top
Conservation information for LBS of EGFR
Multiple alignments for P00533 in multiple species
LBSAA sequence# speciesSpecies
A722VLGSGAFGTVY2Homo sapiens, Mus musculus
A722-----------1Gallus gallus
A743VKIPVAIKELR2Homo sapiens, Mus musculus
A743-----------1Gallus gallus
A763EILDEAYVMAS2Homo sapiens, Mus musculus
A763-----------1Gallus gallus
A920YDGIPASEISS1Homo sapiens
A920-----------1Gallus gallus
A920YDGIPASDISS1Mus musculus
C775DNPHVCRLLGI2Homo sapiens, Mus musculus
C775-----------1Gallus gallus
C797LMPFGCLLDYV1Homo sapiens
C797-----------1Gallus gallus
C797LMPYGCLLDYV1Mus musculus
C939PQPPICTIDVY2Homo sapiens, Mus musculus
C939-----------1Gallus gallus
D1006LMDEEDMDDVV1Homo sapiens
D1006-----------1Gallus gallus
D1006LMDEEDMEDVV1Mus musculus
D347IGEFKDSLSIN1Homo sapiens
D347IGELKGILSIN1Gallus gallus
D347IGEFKDTLSIN1Mus musculus
D770VMASVDNPHVC2Homo sapiens, Mus musculus
D770-----------1Gallus gallus
D800FGCLLDYVREH1Homo sapiens
D800-----------1Gallus gallus
D800YGCLLDYVREH1Mus musculus
D837RLVHRDLAARN2Homo sapiens, Mus musculus
D837-----------1Gallus gallus
D855HVKITDFGLAK2Homo sapiens, Mus musculus
D855-----------1Gallus gallus
E762KEILDEAYVMA2Homo sapiens, Mus musculus
E762-----------1Gallus gallus
E804LDYVREHKDNI2Homo sapiens, Mus musculus
E804-----------1Gallus gallus
E928ISSILEKGERL2Homo sapiens, Mus musculus
E928-----------1Gallus gallus
E931ILEKGERLPQP2Homo sapiens, Mus musculus
E931-----------1Gallus gallus
F723LGSGAFGTVYK2Homo sapiens, Mus musculus
F723-----------1Gallus gallus
F795TQLMPFGCLLD1Homo sapiens
F795-----------1Gallus gallus
F795TQLMPYGCLLD1Mus musculus
F856VKITDFGLAKL2Homo sapiens, Mus musculus
F856-----------1Gallus gallus
F997PTDSNFYRALM2Homo sapiens, Mus musculus
F997-----------1Gallus gallus
G719KIKVLGSGAFG2Homo sapiens, Mus musculus
G719-----------1Gallus gallus
G721KVLGSGAFGTV2Homo sapiens, Mus musculus
G721-----------1Gallus gallus
G724GSGAFGTVYKG2Homo sapiens, Mus musculus
G724-----------1Gallus gallus
G796QLMPFGCLLDY1Homo sapiens
G796-----------1Gallus gallus
G796QLMPYGCLLDY1Mus musculus
G857KITDFGLAKLL2Homo sapiens, Mus musculus
G857-----------1Gallus gallus
G873EYHAEGGKVPI2Homo sapiens, Mus musculus
G873-----------1Gallus gallus
G874YHAEGGKVPIK2Homo sapiens, Mus musculus
G874-----------1Gallus gallus
G930SILEKGERLPQ2Homo sapiens, Mus musculus
G930-----------1Gallus gallus
H805DYVREHKDNIG2Homo sapiens, Mus musculus
H805-----------1Gallus gallus
H988GDERMHLPSPT2Homo sapiens, Mus musculus
H988-----------1Gallus gallus
I744KIPVAIKELRE2Homo sapiens, Mus musculus
I744-----------1Gallus gallus
I759KANKEILDEAY2Homo sapiens, Mus musculus
I759-----------1Gallus gallus
I789STVQLITQLMP2Homo sapiens, Mus musculus
I789-----------1Gallus gallus
I809EHKDNIGSQYL2Homo sapiens, Mus musculus
I809-----------1Gallus gallus
I878GGKVPIKWMAL2Homo sapiens, Mus musculus
I878-----------1Gallus gallus
I886MALESILHRIY2Homo sapiens, Mus musculus
I886-----------1Gallus gallus
I918KPYDGIPASEI1Homo sapiens
I918-----------1Gallus gallus
I918KPYDGIPASDI1Mus musculus
I926SEISSILEKGE1Homo sapiens
I926-----------1Gallus gallus
I926SDISSILEKGE1Mus musculus
I938LPQPPICTIDV2Homo sapiens, Mus musculus
I938-----------1Gallus gallus
I941PPICTIDVYMI2Homo sapiens, Mus musculus
I941-----------1Gallus gallus
I953VKCWMIDADSR2Homo sapiens, Mus musculus
I953-----------1Gallus gallus
K29ALEEKKVCQGT2Homo sapiens, Mus musculus
K29AVEEKKVCQGT1Gallus gallus
K728FGTVYKGLWIP2Homo sapiens, Mus musculus
K728-----------1Gallus gallus
K745IPVAIKELREA2Homo sapiens, Mus musculus
K745-----------1Gallus gallus
K875HAEGGKVPIKW2Homo sapiens, Mus musculus
K875-----------1Gallus gallus
K879GKVPIKWMALE2Homo sapiens, Mus musculus
K879-----------1Gallus gallus
K929SSILEKGERLP2Homo sapiens, Mus musculus
K929-----------1Gallus gallus
K949YMIMVKCWMID2Homo sapiens, Mus musculus
K949-----------1Gallus gallus
L703APNQALLRILK1Homo sapiens
L703-----------1Gallus gallus
L703APNQAHLRILK1Mus musculus
L718KKIKVLGSGAF2Homo sapiens, Mus musculus
L718-----------1Gallus gallus
L747VAIKELREATS2Homo sapiens, Mus musculus
L747-----------1Gallus gallus
L777PHVCRLLGICL2Homo sapiens, Mus musculus
L777-----------1Gallus gallus
L788TSTVQLITQLM2Homo sapiens, Mus musculus
L788-----------1Gallus gallus
L792QLITQLMPFGC1Homo sapiens
L792-----------1Gallus gallus
L792QLITQLMPYGC1Mus musculus
L799PFGCLLDYVRE1Homo sapiens
L799-----------1Gallus gallus
L799PYGCLLDYVRE1Mus musculus
L844AARNVLVKTPQ2Homo sapiens, Mus musculus
L844-----------1Gallus gallus
L858ITDFGLAKLLG2Homo sapiens, Mus musculus
L858-----------1Gallus gallus
L887ALESILHRIYT2Homo sapiens, Mus musculus
L887-----------1Gallus gallus
L927EISSILEKGER1Homo sapiens
L927-----------1Gallus gallus
L927DISSILEKGER1Mus musculus
L989DERMHLPSPTD2Homo sapiens, Mus musculus
L989-----------1Gallus gallus
M766DEAYVMASVDN2Homo sapiens, Mus musculus
M766-----------1Gallus gallus
M793LITQLMPFGCL1Homo sapiens
M793-----------1Gallus gallus
M793LITQLMPYGCL1Mus musculus
M952MVKCWMIDADS2Homo sapiens, Mus musculus
M952-----------1Gallus gallus
M987QGDERMHLPSP2Homo sapiens, Mus musculus
M987-----------1Gallus gallus
N115NMYYENSYALA1Homo sapiens
N115NVLYDNSFALA1Gallus gallus
N115NALYENTYALA1Mus musculus
N57QRMYNNCEVVL2Gallus gallus, Mus musculus
N57QRMFNNCEVVL1Homo sapiens
N808REHKDNIGSQY2Homo sapiens, Mus musculus
N808-----------1Gallus gallus
N842DLAARNVLVKT2Homo sapiens, Mus musculus
N842-----------1Gallus gallus
P772ASVDNPHVCRL2Homo sapiens, Mus musculus
P772-----------1Gallus gallus
P794ITQLMPFGCLL1Homo sapiens
P794-----------1Gallus gallus
P794ITQLMPYGCLL1Mus musculus
P848VLVKTPQHVKI2Homo sapiens, Mus musculus
P848-----------1Gallus gallus
P877EGGKVPIKWMA2Homo sapiens, Mus musculus
P877-----------1Gallus gallus
P919PYDGIPASEIS1Homo sapiens
P919-----------1Gallus gallus
P919PYDGIPASDIS1Mus musculus
P934KGERLPQPPIC2Homo sapiens, Mus musculus
P934-----------1Gallus gallus
P936ERLPQPPICTI2Homo sapiens, Mus musculus
P936-----------1Gallus gallus
P937RLPQPPICTID2Homo sapiens, Mus musculus
P937-----------1Gallus gallus
Q701GEAPNQALLRI1Homo sapiens
Q701-----------1Gallus gallus
Q701GEAPNQAHLRI1Mus musculus
Q791VQLITQLMPFG1Homo sapiens
Q791-----------1Gallus gallus
Q791VQLITQLMPYG1Mus musculus
Q935GERLPQPPICT2Homo sapiens, Mus musculus
Q935-----------1Gallus gallus
R776NPHVCRLLGIC2Homo sapiens, Mus musculus
R776-----------1Gallus gallus
R841RDLAARNVLVK2Homo sapiens, Mus musculus
R841-----------1Gallus gallus
R889ESILHRIYTHQ2Homo sapiens, Mus musculus
R889-----------1Gallus gallus
R932LEKGERLPQPP2Homo sapiens, Mus musculus
R932-----------1Gallus gallus
R977ARDPQRYLVIQ2Homo sapiens, Mus musculus
R977-----------1Gallus gallus
R986IQGDERMHLPS2Homo sapiens, Mus musculus
R986-----------1Gallus gallus
S720IKVLGSGAFGT2Homo sapiens, Mus musculus
S720-----------1Gallus gallus
S885WMALESILHRI2Homo sapiens, Mus musculus
S885-----------1Gallus gallus
S912LMTFGSKPYDG2Homo sapiens, Mus musculus
S912-----------1Gallus gallus
S921DGIPASEISSI1Homo sapiens
S921-----------1Gallus gallus
S921DGIPASDISSI1Mus musculus
T790TVQLITQLMPF1Homo sapiens
T790-----------1Gallus gallus
T790TVQLITQLMPY1Mus musculus
T854QHVKITDFGLA2Homo sapiens, Mus musculus
T854-----------1Gallus gallus
T909VWELMTFGSKP2Homo sapiens, Mus musculus
T909-----------1Gallus gallus
T940QPPICTIDVYM2Homo sapiens, Mus musculus
T940-----------1Gallus gallus
V726GAFGTVYKGLW2Homo sapiens, Mus musculus
V726-----------1Gallus gallus
V876AEGGKVPIKWM2Homo sapiens, Mus musculus
V876-----------1Gallus gallus
V948VYMIMVKCWMI2Homo sapiens, Mus musculus
V948-----------1Gallus gallus
V980PQRYLVIQGDE2Homo sapiens, Mus musculus
V980-----------1Gallus gallus
W880KVPIKWMALES2Homo sapiens, Mus musculus
W880-----------1Gallus gallus
W905YGVTVWELMTF2Homo sapiens, Mus musculus
W905-----------1Gallus gallus
W951IMVKCWMIDAD2Homo sapiens, Mus musculus
W951-----------1Gallus gallus
Y764ILDEAYVMASV2Homo sapiens, Mus musculus
Y764-----------1Gallus gallus
Y801GCLLDYVREHK2Homo sapiens, Mus musculus
Y801-----------1Gallus gallus
Y813NIGSQYLLNWC2Homo sapiens, Mus musculus
Y813-----------1Gallus gallus
Y915FGSKPYDGIPA2Homo sapiens, Mus musculus
Y915-----------1Gallus gallus
Y944CTIDVYMIMVK2Homo sapiens, Mus musculus
Y944-----------1Gallus gallus


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas